DNJB4_HUMAN
Evidence for PS localization
Functions
Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DNJB4_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 41.6667 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 37.5000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 35.4167 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.4167 | 4 | no |
| GO:0005524 | ATP binding | 31.2500 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 31.2500 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 31.2500 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 31.2500 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 31.2500 | 5 | no |
| GO:0003723 | RNA binding | 31.2500 | 4 | no |
| GO:0016887 | ATP hydrolysis activity | 27.0833 | 7 | no |
| GO:0031625 | ubiquitin protein ligase binding | 25.0000 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 25.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DNJB4_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 47.9167 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 45.8333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.8333 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 45.8333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.7500 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 43.7500 | 4 | no |
| GO:0006996 | organelle organization | 39.5833 | 4 | no |
| GO:0010646 | regulation of cell communication | 39.5833 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 39.5833 | 4 | no |
| GO:0010468 | regulation of gene expression | 39.5833 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 37.5000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.4167 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 35.4167 | 4 | no |
| GO:0006986 | response to unfolded protein | 33.3333 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 31.2500 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 29.1667 | 4 | no |
| GO:0010941 | regulation of cell death | 29.1667 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 29.1667 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 29.1667 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 29.1667 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 29.1667 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.1667 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.1667 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.0833 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 27.0833 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 27.0833 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.0833 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 27.0833 | 5 | no |
| GO:0060548 | negative regulation of cell death | 27.0833 | 5 | no |
| GO:0008104 | protein localization | 27.0833 | 4 | no |
| GO:0071310 | cellular response to organic substance | 27.0833 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0080134 | regulation of response to stress | 25.0000 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 25.0000 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0015031 | protein transport | 25.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0051084 | de novo post-translational protein folding | 22.9167 | 4 | yes |
| GO:0051085 | chaperone cofactor-dependent protein refolding | 22.9167 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 22.9167 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 20.8333 | 4 | no |
| GO:0006886 | intracellular protein transport | 20.8333 | 4 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in DNJB4_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 4.1667 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PABP2_HUMAN | [view interactions] | Low throughput | no | yes |
| TBPL2_HUMAN | [view interactions] | Low throughput | no | no |
| NPM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OPRM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD3_HUMAN | [view interactions] | High throughput | no | yes |
| TBL1X_HUMAN | [view interactions] | High throughput | no | yes |
| MDM2_HUMAN | [view interactions] | High throughput | no | yes |
| RPAC2_HUMAN | [view interactions] | High throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| WIPI2_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH3_HUMAN | [view interactions] | High throughput | no | no |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| TGS1_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MANS1_HUMAN | [view interactions] | High throughput | no | yes |
| ABC3D_HUMAN | [view interactions] | High throughput | no | yes |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| SYNEM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TTL12_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB5_HUMAN | [view interactions] | High throughput | no | yes |
| TBL1Y_HUMAN | [view interactions] | High throughput | no | no |
| ANGL4_HUMAN | [view interactions] | High throughput | no | no |
| P2RX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABH15_HUMAN | [view interactions] | High throughput | no | yes |
| TTLL1_HUMAN | [view interactions] | High throughput | no | yes |
| NAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTA70_HUMAN | [view interactions] | High throughput | no | no |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| AKA10_HUMAN | [view interactions] | High throughput | no | no |
| STYK1_HUMAN | [view interactions] | High throughput | no | yes |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| SHRPN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASB4_HUMAN | [view interactions] | High throughput | no | no |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PELI3_HUMAN | [view interactions] | High throughput | no | yes |
| BGAL_HUMAN | [view interactions] | High throughput | no | yes |
| CC038_HUMAN | [view interactions] | High throughput | no | yes |
| TB22A_HUMAN | [view interactions] | High throughput | no | yes |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| ERCC8_HUMAN | [view interactions] | High throughput | no | no |
| ZBT38_HUMAN | [view interactions] | High throughput | no | no |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM231_HUMAN | [view interactions] | High throughput | no | yes |
| IF4H_HUMAN | [view interactions] | High throughput | no | yes |
| ARGL1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR72_HUMAN | [view interactions] | High throughput | no | no |
| KLH26_HUMAN | [view interactions] | High throughput | no | no |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| NALP8_HUMAN | [view interactions] | High throughput | no | no |
| KHDC1_HUMAN | [view interactions] | High throughput | no | no |
| OR6T1_HUMAN | [view interactions] | High throughput | no | no |
| M4A15_HUMAN | [view interactions] | High throughput | no | no |
| SIM2_HUMAN | [view interactions] | High throughput | no | yes |
| TYW4_HUMAN | [view interactions] | High throughput | no | yes |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPTE2_HUMAN | [view interactions] | High throughput | no | no |
| TLE2_HUMAN | [view interactions] | High throughput | no | yes |
| MRGX4_HUMAN | [view interactions] | High throughput | no | no |
| DET1_HUMAN | [view interactions] | High throughput | no | no |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| P5CR3_HUMAN | [view interactions] | High throughput | no | no |
| MAS_HUMAN | [view interactions] | High throughput | no | no |
| KLH34_HUMAN | [view interactions] | High throughput | no | no |
| CARD8_HUMAN | [view interactions] | High throughput | no | yes |
| LOXL4_HUMAN | [view interactions] | High throughput | no | no |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM260_HUMAN | [view interactions] | High throughput | no | yes |
| GSTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC9_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RANB3_HUMAN | [view interactions] | High throughput | no | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| ERF1_HUMAN | [view interactions] | High throughput | no | yes |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS74L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHD1_HUMAN | [view interactions] | High throughput | no | no |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRBP_HUMAN | [view interactions] | High throughput | no | yes |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| WDR41_HUMAN | [view interactions] | High throughput | no | yes |
| TSR1_HUMAN | [view interactions] | High throughput | no | no |
| RS25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F10A1_HUMAN | [view interactions] | High throughput | no | yes |
| CCD61_HUMAN | [view interactions] | High throughput | no | yes |
| LMBL2_HUMAN | [view interactions] | High throughput | no | no |
| CC138_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| TIGAR_HUMAN | [view interactions] | High throughput | no | yes |
| LTV1_HUMAN | [view interactions] | High throughput | no | yes |
| CBX5_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |