Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

APOE_HUMAN

(Microbial infection) Through its interaction with HCV envelope glycoprotein E2, participates in the attachment of HCV to HSPGs and other receptors (LDLr, VLDLr, and SR-B1) on the cell surface and to the assembly, maturation and infectivity of HCV viral particles (PubMed, PubMed). This interaction is probably promoted via the up-regulation of cellular autophagy by the virus (PubMed). [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.
Position Amino acid Mutation Disease Overlap with binding region
31 Glu Lys Hyperlipoproteinemia3(HLPP3) -
130 Cys Arg Alzheimerdisease2(AD2) -
130 Cys Arg Hyperlipoproteinemia3(HLPP3) -
154 Arg Ser Hyperlipoproteinemia3(HLPP3) -
154 Arg Cys Hyperlipoproteinemia3(HLPP3) -
160 Arg Cys Hyperlipoproteinemia3(HLPP3) -
163 Arg Cys Hyperlipoproteinemia3(HLPP3) -
164 Lys Gln Hyperlipoproteinemia3(HLPP3) -
164 Lys Glu Hyperlipoproteinemia3(HLPP3) -
176 Arg Cys Hyperlipoproteinemia3(HLPP3) -
43 Arg Cys Lipoproteinglomerulopathy(LPG) -
163 Arg Pro Lipoproteinglomerulopathy(LPG) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in APOE_HUMAN
GO:0046872 metal ion binding 29.4737 4 yes
GO:0003723 RNA binding 27.3684 4 no
GO:0042803 protein homodimerization activity 9.4737 4 yes
GO:0048156 tau protein binding 9.4737 4 yes
GO:0001540 amyloid-beta binding 8.4211 4 yes
GO:0070325 lipoprotein particle receptor binding 7.3684 4 yes
GO:0050750 low-density lipoprotein particle receptor binding 6.3158 5 yes
GO:0071813 lipoprotein particle binding 4.2105 4 yes
GO:0046911 metal chelating activity 2.1053 5 yes
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity 2.1053 4 yes
GO:0070326 very-low-density lipoprotein particle receptor binding 2.1053 5 yes
GO:0120015 sterol transfer activity 2.1053 4 yes
GO:0120020 cholesterol transfer activity 2.1053 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in APOE_HUMAN
GO:0048522 positive regulation of cellular process 49.4737 4 yes
GO:0060255 regulation of macromolecule metabolic process 44.2105 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 43.1579 4 yes
GO:0080090 regulation of primary metabolic process 43.1579 4 yes
GO:0031323 regulation of cellular metabolic process 43.1579 4 yes
GO:0048523 negative regulation of cellular process 42.1053 4 yes
GO:0010646 regulation of cell communication 38.9474 4 yes
GO:0022607 cellular component assembly 38.9474 4 yes
GO:0010468 regulation of gene expression 36.8421 5 yes
GO:0051128 regulation of cellular component organization 35.7895 4 yes
GO:0009893 positive regulation of metabolic process 35.7895 4 yes
GO:0009966 regulation of signal transduction 34.7368 4 yes
GO:0010941 regulation of cell death 34.7368 4 yes
GO:0051246 regulation of protein metabolic process 33.6842 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 33.6842 5 yes
GO:0009889 regulation of biosynthetic process 32.6316 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 31.5789 5 yes
GO:0031326 regulation of cellular biosynthetic process 31.5789 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 30.5263 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.5263 5 yes
GO:0042981 regulation of apoptotic process 30.5263 6 yes
GO:0043067 regulation of programmed cell death 30.5263 5 yes
GO:0009892 negative regulation of metabolic process 29.4737 4 yes
GO:0031325 positive regulation of cellular metabolic process 29.4737 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 28.4211 5 yes
GO:0043933 protein-containing complex organization 28.4211 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 27.3684 5 yes
GO:0051252 regulation of RNA metabolic process 27.3684 5 yes
GO:0006996 organelle organization 27.3684 4 yes
GO:0048584 positive regulation of response to stimulus 27.3684 4 yes
GO:0051247 positive regulation of protein metabolic process 26.3158 6 yes
GO:0010647 positive regulation of cell communication 26.3158 5 yes
GO:0023056 positive regulation of signaling 26.3158 4 yes
GO:0051240 positive regulation of multicellular organismal process 25.2632 4 yes
GO:0065003 protein-containing complex assembly 25.2632 5 yes
GO:0006355 regulation of DNA-templated transcription 24.2105 6 yes
GO:0008104 protein localization 24.2105 4 yes
GO:0009967 positive regulation of signal transduction 24.2105 5 yes
GO:1902531 regulation of intracellular signal transduction 24.2105 5 yes
GO:0031324 negative regulation of cellular metabolic process 24.2105 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 24.2105 7 yes
GO:2001141 regulation of RNA biosynthetic process 24.2105 6 yes
GO:0043085 positive regulation of catalytic activity 24.2105 4 yes
GO:0051049 regulation of transport 24.2105 4 yes
GO:0071702 organic substance transport 23.1579 4 yes
GO:0031399 regulation of protein modification process 23.1579 6 yes
GO:0051130 positive regulation of cellular component organization 22.1053 5 yes
GO:0071705 nitrogen compound transport 22.1053 4 yes
GO:0048585 negative regulation of response to stimulus 22.1053 4 yes
GO:0009894 regulation of catabolic process 21.0526 4 yes
GO:0009968 negative regulation of signal transduction 21.0526 5 yes
GO:0010648 negative regulation of cell communication 21.0526 5 yes
GO:0023057 negative regulation of signaling 21.0526 4 yes
GO:0060341 regulation of cellular localization 20.0000 4 yes
GO:0060548 negative regulation of cell death 20.0000 5 yes
GO:0009891 positive regulation of biosynthetic process 20.0000 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 20.0000 6 yes
GO:0032880 regulation of protein localization 20.0000 5 yes
GO:0044087 regulation of cellular component biogenesis 20.0000 4 yes
GO:0051174 regulation of phosphorus metabolic process 18.9474 5 yes
GO:0019220 regulation of phosphate metabolic process 18.9474 6 yes
GO:1902533 positive regulation of intracellular signal transduction 18.9474 6 yes
GO:0043066 negative regulation of apoptotic process 18.9474 7 yes
GO:0043069 negative regulation of programmed cell death 18.9474 6 yes
GO:0051094 positive regulation of developmental process 17.8947 4 yes
GO:0051241 negative regulation of multicellular organismal process 17.8947 4 yes
GO:0051248 negative regulation of protein metabolic process 17.8947 6 yes
GO:0051338 regulation of transferase activity 17.8947 4 yes
GO:0010942 positive regulation of cell death 17.8947 5 yes
GO:0015031 protein transport 17.8947 4 yes
GO:0042325 regulation of phosphorylation 17.8947 7 yes
GO:0001932 regulation of protein phosphorylation 16.8421 7 yes
GO:0016192 vesicle-mediated transport 16.8421 4 yes
GO:0030162 regulation of proteolysis 16.8421 6 yes
GO:0031329 regulation of cellular catabolic process 16.8421 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 16.8421 6 yes
GO:0055080 cation homeostasis 15.7895 6 yes
GO:0009059 macromolecule biosynthetic process 15.7895 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 15.7895 6 yes
GO:0080134 regulation of response to stress 15.7895 4 yes
GO:0098771 inorganic ion homeostasis 15.7895 6 yes
GO:0048878 chemical homeostasis 15.7895 4 yes
GO:0050801 ion homeostasis 15.7895 5 yes
GO:0006897 endocytosis 14.7368 5 yes
GO:0055065 metal ion homeostasis 14.7368 7 yes
GO:0009890 negative regulation of biosynthetic process 14.7368 5 yes
GO:0030030 cell projection organization 14.7368 4 yes
GO:1901566 organonitrogen compound biosynthetic process 14.7368 4 yes
GO:0043549 regulation of kinase activity 14.7368 5 yes
GO:0051129 negative regulation of cellular component organization 13.6842 5 yes
GO:0006873 cellular ion homeostasis 13.6842 4 yes
GO:0051254 positive regulation of RNA metabolic process 13.6842 6 yes
GO:0010629 negative regulation of gene expression 13.6842 6 yes
GO:0099177 regulation of trans-synaptic signaling 13.6842 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 13.6842 6 yes
GO:0030003 cellular cation homeostasis 13.6842 5 yes
GO:1902903 regulation of supramolecular fiber organization 13.6842 5 yes
GO:0031344 regulation of cell projection organization 13.6842 5 yes
GO:0034248 regulation of cellular amide metabolic process 13.6842 5 yes
GO:0042127 regulation of cell population proliferation 13.6842 4 yes
GO:0043408 regulation of MAPK cascade 13.6842 6 yes
GO:0044089 positive regulation of cellular component biogenesis 13.6842 5 yes
GO:0050804 modulation of chemical synaptic transmission 13.6842 5 yes
GO:0051050 positive regulation of transport 13.6842 4 yes
GO:0006875 cellular metal ion homeostasis 12.6316 6 yes
GO:0009057 macromolecule catabolic process 12.6316 4 yes
GO:0009896 positive regulation of catabolic process 12.6316 5 yes
GO:1901214 regulation of neuron death 12.6316 5 yes
GO:1902680 positive regulation of RNA biosynthetic process 12.6316 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 12.6316 8 yes
GO:0034645 cellular macromolecule biosynthetic process 12.6316 4 yes
GO:0042176 regulation of protein catabolic process 12.6316 5 yes
GO:0043410 positive regulation of MAPK cascade 12.6316 7 yes
GO:0045859 regulation of protein kinase activity 12.6316 6 yes
GO:0045893 positive regulation of DNA-templated transcription 12.6316 7 yes
GO:0050807 regulation of synapse organization 12.6316 5 yes
GO:0007010 cytoskeleton organization 11.5789 5 yes
GO:0060627 regulation of vesicle-mediated transport 11.5789 4 yes
GO:1901565 organonitrogen compound catabolic process 11.5789 4 yes
GO:0043086 negative regulation of catalytic activity 11.5789 4 yes
GO:0043254 regulation of protein-containing complex assembly 11.5789 5 yes
GO:0050776 regulation of immune response 11.5789 4 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 10.5263 7 yes
GO:0120036 plasma membrane bounded cell projection organization 10.5263 5 yes
GO:0030163 protein catabolic process 10.5263 4 yes
GO:0031400 negative regulation of protein modification process 10.5263 7 yes
GO:0045732 positive regulation of protein catabolic process 10.5263 6 yes
GO:0045862 positive regulation of proteolysis 10.5263 7 yes
GO:0008285 negative regulation of cell population proliferation 9.4737 5 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 9.4737 8 yes
GO:0072503 cellular divalent inorganic cation homeostasis 9.4737 6 yes
GO:0072507 divalent inorganic cation homeostasis 9.4737 7 yes
GO:0010975 regulation of neuron projection development 9.4737 7 yes
GO:0099537 trans-synaptic signaling 9.4737 4 yes
GO:1901216 positive regulation of neuron death 9.4737 6 yes
GO:0030111 regulation of Wnt signaling pathway 9.4737 5 yes
GO:0030334 regulation of cell migration 9.4737 5 yes
GO:0032101 regulation of response to external stimulus 9.4737 4 yes
GO:2000145 regulation of cell motility 9.4737 4 yes
GO:0043393 regulation of protein binding 9.4737 4 yes
GO:0044057 regulation of system process 9.4737 4 yes
GO:0050865 regulation of cell activation 9.4737 4 yes
GO:0050890 cognition 9.4737 4 yes
GO:0051093 negative regulation of developmental process 9.4737 4 yes
GO:0001558 regulation of cell growth 8.4211 4 yes
GO:0006874 cellular calcium ion homeostasis 8.4211 7 yes
GO:0007268 chemical synaptic transmission 8.4211 6 yes
GO:0055074 calcium ion homeostasis 8.4211 8 yes
GO:0070201 regulation of establishment of protein localization 8.4211 6 yes
GO:0098916 anterograde trans-synaptic signaling 8.4211 5 yes
GO:0030100 regulation of endocytosis 8.4211 5 yes
GO:1902905 positive regulation of supramolecular fiber organization 8.4211 6 yes
GO:0031331 positive regulation of cellular catabolic process 8.4211 6 yes
GO:1902991 regulation of amyloid precursor protein catabolic process 8.4211 6 yes
GO:0043523 regulation of neuron apoptotic process 8.4211 6 yes
GO:0051223 regulation of protein transport 7.3684 5 yes
GO:0006898 receptor-mediated endocytosis 7.3684 6 yes
GO:0007613 memory 7.3684 4 yes
GO:0060828 regulation of canonical Wnt signaling pathway 7.3684 6 yes
GO:0062012 regulation of small molecule metabolic process 7.3684 4 yes
GO:0010563 negative regulation of phosphorus metabolic process 7.3684 6 yes
GO:0099175 regulation of postsynapse organization 7.3684 6 yes
GO:0019216 regulation of lipid metabolic process 7.3684 5 yes
GO:1902003 regulation of amyloid-beta formation 7.3684 6 yes
GO:0031346 positive regulation of cell projection organization 7.3684 6 yes
GO:1902992 negative regulation of amyloid precursor protein catabolic process 7.3684 7 yes
GO:1903050 regulation of proteolysis involved in protein catabolic process 7.3684 7 yes
GO:0034250 positive regulation of cellular amide metabolic process 7.3684 6 yes
GO:0042326 negative regulation of phosphorylation 7.3684 8 yes
GO:0045807 positive regulation of endocytosis 7.3684 5 yes
GO:0045936 negative regulation of phosphate metabolic process 7.3684 7 yes
GO:0048638 regulation of developmental growth 7.3684 4 yes
GO:0051051 negative regulation of transport 7.3684 4 yes
GO:0051099 positive regulation of binding 6.3158 4 yes
GO:0001933 negative regulation of protein phosphorylation 6.3158 8 yes
GO:0051348 negative regulation of transferase activity 6.3158 5 yes
GO:0071900 regulation of protein serine/threonine kinase activity 6.3158 7 yes
GO:1900271 regulation of long-term synaptic potentiation 6.3158 4 yes
GO:1901215 negative regulation of neuron death 6.3158 6 yes
GO:1902430 negative regulation of amyloid-beta formation 6.3158 7 yes
GO:1902532 negative regulation of intracellular signal transduction 6.3158 6 yes
GO:0031175 neuron projection development 6.3158 6 yes
GO:1902904 negative regulation of supramolecular fiber organization 6.3158 6 yes
GO:0031345 negative regulation of cell projection organization 6.3158 6 yes
GO:0031347 regulation of defense response 6.3158 5 yes
GO:1902993 positive regulation of amyloid precursor protein catabolic process 6.3158 7 yes
GO:1903530 regulation of secretion by cell 6.3158 4 yes
GO:1903828 negative regulation of protein localization 6.3158 5 yes
GO:0034249 negative regulation of cellular amide metabolic process 6.3158 6 yes
GO:1905906 regulation of amyloid fibril formation 6.3158 6 yes
GO:0051046 regulation of secretion 6.3158 5 yes
GO:0002831 regulation of response to biotic stimulus 5.2632 4 yes
GO:0051341 regulation of oxidoreductase activity 5.2632 4 yes
GO:0061041 regulation of wound healing 5.2632 6 yes
GO:0061136 regulation of proteasomal protein catabolic process 5.2632 6 yes
GO:0072657 protein localization to membrane 5.2632 4 yes
GO:0010976 positive regulation of neuron projection development 5.2632 7 yes
GO:0016042 lipid catabolic process 5.2632 4 yes
GO:1900221 regulation of amyloid-beta clearance 5.2632 4 yes
GO:0019932 second-messenger-mediated signaling 5.2632 4 yes
GO:0030178 negative regulation of Wnt signaling pathway 5.2632 6 yes
GO:1902004 positive regulation of amyloid-beta formation 5.2632 7 yes
GO:1902947 regulation of tau-protein kinase activity 5.2632 7 yes
GO:0031667 response to nutrient levels 5.2632 4 yes
GO:0032092 positive regulation of protein binding 5.2632 5 yes
GO:0032102 negative regulation of response to external stimulus 5.2632 5 yes
GO:1903034 regulation of response to wounding 5.2632 5 yes
GO:0033673 negative regulation of kinase activity 5.2632 6 yes
GO:1905908 positive regulation of amyloid fibril formation 5.2632 7 yes
GO:0045834 positive regulation of lipid metabolic process 5.2632 5 yes
GO:0048168 regulation of neuronal synaptic plasticity 5.2632 4 yes
GO:0048660 regulation of smooth muscle cell proliferation 5.2632 5 yes
GO:0050818 regulation of coagulation 5.2632 4 yes
GO:0050866 negative regulation of cell activation 5.2632 5 yes
GO:0003018 vascular process in circulatory system 4.2105 4 yes
GO:0006469 negative regulation of protein kinase activity 4.2105 7 yes
GO:0051353 positive regulation of oxidoreductase activity 4.2105 5 yes
GO:0051851 modulation by host of symbiont process 4.2105 4 yes
GO:0008202 steroid metabolic process 4.2105 4 yes
GO:0060998 regulation of dendritic spine development 4.2105 4 yes
GO:0060999 positive regulation of dendritic spine development 4.2105 5 yes
GO:0061387 regulation of extent of cell growth 4.2105 5 yes
GO:0090090 negative regulation of canonical Wnt signaling pathway 4.2105 7 yes
GO:0010977 negative regulation of neuron projection development 4.2105 7 yes
GO:0015849 organic acid transport 4.2105 5 yes
GO:0015850 organic hydroxy compound transport 4.2105 5 yes
GO:0016125 sterol metabolic process 4.2105 4 yes
GO:1900272 negative regulation of long-term synaptic potentiation 4.2105 4 yes
GO:1901361 organic cyclic compound catabolic process 4.2105 4 yes
GO:0030193 regulation of blood coagulation 4.2105 4 yes
GO:0030336 negative regulation of cell migration 4.2105 6 yes
GO:0030516 regulation of axon extension 4.2105 5 yes
GO:1902930 regulation of alcohol biosynthetic process 4.2105 5 yes
GO:1902950 regulation of dendritic spine maintenance 4.2105 7 yes
GO:1902951 negative regulation of dendritic spine maintenance 4.2105 7 yes
GO:0032768 regulation of monooxygenase activity 4.2105 5 yes
GO:1903531 negative regulation of secretion by cell 4.2105 5 yes
GO:2000146 negative regulation of cell motility 4.2105 5 yes
GO:0040013 negative regulation of locomotion 4.2105 4 yes
GO:0042982 amyloid precursor protein metabolic process 4.2105 4 yes
GO:0043405 regulation of MAP kinase activity 4.2105 8 yes
GO:0043524 negative regulation of neuron apoptotic process 4.2105 7 yes
GO:0044788 modulation by host of viral process 4.2105 5 yes
GO:0045088 regulation of innate immune response 4.2105 5 yes
GO:0046578 regulation of Ras protein signal transduction 4.2105 7 yes
GO:0050678 regulation of epithelial cell proliferation 4.2105 5 yes
GO:0050727 regulation of inflammatory response 4.2105 5 yes
GO:0051048 negative regulation of secretion 4.2105 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 4.2105 6 yes
GO:0000302 response to reactive oxygen species 4.2105 4 yes
GO:0006638 neutral lipid metabolic process 3.1579 4 yes
GO:0006869 lipid transport 3.1579 5 yes
GO:0007271 synaptic transmission, cholinergic 3.1579 7 yes
GO:0007616 long-term memory 3.1579 5 yes
GO:0008203 cholesterol metabolic process 3.1579 5 yes
GO:0061045 negative regulation of wound healing 3.1579 6 yes
GO:0010543 regulation of platelet activation 3.1579 5 yes
GO:0065005 protein-lipid complex assembly 3.1579 6 yes
GO:0010544 negative regulation of platelet activation 3.1579 6 yes
GO:0071825 protein-lipid complex subunit organization 3.1579 5 yes
GO:0010632 regulation of epithelial cell migration 3.1579 4 yes
GO:0010874 regulation of cholesterol efflux 3.1579 8 yes
GO:0090083 regulation of inclusion body assembly 3.1579 5 yes
GO:0010875 positive regulation of cholesterol efflux 3.1579 8 yes
GO:0090181 regulation of cholesterol metabolic process 3.1579 5 yes
GO:0090261 positive regulation of inclusion body assembly 3.1579 6 yes
GO:0097746 blood vessel diameter maintenance 3.1579 5 yes
GO:0015918 sterol transport 3.1579 6 yes
GO:0106118 regulation of sterol biosynthetic process 3.1579 7 yes
GO:0017038 protein import 3.1579 5 yes
GO:0019218 regulation of steroid metabolic process 3.1579 6 yes
GO:1900047 negative regulation of hemostasis 3.1579 4 yes
GO:1900223 positive regulation of amyloid-beta clearance 3.1579 5 yes
GO:0030195 negative regulation of blood coagulation 3.1579 5 yes
GO:0030301 cholesterol transport 3.1579 7 yes
GO:1902652 secondary alcohol metabolic process 3.1579 4 yes
GO:1902996 regulation of neurofibrillary tangle assembly 3.1579 6 yes
GO:1902998 positive regulation of neurofibrillary tangle assembly 3.1579 7 yes
GO:0032368 regulation of lipid transport 3.1579 5 yes
GO:0032370 positive regulation of lipid transport 3.1579 5 yes
GO:0032371 regulation of sterol transport 3.1579 6 yes
GO:0032373 positive regulation of sterol transport 3.1579 6 yes
GO:1903035 negative regulation of response to wounding 3.1579 5 yes
GO:0032374 regulation of cholesterol transport 3.1579 7 yes
GO:0032376 positive regulation of cholesterol transport 3.1579 7 yes
GO:0032770 positive regulation of monooxygenase activity 3.1579 6 yes
GO:1904950 negative regulation of establishment of protein localization 3.1579 6 yes
GO:1905907 negative regulation of amyloid fibril formation 3.1579 7 yes
GO:1905952 regulation of lipid localization 3.1579 4 yes
GO:1905954 positive regulation of lipid localization 3.1579 4 yes
GO:0035150 regulation of tube size 3.1579 4 yes
GO:0035296 regulation of tube diameter 3.1579 5 yes
GO:0042157 lipoprotein metabolic process 3.1579 4 yes
GO:0043113 receptor clustering 3.1579 5 yes
GO:0043409 negative regulation of MAPK cascade 3.1579 7 yes
GO:0043691 reverse cholesterol transport 3.1579 8 yes
GO:0044794 positive regulation by host of viral process 3.1579 6 yes
GO:0045540 regulation of cholesterol biosynthetic process 3.1579 6 yes
GO:0045940 positive regulation of steroid metabolic process 3.1579 6 yes
GO:0046486 glycerolipid metabolic process 3.1579 4 yes
GO:0046889 positive regulation of lipid biosynthetic process 3.1579 6 yes
GO:0046890 regulation of lipid biosynthetic process 3.1579 5 yes
GO:0048514 blood vessel morphogenesis 3.1579 4 yes
GO:0048662 negative regulation of smooth muscle cell proliferation 3.1579 6 yes
GO:0048844 artery morphogenesis 3.1579 5 yes
GO:0050680 negative regulation of epithelial cell proliferation 3.1579 6 yes
GO:0050708 regulation of protein secretion 3.1579 5 yes
GO:0050810 regulation of steroid biosynthetic process 3.1579 6 yes
GO:0050819 negative regulation of coagulation 3.1579 5 yes
GO:0051043 regulation of membrane protein ectodomain proteolysis 3.1579 6 yes
GO:0051044 positive regulation of membrane protein ectodomain proteolysis 3.1579 7 yes
GO:0001936 regulation of endothelial cell proliferation 2.1053 6 yes
GO:0001937 negative regulation of endothelial cell proliferation 2.1053 7 yes
GO:0006639 acylglycerol metabolic process 2.1053 5 yes
GO:0051224 negative regulation of protein transport 2.1053 5 yes
GO:0006641 triglyceride metabolic process 2.1053 6 yes
GO:0006706 steroid catabolic process 2.1053 5 yes
GO:0006707 cholesterol catabolic process 2.1053 5 yes
GO:0007263 nitric oxide mediated signal transduction 2.1053 5 yes
GO:0055088 lipid homeostasis 2.1053 5 yes
GO:0055089 fatty acid homeostasis 2.1053 6 yes
GO:0055090 acylglycerol homeostasis 2.1053 6 yes
GO:0055092 sterol homeostasis 2.1053 6 yes
GO:0061000 negative regulation of dendritic spine development 2.1053 5 yes
GO:0010467 gene expression 2.1053 4 yes
GO:0062014 negative regulation of small molecule metabolic process 2.1053 5 yes
GO:0070328 triglyceride homeostasis 2.1053 7 yes
GO:0010594 regulation of endothelial cell migration 2.1053 5 yes
GO:0010596 negative regulation of endothelial cell migration 2.1053 6 yes
GO:0071831 intermediate-density lipoprotein particle clearance 2.1053 4 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 2.1053 8 yes
GO:0010633 negative regulation of epithelial cell migration 2.1053 5 yes
GO:0072578 neurotransmitter-gated ion channel clustering 2.1053 6 yes
GO:0010872 regulation of cholesterol esterification 2.1053 5 yes
GO:0010873 positive regulation of cholesterol esterification 2.1053 6 yes
GO:0010877 lipid transport involved in lipid storage 2.1053 6 yes
GO:0010894 negative regulation of steroid biosynthetic process 2.1053 7 yes
GO:0090206 negative regulation of cholesterol metabolic process 2.1053 6 yes
GO:0090207 regulation of triglyceride metabolic process 2.1053 5 yes
GO:0090209 negative regulation of triglyceride metabolic process 2.1053 6 yes
GO:0090370 negative regulation of cholesterol efflux 2.1053 8 yes
GO:0097113 AMPA glutamate receptor clustering 2.1053 8 yes
GO:0097114 NMDA glutamate receptor clustering 2.1053 7 yes
GO:0015748 organophosphate ester transport 2.1053 5 yes
GO:0097688 glutamate receptor clustering 2.1053 7 yes
GO:0015908 fatty acid transport 2.1053 6 yes
GO:0015909 long-chain fatty acid transport 2.1053 7 yes
GO:0015914 phospholipid transport 2.1053 6 yes
GO:0106119 negative regulation of sterol biosynthetic process 2.1053 8 yes
GO:0016127 sterol catabolic process 2.1053 5 yes
GO:0150200 regulation of transport across blood-brain barrier 2.1053 5 yes
GO:0150201 positive regulation of transport across blood-brain barrier 2.1053 5 yes
GO:0150202 negative regulation of transport across blood-brain barrier 2.1053 5 yes
GO:0019934 cGMP-mediated signaling 2.1053 6 yes
GO:0019935 cyclic-nucleotide-mediated signaling 2.1053 5 yes
GO:1901616 organic hydroxy compound catabolic process 2.1053 4 yes
GO:1901626 regulation of postsynaptic membrane organization 2.1053 5 yes
GO:1901627 negative regulation of postsynaptic membrane organization 2.1053 6 yes
GO:1901629 regulation of presynaptic membrane organization 2.1053 6 yes
GO:1901631 positive regulation of presynaptic membrane organization 2.1053 6 yes
GO:1902931 negative regulation of alcohol biosynthetic process 2.1053 6 yes
GO:1902952 positive regulation of dendritic spine maintenance 2.1053 7 yes
GO:0031348 negative regulation of defense response 2.1053 5 yes
GO:1902994 regulation of phospholipid efflux 2.1053 7 yes
GO:1902995 positive regulation of phospholipid efflux 2.1053 7 yes
GO:1902999 negative regulation of phospholipid efflux 2.1053 7 yes
GO:0032369 negative regulation of lipid transport 2.1053 5 yes
GO:1903000 regulation of lipid transport across blood-brain barrier 2.1053 6 yes
GO:1903001 negative regulation of lipid transport across blood-brain barrier 2.1053 6 yes
GO:1903002 positive regulation of lipid transport across blood-brain barrier 2.1053 6 yes
GO:0032372 negative regulation of sterol transport 2.1053 6 yes
GO:0032375 negative regulation of cholesterol transport 2.1053 7 yes
GO:1903365 regulation of fear response 2.1053 4 yes
GO:0032489 regulation of Cdc42 protein signal transduction 2.1053 9 yes
GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process 2.1053 6 yes
GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process 2.1053 7 yes
GO:1905809 negative regulation of synapse organization 2.1053 6 yes
GO:0033344 cholesterol efflux 2.1053 8 yes
GO:1905853 regulation of heparan sulfate binding 2.1053 4 yes
GO:1905855 positive regulation of heparan sulfate binding 2.1053 5 yes
GO:0033700 phospholipid efflux 2.1053 7 yes
GO:1905858 regulation of heparan sulfate proteoglycan binding 2.1053 5 yes
GO:1905860 positive regulation of heparan sulfate proteoglycan binding 2.1053 6 yes
GO:1905890 regulation of cellular response to very-low-density lipoprotein particle stimulus 2.1053 4 yes
GO:0034367 protein-containing complex remodeling 2.1053 5 yes
GO:0034368 protein-lipid complex remodeling 2.1053 6 yes
GO:0034370 triglyceride-rich lipoprotein particle remodeling 2.1053 4 yes
GO:0034372 very-low-density lipoprotein particle remodeling 2.1053 5 yes
GO:1905953 negative regulation of lipid localization 2.1053 4 yes
GO:0034374 low-density lipoprotein particle remodeling 2.1053 4 yes
GO:0034375 high-density lipoprotein particle remodeling 2.1053 4 yes
GO:0034380 high-density lipoprotein particle assembly 2.1053 4 yes
GO:0034382 chylomicron remnant clearance 2.1053 4 yes
GO:2000644 regulation of receptor catabolic process 2.1053 5 yes
GO:2000646 positive regulation of receptor catabolic process 2.1053 6 yes
GO:0035023 regulation of Rho protein signal transduction 2.1053 8 yes
GO:2000822 regulation of behavioral fear response 2.1053 5 yes
GO:2001138 regulation of phospholipid transport 2.1053 6 yes
GO:2001139 negative regulation of phospholipid transport 2.1053 6 yes
GO:0035641 locomotory exploration behavior 2.1053 4 yes
GO:2001140 positive regulation of phospholipid transport 2.1053 6 yes
GO:0042158 lipoprotein biosynthetic process 2.1053 5 yes
GO:0042159 lipoprotein catabolic process 2.1053 5 yes
GO:0042311 vasodilation 2.1053 6 yes
GO:0042632 cholesterol homeostasis 2.1053 7 yes
GO:0043407 negative regulation of MAP kinase activity 2.1053 8 yes
GO:0043535 regulation of blood vessel endothelial cell migration 2.1053 6 yes
GO:0043537 negative regulation of blood vessel endothelial cell migration 2.1053 7 yes
GO:0045541 negative regulation of cholesterol biosynthetic process 2.1053 7 yes
GO:0045833 negative regulation of lipid metabolic process 2.1053 5 yes
GO:0045939 negative regulation of steroid metabolic process 2.1053 6 yes
GO:0046164 alcohol catabolic process 2.1053 4 yes
GO:0050709 negative regulation of protein secretion 2.1053 6 yes
GO:0050728 negative regulation of inflammatory response 2.1053 6 yes
GO:0050795 regulation of behavior 2.1053 4 yes
GO:0050999 regulation of nitric-oxide synthase activity 2.1053 6 yes
GO:0051000 positive regulation of nitric-oxide synthase activity 2.1053 7 yes
GO:0051055 negative regulation of lipid biosynthetic process 2.1053 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in APOE_HUMAN
DOID:1289 neurodegenerative disease 5.2632 4 yes
DOID:331 central nervous system disease 5.2632 3 yes
DOID:0110035 Alzheimers disease 2 2.1053 7 yes
DOID:10652 Alzheimers disease 2.1053 6 yes
DOID:1168 familial hyperlipidemia 2.1053 4 yes
DOID:3145 hyperlipoproteinemia type III 2.1053 5 yes
DOID:3146 lipid metabolism disorder 2.1053 3 yes
DOID:680 tauopathy 2.1053 5 yes
DOID:0050753 cerebellar ataxia 2.1053 6 no
DOID:0050950 autosomal recessive cerebellar ataxia 2.1053 7 no
DOID:0050951 hereditary ataxia 2.1053 5 no
DOID:0080000 muscular disease 2.1053 3 no
DOID:423 myopathy 2.1053 5 no
DOID:66 muscle tissue disease 2.1053 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ECSIT_HUMAN [view interactions] Low throughput no yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
CLCF1_HUMAN [view interactions] Low throughput no yes
A2MG_HUMAN [view interactions] Low throughput no yes
LRP8_HUMAN [view entry] [view interactions] Low throughput yes no
ACHA7_HUMAN [view entry] [view interactions] Low throughput yes yes
NOS3_HUMAN [view interactions] Low throughput no no
PLTP_HUMAN [view interactions] Low throughput no no
SET_HUMAN [view interactions] Low throughput no yes
ITAM_HUMAN [view interactions] Low throughput no no
APOA1_HUMAN [view interactions] Low throughput no no
LRP2_HUMAN [view interactions] Low throughput no no
NFM_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
LCAT_HUMAN [view interactions] Low throughput no no
BCL2_HUMAN [view interactions] Low throughput no no
TMCC2_HUMAN [view interactions] Low throughput no yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
CSTN3_HUMAN [view entry] [view interactions] Low throughput yes no
TREM2_HUMAN [view interactions] Low throughput no yes
TREM1_HUMAN [view interactions] Low throughput no yes
LRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
HPT_HUMAN [view interactions] Low throughput no no
LDLR_HUMAN [view interactions] Low throughput no yes
APOE_HUMAN [view entry] [view interactions] Low throughput yes yes
CFAH_HUMAN [view interactions] Low throughput no no
VLDLR_HUMAN [view interactions] Low throughput no yes
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
SORL_HUMAN [view interactions] Low throughput no yes
CD81_HUMAN [view interactions] High throughput no no
PKHA7_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
GCDH_HUMAN [view interactions] High throughput no yes
CP2C8_HUMAN [view interactions] High throughput no no
LOXL4_HUMAN [view interactions] High throughput no no
IFIT3_HUMAN [view interactions] High throughput no yes
MAST1_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF32_HUMAN [view interactions] High throughput no no
LEG1_HUMAN [view interactions] High throughput no yes
CNTF_HUMAN [view interactions] High throughput no yes
ZNF24_HUMAN [view interactions] High throughput no yes
BACD2_HUMAN [view interactions] High throughput no no
MT2_HUMAN [view interactions] High throughput no no
FX4L6_HUMAN [view interactions] High throughput no no
CT141_HUMAN [view interactions] High throughput no no
SPA2L_HUMAN [view entry] [view interactions] High throughput yes yes
LDH6B_HUMAN [view interactions] High throughput no no
DCR1B_HUMAN [view interactions] High throughput no no
UTP6_HUMAN [view interactions] High throughput no yes
KAD3_HUMAN [view entry] [view interactions] High throughput yes yes
VPP4_HUMAN [view interactions] High throughput no no
HYPM_HUMAN [view interactions] High throughput no no
TTC33_HUMAN [view interactions] High throughput no yes
MSRB2_HUMAN [view interactions] High throughput no no
RBM5_HUMAN [view interactions] High throughput no yes
UBA3_HUMAN [view interactions] High throughput no yes
ACSL1_HUMAN [view interactions] High throughput no no
TOPRS_HUMAN [view interactions] High throughput no yes
PIAS3_HUMAN [view interactions] High throughput no yes
HIPK1_HUMAN [view interactions] High throughput no no
ZN451_HUMAN [view entry] [view interactions] High throughput yes no
PLAG1_HUMAN [view interactions] High throughput no no
RU17_HUMAN [view interactions] High throughput no yes
UBC9_HUMAN [view interactions] High throughput no yes
PIAS1_HUMAN [view interactions] High throughput no yes
PIAS2_HUMAN [view interactions] High throughput no yes
APOA2_HUMAN [view interactions] High throughput no no
APOC2_HUMAN [view interactions] High throughput no no
TIM29_HUMAN [view interactions] High throughput no no
CP2CI_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
SYFA_HUMAN [view entry] [view interactions] High throughput yes yes
FXL12_HUMAN [view interactions] High throughput no yes
IFIT5_HUMAN [view interactions] High throughput no no
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
PRAM_HUMAN [view interactions] High throughput no no
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
RHEB_HUMAN [view entry] [view interactions] High throughput yes yes
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
ANKH_HUMAN [view interactions] High throughput no no
EPN2_HUMAN [view entry] [view interactions] High throughput yes yes
FOXG1_HUMAN [view interactions] High throughput no no
FXYD7_HUMAN [view interactions] High throughput no no
HTRA1_HUMAN [view interactions] High throughput no yes
IQEC1_HUMAN [view entry] [view interactions] High throughput yes yes
M1IP1_HUMAN [view interactions] High throughput no yes
PIMT_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA6_HUMAN [view entry] [view interactions] High throughput yes no
RL4_HUMAN [view entry] [view interactions] High throughput yes yes
TYRO3_HUMAN [view interactions] High throughput no yes
ZN558_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
OXDA_HUMAN [view interactions] High throughput no no
VDAC3_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
RS14_HUMAN [view entry] [view interactions] High throughput yes yes
RS7_HUMAN [view entry] [view interactions] High throughput yes yes
RL8_HUMAN [view entry] [view interactions] High throughput yes yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
RS26_HUMAN [view entry] [view interactions] High throughput yes yes
RL6_HUMAN [view entry] [view interactions] High throughput yes yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
RS28_HUMAN [view entry] [view interactions] High throughput yes yes
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
SENP2_HUMAN [view interactions] High throughput no yes
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
WDR5_HUMAN [view interactions] High throughput no no
CA2D3_HUMAN [view entry] [view interactions] High throughput yes no
CEAM8_HUMAN [view interactions] High throughput no no
MICB_HUMAN [view interactions] High throughput no no
FIMP_HUMAN [view interactions] High throughput no no
CSTL1_HUMAN [view interactions] High throughput no no
TMM59_HUMAN [view interactions] High throughput no yes
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
KLK10_HUMAN [view interactions] High throughput no no
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
ATPB_HUMAN [view interactions] High throughput no yes
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
ADAS_HUMAN [view interactions] High throughput no yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
NCPR_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
P4HA1_HUMAN [view interactions] High throughput no yes
ATPA_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
NNTM_HUMAN [view entry] [view interactions] High throughput yes yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
NB5R3_HUMAN [view interactions] High throughput no yes
HMOX2_HUMAN [view entry] [view interactions] High throughput yes yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
NB5R1_HUMAN [view entry] [view interactions] High throughput yes yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS8_HUMAN [view interactions] High throughput no yes
SCMC1_HUMAN [view interactions] High throughput no no
NIPS1_HUMAN [view entry] [view interactions] High throughput yes yes
PGES2_HUMAN [view interactions] High throughput no yes
EMC8_HUMAN [view interactions] High throughput no no
PRDX3_HUMAN [view interactions] High throughput no yes
ATPO_HUMAN [view interactions] High throughput no yes
QCR6_HUMAN [view interactions] High throughput no yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
TPP1_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
ODBA_HUMAN [view interactions] High throughput no yes
EMC2_HUMAN [view interactions] High throughput no yes
RCN2_HUMAN [view interactions] High throughput no yes
AT2A2_HUMAN [view entry] [view interactions] High throughput yes yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
ATPG_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
SCPDL_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
LETM1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB8_HUMAN [view entry] [view interactions] High throughput yes yes
TFR1_HUMAN [view interactions] High throughput no yes
MTAP2_HUMAN [view entry] [view interactions] High throughput yes yes
PCYOX_HUMAN [view interactions] High throughput no yes
SEPP1_HUMAN [view interactions] High throughput no yes
CATB_HUMAN [view interactions] High throughput no yes
FIBG_HUMAN [view entry] [view interactions] High throughput yes no
HEMO_HUMAN [view interactions] High throughput no no
APOH_HUMAN [view interactions] High throughput no no
F10A1_HUMAN [view interactions] High throughput no yes
ARFG1_HUMAN [view interactions] High throughput no no
LCK_HUMAN [view entry] [view interactions] High throughput yes no
DPA1_HUMAN [view interactions] High throughput no yes
MANS1_HUMAN [view interactions] High throughput no yes
IFNA8_HUMAN [view interactions] High throughput no no
MMRN1_HUMAN [view interactions] High throughput no yes
MMP10_HUMAN [view interactions] High throughput no no
MMP3_HUMAN [view interactions] High throughput no no
CO9_HUMAN [view interactions] High throughput no no
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
GRID2_HUMAN [view entry] [view interactions] High throughput yes no
VCAM1_HUMAN [view interactions] High throughput no no
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
SOST_HUMAN [view interactions] High throughput no no
ALBU_HUMAN [view interactions] High throughput no no
PDCD4_HUMAN [view interactions] High throughput no yes
CDC37_HUMAN [view interactions] High throughput no yes
PICAL_HUMAN [view entry] [view interactions] Computational yes yes
SDC1_HUMAN [view interactions] Computational no no
PEX3_HUMAN [view interactions] Computational no yes
ACBP_HUMAN [view interactions] Computational no yes
LIPC_HUMAN [view interactions] Computational no no
BACE1_HUMAN [view interactions] Computational no yes
LRP10_HUMAN [view interactions] Computational no no
APOL1_HUMAN [view interactions] Computational no no
APOB_HUMAN [view interactions] Computational no no
APOC3_HUMAN [view interactions] Computational no no
CD44_HUMAN [view interactions] Computational no yes
BDNF_HUMAN [view interactions] Computational no yes
ERBB4_HUMAN [view entry] [view interactions] Computational yes yes
ABCG1_HUMAN [view interactions] Computational no yes
HDBP1_HUMAN [view interactions] Computational no no
ARH_HUMAN [view interactions] Computational no yes
CHLE_HUMAN [view interactions] Computational no no
SCRB1_HUMAN [view interactions] Computational no no
CETP_HUMAN [view interactions] Computational no no
CLUS_HUMAN [view entry] [view interactions] Computational yes yes
NR1H2_HUMAN [view interactions] Computational no yes
RXRA_HUMAN [view interactions] Computational no yes
PON1_HUMAN [view interactions] Computational no no
RXRB_HUMAN [view interactions] Computational no yes
PAFA_HUMAN [view interactions] Computational no no
ABCA7_HUMAN [view interactions] Computational no yes
APOA5_HUMAN [view interactions] Computational no no
APOC4_HUMAN [view interactions] Computational no no
APOC1_HUMAN [view interactions] Computational no no
BIN1_HUMAN [view entry] [view interactions] Computational yes yes
APOA_HUMAN [view interactions] Computational no no
LRP12_HUMAN [view interactions] Computational no yes
TOM40_HUMAN [view interactions] Computational no yes
ABCA1_HUMAN [view interactions] Computational no yes
UBIA1_HUMAN [view interactions] Computational no no
PSN2_HUMAN [view entry] [view interactions] Computational yes no
SORT_HUMAN [view interactions] Computational no yes
APOM_HUMAN [view interactions] Computational no no
RELN_HUMAN [view interactions] Computational no no
APOA4_HUMAN [view interactions] Computational no no