Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PGAM5_HUMAN

Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. [View more on UniProt]

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ELM instance Name Type Start End Partner
ELMI002824 DEG_Kelch_Keap1_1 DEG 77 82 -

Molecular function

Term Name % Distance from the top of the tree Annotated in PGAM5_HUMAN
GO:0046872 metal ion binding 25.0000 4 no
GO:0003723 RNA binding 22.9167 4 no
GO:0017076 purine nucleotide binding 22.9167 4 no
GO:0032555 purine ribonucleotide binding 22.9167 4 no
GO:0035639 purine ribonucleoside triphosphate binding 20.8333 4 no
GO:0045296 cadherin binding 20.8333 4 no
GO:0004722 protein serine/threonine phosphatase activity 6.2500 4 yes
GO:0005096 GTPase activator activity 6.2500 4 yes
GO:0016791 phosphatase activity 6.2500 5 yes
GO:0030695 GTPase regulator activity 6.2500 4 yes
GO:0042578 phosphoric ester hydrolase activity 6.2500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PGAM5_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0048523 negative regulation of cellular process 58.3333 4 no
GO:0051128 regulation of cellular component organization 52.0833 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0006996 organelle organization 47.9167 4 no
GO:0051171 regulation of nitrogen compound metabolic process 45.8333 4 no
GO:0080090 regulation of primary metabolic process 45.8333 4 no
GO:0010646 regulation of cell communication 41.6667 4 no
GO:0009966 regulation of signal transduction 39.5833 4 no
GO:0051246 regulation of protein metabolic process 39.5833 5 no
GO:0033043 regulation of organelle organization 37.5000 5 yes
GO:0010468 regulation of gene expression 37.5000 5 no
GO:0009892 negative regulation of metabolic process 35.4167 4 yes
GO:0009893 positive regulation of metabolic process 35.4167 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.4167 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 35.4167 5 no
GO:0008104 protein localization 35.4167 4 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0036211 protein modification process 31.2500 4 yes
GO:0043412 macromolecule modification 31.2500 4 yes
GO:0042127 regulation of cell population proliferation 31.2500 4 no
GO:0010941 regulation of cell death 31.2500 4 no
GO:0051247 positive regulation of protein metabolic process 31.2500 6 no
GO:0051130 positive regulation of cellular component organization 29.1667 5 yes
GO:0071702 organic substance transport 29.1667 4 no
GO:0009889 regulation of biosynthetic process 29.1667 4 no
GO:0010556 regulation of macromolecule biosynthetic process 29.1667 5 no
GO:0010605 negative regulation of macromolecule metabolic process 29.1667 5 no
GO:0010648 negative regulation of cell communication 29.1667 5 no
GO:0023057 negative regulation of signaling 29.1667 4 no
GO:0031326 regulation of cellular biosynthetic process 29.1667 5 no
GO:0042981 regulation of apoptotic process 29.1667 6 no
GO:0043067 regulation of programmed cell death 29.1667 5 no
GO:0051252 regulation of RNA metabolic process 29.1667 5 no
GO:0022607 cellular component assembly 29.1667 4 no
GO:0006355 regulation of DNA-templated transcription 27.0833 6 no
GO:0009968 negative regulation of signal transduction 27.0833 5 no
GO:0031325 positive regulation of cellular metabolic process 27.0833 5 no
GO:0031399 regulation of protein modification process 27.0833 6 no
GO:0048584 positive regulation of response to stimulus 27.0833 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 27.0833 5 no
GO:1902531 regulation of intracellular signal transduction 27.0833 5 no
GO:1903506 regulation of nucleic acid-templated transcription 27.0833 7 no
GO:2001141 regulation of RNA biosynthetic process 27.0833 6 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 yes
GO:0051094 positive regulation of developmental process 25.0000 4 yes
GO:0051049 regulation of transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0051493 regulation of cytoskeleton organization 25.0000 6 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 22.9167 4 yes
GO:0007010 cytoskeleton organization 22.9167 5 no
GO:0033365 protein localization to organelle 22.9167 5 no
GO:0044087 regulation of cellular component biogenesis 22.9167 4 no
GO:0009057 macromolecule catabolic process 22.9167 4 no
GO:0044265 cellular macromolecule catabolic process 22.9167 4 no
GO:0010638 positive regulation of organelle organization 20.8333 6 yes
GO:0008285 negative regulation of cell population proliferation 20.8333 5 no
GO:0010628 positive regulation of gene expression 20.8333 6 no
GO:0051248 negative regulation of protein metabolic process 20.8333 6 no
GO:0071310 cellular response to organic substance 20.8333 4 no
GO:0051129 negative regulation of cellular component organization 20.8333 5 no
GO:0060548 negative regulation of cell death 20.8333 5 no
GO:0080134 regulation of response to stress 20.8333 4 no
GO:1902903 regulation of supramolecular fiber organization 20.8333 5 no
GO:0031329 regulation of cellular catabolic process 20.8333 5 no
GO:0051726 regulation of cell cycle 20.8333 4 no
GO:0051241 negative regulation of multicellular organismal process 14.5833 4 yes
GO:0010821 regulation of mitochondrion organization 12.5000 6 yes
GO:0016236 macroautophagy 12.5000 4 yes
GO:0010822 positive regulation of mitochondrion organization 8.3333 7 yes
GO:0070266 necroptotic process 8.3333 5 yes
GO:0090140 regulation of mitochondrial fission 8.3333 5 yes
GO:0090141 positive regulation of mitochondrial fission 8.3333 5 yes
GO:0097300 programmed necrotic cell death 8.3333 4 yes
GO:0006470 protein dephosphorylation 6.2500 5 yes
GO:0016311 dephosphorylation 6.2500 5 yes
GO:0035970 peptidyl-threonine dephosphorylation 4.1667 6 yes
GO:0120163 negative regulation of cold-induced thermogenesis 4.1667 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in PGAM5_HUMAN
DOID:574 peripheral nervous system disease 6.2500 3 no
DOID:870 neuropathy 6.2500 4 no
DOID:10595 Charcot-Marie-Tooth disease 4.1667 6 no
DOID:440 neuromuscular disease 4.1667 5 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PINK1_HUMAN [view interactions] Low throughput no yes
NF2L2_HUMAN [view interactions] Low throughput no yes
BIRC2_HUMAN [view interactions] Low throughput no yes
XIAP_HUMAN [view interactions] Low throughput no yes
PGAM5_HUMAN [view entry] [view interactions] Low throughput yes yes
PHB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PHB2_HUMAN [view entry] [view interactions] Low throughput yes yes
RNF5_HUMAN [view interactions] Low throughput no yes
KEAP1_HUMAN [view interactions] Low throughput no yes
RIPK3_HUMAN [view interactions] Low throughput no no
M3K5_HUMAN [view interactions] Low throughput no yes
MAVS_HUMAN [view interactions] Low throughput no yes
CUL3_HUMAN [view entry] [view interactions] Low throughput yes yes
B2CL1_HUMAN [view interactions] Low throughput no yes
RBX1_HUMAN [view entry] [view interactions] Low throughput yes no
ICT1_HUMAN [view interactions] High throughput no yes
HDAC5_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
BARD1_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
MDC1_HUMAN [view interactions] High throughput no yes
PAXI1_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ASB3_HUMAN [view interactions] High throughput no yes
ASB10_HUMAN [view interactions] High throughput no no
ASB14_HUMAN [view interactions] High throughput no no
ASB18_HUMAN [view interactions] High throughput no no
HAUS1_HUMAN [view interactions] High throughput no yes
STB5L_HUMAN [view interactions] High throughput no no
HUWE1_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
SUZ12_HUMAN [view interactions] High throughput no no
RING2_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
GLI1_HUMAN [view interactions] High throughput no no
MERL_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
NKX21_HUMAN [view interactions] High throughput no no
ZN746_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
CLC14_HUMAN [view interactions] High throughput no yes
ZN598_HUMAN [view interactions] High throughput no no
DPOD1_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
RMD5A_HUMAN [view interactions] High throughput no yes
LAP2A_HUMAN [view interactions] High throughput no yes
PRP8_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
SOCS6_HUMAN [view interactions] High throughput no yes
SHRPN_HUMAN [view entry] [view interactions] High throughput yes yes
CHD3_HUMAN [view interactions] High throughput no yes
RNF31_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
MEPCE_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
HABP4_HUMAN [view interactions] High throughput no yes
PAIRB_HUMAN [view interactions] High throughput no yes
DCPS_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
TFE3_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
ATX3_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
RU17_HUMAN [view interactions] High throughput no yes
MTMR4_HUMAN [view interactions] High throughput no no
CLUA1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
NFX1_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no
BRD7_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
SNIP1_HUMAN [view interactions] High throughput no no
ANR55_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
BRD8_HUMAN [view interactions] High throughput no yes
BRD9_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
NINL_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CIC_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
F16P1_HUMAN [view interactions] High throughput no no
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB8_HUMAN [view interactions] High throughput no no
PO2F1_HUMAN [view interactions] High throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
FZR1_HUMAN [view interactions] High throughput no no
PAGE4_HUMAN [view interactions] High throughput no no
EDEM1_HUMAN [view interactions] High throughput no yes
ZBTB2_HUMAN [view interactions] High throughput no yes
SPRTN_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
HECD1_HUMAN [view interactions] High throughput no yes
BRD3_HUMAN [view interactions] High throughput no yes
LC7L2_HUMAN [view interactions] High throughput no yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
UBE4B_HUMAN [view interactions] High throughput no yes
A16A1_HUMAN [view entry] [view interactions] High throughput yes no
DHB4_HUMAN [view entry] [view interactions] High throughput yes yes
ILF3_HUMAN [view interactions] High throughput no yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
COR1B_HUMAN [view entry] [view interactions] High throughput yes no
EMC7_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
PKP2_HUMAN [view interactions] High throughput no yes
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
COIA1_HUMAN [view interactions] High throughput no no
DJC10_HUMAN [view interactions] High throughput no yes
GALT2_HUMAN [view interactions] High throughput no yes
FUBP2_HUMAN [view interactions] High throughput no yes
KTN1_HUMAN [view entry] [view interactions] High throughput yes yes
EMC5_HUMAN [view interactions] High throughput no yes
RNS10_HUMAN [view interactions] High throughput no no
UBXN4_HUMAN [view interactions] High throughput no yes
MGN2_HUMAN [view interactions] High throughput no yes
MLKL_HUMAN [view interactions] High throughput no no
EXPH5_HUMAN [view interactions] High throughput no no
Z3H7A_HUMAN [view interactions] High throughput no no
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
ERF1_HUMAN [view interactions] High throughput no yes
DBLOH_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
CP135_HUMAN [view interactions] High throughput no no
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
NDC80_HUMAN [view interactions] High throughput no no
RPB3_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
AGO4_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SLX4_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
UBP11_HUMAN [view interactions] High throughput no yes
OSB10_HUMAN [view interactions] High throughput no no
FTM_HUMAN [view interactions] High throughput no yes
MGN_HUMAN [view interactions] High throughput no yes
IF4A3_HUMAN [view entry] [view interactions] High throughput yes yes
STRN_HUMAN [view entry] [view interactions] High throughput yes yes
STRN3_HUMAN [view interactions] High throughput no yes
TTL12_HUMAN [view interactions] High throughput no yes
RBM8A_HUMAN [view interactions] High throughput no yes
CD2AP_HUMAN [view interactions] High throughput no no
MYH7B_HUMAN [view interactions] High throughput no no
OSGEP_HUMAN [view interactions] High throughput no yes
ZSC26_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
TMED2_HUMAN [view interactions] High throughput no yes
SMC1A_HUMAN [view interactions] High throughput no yes
TBA1C_HUMAN [view interactions] High throughput no yes
RRP1B_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
NEK4_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
SH3L1_HUMAN [view interactions] High throughput no yes
FGR_HUMAN [view interactions] High throughput no no
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
PAXI_HUMAN [view interactions] High throughput no yes
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
HCK_HUMAN [view entry] [view interactions] High throughput yes no
BLK_HUMAN [view interactions] High throughput no no
NDKA_HUMAN [view entry] [view interactions] High throughput yes yes
VAV_HUMAN [view interactions] High throughput no no
KS6A3_HUMAN [view entry] [view interactions] High throughput yes yes
MIA40_HUMAN [view interactions] High throughput no yes
NCBP3_HUMAN [view interactions] High throughput no yes
NCBP1_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
T2FB_HUMAN [view interactions] High throughput no yes
LRC8E_HUMAN [view interactions] High throughput no no
MICA3_HUMAN [view interactions] High throughput no yes
TNS2_HUMAN [view interactions] High throughput no no
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view interactions] High throughput no yes
SCRB2_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
ESR1_HUMAN [view interactions] High throughput no no
SP7_HUMAN [view interactions] High throughput no no
KLF16_HUMAN [view interactions] High throughput no yes
SOX6_HUMAN [view interactions] High throughput no yes
RNPS1_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
MYOME_HUMAN [view interactions] High throughput no no
LITD1_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
CNDD3_HUMAN [view interactions] High throughput no no
ZBT16_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
SETB1_HUMAN [view interactions] High throughput no yes
TOP3A_HUMAN [view interactions] High throughput no yes
MD2L2_HUMAN [view interactions] High throughput no yes
HDGF_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
CUL4B_HUMAN [view interactions] High throughput no yes
ASXL1_HUMAN [view interactions] High throughput no no
BAP1_HUMAN [view interactions] High throughput no yes
KATIP_HUMAN [view interactions] High throughput no yes
PHS_HUMAN [view interactions] High throughput no yes
ZO2_HUMAN [view entry] [view interactions] High throughput yes no
RON_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
FUND1_HUMAN [view interactions] Computational no yes
DNM1L_HUMAN [view entry] [view interactions] Computational yes yes
RIPK1_HUMAN [view interactions] Computational no yes