Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MIC19_HUMAN

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in MIC19_HUMAN
GO:0017076 purine nucleotide binding 27.8351 4 no
GO:0032555 purine ribonucleotide binding 27.8351 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.8041 4 no
GO:0046872 metal ion binding 20.6186 4 no
GO:0016462 pyrophosphatase activity 20.6186 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 20.6186 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 20.6186 6 no
GO:0019902 phosphatase binding 3.0928 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MIC19_HUMAN
GO:0006996 organelle organization 45.3608 4 yes
GO:0048522 positive regulation of cellular process 42.2680 4 no
GO:0031323 regulation of cellular metabolic process 37.1134 4 no
GO:0048523 negative regulation of cellular process 35.0515 4 no
GO:0060255 regulation of macromolecule metabolic process 32.9897 4 no
GO:0080090 regulation of primary metabolic process 32.9897 4 no
GO:0022607 cellular component assembly 31.9588 4 no
GO:0010646 regulation of cell communication 31.9588 4 no
GO:0051128 regulation of cellular component organization 31.9588 4 no
GO:0009966 regulation of signal transduction 30.9278 4 no
GO:0051171 regulation of nitrogen compound metabolic process 30.9278 4 no
GO:0009893 positive regulation of metabolic process 29.8969 4 no
GO:0061024 membrane organization 27.8351 4 yes
GO:0071702 organic substance transport 27.8351 4 no
GO:0008104 protein localization 26.8041 4 no
GO:0010941 regulation of cell death 25.7732 4 no
GO:0071705 nitrogen compound transport 25.7732 4 no
GO:0033043 regulation of organelle organization 24.7423 5 no
GO:0043067 regulation of programmed cell death 24.7423 5 no
GO:0009889 regulation of biosynthetic process 24.7423 4 no
GO:0031325 positive regulation of cellular metabolic process 23.7113 5 no
GO:0042981 regulation of apoptotic process 23.7113 6 no
GO:0010468 regulation of gene expression 23.7113 5 no
GO:0010604 positive regulation of macromolecule metabolic process 23.7113 5 no
GO:0031326 regulation of cellular biosynthetic process 23.7113 5 no
GO:0051246 regulation of protein metabolic process 22.6804 5 no
GO:0009892 negative regulation of metabolic process 22.6804 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 22.6804 5 no
GO:0048584 positive regulation of response to stimulus 21.6495 4 no
GO:1902531 regulation of intracellular signal transduction 21.6495 5 no
GO:0015031 protein transport 20.6186 4 no
GO:0010556 regulation of macromolecule biosynthetic process 20.6186 5 no
GO:0007005 mitochondrion organization 18.5567 5 yes
GO:0007006 mitochondrial membrane organization 13.4021 5 yes
GO:0007007 inner mitochondrial membrane organization 11.3402 6 yes
GO:0042407 cristae formation 7.2165 7 yes
GO:0048284 organelle fusion 4.1237 5 yes
GO:0008053 mitochondrial fusion 2.0619 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in MIC19_HUMAN
DOID:331 central nervous system disease 4.1237 3 no
DOID:574 peripheral nervous system disease 4.1237 3 no
DOID:870 neuropathy 4.1237 4 no
DOID:10595 Charcot-Marie-Tooth disease 3.0928 6 no
DOID:440 neuromuscular disease 3.0928 5 no
DOID:612 primary immunodeficiency disease 2.0619 3 no
DOID:10579 leukodystrophy 2.0619 6 no
DOID:1443 cerebral degeneration 2.0619 5 no
DOID:936 brain disease 2.0619 4 no
DOID:0050155 sensory system disease 2.0619 3 no
DOID:5614 eye disease 2.0619 4 no
DOID:0050539 Charcot-Marie-Tooth disease type 2 2.0619 7 no
DOID:1289 neurodegenerative disease 2.0619 4 no
DOID:700 mitochondrial metabolism disease 2.0619 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CHC10_HUMAN [view interactions] Low throughput no yes
S2546_HUMAN [view entry] [view interactions] Low throughput yes yes
SERA_HUMAN [view entry] [view interactions] Low throughput yes yes
CLPP_HUMAN [view interactions] Low throughput no yes
MIC25_HUMAN [view entry] [view interactions] Low throughput yes yes
MIC60_HUMAN [view entry] [view interactions] Low throughput yes yes
NT2NA_HUMAN [view interactions] High throughput no no
LZTS2_HUMAN [view interactions] High throughput no no
SPAG5_HUMAN [view interactions] High throughput no yes
RAB3I_HUMAN [view interactions] High throughput no no
FANCL_HUMAN [view interactions] High throughput no yes
GO45_HUMAN [view interactions] High throughput no yes
ADIP_HUMAN [view interactions] High throughput no yes
NT2NC_HUMAN [view interactions] High throughput no no
CEP72_HUMAN [view interactions] High throughput no yes
CRTP1_HUMAN [view interactions] High throughput no yes
NTAQ1_HUMAN [view interactions] High throughput no yes
EFHC1_HUMAN [view interactions] High throughput no yes
NTF2_HUMAN [view interactions] High throughput no yes
ENKD1_HUMAN [view interactions] High throughput no yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
C2CD6_HUMAN [view interactions] High throughput no no
ARMC7_HUMAN [view interactions] High throughput no yes
KANK2_HUMAN [view entry] [view interactions] High throughput yes yes
RBTN1_HUMAN [view interactions] High throughput no no
R3GEF_HUMAN [view interactions] High throughput no yes
WFS1_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
KAT5_HUMAN [view interactions] High throughput no yes
KR412_HUMAN [view interactions] High throughput no no
ERH_HUMAN [view interactions] High throughput no yes
SCC4_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
RAB8A_HUMAN [view entry] [view interactions] High throughput yes no
USBP1_HUMAN [view interactions] High throughput no no
COX14_HUMAN [view interactions] High throughput no yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
PLRKT_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
TOM20_HUMAN [view entry] [view interactions] High throughput yes yes
TOM22_HUMAN [view interactions] High throughput no yes
IMP2L_HUMAN [view interactions] High throughput no yes
HTRA2_HUMAN [view interactions] High throughput no yes
IMP1L_HUMAN [view interactions] High throughput no yes
LACTB_HUMAN [view interactions] High throughput no yes
OMA1_HUMAN [view interactions] High throughput no no
PARL_HUMAN [view interactions] High throughput no yes
YMEL1_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
FHI2B_HUMAN [view interactions] High throughput no yes
CCD33_HUMAN [view interactions] High throughput no no
AMOL2_HUMAN [view interactions] High throughput no no
ANS1A_HUMAN [view interactions] High throughput no yes
NUTM1_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
MIC10_HUMAN [view interactions] High throughput no yes
TFE2_HUMAN [view interactions] High throughput no no
ECT2_HUMAN [view interactions] High throughput no no
MDC1_HUMAN [view interactions] High throughput no yes
FMNL1_HUMAN [view entry] [view interactions] High throughput yes no
PAN2_HUMAN [view interactions] High throughput no no
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
GASP2_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
CUL7_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
SUZ12_HUMAN [view interactions] High throughput no no
RING2_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
DUS22_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
NUCL_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
EGLN3_HUMAN [view interactions] High throughput no no
AAR2_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
HEXI1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
MTM1_HUMAN [view interactions] High throughput no yes
PTPRM_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
ABR_HUMAN [view entry] [view interactions] High throughput yes yes
RHG20_HUMAN [view interactions] High throughput no no
RHG35_HUMAN [view interactions] High throughput no yes
RHG36_HUMAN [view interactions] High throughput no yes
ARGAL_HUMAN [view interactions] High throughput no yes
ARHG4_HUMAN [view interactions] High throughput no yes
DEP1B_HUMAN [view interactions] High throughput no yes
NGEF_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
RNF11_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
MT21E_HUMAN [view interactions] High throughput no no
DNJB8_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
PAGE4_HUMAN [view interactions] High throughput no no
TRAK1_HUMAN [view interactions] High throughput no yes
FAXC_HUMAN [view interactions] High throughput no no
MTX3_HUMAN [view interactions] High throughput no yes
TRAK2_HUMAN [view interactions] High throughput no yes
EXOC5_HUMAN [view entry] [view interactions] High throughput yes yes
CAR19_HUMAN [view interactions] High throughput no yes
SPRTN_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
FURIN_HUMAN [view interactions] High throughput no yes
IFM3_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
PDE2A_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
LMNB1_HUMAN [view entry] [view interactions] High throughput yes yes
SPRNG_HUMAN [view interactions] High throughput no yes
OTUD4_HUMAN [view interactions] High throughput no yes
SMD3_HUMAN [view interactions] High throughput no yes
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
ODP2_HUMAN [view entry] [view interactions] High throughput yes yes
ABCD1_HUMAN [view entry] [view interactions] High throughput yes no
ARMX2_HUMAN [view interactions] High throughput no yes
ATPO_HUMAN [view interactions] High throughput no yes
TBL2_HUMAN [view interactions] High throughput no no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS4_HUMAN [view interactions] High throughput no yes
PGAM5_HUMAN [view entry] [view interactions] High throughput yes yes
MIC26_HUMAN [view entry] [view interactions] High throughput yes yes
CPNE3_HUMAN [view interactions] High throughput no yes
ECI1_HUMAN [view interactions] High throughput no yes
KGD4_HUMAN [view entry] [view interactions] High throughput yes yes
UCRI_HUMAN [view entry] [view interactions] High throughput yes yes
PGM1_HUMAN [view interactions] High throughput no no
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
NDUV3_HUMAN [view interactions] High throughput no yes
SDHB_HUMAN [view interactions] High throughput no yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
IDH3A_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
TRI14_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
CC90B_HUMAN [view interactions] High throughput no yes
CLPB_HUMAN [view interactions] High throughput no yes
COX15_HUMAN [view interactions] High throughput no yes
DBLOH_HUMAN [view interactions] High throughput no no
MTCH1_HUMAN [view entry] [view interactions] High throughput yes yes
NUDT3_HUMAN [view interactions] High throughput no yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC8_HUMAN [view interactions] High throughput no yes
OPA1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
RMD3_HUMAN [view interactions] High throughput no yes
RMND1_HUMAN [view interactions] High throughput no yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
CMC1_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
S2551_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
SURF1_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
TIM29_HUMAN [view interactions] High throughput no no
ATPA_HUMAN [view interactions] High throughput no yes
TMM70_HUMAN [view interactions] High throughput no yes
CALL3_HUMAN [view interactions] High throughput no yes
SC61B_HUMAN [view interactions] High throughput no yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPF_HUMAN [view interactions] High throughput no yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
MTX2_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB5_HUMAN [view interactions] High throughput no yes
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC1_HUMAN [view interactions] High throughput no yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
DJC30_HUMAN [view interactions] High throughput no no
TOM40_HUMAN [view interactions] High throughput no yes
DNJC4_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC5_HUMAN [view interactions] High throughput no yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC7_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI29_HUMAN [view interactions] High throughput no no
B3GA1_HUMAN [view interactions] High throughput no yes
TOIP1_HUMAN [view interactions] High throughput no yes
LAMP2_HUMAN [view interactions] High throughput no yes
GOT1B_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
HERC2_HUMAN [view interactions] High throughput no yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
ADCK1_HUMAN [view interactions] High throughput no no
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
MIC27_HUMAN [view entry] [view interactions] High throughput yes yes
TM11B_HUMAN [view interactions] High throughput no no
NMES1_HUMAN [view interactions] High throughput no no
DDX6_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
NDUF4_HUMAN [view interactions] High throughput no yes
OCAD1_HUMAN [view interactions] High throughput no yes
OPA3_HUMAN [view interactions] High throughput no yes
MIC13_HUMAN [view interactions] High throughput no yes
ADCK5_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
FA13B_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
VCAM1_HUMAN [view interactions] High throughput no no
COQ2_HUMAN [view interactions] High throughput no yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
SDHA_HUMAN [view interactions] High throughput no yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
CLCN3_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
MYO5C_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC4_HUMAN [view interactions] High throughput no yes
TR64C_HUMAN [view interactions] High throughput no no
PRC1_HUMAN [view interactions] High throughput no yes
RGL3_HUMAN [view interactions] High throughput no yes
ATG2A_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
CC85B_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
TBCK_HUMAN [view interactions] High throughput no yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
KCNQ1_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
EGLN_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
TRI27_HUMAN [view interactions] High throughput no yes
TRAF1_HUMAN [view interactions] High throughput no no
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
K1C40_HUMAN [view interactions] High throughput no no
MYOME_HUMAN [view interactions] High throughput no no
CACO2_HUMAN [view interactions] High throughput no yes
RPGR1_HUMAN [view interactions] High throughput no no
GMCL2_HUMAN [view interactions] High throughput no yes
CBY2_HUMAN [view interactions] High throughput no no
MTX1_HUMAN [view entry] [view interactions] Computational yes yes
COX19_HUMAN [view interactions] Computational no yes
COX17_HUMAN [view interactions] Computational no yes
COA4_HUMAN [view interactions] Computational no yes
MFN1_HUMAN [view interactions] Computational no yes
CMC4_HUMAN [view interactions] Computational no yes
COA6_HUMAN [view interactions] Computational no yes
TOM70_HUMAN [view interactions] Computational no yes
CHCH2_HUMAN [view interactions] Computational no yes
GRP75_HUMAN [view entry] [view interactions] Computational yes yes
MIA40_HUMAN [view interactions] Computational no yes
CHCH5_HUMAN [view interactions] Computational no yes
ALR_HUMAN [view interactions] Computational no yes
TIM13_HUMAN [view interactions] Computational no yes
CHCH7_HUMAN [view interactions] Computational no yes
NDUBA_HUMAN [view entry] [view interactions] Computational yes yes
COXM2_HUMAN [view interactions] Computational no yes
TIM8A_HUMAN [view interactions] Computational no yes