Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

P2RX6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Receptor for ATP that acts as a ligand-gated ion channel. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in P2RX6_HUMAN
GO:0005216 ion channel activity 41.1765 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 41.1765 6 yes
GO:0005261 cation channel activity 41.1765 5 yes
GO:0008324 cation transmembrane transporter activity 41.1765 4 yes
GO:0015267 channel activity 41.1765 4 yes
GO:0015276 ligand-gated ion channel activity 41.1765 5 yes
GO:0022834 ligand-gated channel activity 41.1765 6 yes
GO:0022836 gated channel activity 41.1765 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 41.1765 4 yes
GO:0099094 ligand-gated cation channel activity 41.1765 6 yes
GO:0046872 metal ion binding 41.1765 4 no
GO:0005262 calcium channel activity 29.4118 6 no
GO:0015085 calcium ion transmembrane transporter activity 29.4118 6 no
GO:0046873 metal ion transmembrane transporter activity 29.4118 5 no
GO:0099604 ligand-gated calcium channel activity 29.4118 7 no
GO:0017076 purine nucleotide binding 23.5294 4 yes
GO:0030554 adenyl nucleotide binding 23.5294 5 yes
GO:0004970 ionotropic glutamate receptor activity 23.5294 5 no
GO:0004972 NMDA glutamate receptor activity 23.5294 6 no
GO:0005244 voltage-gated ion channel activity 23.5294 4 no
GO:0008066 glutamate receptor activity 23.5294 4 no
GO:0022824 transmitter-gated ion channel activity 23.5294 5 no
GO:0022832 voltage-gated channel activity 23.5294 6 no
GO:0022835 transmitter-gated channel activity 23.5294 4 no
GO:0022843 voltage-gated cation channel activity 23.5294 5 no
GO:0022849 glutamate-gated calcium ion channel activity 23.5294 6 no
GO:0001614 purinergic nucleotide receptor activity 17.6471 5 yes
GO:0004931 extracellularly ATP-gated cation channel activity 17.6471 5 yes
GO:0005231 excitatory extracellular ligand-gated ion channel activity 17.6471 7 yes
GO:0005524 ATP binding 17.6471 5 yes
GO:0016502 nucleotide receptor activity 17.6471 4 yes
GO:0032555 purine ribonucleotide binding 17.6471 4 yes
GO:0032559 adenyl ribonucleotide binding 17.6471 5 yes
GO:0035381 ATP-gated ion channel activity 17.6471 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 17.6471 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in P2RX6_HUMAN
GO:0010646 regulation of cell communication 64.7059 4 no
GO:0048522 positive regulation of cellular process 64.7059 4 no
GO:0051171 regulation of nitrogen compound metabolic process 58.8235 4 no
GO:0051049 regulation of transport 52.9412 4 no
GO:0051246 regulation of protein metabolic process 52.9412 5 no
GO:0060255 regulation of macromolecule metabolic process 52.9412 4 no
GO:0080090 regulation of primary metabolic process 52.9412 4 no
GO:0010647 positive regulation of cell communication 52.9412 5 no
GO:0023056 positive regulation of signaling 52.9412 4 no
GO:0009966 regulation of signal transduction 47.0588 4 no
GO:0009893 positive regulation of metabolic process 41.1765 4 no
GO:0030162 regulation of proteolysis 41.1765 6 no
GO:0044057 regulation of system process 41.1765 4 no
GO:0051050 positive regulation of transport 41.1765 4 no
GO:0009967 positive regulation of signal transduction 41.1765 5 no
GO:0031323 regulation of cellular metabolic process 41.1765 4 no
GO:0048584 positive regulation of response to stimulus 41.1765 4 no
GO:0010243 response to organonitrogen compound 35.2941 4 yes
GO:0006811 ion transport 35.2941 4 no
GO:0006812 cation transport 35.2941 5 no
GO:0034762 regulation of transmembrane transport 35.2941 4 no
GO:0050804 modulation of chemical synaptic transmission 35.2941 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 35.2941 5 no
GO:0051336 regulation of hydrolase activity 35.2941 4 no
GO:0052547 regulation of peptidase activity 35.2941 5 no
GO:0052548 regulation of endopeptidase activity 35.2941 6 no
GO:0099177 regulation of trans-synaptic signaling 35.2941 4 no
GO:0060341 regulation of cellular localization 35.2941 4 no
GO:0009892 negative regulation of metabolic process 35.2941 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.2941 5 no
GO:0010941 regulation of cell death 35.2941 4 no
GO:0042981 regulation of apoptotic process 35.2941 6 no
GO:0043067 regulation of programmed cell death 35.2941 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 35.2941 5 no
GO:0014070 response to organic cyclic compound 29.4118 4 yes
GO:0007268 chemical synaptic transmission 29.4118 6 no
GO:0010604 positive regulation of macromolecule metabolic process 29.4118 5 no
GO:0034765 regulation of ion transmembrane transport 29.4118 5 no
GO:0043269 regulation of ion transport 29.4118 5 no
GO:0051247 positive regulation of protein metabolic process 29.4118 6 no
GO:0060627 regulation of vesicle-mediated transport 29.4118 4 no
GO:0098916 anterograde trans-synaptic signaling 29.4118 5 no
GO:0099537 trans-synaptic signaling 29.4118 4 no
GO:1903522 regulation of blood circulation 29.4118 5 no
GO:1904062 regulation of cation transmembrane transport 29.4118 6 no
GO:2000116 regulation of cysteine-type endopeptidase activity 29.4118 7 no
GO:0006816 calcium ion transport 29.4118 7 no
GO:0009889 regulation of biosynthetic process 29.4118 4 no
GO:0022607 cellular component assembly 29.4118 4 no
GO:0030001 metal ion transport 29.4118 6 no
GO:0031325 positive regulation of cellular metabolic process 29.4118 5 no
GO:0031326 regulation of cellular biosynthetic process 29.4118 5 no
GO:0043933 protein-containing complex organization 29.4118 4 no
GO:0065003 protein-containing complex assembly 29.4118 5 no
GO:0070588 calcium ion transmembrane transport 29.4118 6 no
GO:0098655 cation transmembrane transport 29.4118 4 no
GO:0098660 inorganic ion transmembrane transport 29.4118 4 no
GO:0098662 inorganic cation transmembrane transport 29.4118 5 no
GO:0048523 negative regulation of cellular process 29.4118 4 no
GO:0051248 negative regulation of protein metabolic process 29.4118 6 no
GO:0060548 negative regulation of cell death 29.4118 5 no
GO:0080134 regulation of response to stress 29.4118 4 no
GO:1902531 regulation of intracellular signal transduction 29.4118 5 no
GO:0032101 regulation of response to external stimulus 29.4118 4 no
GO:0014074 response to purine-containing compound 23.5294 5 yes
GO:0046683 response to organophosphorus 23.5294 4 yes
GO:0010950 positive regulation of endopeptidase activity 23.5294 7 no
GO:0010952 positive regulation of peptidase activity 23.5294 6 no
GO:0034764 positive regulation of transmembrane transport 23.5294 5 no
GO:0043085 positive regulation of catalytic activity 23.5294 4 no
GO:0045862 positive regulation of proteolysis 23.5294 7 no
GO:0051046 regulation of secretion 23.5294 5 no
GO:0051345 positive regulation of hydrolase activity 23.5294 5 no
GO:1903530 regulation of secretion by cell 23.5294 4 no
GO:2001056 positive regulation of cysteine-type endopeptidase activity 23.5294 8 no
GO:0007215 glutamate receptor signaling pathway 23.5294 4 no
GO:0007420 brain development 23.5294 4 no
GO:0010468 regulation of gene expression 23.5294 5 no
GO:0060078 regulation of postsynaptic membrane potential 23.5294 4 no
GO:0060079 excitatory postsynaptic potential 23.5294 5 no
GO:0097553 calcium ion transmembrane import into cytosol 23.5294 7 no
GO:0098976 excitatory chemical synaptic transmission 23.5294 7 no
GO:2000377 regulation of reactive oxygen species metabolic process 23.5294 5 no
GO:0009894 regulation of catabolic process 23.5294 4 no
GO:0009968 negative regulation of signal transduction 23.5294 5 no
GO:0010648 negative regulation of cell communication 23.5294 5 no
GO:0023057 negative regulation of signaling 23.5294 4 no
GO:0042176 regulation of protein catabolic process 23.5294 5 no
GO:0043066 negative regulation of apoptotic process 23.5294 7 no
GO:0043069 negative regulation of programmed cell death 23.5294 6 no
GO:0048585 negative regulation of response to stimulus 23.5294 4 no
GO:0051128 regulation of cellular component organization 23.5294 4 no
GO:0010038 response to metal ion 23.5294 4 no
GO:0050806 positive regulation of synaptic transmission 23.5294 5 no
GO:0050905 neuromuscular process 23.5294 4 no
GO:0051094 positive regulation of developmental process 23.5294 4 no
GO:0051240 positive regulation of multicellular organismal process 23.5294 4 no
GO:0051241 negative regulation of multicellular organismal process 23.5294 4 no
GO:0071310 cellular response to organic substance 23.5294 4 no
GO:1902533 positive regulation of intracellular signal transduction 23.5294 6 no
GO:0006508 proteolysis 23.5294 4 no
GO:0033198 response to ATP 17.6471 4 yes
GO:0006936 muscle contraction 11.7647 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
P2RX4_HUMAN [view entry] [view interactions] Low throughput yes yes
P2RX2_HUMAN [view interactions] Low throughput no no
DNJB4_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB5_HUMAN [view interactions] High throughput no yes
SRPK1_HUMAN [view interactions] High throughput no yes
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
EVPL_HUMAN [view interactions] High throughput no yes
ARL8B_HUMAN [view interactions] High throughput no yes
CBR1_HUMAN [view entry] [view interactions] High throughput yes yes
NAGK_HUMAN [view interactions] High throughput no no
PLMN_HUMAN [view interactions] High throughput no no
A2MG_HUMAN [view interactions] High throughput no yes
CALL5_HUMAN [view entry] [view interactions] High throughput yes no
CRYAB_HUMAN [view entry] [view interactions] High throughput yes no
A1AT_HUMAN [view interactions] High throughput no no
A1AG2_HUMAN [view interactions] High throughput no no
VTDB_HUMAN [view interactions] High throughput no yes
RDHE2_HUMAN [view interactions] High throughput no yes
KLK10_HUMAN [view interactions] High throughput no no
CALL3_HUMAN [view interactions] High throughput no yes
POF1B_HUMAN [view interactions] High throughput no no
KLK9_HUMAN [view interactions] High throughput no no
HEMO_HUMAN [view interactions] High throughput no no
ST2B1_HUMAN [view interactions] High throughput no yes
A1AG1_HUMAN [view interactions] High throughput no no
HUTH_HUMAN [view interactions] High throughput no yes
ITIH4_HUMAN [view interactions] High throughput no no
TRFE_HUMAN [view interactions] High throughput no no
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
FIBA_HUMAN [view interactions] High throughput no no
SBSN_HUMAN [view interactions] High throughput no no
FBX50_HUMAN [view interactions] High throughput no no
CO4A_HUMAN [view interactions] High throughput no no
TTHY_HUMAN [view interactions] High throughput no no
ALBU_HUMAN [view interactions] High throughput no no
CERU_HUMAN [view interactions] High throughput no no
HPT_HUMAN [view interactions] High throughput no no
HBA_HUMAN [view interactions] High throughput no no
PKP1_HUMAN [view interactions] High throughput no no
PEPL_HUMAN [view interactions] High throughput no yes
APOA1_HUMAN [view interactions] High throughput no no
ITIH2_HUMAN [view interactions] High throughput no no
AL3A1_HUMAN [view interactions] High throughput no no
FILA_HUMAN [view interactions] High throughput no no
TRI29_HUMAN [view interactions] High throughput no no
THRB_HUMAN [view interactions] High throughput no no
FIBG_HUMAN [view entry] [view interactions] High throughput yes no
CO3_HUMAN [view entry] [view interactions] High throughput yes no
HBB_HUMAN [view interactions] High throughput no no
INVO_HUMAN [view interactions] High throughput no no
AACT_HUMAN [view entry] [view interactions] High throughput yes no
ATG3_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE3_HUMAN [view entry] [view interactions] Computational yes no
P2RX5_HUMAN [view interactions] Computational no no
NMDE1_HUMAN [view entry] [view interactions] Computational yes yes
NMDE4_HUMAN [view entry] [view interactions] Computational yes yes
P2RX3_HUMAN [view interactions] Computational no no
P2RY4_HUMAN [view interactions] Computational no no
P2RX7_HUMAN [view interactions] Computational no yes
NMDZ1_HUMAN [view entry] [view interactions] Computational yes yes
P2RX1_HUMAN [view entry] [view interactions] Computational yes no