Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SHRPN_HUMAN

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SHRPN_HUMAN
GO:0046872 metal ion binding 19.2308 4 yes
GO:0004842 ubiquitin-protein transferase activity 9.6154 4 yes
GO:0031593 polyubiquitin modification-dependent protein binding 5.7692 4 yes
GO:0043130 ubiquitin binding 5.7692 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SHRPN_HUMAN
GO:0048522 positive regulation of cellular process 63.4615 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 48.0769 4 no
GO:0060255 regulation of macromolecule metabolic process 48.0769 4 no
GO:0080090 regulation of primary metabolic process 48.0769 4 no
GO:0031323 regulation of cellular metabolic process 44.2308 4 no
GO:0048523 negative regulation of cellular process 44.2308 4 no
GO:0010646 regulation of cell communication 42.3077 4 yes
GO:0009966 regulation of signal transduction 40.3846 4 yes
GO:0051128 regulation of cellular component organization 40.3846 4 no
GO:0048584 positive regulation of response to stimulus 38.4615 4 yes
GO:0009893 positive regulation of metabolic process 36.5385 4 no
GO:0010647 positive regulation of cell communication 34.6154 5 yes
GO:0023056 positive regulation of signaling 34.6154 4 yes
GO:0051246 regulation of protein metabolic process 34.6154 5 no
GO:0010468 regulation of gene expression 32.6923 5 no
GO:0010604 positive regulation of macromolecule metabolic process 32.6923 5 no
GO:0051094 positive regulation of developmental process 32.6923 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 32.6923 5 no
GO:0006996 organelle organization 30.7692 4 yes
GO:0009967 positive regulation of signal transduction 30.7692 5 yes
GO:0036211 protein modification process 30.7692 4 yes
GO:0043412 macromolecule modification 30.7692 4 yes
GO:0009889 regulation of biosynthetic process 30.7692 4 no
GO:0010556 regulation of macromolecule biosynthetic process 30.7692 5 no
GO:0031326 regulation of cellular biosynthetic process 30.7692 5 no
GO:0010941 regulation of cell death 28.8462 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.8462 5 no
GO:0031325 positive regulation of cellular metabolic process 28.8462 5 no
GO:0042981 regulation of apoptotic process 28.8462 6 no
GO:0043067 regulation of programmed cell death 28.8462 5 no
GO:0022607 cellular component assembly 28.8462 4 no
GO:0009892 negative regulation of metabolic process 26.9231 4 no
GO:0051252 regulation of RNA metabolic process 26.9231 5 no
GO:0009894 regulation of catabolic process 26.9231 4 no
GO:0031344 regulation of cell projection organization 26.9231 5 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 yes
GO:1902531 regulation of intracellular signal transduction 25.0000 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0006508 proteolysis 23.0769 4 yes
GO:0009057 macromolecule catabolic process 23.0769 4 yes
GO:0080134 regulation of response to stress 23.0769 4 yes
GO:0006355 regulation of DNA-templated transcription 23.0769 6 no
GO:0010648 negative regulation of cell communication 23.0769 5 no
GO:0023057 negative regulation of signaling 23.0769 4 no
GO:0045595 regulation of cell differentiation 23.0769 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 23.0769 5 no
GO:1903506 regulation of nucleic acid-templated transcription 23.0769 7 no
GO:2001141 regulation of RNA biosynthetic process 23.0769 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.0769 6 no
GO:0008104 protein localization 23.0769 4 no
GO:0051049 regulation of transport 23.0769 4 no
GO:0019941 modification-dependent protein catabolic process 21.1538 6 yes
GO:0043632 modification-dependent macromolecule catabolic process 21.1538 5 yes
GO:0044265 cellular macromolecule catabolic process 21.1538 4 yes
GO:0051603 proteolysis involved in protein catabolic process 21.1538 5 yes
GO:0009968 negative regulation of signal transduction 21.1538 5 no
GO:0031324 negative regulation of cellular metabolic process 21.1538 5 no
GO:0043066 negative regulation of apoptotic process 21.1538 7 no
GO:0043069 negative regulation of programmed cell death 21.1538 6 no
GO:0060548 negative regulation of cell death 21.1538 5 no
GO:0031329 regulation of cellular catabolic process 21.1538 5 no
GO:0006511 ubiquitin-dependent protein catabolic process 19.2308 7 yes
GO:0030163 protein catabolic process 17.3077 4 yes
GO:0070647 protein modification by small protein conjugation or removal 17.3077 5 yes
GO:1901565 organonitrogen compound catabolic process 17.3077 4 yes
GO:0010498 proteasomal protein catabolic process 15.3846 5 yes
GO:0016567 protein ubiquitination 13.4615 7 yes
GO:0032446 protein modification by small protein conjugation 13.4615 6 yes
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 13.4615 6 yes
GO:1902533 positive regulation of intracellular signal transduction 13.4615 6 yes
GO:0022411 cellular component disassembly 11.5385 4 yes
GO:0000209 protein polyubiquitination 9.6154 8 yes
GO:0007420 brain development 9.6154 4 yes
GO:0032101 regulation of response to external stimulus 9.6154 4 yes
GO:0007005 mitochondrion organization 7.6923 5 yes
GO:0031347 regulation of defense response 7.6923 5 yes
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 7.6923 6 yes
GO:0001959 regulation of cytokine-mediated signaling pathway 5.7692 5 yes
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 5.7692 6 yes
GO:0032102 negative regulation of response to external stimulus 5.7692 5 yes
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 5.7692 7 yes
GO:0050727 regulation of inflammatory response 5.7692 5 yes
GO:0060759 regulation of response to cytokine stimulus 5.7692 4 yes
GO:0006921 cellular component disassembly involved in execution phase of apoptosis 3.8462 5 yes
GO:0030262 apoptotic nuclear changes 3.8462 6 yes
GO:0031348 negative regulation of defense response 3.8462 5 yes
GO:0042742 defense response to bacterium 3.8462 4 yes
GO:0050728 negative regulation of inflammatory response 3.8462 6 yes
GO:0097039 protein linear polyubiquitination 3.8462 9 yes
GO:2000348 regulation of CD40 signaling pathway 3.8462 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in SHRPN_HUMAN
DOID:0050686 organ system cancer 3.8462 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PTEN_HUMAN [view entry] [view interactions] Low throughput yes yes
OTUL_HUMAN [view interactions] Low throughput no yes
TNR1A_HUMAN [view interactions] Low throughput no yes
ITAL_HUMAN [view interactions] Low throughput no no
TRAF1_HUMAN [view interactions] Low throughput no no
PDLI7_HUMAN [view entry] [view interactions] Low throughput yes no
MDM2_HUMAN [view interactions] Low throughput no yes
ESR1_HUMAN [view interactions] Low throughput no no
ANM5_HUMAN [view entry] [view interactions] Low throughput yes yes
SKI_HUMAN [view interactions] Low throughput no yes
ARP2_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP20_HUMAN [view interactions] Low throughput no yes
ITA2B_HUMAN [view interactions] Low throughput no no
CASP1_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
VHL_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB2_HUMAN [view interactions] Low throughput no no
PPIL3_HUMAN [view interactions] Low throughput no yes
ARP3_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN2_HUMAN [view entry] [view interactions] Low throughput yes yes
ITAM_HUMAN [view interactions] Low throughput no no
ITAD_HUMAN [view interactions] Low throughput no no
HD_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN1_HUMAN [view entry] [view interactions] Low throughput yes yes
EYA1_HUMAN [view interactions] Low throughput no no
EYA2_HUMAN [view interactions] Low throughput no yes
RNF31_HUMAN [view interactions] Low throughput no yes
SHRPN_HUMAN [view entry] [view interactions] Low throughput yes yes
ITA5_HUMAN [view entry] [view interactions] Low throughput yes no
TNFA_HUMAN [view interactions] Low throughput no no
TNAP3_HUMAN [view interactions] Low throughput no yes
HOIL1_HUMAN [view interactions] Low throughput no no
NEMO_HUMAN [view interactions] Low throughput no yes
NOD2_HUMAN [view interactions] Low throughput no yes
ITA1_HUMAN [view interactions] Low throughput no yes
ITA2_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
IL1A_HUMAN [view interactions] Low throughput no no
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
TRAF3_HUMAN [view entry] [view interactions] High throughput yes yes
TEN3_HUMAN [view interactions] High throughput no yes
TAB1_HUMAN [view interactions] High throughput no yes
NCS1_HUMAN [view entry] [view interactions] High throughput yes yes
M3K7_HUMAN [view interactions] High throughput no yes
ZCHC3_HUMAN [view interactions] High throughput no no
UMAD1_HUMAN [view interactions] High throughput no yes
UEVLD_HUMAN [view interactions] High throughput no yes
S1PR2_HUMAN [view interactions] High throughput no no
CRCM1_HUMAN [view interactions] High throughput no yes
FZD7_HUMAN [view interactions] High throughput no yes
DNJB4_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
OTU1_HUMAN [view interactions] High throughput no yes
ZBT32_HUMAN [view interactions] High throughput no yes
PCH2_HUMAN [view interactions] High throughput no no
UBP54_HUMAN [view interactions] High throughput no yes
KRA62_HUMAN [view interactions] High throughput no no
KRA71_HUMAN [view interactions] High throughput no no
FYB1_HUMAN [view interactions] High throughput no no
SCNBA_HUMAN [view interactions] High throughput no no
ZN106_HUMAN [view interactions] High throughput no no
STK24_HUMAN [view interactions] High throughput no yes
CUX1_HUMAN [view interactions] High throughput no yes
TEKT4_HUMAN [view interactions] High throughput no no
ASAP2_HUMAN [view interactions] High throughput no yes
CEBPA_HUMAN [view interactions] High throughput no yes
PSMD1_HUMAN [view entry] [view interactions] High throughput yes yes
PACA_HUMAN [view interactions] High throughput no no
BRE1A_HUMAN [view interactions] High throughput no yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
UCHL1_HUMAN [view entry] [view interactions] High throughput yes yes
SURF6_HUMAN [view interactions] High throughput no yes
CAN13_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
TLR3_HUMAN [view interactions] High throughput no yes
RABX5_HUMAN [view interactions] High throughput no no
RBTN2_HUMAN [view interactions] High throughput no yes
SPAT2_HUMAN [view interactions] High throughput no yes
WDR82_HUMAN [view interactions] High throughput no no
UBL4A_HUMAN [view entry] [view interactions] High throughput yes yes
TXNL1_HUMAN [view entry] [view interactions] High throughput yes yes
TSNAX_HUMAN [view interactions] High throughput no yes
TPIS_HUMAN [view entry] [view interactions] High throughput yes yes
TIGAR_HUMAN [view interactions] High throughput no yes
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
RN114_HUMAN [view interactions] High throughput no no
RL23A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD7_HUMAN [view interactions] High throughput no yes
PSD13_HUMAN [view interactions] High throughput no yes
PSD12_HUMAN [view interactions] High throughput no yes
PSB3_HUMAN [view interactions] High throughput no yes
PSB2_HUMAN [view interactions] High throughput no yes
PSA7_HUMAN [view interactions] High throughput no yes
PSA6_HUMAN [view interactions] High throughput no yes
PSA4_HUMAN [view entry] [view interactions] High throughput yes yes
PSA3_HUMAN [view interactions] High throughput no no
PSA1_HUMAN [view interactions] High throughput no yes
PRS6B_HUMAN [view interactions] High throughput no yes
PRDX5_HUMAN [view entry] [view interactions] High throughput yes yes
PRDC1_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
PGTB2_HUMAN [view interactions] High throughput no yes
PGAM5_HUMAN [view entry] [view interactions] High throughput yes yes
OTUB1_HUMAN [view interactions] High throughput no yes
OSGEP_HUMAN [view interactions] High throughput no yes
NEK7_HUMAN [view interactions] High throughput no yes
NANP_HUMAN [view interactions] High throughput no no
NAA10_HUMAN [view interactions] High throughput no yes
METH_HUMAN [view interactions] High throughput no yes
M2OM_HUMAN [view entry] [view interactions] High throughput yes yes
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
GET4_HUMAN [view interactions] High throughput no yes
EPN4_HUMAN [view interactions] High throughput no yes
EMD_HUMAN [view interactions] High throughput no yes
DECR2_HUMAN [view entry] [view interactions] High throughput yes no
DCA12_HUMAN [view interactions] High throughput no yes
STEEP_HUMAN [view interactions] High throughput no yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
CCHL_HUMAN [view interactions] High throughput no yes
CBR3_HUMAN [view entry] [view interactions] High throughput yes yes
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
ARPC2_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
ADIPO_HUMAN [view interactions] High throughput no no
GFRP_HUMAN [view interactions] High throughput no no
F91A1_HUMAN [view interactions] High throughput no yes
SATB2_HUMAN [view interactions] High throughput no yes
TRI65_HUMAN [view interactions] High throughput no yes
MIO_HUMAN [view interactions] High throughput no yes
O52N5_HUMAN [view interactions] High throughput no no
IF4G3_HUMAN [view interactions] High throughput no yes
CSRN1_HUMAN [view interactions] High throughput no no
MTA70_HUMAN [view interactions] High throughput no no
DMWD_HUMAN [view entry] [view interactions] High throughput yes no
ZN703_HUMAN [view interactions] High throughput no yes
O52N4_HUMAN [view interactions] High throughput no no
HIPK1_HUMAN [view interactions] High throughput no no
MED12_HUMAN [view interactions] High throughput no yes
ZN609_HUMAN [view interactions] High throughput no yes
ZN507_HUMAN [view interactions] High throughput no no
BCOR_HUMAN [view interactions] High throughput no no
TRI33_HUMAN [view interactions] High throughput no yes
WDR11_HUMAN [view interactions] High throughput no yes
NIT1_HUMAN [view interactions] High throughput no yes
SAM11_HUMAN [view interactions] High throughput no no
ARNT_HUMAN [view entry] [view interactions] High throughput yes yes
ATX2_HUMAN [view interactions] High throughput no yes
TCAB1_HUMAN [view interactions] High throughput no yes
PRI2_HUMAN [view interactions] High throughput no no
TCAF1_HUMAN [view interactions] High throughput no no
QRIC1_HUMAN [view interactions] High throughput no yes
C19L1_HUMAN [view interactions] High throughput no yes
EPHA2_HUMAN [view interactions] High throughput no no
LAR4B_HUMAN [view interactions] High throughput no yes
NISCH_HUMAN [view interactions] High throughput no yes
RD23A_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CTC1_HUMAN [view interactions] High throughput no no
GSE1_HUMAN [view interactions] High throughput no yes
TBB8_HUMAN [view interactions] High throughput no no
CACO2_HUMAN [view interactions] High throughput no yes
AGO2_HUMAN [view interactions] High throughput no yes
TNR6A_HUMAN [view interactions] High throughput no yes
FITM2_HUMAN [view interactions] High throughput no no
ATG12_HUMAN [view interactions] High throughput no yes
TRAF2_HUMAN [view interactions] High throughput no yes
THIOM_HUMAN [view interactions] High throughput no yes
AP2C_HUMAN [view interactions] High throughput no no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
TNR3_HUMAN [view interactions] High throughput no yes
LIPG_HUMAN [view interactions] High throughput no no
GRIP1_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC2_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
MALT1_HUMAN [view interactions] High throughput no no
BCL10_HUMAN [view interactions] High throughput no yes
IKKB_HUMAN [view interactions] High throughput no yes
IKKA_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
VP37D_HUMAN [view interactions] High throughput no no
SEM4G_HUMAN [view interactions] High throughput no yes
MOXD1_HUMAN [view interactions] High throughput no no
MEAK7_HUMAN [view interactions] High throughput no yes
PDPN_HUMAN [view interactions] High throughput no no
MKRN4_HUMAN [view interactions] High throughput no no
MKRN2_HUMAN [view interactions] High throughput no yes
RTL6_HUMAN [view interactions] High throughput no yes
HPRT_HUMAN [view interactions] High throughput no yes
ULBP3_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
GDIA_HUMAN [view entry] [view interactions] High throughput yes yes
ULK3_HUMAN [view interactions] High throughput no yes
TAB2_HUMAN [view interactions] High throughput no yes
DYR_HUMAN [view interactions] High throughput no yes
RIPK1_HUMAN [view interactions] Computational no yes
XIAP_HUMAN [view interactions] Computational no yes
UBP2_HUMAN [view interactions] Computational no yes
RIPK2_HUMAN [view interactions] Computational no yes
UBP4_HUMAN [view interactions] Computational no no
SPA2L_HUMAN [view entry] [view interactions] Computational yes yes
OTU7B_HUMAN [view interactions] Computational no yes
RACK1_HUMAN [view interactions] Computational no yes
TRADD_HUMAN [view interactions] Computational no yes
UBP21_HUMAN [view interactions] Computational no no