Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

P2RX2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
60 Val Leu Deafness,autosomaldominant,41(DFNA41) -
353 Gly Arg Deafness,autosomaldominant,41(DFNA41) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in P2RX2_HUMAN
GO:0008324 monoatomic cation transmembrane transporter activity 47.6190 4 yes
GO:0043169 cation binding 47.6190 4 no
GO:0005216 monoatomic ion channel activity 42.8571 4 yes
GO:0005261 monoatomic cation channel activity 42.8571 5 yes
GO:0015267 channel activity 42.8571 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 42.8571 5 yes
GO:0022834 ligand-gated channel activity 42.8571 6 yes
GO:0022836 gated channel activity 42.8571 5 yes
GO:0099094 ligand-gated monoatomic cation channel activity 42.8571 6 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 38.0952 6 yes
GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 38.0952 7 yes
GO:0000166 nucleotide binding 33.3333 4 yes
GO:0017076 purine nucleotide binding 33.3333 5 yes
GO:0032555 purine ribonucleotide binding 33.3333 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 yes
GO:0043168 anion binding 33.3333 4 yes
GO:0046872 metal ion binding 33.3333 5 no
GO:0005524 ATP binding 28.5714 5 yes
GO:0030554 adenyl nucleotide binding 28.5714 6 yes
GO:0032559 adenyl ribonucleotide binding 28.5714 5 yes
GO:0001614 purinergic nucleotide receptor activity 19.0476 5 yes
GO:0004931 extracellularly ATP-gated monoatomic cation channel activity 19.0476 7 yes
GO:0016502 nucleotide receptor activity 19.0476 4 yes
GO:0035381 ATP-gated ion channel activity 19.0476 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in P2RX2_HUMAN
GO:0010646 regulation of cell communication 52.3810 4 yes
GO:0048522 positive regulation of cellular process 42.8571 4 yes
GO:0006811 monoatomic ion transport 42.8571 4 yes
GO:0030001 metal ion transport 38.0952 6 yes
GO:0051049 regulation of transport 38.0952 4 yes
GO:0006812 monoatomic cation transport 38.0952 5 yes
GO:0098916 anterograde trans-synaptic signaling 33.3333 6 yes
GO:0099536 synaptic signaling 33.3333 4 yes
GO:0099537 trans-synaptic signaling 33.3333 5 yes
GO:0006816 calcium ion transport 33.3333 7 yes
GO:0007268 chemical synaptic transmission 33.3333 7 yes
GO:0007600 sensory perception 33.3333 4 yes
GO:0010243 response to organonitrogen compound 33.3333 4 yes
GO:0098655 monoatomic cation transmembrane transport 28.5714 4 yes
GO:0098662 inorganic cation transmembrane transport 28.5714 4 yes
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:0014070 response to organic cyclic compound 28.5714 4 yes
GO:0023056 positive regulation of signaling 23.8095 4 yes
GO:0050954 sensory perception of mechanical stimulus 23.8095 5 yes
GO:0051050 positive regulation of transport 23.8095 4 yes
GO:0070588 calcium ion transmembrane transport 23.8095 5 yes
GO:1902531 regulation of intracellular signal transduction 23.8095 5 yes
GO:0051046 regulation of secretion 23.8095 5 no
GO:1903530 regulation of secretion by cell 23.8095 4 no
GO:0009893 positive regulation of metabolic process 23.8095 4 no
GO:0051128 regulation of cellular component organization 23.8095 4 no
GO:0080090 regulation of primary metabolic process 23.8095 4 no
GO:0008104 protein localization 23.8095 4 no
GO:0009966 regulation of signal transduction 23.8095 4 yes
GO:0010647 positive regulation of cell communication 23.8095 5 yes
GO:0014074 response to purine-containing compound 19.0476 5 yes
GO:0033198 response to ATP 19.0476 4 yes
GO:0034330 cell junction organization 19.0476 4 yes
GO:0036293 response to decreased oxygen levels 19.0476 4 yes
GO:0043269 regulation of monoatomic ion transport 19.0476 5 yes
GO:0043270 positive regulation of monoatomic ion transport 19.0476 5 yes
GO:0046683 response to organophosphorus 19.0476 4 yes
GO:0048584 positive regulation of response to stimulus 19.0476 4 yes
GO:0050808 synapse organization 19.0476 5 yes
GO:0051924 regulation of calcium ion transport 19.0476 7 yes
GO:0051928 positive regulation of calcium ion transport 19.0476 6 yes
GO:0060341 regulation of cellular localization 19.0476 4 yes
GO:0006936 muscle contraction 19.0476 4 yes
GO:0007274 neuromuscular synaptic transmission 19.0476 8 yes
GO:0007605 sensory perception of sound 19.0476 6 yes
GO:0010959 regulation of metal ion transport 19.0476 6 yes
GO:0034762 regulation of transmembrane transport 14.2857 4 yes
GO:0034764 positive regulation of transmembrane transport 14.2857 5 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 14.2857 5 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 14.2857 6 yes
GO:0050848 regulation of calcium-mediated signaling 14.2857 6 yes
GO:0050850 positive regulation of calcium-mediated signaling 14.2857 7 yes
GO:0050909 sensory perception of taste 14.2857 6 yes
GO:1902533 positive regulation of intracellular signal transduction 14.2857 6 yes
GO:1903169 regulation of calcium ion transmembrane transport 14.2857 7 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 14.2857 6 yes
GO:1904064 positive regulation of cation transmembrane transport 14.2857 7 yes
GO:1904427 positive regulation of calcium ion transmembrane transport 14.2857 7 yes
GO:0006939 smooth muscle contraction 14.2857 5 yes
GO:0007606 sensory perception of chemical stimulus 14.2857 5 yes
GO:0009967 positive regulation of signal transduction 14.2857 5 yes
GO:0010524 positive regulation of calcium ion transport into cytosol 14.2857 4 yes
GO:0014821 phasic smooth muscle contraction 9.5238 6 yes
GO:0014832 urinary bladder smooth muscle contraction 9.5238 7 yes
GO:0014848 urinary tract smooth muscle contraction 9.5238 6 yes
GO:0014904 myotube cell development 9.5238 5 yes
GO:0030432 peristalsis 9.5238 7 yes
GO:0048741 skeletal muscle fiber development 9.5238 6 yes
GO:0055001 muscle cell development 9.5238 4 yes
GO:0002007 detection of hypoxic conditions in blood by chemoreceptor signaling 9.5238 4 yes
GO:0003029 detection of hypoxic conditions in blood by carotid body chemoreceptor signaling 9.5238 5 yes
GO:0007528 neuromuscular junction development 9.5238 6 yes
GO:0009743 response to carbohydrate 9.5238 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
P2RX6_HUMAN [view entry] [view interactions] Low throughput yes no
P2RX4_HUMAN [view entry] [view interactions] Low throughput yes yes
P2RX2_HUMAN [view entry] [view interactions] Low throughput yes no
ACHB2_HUMAN [view entry] [view interactions] Low throughput yes no
ACHA3_HUMAN [view entry] [view interactions] Low throughput yes no
ACHA4_HUMAN [view entry] [view interactions] Low throughput yes no
AMY1A_HUMAN [view interactions] High throughput no no
AMY1C_HUMAN [view interactions] High throughput no no
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
SGCB_HUMAN [view interactions] High throughput no no
TF_HUMAN [view interactions] High throughput no no
S39A6_HUMAN [view interactions] High throughput no yes
PVR_HUMAN [view interactions] High throughput no yes
IPRI_HUMAN [view interactions] High throughput no no
PTSS2_HUMAN [view interactions] High throughput no yes
ASIC1_HUMAN [view entry] [view interactions] High throughput yes no
CSTN1_HUMAN [view entry] [view interactions] High throughput yes yes
GPI8_HUMAN [view entry] [view interactions] High throughput yes no
AT133_HUMAN [view interactions] High throughput no yes
T131L_HUMAN [view interactions] High throughput no yes
AGRF1_HUMAN [view interactions] High throughput no no
JAG2_HUMAN [view interactions] High throughput no yes
ZNG1A_HUMAN [view interactions] High throughput no yes
FNTB_HUMAN [view interactions] High throughput no no
METL9_HUMAN [view interactions] High throughput no yes
NOMO1_HUMAN [view entry] [view interactions] High throughput yes yes
HEAT1_HUMAN [view interactions] High throughput no yes
ST14_HUMAN [view entry] [view interactions] High throughput yes yes
TFB2M_HUMAN [view interactions] High throughput no no
AT2C1_HUMAN [view interactions] High throughput no yes
LRP6_HUMAN [view interactions] High throughput no yes
IDD_HUMAN [view interactions] High throughput no no
TMX3_HUMAN [view interactions] High throughput no yes
GLBL2_HUMAN [view interactions] High throughput no no
CHID1_HUMAN [view interactions] High throughput no yes
ACHA5_HUMAN [view entry] [view interactions] High throughput yes yes
ADPGK_HUMAN [view interactions] High throughput no no
TPC_HUMAN [view interactions] High throughput no no
CSTN3_HUMAN [view entry] [view interactions] High throughput yes no
C1QL4_HUMAN [view interactions] High throughput no no
LDLR_HUMAN [view interactions] High throughput no yes
K1586_HUMAN [view interactions] High throughput no no
E2AK3_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
C1QRF_HUMAN [view interactions] High throughput no no
EVI5L_HUMAN [view interactions] High throughput no yes
D2HDH_HUMAN [view interactions] High throughput no no
STAR3_HUMAN [view interactions] High throughput no yes
GXLT1_HUMAN [view interactions] High throughput no no
FKBP7_HUMAN [view interactions] High throughput no yes
HS2ST_HUMAN [view interactions] High throughput no yes
EPHB4_HUMAN [view interactions] High throughput no yes
GLT11_HUMAN [view interactions] High throughput no yes
SPPL3_HUMAN [view interactions] High throughput no no
TBB8_HUMAN [view interactions] High throughput no no
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
DUSTY_HUMAN [view interactions] High throughput no yes
S26A6_HUMAN [view interactions] High throughput no yes
LRP11_HUMAN [view interactions] High throughput no no
WDFY3_HUMAN [view interactions] High throughput no yes
WFS1_HUMAN [view entry] [view interactions] High throughput yes yes
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
CCD47_HUMAN [view interactions] High throughput no yes
GPN3_HUMAN [view interactions] High throughput no yes
HFE_HUMAN [view interactions] High throughput no yes
MBRL_HUMAN [view interactions] High throughput no yes
FIRRM_HUMAN [view interactions] High throughput no yes
CLPT1_HUMAN [view entry] [view interactions] High throughput yes yes
PLCA_HUMAN [view interactions] High throughput no yes
AMY1B_HUMAN [view interactions] High throughput no no