SHRPN_HUMAN
Evidence for PS localization
Functions
Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SHRPN_HUMAN |
|---|---|---|---|---|
| GO:0031625 | ubiquitin protein ligase binding | 24.1379 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 24.1379 | 4 | no |
| GO:0043169 | cation binding | 22.4138 | 4 | yes |
| GO:0046872 | metal ion binding | 22.4138 | 5 | yes |
| GO:0019900 | kinase binding | 20.6897 | 4 | no |
| GO:0016755 | aminoacyltransferase activity | 15.5172 | 4 | yes |
| GO:0004842 | ubiquitin-protein transferase activity | 13.7931 | 4 | yes |
| GO:0043130 | ubiquitin binding | 6.8966 | 4 | yes |
| GO:0031593 | polyubiquitin modification-dependent protein binding | 5.1724 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SHRPN_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.5172 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 53.4483 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 53.4483 | 4 | no |
| GO:0010646 | regulation of cell communication | 48.2759 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 48.2759 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.2759 | 4 | no |
| GO:0009966 | regulation of signal transduction | 44.8276 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 43.1034 | 4 | no |
| GO:0022607 | cellular component assembly | 43.1034 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 43.1034 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.6552 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 39.6552 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 37.9310 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 37.9310 | 4 | no |
| GO:0010468 | regulation of gene expression | 37.9310 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 37.9310 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 37.9310 | 5 | no |
| GO:0006996 | organelle organization | 36.2069 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 34.4828 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 34.4828 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 32.7586 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 32.7586 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 32.7586 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 32.7586 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 32.7586 | 4 | no |
| GO:0036211 | protein modification process | 31.0345 | 4 | yes |
| GO:0043412 | macromolecule modification | 31.0345 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 31.0345 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.0345 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 31.0345 | 6 | no |
| GO:0009894 | regulation of catabolic process | 31.0345 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 29.3103 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 29.3103 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 29.3103 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 29.3103 | 6 | no |
| GO:0043933 | protein-containing complex organization | 29.3103 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 29.3103 | 4 | no |
| GO:0080134 | regulation of response to stress | 27.5862 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 27.5862 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 27.5862 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.5862 | 5 | no |
| GO:0031399 | regulation of protein modification process | 27.5862 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 27.5862 | 5 | no |
| GO:0006508 | proteolysis | 25.8621 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 25.8621 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.8621 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.8621 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.8621 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 25.8621 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 25.8621 | 4 | no |
| GO:0019941 | modification-dependent protein catabolic process | 24.1379 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 24.1379 | 5 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 24.1379 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 24.1379 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 24.1379 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.1379 | 6 | no |
| GO:0008104 | protein localization | 24.1379 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 24.1379 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 24.1379 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 24.1379 | 6 | no |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 22.4138 | 7 | yes |
| GO:0030163 | protein catabolic process | 22.4138 | 4 | yes |
| GO:0051049 | regulation of transport | 22.4138 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 22.4138 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 22.4138 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 22.4138 | 5 | no |
| GO:0060284 | regulation of cell development | 22.4138 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 22.4138 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 22.4138 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.4138 | 4 | no |
| GO:0023057 | negative regulation of signaling | 22.4138 | 4 | no |
| GO:0010498 | proteasomal protein catabolic process | 20.6897 | 5 | yes |
| GO:0043687 | post-translational protein modification | 20.6897 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 20.6897 | 6 | yes |
| GO:0010628 | positive regulation of gene expression | 20.6897 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.6897 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 20.6897 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.6897 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.6897 | 4 | no |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 18.9655 | 6 | yes |
| GO:0016567 | protein ubiquitination | 17.2414 | 8 | yes |
| GO:0032101 | regulation of response to external stimulus | 17.2414 | 4 | yes |
| GO:0032446 | protein modification by small protein conjugation | 17.2414 | 7 | yes |
| GO:0000209 | protein polyubiquitination | 13.7931 | 9 | yes |
| GO:0031347 | regulation of defense response | 13.7931 | 5 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 12.0690 | 6 | yes |
| GO:0022411 | cellular component disassembly | 10.3448 | 4 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 10.3448 | 5 | yes |
| GO:0031348 | negative regulation of defense response | 8.6207 | 5 | yes |
| GO:0043122 | regulation of canonical NF-kappaB signal transduction | 8.6207 | 6 | yes |
| GO:0050727 | regulation of inflammatory response | 8.6207 | 5 | yes |
| GO:0050728 | negative regulation of inflammatory response | 8.6207 | 6 | yes |
| GO:0007005 | mitochondrion organization | 6.8966 | 5 | yes |
| GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 6.8966 | 7 | yes |
| GO:0001959 | regulation of cytokine-mediated signaling pathway | 5.1724 | 5 | yes |
| GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway | 5.1724 | 6 | yes |
| GO:0060759 | regulation of response to cytokine stimulus | 5.1724 | 4 | yes |
| GO:0006921 | cellular component disassembly involved in execution phase of apoptosis | 3.4483 | 5 | yes |
| GO:0030262 | apoptotic nuclear changes | 3.4483 | 6 | yes |
| GO:0042742 | defense response to bacterium | 3.4483 | 4 | yes |
| GO:0097039 | protein linear polyubiquitination | 3.4483 | 10 | yes |
| GO:2000348 | regulation of CD40 signaling pathway | 3.4483 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SHAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EYA1_HUMAN | [view interactions] | Low throughput | no | no |
| EYA2_HUMAN | [view interactions] | Low throughput | no | yes |
| RNF31_HUMAN | [view interactions] | Low throughput | no | yes |
| SHRPN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITA5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TNFA_HUMAN | [view interactions] | Low throughput | no | no |
| TNAP3_HUMAN | [view interactions] | Low throughput | no | yes |
| HOIL1_HUMAN | [view interactions] | Low throughput | no | no |
| NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
| NOD2_HUMAN | [view interactions] | Low throughput | no | yes |
| ITA2_HUMAN | [view interactions] | Low throughput | no | yes |
| ITA1_HUMAN | [view interactions] | Low throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IL1A_HUMAN | [view interactions] | Low throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTEN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OTUL_HUMAN | [view interactions] | Low throughput | no | yes |
| TNR1A_HUMAN | [view interactions] | Low throughput | no | yes |
| ITAL_HUMAN | [view interactions] | Low throughput | no | no |
| TRAF1_HUMAN | [view interactions] | Low throughput | no | no |
| PDLI7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MDM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| ANM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SKI_HUMAN | [view interactions] | Low throughput | no | yes |
| ARP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP20_HUMAN | [view interactions] | Low throughput | no | yes |
| ITA2B_HUMAN | [view interactions] | Low throughput | no | no |
| CASP1_HUMAN | [view interactions] | Low throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VHL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNF11_HUMAN | [view interactions] | Low throughput | no | no |
| GPX4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| YAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| ITB2_HUMAN | [view interactions] | Low throughput | no | no |
| PPIL3_HUMAN | [view interactions] | Low throughput | no | yes |
| ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHAN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITAM_HUMAN | [view interactions] | Low throughput | no | no |
| ITAD_HUMAN | [view interactions] | Low throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| THIOM_HUMAN | [view interactions] | High throughput | no | yes |
| AP2C_HUMAN | [view interactions] | High throughput | no | no |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNR3_HUMAN | [view interactions] | High throughput | no | yes |
| LIPF_HUMAN | [view interactions] | High throughput | no | no |
| GRIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| BIRC2_HUMAN | [view interactions] | High throughput | no | yes |
| MALT1_HUMAN | [view interactions] | High throughput | no | no |
| BCL10_HUMAN | [view interactions] | High throughput | no | yes |
| IKKA_HUMAN | [view interactions] | High throughput | no | yes |
| IKKB_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| MOXD1_HUMAN | [view interactions] | High throughput | no | no |
| NCS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAB1_HUMAN | [view interactions] | High throughput | no | yes |
| TEN3_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR_HUMAN | [view interactions] | High throughput | no | yes |
| TAB2_HUMAN | [view interactions] | High throughput | no | yes |
| ULK3_HUMAN | [view interactions] | High throughput | no | yes |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEM4G_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| ULBP3_HUMAN | [view interactions] | High throughput | no | yes |
| HPRT_HUMAN | [view interactions] | High throughput | no | yes |
| RTL6_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN4_HUMAN | [view interactions] | High throughput | no | no |
| PDPN_HUMAN | [view interactions] | High throughput | no | no |
| MEAK7_HUMAN | [view interactions] | High throughput | no | yes |
| VP37D_HUMAN | [view interactions] | High throughput | no | no |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZD7_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM1_HUMAN | [view interactions] | High throughput | no | yes |
| S1PR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UEVLD_HUMAN | [view interactions] | High throughput | no | yes |
| UMAD1_HUMAN | [view interactions] | High throughput | no | yes |
| ZCHC3_HUMAN | [view interactions] | High throughput | no | no |
| OTU1_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT32_HUMAN | [view interactions] | High throughput | no | yes |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| UBP54_HUMAN | [view interactions] | High throughput | no | yes |
| KRA62_HUMAN | [view interactions] | High throughput | no | no |
| KRA71_HUMAN | [view interactions] | High throughput | no | no |
| FYB1_HUMAN | [view interactions] | High throughput | no | no |
| SCNBA_HUMAN | [view interactions] | High throughput | no | no |
| ZN106_HUMAN | [view interactions] | High throughput | no | no |
| STK24_HUMAN | [view interactions] | High throughput | no | yes |
| CUX1_HUMAN | [view interactions] | High throughput | no | yes |
| TEKT4_HUMAN | [view interactions] | High throughput | no | no |
| ASAP2_HUMAN | [view interactions] | High throughput | no | yes |
| CEBPA_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PACA_HUMAN | [view interactions] | High throughput | no | no |
| BRE1A_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SURF6_HUMAN | [view interactions] | High throughput | no | yes |
| CAN13_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLR3_HUMAN | [view interactions] | High throughput | no | yes |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
| SPAT2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR82_HUMAN | [view interactions] | High throughput | no | no |
| UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSNAX_HUMAN | [view interactions] | High throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIGAR_HUMAN | [view interactions] | High throughput | no | yes |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN114_HUMAN | [view interactions] | High throughput | no | no |
| RL23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
| PSD13_HUMAN | [view interactions] | High throughput | no | yes |
| PSD12_HUMAN | [view interactions] | High throughput | no | yes |
| PSB3_HUMAN | [view interactions] | High throughput | no | yes |
| PSB2_HUMAN | [view interactions] | High throughput | no | yes |
| PSA7_HUMAN | [view interactions] | High throughput | no | yes |
| PSA6_HUMAN | [view interactions] | High throughput | no | yes |
| PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDC1_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGTB2_HUMAN | [view interactions] | High throughput | no | yes |
| PGAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| NANP_HUMAN | [view interactions] | High throughput | no | no |
| NAA10_HUMAN | [view interactions] | High throughput | no | yes |
| METH_HUMAN | [view interactions] | High throughput | no | yes |
| M2OM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GET4_HUMAN | [view interactions] | High throughput | no | yes |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| DECR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCA12_HUMAN | [view interactions] | High throughput | no | yes |
| STEEP_HUMAN | [view interactions] | High throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCHL_HUMAN | [view interactions] | High throughput | no | yes |
| CBR3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARPC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| ADIPO_HUMAN | [view interactions] | High throughput | no | no |
| GFRP_HUMAN | [view interactions] | High throughput | no | no |
| F91A1_HUMAN | [view interactions] | High throughput | no | yes |
| SATB2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI65_HUMAN | [view interactions] | High throughput | no | yes |
| MIOS_HUMAN | [view interactions] | High throughput | no | yes |
| O52N5_HUMAN | [view interactions] | High throughput | no | no |
| IF4G3_HUMAN | [view interactions] | High throughput | no | yes |
| CSRN1_HUMAN | [view interactions] | High throughput | no | no |
| MTA70_HUMAN | [view interactions] | High throughput | no | no |
| DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN703_HUMAN | [view interactions] | High throughput | no | yes |
| O52N4_HUMAN | [view interactions] | High throughput | no | no |
| HIPK1_HUMAN | [view interactions] | High throughput | no | no |
| MED12_HUMAN | [view interactions] | High throughput | no | yes |
| ZN609_HUMAN | [view interactions] | High throughput | no | yes |
| ZN507_HUMAN | [view interactions] | High throughput | no | no |
| BCOR_HUMAN | [view interactions] | High throughput | no | no |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| WDR11_HUMAN | [view interactions] | High throughput | no | yes |
| NIT1_HUMAN | [view interactions] | High throughput | no | yes |
| SAM11_HUMAN | [view interactions] | High throughput | no | no |
| ARNT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX2_HUMAN | [view interactions] | High throughput | no | yes |
| TCAB1_HUMAN | [view interactions] | High throughput | no | yes |
| PRI2_HUMAN | [view interactions] | High throughput | no | no |
| TCAF1_HUMAN | [view interactions] | High throughput | no | no |
| QRIC1_HUMAN | [view interactions] | High throughput | no | yes |
| C19L1_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| LAR4B_HUMAN | [view interactions] | High throughput | no | yes |
| NISCH_HUMAN | [view interactions] | High throughput | no | yes |
| RD23A_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTC1_HUMAN | [view interactions] | High throughput | no | no |
| GSE1_HUMAN | [view interactions] | High throughput | no | yes |
| TBB8_HUMAN | [view interactions] | High throughput | no | no |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| ATG12_HUMAN | [view interactions] | High throughput | no | yes |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |