Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

P2RX6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Receptor for ATP that acts as a ligand-gated ion channel. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in P2RX6_HUMAN
GO:0043169 cation binding 38.4615 4 no
GO:0046872 metal ion binding 38.4615 5 no
GO:0000166 nucleotide binding 23.0769 4 yes
GO:0001614 purinergic nucleotide receptor activity 23.0769 5 yes
GO:0004931 extracellularly ATP-gated monoatomic cation channel activity 23.0769 7 yes
GO:0005216 monoatomic ion channel activity 23.0769 4 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 23.0769 6 yes
GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 23.0769 7 yes
GO:0005261 monoatomic cation channel activity 23.0769 5 yes
GO:0005524 ATP binding 23.0769 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 23.0769 4 yes
GO:0015267 channel activity 23.0769 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 23.0769 5 yes
GO:0016502 nucleotide receptor activity 23.0769 4 yes
GO:0017076 purine nucleotide binding 23.0769 5 yes
GO:0022834 ligand-gated channel activity 23.0769 6 yes
GO:0022836 gated channel activity 23.0769 5 yes
GO:0030554 adenyl nucleotide binding 23.0769 6 yes
GO:0032555 purine ribonucleotide binding 23.0769 4 yes
GO:0032559 adenyl ribonucleotide binding 23.0769 5 yes
GO:0035381 ATP-gated ion channel activity 23.0769 7 yes
GO:0035639 purine ribonucleoside triphosphate binding 23.0769 4 yes
GO:0043168 anion binding 23.0769 4 yes
GO:0099094 ligand-gated monoatomic cation channel activity 23.0769 6 yes
GO:0004866 endopeptidase inhibitor activity 23.0769 5 no
GO:0030414 peptidase inhibitor activity 23.0769 4 no
GO:0061135 endopeptidase regulator activity 23.0769 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in P2RX6_HUMAN
GO:0009966 regulation of signal transduction 53.8462 4 no
GO:0010646 regulation of cell communication 53.8462 4 no
GO:0048522 positive regulation of cellular process 53.8462 4 no
GO:0051049 regulation of transport 53.8462 4 no
GO:1902531 regulation of intracellular signal transduction 46.1538 5 no
GO:0009967 positive regulation of signal transduction 46.1538 5 no
GO:0010647 positive regulation of cell communication 46.1538 5 no
GO:0023056 positive regulation of signaling 46.1538 4 no
GO:0048584 positive regulation of response to stimulus 46.1538 4 no
GO:0080090 regulation of primary metabolic process 46.1538 4 no
GO:0048523 negative regulation of cellular process 46.1538 4 no
GO:1902533 positive regulation of intracellular signal transduction 38.4615 6 no
GO:0009889 regulation of biosynthetic process 38.4615 4 no
GO:0031323 regulation of cellular metabolic process 38.4615 4 no
GO:0032101 regulation of response to external stimulus 38.4615 4 no
GO:0051050 positive regulation of transport 38.4615 4 no
GO:0060255 regulation of macromolecule metabolic process 38.4615 4 no
GO:0060341 regulation of cellular localization 38.4615 4 no
GO:0071310 cellular response to organic substance 30.7692 4 no
GO:0009892 negative regulation of metabolic process 30.7692 4 no
GO:0010605 negative regulation of macromolecule metabolic process 30.7692 5 no
GO:0010243 response to organonitrogen compound 30.7692 4 yes
GO:0014070 response to organic cyclic compound 30.7692 4 yes
GO:0009893 positive regulation of metabolic process 30.7692 4 no
GO:0010468 regulation of gene expression 30.7692 6 no
GO:0010556 regulation of macromolecule biosynthetic process 30.7692 5 no
GO:0031326 regulation of cellular biosynthetic process 30.7692 5 no
GO:0034762 regulation of transmembrane transport 30.7692 4 no
GO:0051128 regulation of cellular component organization 30.7692 4 no
GO:0051240 positive regulation of multicellular organismal process 30.7692 4 no
GO:0051246 regulation of protein metabolic process 30.7692 5 no
GO:0080134 regulation of response to stress 30.7692 4 no
GO:0022607 cellular component assembly 30.7692 4 no
GO:0042981 regulation of apoptotic process 30.7692 5 no
GO:0043066 negative regulation of apoptotic process 30.7692 6 no
GO:0043067 regulation of programmed cell death 30.7692 4 no
GO:0043069 negative regulation of programmed cell death 30.7692 5 no
GO:0044057 regulation of system process 30.7692 4 no
GO:1903522 regulation of blood circulation 23.0769 5 no
GO:1903530 regulation of secretion by cell 23.0769 4 no
GO:1903532 positive regulation of secretion by cell 23.0769 5 no
GO:2001233 regulation of apoptotic signaling pathway 23.0769 5 no
GO:2001234 negative regulation of apoptotic signaling pathway 23.0769 6 no
GO:0050848 regulation of calcium-mediated signaling 23.0769 6 no
GO:0050850 positive regulation of calcium-mediated signaling 23.0769 7 no
GO:0006355 regulation of DNA-templated transcription 23.0769 7 no
GO:0009890 negative regulation of biosynthetic process 23.0769 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.0769 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0031324 negative regulation of cellular metabolic process 23.0769 5 no
GO:0031327 negative regulation of cellular biosynthetic process 23.0769 6 no
GO:0051252 regulation of RNA metabolic process 23.0769 5 no
GO:2001141 regulation of RNA biosynthetic process 23.0769 6 no
GO:0044087 regulation of cellular component biogenesis 23.0769 4 no
GO:0006811 monoatomic ion transport 23.0769 4 yes
GO:0006812 monoatomic cation transport 23.0769 5 yes
GO:0006816 calcium ion transport 23.0769 7 yes
GO:0006936 muscle contraction 23.0769 4 yes
GO:0014074 response to purine-containing compound 23.0769 5 yes
GO:0030001 metal ion transport 23.0769 6 yes
GO:0033198 response to ATP 23.0769 4 yes
GO:0046683 response to organophosphorus 23.0769 4 yes
GO:0070588 calcium ion transmembrane transport 23.0769 5 yes
GO:0098655 monoatomic cation transmembrane transport 23.0769 4 yes
GO:0098662 inorganic cation transmembrane transport 23.0769 4 yes
GO:0002684 positive regulation of immune system process 23.0769 4 no
GO:0009891 positive regulation of biosynthetic process 23.0769 5 no
GO:0031325 positive regulation of cellular metabolic process 23.0769 5 no
GO:0031399 regulation of protein modification process 23.0769 6 no
GO:0032103 positive regulation of response to external stimulus 23.0769 5 no
GO:0034330 cell junction organization 23.0769 4 no
GO:0034764 positive regulation of transmembrane transport 23.0769 5 no
GO:0050808 synapse organization 23.0769 5 no
GO:0060627 regulation of vesicle-mediated transport 23.0769 4 no
GO:0009968 negative regulation of signal transduction 23.0769 5 no
GO:0010038 response to metal ion 23.0769 4 no
GO:0010648 negative regulation of cell communication 23.0769 5 no
GO:0023057 negative regulation of signaling 23.0769 4 no
GO:0034097 response to cytokine 23.0769 4 no
GO:0043408 regulation of MAPK cascade 23.0769 6 no
GO:0043410 positive regulation of MAPK cascade 23.0769 7 no
GO:0043933 protein-containing complex organization 23.0769 4 no
GO:0048585 negative regulation of response to stimulus 23.0769 4 no
GO:0051046 regulation of secretion 23.0769 5 no
GO:0051047 positive regulation of secretion 23.0769 5 no
GO:0051241 negative regulation of multicellular organismal process 23.0769 4 no
GO:0065003 protein-containing complex assembly 23.0769 5 no
GO:0070372 regulation of ERK1 and ERK2 cascade 23.0769 7 no
GO:0070374 positive regulation of ERK1 and ERK2 cascade 23.0769 8 no
GO:0070555 response to interleukin-1 23.0769 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
P2RX2_HUMAN [view entry] [view interactions] Low throughput yes no
P2RX4_HUMAN [view entry] [view interactions] Low throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
ATG3_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB5_HUMAN [view interactions] High throughput no yes
DNJB4_HUMAN [view entry] [view interactions] High throughput yes yes
SRPK1_HUMAN [view interactions] High throughput no yes
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
EVPL_HUMAN [view interactions] High throughput no yes
ARL8B_HUMAN [view interactions] High throughput no yes
CBR1_HUMAN [view entry] [view interactions] High throughput yes yes
NAGK_HUMAN [view interactions] High throughput no no
PLMN_HUMAN [view interactions] High throughput no no
A2MG_HUMAN [view interactions] High throughput no yes
CALL5_HUMAN [view entry] [view interactions] High throughput yes no
CRYAB_HUMAN [view entry] [view interactions] High throughput yes no
A1AT_HUMAN [view interactions] High throughput no no
A1AG2_HUMAN [view interactions] High throughput no no
VTDB_HUMAN [view interactions] High throughput no yes
RDHE2_HUMAN [view interactions] High throughput no yes
KLK10_HUMAN [view interactions] High throughput no no
CALL3_HUMAN [view interactions] High throughput no yes
POF1B_HUMAN [view interactions] High throughput no no
KLK9_HUMAN [view interactions] High throughput no no
HEMO_HUMAN [view interactions] High throughput no no
ST2B1_HUMAN [view interactions] High throughput no yes
A1AG1_HUMAN [view interactions] High throughput no no
HUTH_HUMAN [view interactions] High throughput no yes
ITIH4_HUMAN [view interactions] High throughput no no
TRFE_HUMAN [view interactions] High throughput no no
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
FIBA_HUMAN [view interactions] High throughput no no
SBSN_HUMAN [view interactions] High throughput no no
FBX50_HUMAN [view interactions] High throughput no no
CO4A_HUMAN [view interactions] High throughput no no
TTHY_HUMAN [view interactions] High throughput no no
ALBU_HUMAN [view interactions] High throughput no no
CERU_HUMAN [view interactions] High throughput no no
HPT_HUMAN [view interactions] High throughput no no
HBA_HUMAN [view interactions] High throughput no no
PKP1_HUMAN [view interactions] High throughput no no
PEPL_HUMAN [view interactions] High throughput no yes
APOA1_HUMAN [view interactions] High throughput no no
ITIH2_HUMAN [view interactions] High throughput no no
AL3A1_HUMAN [view interactions] High throughput no no
FILA_HUMAN [view interactions] High throughput no no
TRI29_HUMAN [view interactions] High throughput no no
THRB_HUMAN [view interactions] High throughput no no
FIBG_HUMAN [view entry] [view interactions] High throughput yes no
CO3_HUMAN [view entry] [view interactions] High throughput yes no
HBB_HUMAN [view interactions] High throughput no no
INVO_HUMAN [view interactions] High throughput no no
AACT_HUMAN [view entry] [view interactions] High throughput yes no