Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CSTN3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CSTN3_HUMAN
GO:0043169 cation binding 66.6667 4 yes
GO:0046872 metal ion binding 66.6667 5 yes
GO:0005216 monoatomic ion channel activity 33.3333 4 no
GO:0005261 monoatomic cation channel activity 33.3333 5 no
GO:0008324 monoatomic cation transmembrane transporter activity 33.3333 4 no
GO:0015267 channel activity 33.3333 4 no
GO:0022836 gated channel activity 33.3333 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in CSTN3_HUMAN
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0010647 positive regulation of cell communication 66.6667 5 yes
GO:0023056 positive regulation of signaling 66.6667 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0051049 regulation of transport 66.6667 4 no
GO:0007268 chemical synaptic transmission 50.0000 7 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 yes
GO:0009894 regulation of catabolic process 50.0000 4 yes
GO:0009896 positive regulation of catabolic process 50.0000 5 yes
GO:0022607 cellular component assembly 50.0000 4 yes
GO:0034330 cell junction organization 50.0000 4 yes
GO:0044087 regulation of cellular component biogenesis 50.0000 4 yes
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 yes
GO:0050807 regulation of synapse organization 50.0000 5 yes
GO:0050808 synapse organization 50.0000 5 yes
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0051130 positive regulation of cellular component organization 50.0000 5 yes
GO:0051240 positive regulation of multicellular organismal process 50.0000 4 yes
GO:0060341 regulation of cellular localization 50.0000 4 yes
GO:0080090 regulation of primary metabolic process 50.0000 4 yes
GO:0098916 anterograde trans-synaptic signaling 50.0000 6 yes
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 yes
GO:0099536 synaptic signaling 50.0000 4 yes
GO:0099537 trans-synaptic signaling 50.0000 5 yes
GO:0034762 regulation of transmembrane transport 50.0000 4 no
GO:0044057 regulation of system process 50.0000 4 no
GO:0098657 import into cell 50.0000 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0009967 positive regulation of signal transduction 50.0000 5 no
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:1902531 regulation of intracellular signal transduction 50.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 50.0000 6 no
GO:1905906 regulation of amyloid fibril formation 33.3333 6 no
GO:1905908 positive regulation of amyloid fibril formation 33.3333 7 no
GO:2000145 regulation of cell motility 33.3333 4 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0001558 regulation of cell growth 33.3333 4 yes
GO:0007416 synapse assembly 33.3333 6 yes
GO:0008104 protein localization 33.3333 4 yes
GO:0015031 protein transport 33.3333 4 yes
GO:0019216 regulation of lipid metabolic process 33.3333 5 yes
GO:0032880 regulation of protein localization 33.3333 5 yes
GO:0034329 cell junction assembly 33.3333 5 yes
GO:0045834 positive regulation of lipid metabolic process 33.3333 5 yes
GO:0050806 positive regulation of synaptic transmission 33.3333 5 yes
GO:0051093 negative regulation of developmental process 33.3333 4 yes
GO:0051094 positive regulation of developmental process 33.3333 4 yes
GO:0051129 negative regulation of cellular component organization 33.3333 5 yes
GO:0051241 negative regulation of multicellular organismal process 33.3333 4 yes
GO:0051963 regulation of synapse assembly 33.3333 6 yes
GO:0071702 organic substance transport 33.3333 4 yes
GO:0071705 nitrogen compound transport 33.3333 4 yes
GO:0099174 regulation of presynapse organization 33.3333 6 yes
GO:1901888 regulation of cell junction assembly 33.3333 5 yes
GO:1905606 regulation of presynapse assembly 33.3333 7 yes
GO:1905952 regulation of lipid localization 33.3333 4 yes
GO:0006811 monoatomic ion transport 33.3333 4 no
GO:0006812 monoatomic cation transport 33.3333 5 no
GO:0006816 calcium ion transport 33.3333 7 no
GO:0010959 regulation of metal ion transport 33.3333 6 no
GO:0030001 metal ion transport 33.3333 6 no
GO:0034765 regulation of monoatomic ion transmembrane transport 33.3333 5 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0043269 regulation of monoatomic ion transport 33.3333 5 no
GO:0051924 regulation of calcium ion transport 33.3333 7 no
GO:0070588 calcium ion transmembrane transport 33.3333 5 no
GO:0098655 monoatomic cation transmembrane transport 33.3333 4 no
GO:0098662 inorganic cation transmembrane transport 33.3333 4 no
GO:0141124 intracellular signaling cassette 33.3333 4 no
GO:1903169 regulation of calcium ion transmembrane transport 33.3333 7 no
GO:1904062 regulation of monoatomic cation transmembrane transport 33.3333 6 no
GO:0007528 neuromuscular junction development 33.3333 6 no
GO:0010243 response to organonitrogen compound 33.3333 4 no
GO:0050848 regulation of calcium-mediated signaling 33.3333 6 no
GO:0050850 positive regulation of calcium-mediated signaling 33.3333 7 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0006355 regulation of DNA-templated transcription 33.3333 7 no
GO:0006873 intracellular monoatomic ion homeostasis 33.3333 4 no
GO:0006874 intracellular calcium ion homeostasis 33.3333 5 no
GO:0008202 steroid metabolic process 33.3333 4 no
GO:0008203 cholesterol metabolic process 33.3333 5 no
GO:0008285 negative regulation of cell population proliferation 33.3333 5 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0009890 negative regulation of biosynthetic process 33.3333 5 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0010629 negative regulation of gene expression 33.3333 7 no
GO:0016125 sterol metabolic process 33.3333 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0030003 intracellular monoatomic cation homeostasis 33.3333 5 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0030111 regulation of Wnt signaling pathway 33.3333 5 no
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0031175 neuron projection development 33.3333 6 no
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0031327 negative regulation of cellular biosynthetic process 33.3333 6 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0031329 regulation of cellular catabolic process 33.3333 5 no
GO:0031331 positive regulation of cellular catabolic process 33.3333 6 no
GO:0031347 regulation of defense response 33.3333 5 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0032092 positive regulation of protein binding 33.3333 5 no
GO:0032101 regulation of response to external stimulus 33.3333 4 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0043393 regulation of protein binding 33.3333 4 no
GO:0043408 regulation of MAPK cascade 33.3333 6 no
GO:0043410 positive regulation of MAPK cascade 33.3333 7 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0045859 regulation of protein kinase activity 33.3333 6 no
GO:0045893 positive regulation of DNA-templated transcription 33.3333 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0048168 regulation of neuronal synaptic plasticity 33.3333 4 no
GO:0048638 regulation of developmental growth 33.3333 4 no
GO:0050727 regulation of inflammatory response 33.3333 5 no
GO:0050890 cognition 33.3333 4 no
GO:0051099 positive regulation of binding 33.3333 4 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0051254 positive regulation of RNA metabolic process 33.3333 6 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0055074 calcium ion homeostasis 33.3333 4 no
GO:0055080 monoatomic cation homeostasis 33.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0062012 regulation of small molecule metabolic process 33.3333 4 no
GO:0062013 positive regulation of small molecule metabolic process 33.3333 5 no
GO:0070372 regulation of ERK1 and ERK2 cascade 33.3333 7 no
GO:0070374 positive regulation of ERK1 and ERK2 cascade 33.3333 8 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 no
GO:1900271 regulation of long-term synaptic potentiation 33.3333 4 no
GO:1900272 negative regulation of long-term synaptic potentiation 33.3333 4 no
GO:1902652 secondary alcohol metabolic process 33.3333 4 no
GO:1902680 positive regulation of RNA biosynthetic process 33.3333 7 no
GO:1902903 regulation of supramolecular fiber organization 33.3333 5 no
GO:1902905 positive regulation of supramolecular fiber organization 33.3333 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
APOE_HUMAN [view entry] [view interactions] Low throughput yes yes
SIA8D_HUMAN [view interactions] High throughput no yes
TECT2_HUMAN [view interactions] High throughput no yes
SCNND_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
OLFM4_HUMAN [view interactions] High throughput no no
MAL_HUMAN [view interactions] High throughput no no
TR1L1_HUMAN [view interactions] High throughput no no
ZDH22_HUMAN [view interactions] High throughput no no
CKLF7_HUMAN [view interactions] High throughput no no
TM107_HUMAN [view interactions] High throughput no yes
SGMR2_HUMAN [view interactions] High throughput no no
TMM54_HUMAN [view interactions] High throughput no no
NKG7_HUMAN [view interactions] High throughput no no
PGAP2_HUMAN [view interactions] High throughput no yes
RSPH1_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
CL12B_HUMAN [view interactions] High throughput no no
CGB7_HUMAN [view interactions] High throughput no no
CGB3_HUMAN [view interactions] High throughput no no
NRSN1_HUMAN [view interactions] High throughput no yes
ATS12_HUMAN [view interactions] High throughput no no
APOM_HUMAN [view interactions] High throughput no no
DRB1_HUMAN [view interactions] High throughput no no
DRB3_HUMAN [view interactions] High throughput no no
TNF13_HUMAN [view interactions] High throughput no yes
KLK15_HUMAN [view interactions] High throughput no no
T106A_HUMAN [view interactions] High throughput no no
KLK5_HUMAN [view interactions] High throughput no no
CLC2B_HUMAN [view interactions] High throughput no yes
CATG_HUMAN [view interactions] High throughput no no
GRAH_HUMAN [view interactions] High throughput no no
SDF2L_HUMAN [view interactions] High throughput no yes
ADA30_HUMAN [view interactions] High throughput no no
CNTP3_HUMAN [view interactions] High throughput no yes
B3GN3_HUMAN [view interactions] High throughput no no
CBLN4_HUMAN [view interactions] High throughput no no
ITM2C_HUMAN [view interactions] High throughput no no
ECEL1_HUMAN [view interactions] High throughput no yes
PCDB7_HUMAN [view interactions] High throughput no yes
CHST8_HUMAN [view interactions] High throughput no no
PRG2_HUMAN [view interactions] High throughput no no
CMA1_HUMAN [view interactions] High throughput no no
B3GA2_HUMAN [view interactions] High throughput no no
SIA4C_HUMAN [view interactions] High throughput no yes
CFC1_HUMAN [view interactions] High throughput no no
SIA8E_HUMAN [view interactions] High throughput no yes
CAH14_HUMAN [view interactions] High throughput no yes
EDN3_HUMAN [view interactions] High throughput no no
PSPC_HUMAN [view interactions] High throughput no no
CLC2D_HUMAN [view interactions] High throughput no yes
ASIC4_HUMAN [view interactions] High throughput no no
HDBP1_HUMAN [view interactions] High throughput no no
CD1A_HUMAN [view interactions] High throughput no no
GXLT1_HUMAN [view interactions] High throughput no no
HLAC_HUMAN [view interactions] High throughput no no
UQCC1_HUMAN [view interactions] High throughput no yes
HLAG_HUMAN [view interactions] High throughput no no
P2RX2_HUMAN [view entry] [view interactions] High throughput yes no
UPK2_HUMAN [view interactions] High throughput no no
CDHR4_HUMAN [view interactions] High throughput no no
APBA3_HUMAN [view interactions] High throughput no yes
DQB1_HUMAN [view interactions] High throughput no no
LY86_HUMAN [view interactions] High throughput no no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes