CSTN3_HUMAN
Evidence for PS localization
Functions
May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CSTN3_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 100.0000 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 66.6667 | 4 | no |
| GO:0050750 | low-density lipoprotein particle receptor binding | 66.6667 | 5 | no |
| GO:0070325 | lipoprotein particle receptor binding | 66.6667 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CSTN3_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 100.0000 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 100.0000 | 5 | yes |
| GO:0022607 | cellular component assembly | 100.0000 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 100.0000 | 4 | yes |
| GO:0032880 | regulation of protein localization | 100.0000 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 100.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 100.0000 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 100.0000 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 100.0000 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 100.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 100.0000 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 100.0000 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 100.0000 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 100.0000 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 100.0000 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 66.6667 | 6 | no |
| GO:0062012 | regulation of small molecule metabolic process | 66.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 66.6667 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 66.6667 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 66.6667 | 5 | no |
| GO:0070201 | regulation of establishment of protein localization | 66.6667 | 6 | no |
| GO:0010629 | negative regulation of gene expression | 66.6667 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 66.6667 | 5 | no |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 66.6667 | 7 | no |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 66.6667 | 8 | no |
| GO:0010941 | regulation of cell death | 66.6667 | 4 | no |
| GO:0010942 | positive regulation of cell death | 66.6667 | 5 | no |
| GO:0016125 | sterol metabolic process | 66.6667 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 66.6667 | 4 | no |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 66.6667 | 7 | no |
| GO:0019216 | regulation of lipid metabolic process | 66.6667 | 5 | no |
| GO:0072503 | cellular divalent inorganic cation homeostasis | 66.6667 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 66.6667 | 5 | no |
| GO:0072507 | divalent inorganic cation homeostasis | 66.6667 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 66.6667 | 6 | no |
| GO:0080090 | regulation of primary metabolic process | 66.6667 | 4 | no |
| GO:0080134 | regulation of response to stress | 66.6667 | 4 | no |
| GO:0019932 | second-messenger-mediated signaling | 66.6667 | 4 | no |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway | 66.6667 | 7 | no |
| GO:0023057 | negative regulation of signaling | 66.6667 | 4 | no |
| GO:0030003 | cellular cation homeostasis | 66.6667 | 5 | no |
| GO:0030030 | cell projection organization | 66.6667 | 4 | no |
| GO:0030100 | regulation of endocytosis | 66.6667 | 5 | no |
| GO:0030111 | regulation of Wnt signaling pathway | 66.6667 | 5 | no |
| GO:0098771 | inorganic ion homeostasis | 66.6667 | 6 | no |
| GO:0030162 | regulation of proteolysis | 66.6667 | 6 | no |
| GO:0030178 | negative regulation of Wnt signaling pathway | 66.6667 | 6 | no |
| GO:0030334 | regulation of cell migration | 66.6667 | 5 | no |
| GO:0099175 | regulation of postsynapse organization | 66.6667 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 66.6667 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 66.6667 | 5 | no |
| GO:0031175 | neuron projection development | 66.6667 | 6 | no |
| GO:0031323 | regulation of cellular metabolic process | 66.6667 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 66.6667 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 66.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 66.6667 | 5 | no |
| GO:1900221 | regulation of amyloid-beta clearance | 66.6667 | 4 | no |
| GO:1900271 | regulation of long-term synaptic potentiation | 66.6667 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 66.6667 | 6 | no |
| GO:1900272 | negative regulation of long-term synaptic potentiation | 66.6667 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 66.6667 | 5 | no |
| GO:0031331 | positive regulation of cellular catabolic process | 66.6667 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 66.6667 | 5 | no |
| GO:0031345 | negative regulation of cell projection organization | 66.6667 | 6 | no |
| GO:0031347 | regulation of defense response | 66.6667 | 5 | no |
| GO:0031399 | regulation of protein modification process | 66.6667 | 6 | no |
| GO:1901214 | regulation of neuron death | 66.6667 | 5 | no |
| GO:1901215 | negative regulation of neuron death | 66.6667 | 6 | no |
| GO:1901216 | positive regulation of neuron death | 66.6667 | 6 | no |
| GO:0032092 | positive regulation of protein binding | 66.6667 | 5 | no |
| GO:0032101 | regulation of response to external stimulus | 66.6667 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 66.6667 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 66.6667 | 6 | no |
| GO:1902652 | secondary alcohol metabolic process | 66.6667 | 4 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 66.6667 | 7 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 66.6667 | 5 | no |
| GO:1902905 | positive regulation of supramolecular fiber organization | 66.6667 | 6 | no |
| GO:1902947 | regulation of tau-protein kinase activity | 66.6667 | 7 | no |
| GO:1902950 | regulation of dendritic spine maintenance | 66.6667 | 7 | no |
| GO:1902951 | negative regulation of dendritic spine maintenance | 66.6667 | 7 | no |
| GO:0034248 | regulation of cellular amide metabolic process | 66.6667 | 5 | no |
| GO:1902991 | regulation of amyloid precursor protein catabolic process | 66.6667 | 6 | no |
| GO:1902993 | positive regulation of amyloid precursor protein catabolic process | 66.6667 | 7 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 66.6667 | 7 | no |
| GO:0042127 | regulation of cell population proliferation | 66.6667 | 4 | no |
| GO:0042157 | lipoprotein metabolic process | 66.6667 | 4 | no |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 66.6667 | 8 | no |
| GO:0042176 | regulation of protein catabolic process | 66.6667 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 66.6667 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 66.6667 | 6 | no |
| GO:1903828 | negative regulation of protein localization | 66.6667 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 66.6667 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 66.6667 | 4 | no |
| GO:0043393 | regulation of protein binding | 66.6667 | 4 | no |
| GO:0043405 | regulation of MAP kinase activity | 66.6667 | 8 | no |
| GO:0043408 | regulation of MAPK cascade | 66.6667 | 6 | no |
| GO:0043410 | positive regulation of MAPK cascade | 66.6667 | 7 | no |
| GO:0043523 | regulation of neuron apoptotic process | 66.6667 | 6 | no |
| GO:1905906 | regulation of amyloid fibril formation | 66.6667 | 6 | no |
| GO:1905908 | positive regulation of amyloid fibril formation | 66.6667 | 7 | no |
| GO:0043549 | regulation of kinase activity | 66.6667 | 5 | no |
| GO:0043933 | protein-containing complex organization | 66.6667 | 4 | no |
| GO:0001558 | regulation of cell growth | 66.6667 | 4 | yes |
| GO:0044057 | regulation of system process | 66.6667 | 4 | no |
| GO:2000145 | regulation of cell motility | 66.6667 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 66.6667 | 6 | yes |
| GO:0007416 | synapse assembly | 66.6667 | 6 | yes |
| GO:0034329 | cell junction assembly | 66.6667 | 5 | yes |
| GO:0034330 | cell junction organization | 66.6667 | 4 | yes |
| GO:0045732 | positive regulation of protein catabolic process | 66.6667 | 6 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 66.6667 | 5 | yes |
| GO:0045807 | positive regulation of endocytosis | 66.6667 | 5 | no |
| GO:0045834 | positive regulation of lipid metabolic process | 66.6667 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 66.6667 | 6 | no |
| GO:0050806 | positive regulation of synaptic transmission | 66.6667 | 5 | yes |
| GO:0045859 | regulation of protein kinase activity | 66.6667 | 6 | no |
| GO:0050808 | synapse organization | 66.6667 | 5 | yes |
| GO:0045862 | positive regulation of proteolysis | 66.6667 | 7 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 66.6667 | 7 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 66.6667 | 6 | no |
| GO:0051963 | regulation of synapse assembly | 66.6667 | 6 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 66.6667 | 5 | yes |
| GO:0099174 | regulation of presynapse organization | 66.6667 | 6 | yes |
| GO:0099537 | trans-synaptic signaling | 66.6667 | 4 | yes |
| GO:1901888 | regulation of cell junction assembly | 66.6667 | 5 | yes |
| GO:0048168 | regulation of neuronal synaptic plasticity | 66.6667 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 66.6667 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 66.6667 | 4 | no |
| GO:1905606 | regulation of presynapse assembly | 66.6667 | 7 | yes |
| GO:0048584 | positive regulation of response to stimulus | 66.6667 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 66.6667 | 4 | no |
| GO:0048638 | regulation of developmental growth | 66.6667 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 66.6667 | 7 | no |
| GO:0048878 | chemical homeostasis | 66.6667 | 4 | no |
| GO:0050727 | regulation of inflammatory response | 66.6667 | 5 | no |
| GO:0050776 | regulation of immune response | 66.6667 | 4 | no |
| GO:0050801 | ion homeostasis | 66.6667 | 5 | no |
| GO:0050865 | regulation of cell activation | 66.6667 | 4 | no |
| GO:0050890 | cognition | 66.6667 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 66.6667 | 6 | no |
| GO:0051043 | regulation of membrane protein ectodomain proteolysis | 66.6667 | 6 | no |
| GO:0051044 | positive regulation of membrane protein ectodomain proteolysis | 66.6667 | 7 | no |
| GO:0051049 | regulation of transport | 66.6667 | 4 | no |
| GO:0051050 | positive regulation of transport | 66.6667 | 4 | no |
| GO:0006873 | cellular ion homeostasis | 66.6667 | 4 | no |
| GO:0006874 | cellular calcium ion homeostasis | 66.6667 | 7 | no |
| GO:0051093 | negative regulation of developmental process | 66.6667 | 4 | no |
| GO:0006875 | cellular metal ion homeostasis | 66.6667 | 6 | no |
| GO:0051099 | positive regulation of binding | 66.6667 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 66.6667 | 5 | no |
| GO:0006897 | endocytosis | 66.6667 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 66.6667 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 66.6667 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 66.6667 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 66.6667 | 5 | no |
| GO:0051223 | regulation of protein transport | 66.6667 | 5 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 66.6667 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 66.6667 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 66.6667 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 66.6667 | 5 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 66.6667 | 6 | no |
| GO:0007613 | memory | 66.6667 | 4 | no |
| GO:0008202 | steroid metabolic process | 66.6667 | 4 | no |
| GO:0008203 | cholesterol metabolic process | 66.6667 | 5 | no |
| GO:0051338 | regulation of transferase activity | 66.6667 | 4 | no |
| GO:0008285 | negative regulation of cell population proliferation | 66.6667 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 66.6667 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 66.6667 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 66.6667 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 66.6667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 66.6667 | 4 | no |
| GO:0009894 | regulation of catabolic process | 66.6667 | 4 | no |
| GO:0055065 | metal ion homeostasis | 66.6667 | 7 | no |
| GO:0009896 | positive regulation of catabolic process | 66.6667 | 5 | no |
| GO:0009966 | regulation of signal transduction | 66.6667 | 4 | no |
| GO:0055074 | calcium ion homeostasis | 66.6667 | 8 | no |
| GO:0009967 | positive regulation of signal transduction | 66.6667 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 66.6667 | 5 | no |
| GO:0055080 | cation homeostasis | 66.6667 | 6 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 66.6667 | 4 | no |
| GO:0060548 | negative regulation of cell death | 66.6667 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 66.6667 | 4 | no |
| GO:0060828 | regulation of canonical Wnt signaling pathway | 66.6667 | 6 | no |
| GO:0010468 | regulation of gene expression | 66.6667 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 66.6667 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| APOE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SIA8D_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| SCNND_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OLFM4_HUMAN | [view interactions] | High throughput | no | no |
| MAL_HUMAN | [view interactions] | High throughput | no | no |
| TR1L1_HUMAN | [view interactions] | High throughput | no | no |
| ZDH22_HUMAN | [view interactions] | High throughput | no | no |
| CKLF7_HUMAN | [view interactions] | High throughput | no | no |
| TM107_HUMAN | [view interactions] | High throughput | no | yes |
| SGMR2_HUMAN | [view interactions] | High throughput | no | no |
| TMM54_HUMAN | [view interactions] | High throughput | no | no |
| NKG7_HUMAN | [view interactions] | High throughput | no | no |
| PGAP2_HUMAN | [view interactions] | High throughput | no | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| CL12B_HUMAN | [view interactions] | High throughput | no | no |
| CGB7_HUMAN | [view interactions] | High throughput | no | no |
| CGB3_HUMAN | [view interactions] | High throughput | no | no |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| ATS12_HUMAN | [view interactions] | High throughput | no | no |
| APOM_HUMAN | [view interactions] | High throughput | no | no |
| DRB1_HUMAN | [view interactions] | High throughput | no | no |
| DRB3_HUMAN | [view interactions] | High throughput | no | no |
| TNF13_HUMAN | [view interactions] | High throughput | no | yes |
| KLK15_HUMAN | [view interactions] | High throughput | no | no |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| KLK5_HUMAN | [view interactions] | High throughput | no | no |
| CLC2B_HUMAN | [view interactions] | High throughput | no | yes |
| CATG_HUMAN | [view interactions] | High throughput | no | no |
| GRAH_HUMAN | [view interactions] | High throughput | no | no |
| SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
| ADA30_HUMAN | [view interactions] | High throughput | no | no |
| CNTP3_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN3_HUMAN | [view interactions] | High throughput | no | no |
| CBLN4_HUMAN | [view interactions] | High throughput | no | no |
| ITM2C_HUMAN | [view interactions] | High throughput | no | no |
| ECEL1_HUMAN | [view interactions] | High throughput | no | yes |
| PCDB7_HUMAN | [view interactions] | High throughput | no | yes |
| CHST8_HUMAN | [view interactions] | High throughput | no | no |
| PRG2_HUMAN | [view interactions] | High throughput | no | no |
| CMA1_HUMAN | [view interactions] | High throughput | no | no |
| B3GA2_HUMAN | [view interactions] | High throughput | no | no |
| SIA4C_HUMAN | [view interactions] | High throughput | no | yes |
| CFC1_HUMAN | [view interactions] | High throughput | no | no |
| SIA8E_HUMAN | [view interactions] | High throughput | no | yes |
| CAH14_HUMAN | [view interactions] | High throughput | no | yes |
| EDN3_HUMAN | [view interactions] | High throughput | no | no |
| PSPC_HUMAN | [view interactions] | High throughput | no | no |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| ASIC4_HUMAN | [view interactions] | High throughput | no | no |
| HDBP1_HUMAN | [view interactions] | High throughput | no | no |
| CD1A_HUMAN | [view interactions] | High throughput | no | no |
| GXLT1_HUMAN | [view interactions] | High throughput | no | no |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| UQCC1_HUMAN | [view interactions] | High throughput | no | yes |
| HLAG_HUMAN | [view interactions] | High throughput | no | no |
| P2RX2_HUMAN | [view interactions] | High throughput | no | no |
| UPK2_HUMAN | [view interactions] | High throughput | no | no |
| CDHR4_HUMAN | [view interactions] | High throughput | no | no |
| APBA3_HUMAN | [view interactions] | High throughput | no | yes |
| DQB1_HUMAN | [view interactions] | High throughput | no | no |
| LY86_HUMAN | [view interactions] | High throughput | no | no |