Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

APOE_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

(Microbial infection) Through its interaction with HCV envelope glycoprotein E2, participates in the attachment of HCV to HSPGs and other receptors (LDLr, VLDLr, and SR-B1) on the cell surface and to the assembly, maturation and infectivity of HCV viral particles (PubMed, PubMed). This interaction is probably promoted via the up-regulation of cellular autophagy by the virus (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
31 Glu Lys Hyperlipoproteinemia3(HLPP3) -
130 Cys Arg Alzheimerdisease2(AD2) -
130 Cys Arg Hyperlipoproteinemia3(HLPP3) -
154 Arg Ser Hyperlipoproteinemia3(HLPP3) -
154 Arg Cys Hyperlipoproteinemia3(HLPP3) -
160 Arg Cys Hyperlipoproteinemia3(HLPP3) -
163 Arg Cys Hyperlipoproteinemia3(HLPP3) -
164 Lys Gln Hyperlipoproteinemia3(HLPP3) -
164 Lys Glu Hyperlipoproteinemia3(HLPP3) -
176 Arg Cys Hyperlipoproteinemia3(HLPP3) -
43 Arg Cys Lipoproteinglomerulopathy(LPG) -
163 Arg Pro Lipoproteinglomerulopathy(LPG) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in APOE_HUMAN
GO:0043169 cation binding 35.4167 4 yes
GO:0046872 metal ion binding 33.3333 5 yes
GO:0003723 RNA binding 30.2083 4 no
GO:0043168 anion binding 27.0833 4 no
GO:0000166 nucleotide binding 26.0417 4 no
GO:0017076 purine nucleotide binding 23.9583 5 no
GO:0032555 purine ribonucleotide binding 20.8333 4 no
GO:0042803 protein homodimerization activity 10.4167 4 yes
GO:0048156 tau protein binding 7.2917 4 yes
GO:0070325 lipoprotein particle receptor binding 4.1667 4 yes
GO:0071813 lipoprotein particle binding 4.1667 4 yes
GO:0050750 low-density lipoprotein particle receptor binding 3.1250 5 yes
GO:0046911 metal chelating activity 2.0833 6 yes
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity 2.0833 4 yes
GO:0070326 very-low-density lipoprotein particle receptor binding 2.0833 5 yes
GO:0120015 sterol transfer activity 2.0833 4 yes
GO:0120020 cholesterol transfer activity 2.0833 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in APOE_HUMAN
GO:0048522 positive regulation of cellular process 47.9167 4 yes
GO:0031323 regulation of cellular metabolic process 45.8333 4 yes
GO:0060255 regulation of macromolecule metabolic process 44.7917 4 yes
GO:0080090 regulation of primary metabolic process 44.7917 4 yes
GO:0048523 negative regulation of cellular process 43.7500 4 yes
GO:0009889 regulation of biosynthetic process 39.5833 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 38.5417 5 yes
GO:0031326 regulation of cellular biosynthetic process 38.5417 5 yes
GO:0010468 regulation of gene expression 37.5000 6 yes
GO:0010646 regulation of cell communication 37.5000 4 yes
GO:0022607 cellular component assembly 37.5000 4 yes
GO:0009893 positive regulation of metabolic process 35.4167 4 yes
GO:0051128 regulation of cellular component organization 34.3750 4 yes
GO:0051246 regulation of protein metabolic process 34.3750 5 yes
GO:0009966 regulation of signal transduction 33.3333 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 32.2917 5 yes
GO:0009892 negative regulation of metabolic process 31.2500 4 yes
GO:0042981 regulation of apoptotic process 30.2083 5 yes
GO:0043067 regulation of programmed cell death 30.2083 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 29.1667 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.1667 5 yes
GO:0031324 negative regulation of cellular metabolic process 28.1250 5 yes
GO:0031325 positive regulation of cellular metabolic process 28.1250 5 yes
GO:0043933 protein-containing complex organization 27.0833 4 yes
GO:0048584 positive regulation of response to stimulus 27.0833 4 yes
GO:0051247 positive regulation of protein metabolic process 27.0833 6 yes
GO:0051252 regulation of RNA metabolic process 27.0833 5 yes
GO:0009890 negative regulation of biosynthetic process 26.0417 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 26.0417 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 26.0417 6 yes
GO:0031399 regulation of protein modification process 26.0417 6 yes
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 yes
GO:0008104 protein localization 25.0000 4 yes
GO:0006355 regulation of DNA-templated transcription 23.9583 7 yes
GO:0006996 organelle organization 23.9583 4 yes
GO:0071702 organic substance transport 23.9583 4 yes
GO:0009894 regulation of catabolic process 23.9583 4 yes
GO:0023056 positive regulation of signaling 23.9583 4 yes
GO:2001141 regulation of RNA biosynthetic process 23.9583 6 yes
GO:0048585 negative regulation of response to stimulus 22.9167 4 yes
GO:0071705 nitrogen compound transport 22.9167 4 yes
GO:0010647 positive regulation of cell communication 22.9167 5 yes
GO:1902531 regulation of intracellular signal transduction 22.9167 5 yes
GO:0065003 protein-containing complex assembly 21.8750 5 yes
GO:0009968 negative regulation of signal transduction 21.8750 5 yes
GO:0010648 negative regulation of cell communication 21.8750 5 yes
GO:0023057 negative regulation of signaling 21.8750 4 yes
GO:0006796 phosphate-containing compound metabolic process 21.8750 4 no
GO:0032880 regulation of protein localization 20.8333 5 yes
GO:0060341 regulation of cellular localization 20.8333 4 yes
GO:0009891 positive regulation of biosynthetic process 20.8333 5 yes
GO:0009967 positive regulation of signal transduction 20.8333 5 yes
GO:1901566 organonitrogen compound biosynthetic process 20.8333 4 yes
GO:0044087 regulation of cellular component biogenesis 19.7917 4 yes
GO:0051049 regulation of transport 19.7917 4 yes
GO:0051130 positive regulation of cellular component organization 19.7917 5 yes
GO:0051174 regulation of phosphorus metabolic process 19.7917 5 yes
GO:0009059 macromolecule biosynthetic process 19.7917 4 yes
GO:0019220 regulation of phosphate metabolic process 19.7917 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 19.7917 6 yes
GO:0042325 regulation of phosphorylation 18.7500 7 yes
GO:0043066 negative regulation of apoptotic process 18.7500 6 yes
GO:0043069 negative regulation of programmed cell death 18.7500 5 yes
GO:0080134 regulation of response to stress 18.7500 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 18.7500 6 yes
GO:0015031 protein transport 18.7500 4 yes
GO:0043085 positive regulation of catalytic activity 17.7083 4 yes
GO:0051094 positive regulation of developmental process 17.7083 4 yes
GO:0001932 regulation of protein phosphorylation 17.7083 7 yes
GO:0051241 negative regulation of multicellular organismal process 16.6667 4 yes
GO:0042127 regulation of cell population proliferation 15.6250 4 yes
GO:0051248 negative regulation of protein metabolic process 15.6250 6 yes
GO:0051338 regulation of transferase activity 15.6250 4 yes
GO:0009896 positive regulation of catabolic process 15.6250 5 yes
GO:0010629 negative regulation of gene expression 15.6250 7 yes
GO:1902533 positive regulation of intracellular signal transduction 15.6250 6 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 14.5833 5 yes
GO:0050804 modulation of chemical synaptic transmission 14.5833 5 yes
GO:0050807 regulation of synapse organization 14.5833 5 yes
GO:0055080 monoatomic cation homeostasis 14.5833 4 yes
GO:0006873 intracellular monoatomic ion homeostasis 14.5833 4 yes
GO:0009057 macromolecule catabolic process 14.5833 4 yes
GO:0099177 regulation of trans-synaptic signaling 14.5833 4 yes
GO:0030003 intracellular monoatomic cation homeostasis 14.5833 5 yes
GO:0051129 negative regulation of cellular component organization 13.5417 5 yes
GO:1901565 organonitrogen compound catabolic process 13.5417 4 yes
GO:0030030 cell projection organization 13.5417 4 yes
GO:0030162 regulation of proteolysis 13.5417 6 yes
GO:0032101 regulation of response to external stimulus 13.5417 4 yes
GO:0042176 regulation of protein catabolic process 12.5000 5 yes
GO:0043549 regulation of kinase activity 12.5000 5 yes
GO:0050776 regulation of immune response 12.5000 4 yes
GO:0051347 positive regulation of transferase activity 12.5000 5 yes
GO:0098657 import into cell 12.5000 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 12.5000 6 yes
GO:0031344 regulation of cell projection organization 12.5000 5 yes
GO:0045859 regulation of protein kinase activity 11.4583 6 yes
GO:0045893 positive regulation of DNA-templated transcription 11.4583 8 yes
GO:0050890 cognition 11.4583 4 yes
GO:0051050 positive regulation of transport 11.4583 4 yes
GO:0051254 positive regulation of RNA metabolic process 11.4583 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 11.4583 7 yes
GO:1902903 regulation of supramolecular fiber organization 11.4583 5 yes
GO:0030163 protein catabolic process 11.4583 4 yes
GO:0031329 regulation of cellular catabolic process 11.4583 5 yes
GO:0031400 negative regulation of protein modification process 11.4583 7 yes
GO:0043254 regulation of protein-containing complex assembly 10.4167 5 yes
GO:0043393 regulation of protein binding 10.4167 4 yes
GO:0043408 regulation of MAPK cascade 10.4167 6 yes
GO:0045732 positive regulation of protein catabolic process 10.4167 6 yes
GO:0050865 regulation of cell activation 10.4167 4 yes
GO:0060627 regulation of vesicle-mediated transport 10.4167 4 yes
GO:0007010 cytoskeleton organization 10.4167 5 yes
GO:0007268 chemical synaptic transmission 10.4167 7 yes
GO:0098916 anterograde trans-synaptic signaling 10.4167 6 yes
GO:0099536 synaptic signaling 10.4167 4 yes
GO:0099537 trans-synaptic signaling 10.4167 5 yes
GO:0030334 regulation of cell migration 10.4167 5 yes
GO:2000145 regulation of cell motility 10.4167 4 yes
GO:0031347 regulation of defense response 10.4167 5 yes
GO:0043410 positive regulation of MAPK cascade 9.3750 7 yes
GO:0045862 positive regulation of proteolysis 9.3750 7 yes
GO:0001558 regulation of cell growth 9.3750 4 yes
GO:0002831 regulation of response to biotic stimulus 9.3750 4 yes
GO:0120036 plasma membrane bounded cell projection organization 9.3750 5 yes
GO:0010975 regulation of neuron projection development 9.3750 7 yes
GO:1902532 negative regulation of intracellular signal transduction 9.3750 6 yes
GO:0030111 regulation of Wnt signaling pathway 9.3750 5 yes
GO:0042326 negative regulation of phosphorylation 8.3333 8 yes
GO:0043086 negative regulation of catalytic activity 8.3333 4 yes
GO:0043523 regulation of neuron apoptotic process 8.3333 6 yes
GO:0044057 regulation of system process 8.3333 4 yes
GO:0045088 regulation of innate immune response 8.3333 5 yes
GO:0045936 negative regulation of phosphate metabolic process 8.3333 7 yes
GO:0055074 calcium ion homeostasis 8.3333 4 yes
GO:0006874 intracellular calcium ion homeostasis 8.3333 5 yes
GO:0008285 negative regulation of cell population proliferation 8.3333 5 yes
GO:0070201 regulation of establishment of protein localization 8.3333 6 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 8.3333 7 yes
GO:0010563 negative regulation of phosphorus metabolic process 8.3333 6 yes
GO:1903050 regulation of proteolysis involved in protein catabolic process 8.3333 7 yes
GO:0048638 regulation of developmental growth 7.2917 4 yes
GO:0001933 negative regulation of protein phosphorylation 7.2917 8 yes
GO:0006898 receptor-mediated endocytosis 7.2917 4 yes
GO:0007613 memory 7.2917 4 yes
GO:0062012 regulation of small molecule metabolic process 7.2917 4 yes
GO:0062013 positive regulation of small molecule metabolic process 7.2917 5 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 7.2917 8 yes
GO:0099175 regulation of postsynapse organization 7.2917 6 yes
GO:0019216 regulation of lipid metabolic process 7.2917 5 yes
GO:1903828 negative regulation of protein localization 7.2917 5 yes
GO:0031331 positive regulation of cellular catabolic process 7.2917 6 yes
GO:0031346 positive regulation of cell projection organization 7.2917 6 yes
GO:0048168 regulation of neuronal synaptic plasticity 6.2500 4 yes
GO:0048660 regulation of smooth muscle cell proliferation 6.2500 5 yes
GO:0051046 regulation of secretion 6.2500 5 yes
GO:0051051 negative regulation of transport 6.2500 4 yes
GO:0051223 regulation of protein transport 6.2500 5 yes
GO:0051341 regulation of oxidoreductase activity 6.2500 4 yes
GO:0003018 vascular process in circulatory system 6.2500 4 yes
GO:0051348 negative regulation of transferase activity 6.2500 5 yes
GO:0060828 regulation of canonical Wnt signaling pathway 6.2500 6 yes
GO:0061136 regulation of proteasomal protein catabolic process 6.2500 6 yes
GO:0141124 intracellular signaling cassette 6.2500 4 yes
GO:1901361 organic cyclic compound catabolic process 6.2500 4 yes
GO:1902905 positive regulation of supramolecular fiber organization 6.2500 6 yes
GO:0030100 regulation of endocytosis 6.2500 5 yes
GO:1903530 regulation of secretion by cell 6.2500 4 yes
GO:0031345 negative regulation of cell projection organization 6.2500 6 yes
GO:0032102 negative regulation of response to external stimulus 6.2500 5 yes
GO:0032768 regulation of monooxygenase activity 5.2083 5 yes
GO:0033673 negative regulation of kinase activity 5.2083 6 yes
GO:0034248 regulation of amide metabolic process 5.2083 4 yes
GO:0040013 negative regulation of locomotion 5.2083 4 yes
GO:0043524 negative regulation of neuron apoptotic process 5.2083 7 yes
GO:0045834 positive regulation of lipid metabolic process 5.2083 5 yes
GO:0050678 regulation of epithelial cell proliferation 5.2083 5 yes
GO:0050818 regulation of coagulation 5.2083 4 yes
GO:0051099 positive regulation of binding 5.2083 4 yes
GO:0000302 response to reactive oxygen species 5.2083 4 yes
GO:0051353 positive regulation of oxidoreductase activity 5.2083 5 yes
GO:0061041 regulation of wound healing 5.2083 6 yes
GO:0071900 regulation of protein serine/threonine kinase activity 5.2083 7 yes
GO:0072657 protein localization to membrane 5.2083 4 yes
GO:0015711 organic anion transport 5.2083 5 yes
GO:1900271 regulation of long-term synaptic potentiation 5.2083 4 yes
GO:0016042 lipid catabolic process 5.2083 4 yes
GO:1902904 negative regulation of supramolecular fiber organization 5.2083 6 yes
GO:1903034 regulation of response to wounding 5.2083 5 yes
GO:0030336 negative regulation of cell migration 5.2083 6 yes
GO:0031175 neuron projection development 5.2083 6 yes
GO:1905906 regulation of amyloid fibril formation 5.2083 6 yes
GO:1905952 regulation of lipid localization 5.2083 4 yes
GO:2000146 negative regulation of cell motility 5.2083 5 yes
GO:0032092 positive regulation of protein binding 5.2083 5 yes
GO:0032770 positive regulation of monooxygenase activity 4.1667 6 yes
GO:0034249 negative regulation of amide metabolic process 4.1667 5 yes
GO:0035150 regulation of tube size 4.1667 4 yes
GO:0035296 regulation of tube diameter 4.1667 5 yes
GO:0045807 positive regulation of endocytosis 4.1667 5 yes
GO:0046942 carboxylic acid transport 4.1667 6 yes
GO:0050727 regulation of inflammatory response 4.1667 5 yes
GO:0050866 negative regulation of cell activation 4.1667 5 yes
GO:0051048 negative regulation of secretion 4.1667 5 yes
GO:0006469 negative regulation of protein kinase activity 4.1667 7 yes
GO:0060998 regulation of dendritic spine development 4.1667 4 yes
GO:0060999 positive regulation of dendritic spine development 4.1667 5 yes
GO:0061387 regulation of extent of cell growth 4.1667 5 yes
GO:0008202 steroid metabolic process 4.1667 4 yes
GO:0010467 gene expression 4.1667 5 yes
GO:0097746 blood vessel diameter maintenance 4.1667 5 yes
GO:0010632 regulation of epithelial cell migration 4.1667 4 yes
GO:0010976 positive regulation of neuron projection development 4.1667 7 yes
GO:0010977 negative regulation of neuron projection development 4.1667 7 yes
GO:0015849 organic acid transport 4.1667 5 yes
GO:1900272 negative regulation of long-term synaptic potentiation 4.1667 4 yes
GO:1902003 regulation of amyloid-beta formation 4.1667 5 yes
GO:1902430 negative regulation of amyloid-beta formation 4.1667 6 yes
GO:0016125 sterol metabolic process 4.1667 4 yes
GO:1902991 regulation of amyloid precursor protein catabolic process 4.1667 6 yes
GO:1902992 negative regulation of amyloid precursor protein catabolic process 4.1667 7 yes
GO:0030178 negative regulation of Wnt signaling pathway 4.1667 6 yes
GO:0030193 regulation of blood coagulation 4.1667 4 yes
GO:1903531 negative regulation of secretion by cell 4.1667 5 yes
GO:0030516 regulation of axon extension 4.1667 5 yes
GO:1905908 positive regulation of amyloid fibril formation 4.1667 7 yes
GO:0032368 regulation of lipid transport 4.1667 5 yes
GO:0032376 positive regulation of cholesterol transport 3.1250 7 yes
GO:0042311 vasodilation 3.1250 6 yes
GO:0042982 amyloid precursor protein metabolic process 3.1250 4 yes
GO:0043113 receptor clustering 3.1250 5 yes
GO:0043409 negative regulation of MAPK cascade 3.1250 7 yes
GO:0043535 regulation of blood vessel endothelial cell migration 3.1250 6 yes
GO:0044788 modulation by host of viral process 3.1250 5 yes
GO:0045833 negative regulation of lipid metabolic process 3.1250 5 yes
GO:0046486 glycerolipid metabolic process 3.1250 4 yes
GO:0046889 positive regulation of lipid biosynthetic process 3.1250 6 yes
GO:0046890 regulation of lipid biosynthetic process 3.1250 5 yes
GO:0048514 blood vessel morphogenesis 3.1250 4 yes
GO:0048662 negative regulation of smooth muscle cell proliferation 3.1250 6 yes
GO:0048844 artery morphogenesis 3.1250 5 yes
GO:0050680 negative regulation of epithelial cell proliferation 3.1250 6 yes
GO:0050708 regulation of protein secretion 3.1250 5 yes
GO:0050819 negative regulation of coagulation 3.1250 5 yes
GO:0050999 regulation of nitric-oxide synthase activity 3.1250 6 yes
GO:0051000 positive regulation of nitric-oxide synthase activity 3.1250 7 yes
GO:0051056 regulation of small GTPase mediated signal transduction 3.1250 6 yes
GO:0001936 regulation of endothelial cell proliferation 3.1250 6 yes
GO:0051851 modulation by host of symbiont process 3.1250 4 yes
GO:0006638 neutral lipid metabolic process 3.1250 4 yes
GO:0061045 negative regulation of wound healing 3.1250 6 yes
GO:0007271 synaptic transmission, cholinergic 3.1250 8 yes
GO:0007616 long-term memory 3.1250 5 yes
GO:0062014 negative regulation of small molecule metabolic process 3.1250 5 yes
GO:0008203 cholesterol metabolic process 3.1250 5 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 3.1250 8 yes
GO:0090090 negative regulation of canonical Wnt signaling pathway 3.1250 7 yes
GO:0010594 regulation of endothelial cell migration 3.1250 5 yes
GO:0010874 regulation of cholesterol efflux 3.1250 8 yes
GO:0010875 positive regulation of cholesterol efflux 3.1250 8 yes
GO:1900047 negative regulation of hemostasis 3.1250 4 yes
GO:1900221 regulation of amyloid-beta clearance 3.1250 4 yes
GO:1900223 positive regulation of amyloid-beta clearance 3.1250 5 yes
GO:0015850 organic hydroxy compound transport 3.1250 5 yes
GO:0016050 vesicle organization 3.1250 5 yes
GO:1902652 secondary alcohol metabolic process 3.1250 4 yes
GO:1902930 regulation of alcohol biosynthetic process 3.1250 5 yes
GO:1902950 regulation of dendritic spine maintenance 3.1250 7 yes
GO:1903035 negative regulation of response to wounding 3.1250 5 yes
GO:0030195 negative regulation of blood coagulation 3.1250 5 yes
GO:1904950 negative regulation of establishment of protein localization 3.1250 6 yes
GO:1905918 regulation of CoA-transferase activity 3.1250 5 yes
GO:1905920 positive regulation of CoA-transferase activity 3.1250 6 yes
GO:1905954 positive regulation of lipid localization 3.1250 4 yes
GO:0031348 negative regulation of defense response 3.1250 5 yes
GO:0032370 positive regulation of lipid transport 3.1250 5 yes
GO:0032371 regulation of sterol transport 3.1250 6 yes
GO:0032373 positive regulation of sterol transport 3.1250 6 yes
GO:0032374 regulation of cholesterol transport 3.1250 7 yes
GO:0032438 melanosome organization 2.0833 7 yes
GO:0032489 regulation of Cdc42 protein signal transduction 2.0833 8 yes
GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process 2.0833 6 yes
GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process 2.0833 7 yes
GO:0033344 cholesterol efflux 2.0833 8 yes
GO:0033700 phospholipid efflux 2.0833 7 yes
GO:0034367 protein-containing complex remodeling 2.0833 5 yes
GO:0034368 protein-lipid complex remodeling 2.0833 6 yes
GO:0034370 triglyceride-rich lipoprotein particle remodeling 2.0833 4 yes
GO:0034372 very-low-density lipoprotein particle remodeling 2.0833 5 yes
GO:0034374 low-density lipoprotein particle remodeling 2.0833 4 yes
GO:0034375 high-density lipoprotein particle remodeling 2.0833 4 yes
GO:0034380 high-density lipoprotein particle assembly 2.0833 4 yes
GO:0034382 chylomicron remnant clearance 2.0833 4 yes
GO:0035023 regulation of Rho protein signal transduction 2.0833 7 yes
GO:0035641 locomotory exploration behavior 2.0833 4 yes
GO:0042157 lipoprotein metabolic process 2.0833 4 yes
GO:0042158 lipoprotein biosynthetic process 2.0833 5 yes
GO:0042159 lipoprotein catabolic process 2.0833 5 yes
GO:0042632 cholesterol homeostasis 2.0833 5 yes
GO:0043405 regulation of MAP kinase activity 2.0833 8 yes
GO:0043407 negative regulation of MAP kinase activity 2.0833 8 yes
GO:0043537 negative regulation of blood vessel endothelial cell migration 2.0833 7 yes
GO:0043691 reverse cholesterol transport 2.0833 8 yes
GO:0044794 positive regulation by host of viral process 2.0833 6 yes
GO:0045540 regulation of cholesterol biosynthetic process 2.0833 6 yes
GO:0045541 negative regulation of cholesterol biosynthetic process 2.0833 7 yes
GO:0045939 negative regulation of steroid metabolic process 2.0833 6 yes
GO:0045940 positive regulation of steroid metabolic process 2.0833 6 yes
GO:0046164 alcohol catabolic process 2.0833 4 yes
GO:0048753 pigment granule organization 2.0833 6 yes
GO:0050709 negative regulation of protein secretion 2.0833 6 yes
GO:0050728 negative regulation of inflammatory response 2.0833 6 yes
GO:0050795 regulation of behavior 2.0833 4 yes
GO:0050810 regulation of steroid biosynthetic process 2.0833 6 yes
GO:0051043 regulation of membrane protein ectodomain proteolysis 2.0833 6 yes
GO:0051044 positive regulation of membrane protein ectodomain proteolysis 2.0833 7 yes
GO:0051055 negative regulation of lipid biosynthetic process 2.0833 6 yes
GO:0051224 negative regulation of protein transport 2.0833 5 yes
GO:0001937 negative regulation of endothelial cell proliferation 2.0833 7 yes
GO:0006639 acylglycerol metabolic process 2.0833 5 yes
GO:0006641 triglyceride metabolic process 2.0833 6 yes
GO:0055089 fatty acid homeostasis 2.0833 4 yes
GO:0006706 steroid catabolic process 2.0833 5 yes
GO:0055090 acylglycerol homeostasis 2.0833 4 yes
GO:0006707 cholesterol catabolic process 2.0833 5 yes
GO:0055092 sterol homeostasis 2.0833 4 yes
GO:0006869 lipid transport 2.0833 5 yes
GO:0007263 nitric oxide mediated signal transduction 2.0833 5 yes
GO:0065005 protein-lipid complex assembly 2.0833 6 yes
GO:0070328 triglyceride homeostasis 2.0833 5 yes
GO:0071825 protein-lipid complex organization 2.0833 5 yes
GO:0071831 intermediate-density lipoprotein particle clearance 2.0833 4 yes
GO:0072578 neurotransmitter-gated ion channel clustering 2.0833 6 yes
GO:0010543 regulation of platelet activation 2.0833 5 yes
GO:0010544 negative regulation of platelet activation 2.0833 6 yes
GO:0090181 regulation of cholesterol metabolic process 2.0833 5 yes
GO:0090205 positive regulation of cholesterol metabolic process 2.0833 6 yes
GO:0090206 negative regulation of cholesterol metabolic process 2.0833 6 yes
GO:0090207 regulation of triglyceride metabolic process 2.0833 5 yes
GO:0090209 negative regulation of triglyceride metabolic process 2.0833 6 yes
GO:0097113 AMPA glutamate receptor clustering 2.0833 8 yes
GO:0010596 negative regulation of endothelial cell migration 2.0833 6 yes
GO:0097114 NMDA glutamate receptor clustering 2.0833 7 yes
GO:0097688 glutamate receptor clustering 2.0833 7 yes
GO:0010633 negative regulation of epithelial cell migration 2.0833 5 yes
GO:0106118 regulation of sterol biosynthetic process 2.0833 7 yes
GO:0106119 negative regulation of sterol biosynthetic process 2.0833 8 yes
GO:0010877 lipid transport involved in lipid storage 2.0833 6 yes
GO:0010894 negative regulation of steroid biosynthetic process 2.0833 7 yes
GO:0150200 regulation of transport across blood-brain barrier 2.0833 5 yes
GO:0150201 positive regulation of transport across blood-brain barrier 2.0833 5 yes
GO:0015718 monocarboxylic acid transport 2.0833 7 yes
GO:0015748 organophosphate ester transport 2.0833 5 yes
GO:0015908 fatty acid transport 2.0833 6 yes
GO:0015909 long-chain fatty acid transport 2.0833 7 yes
GO:0015914 phospholipid transport 2.0833 6 yes
GO:1901616 organic hydroxy compound catabolic process 2.0833 4 yes
GO:0015918 sterol transport 2.0833 6 yes
GO:0016127 sterol catabolic process 2.0833 5 yes
GO:0017038 protein import 2.0833 5 yes
GO:0019218 regulation of steroid metabolic process 2.0833 6 yes
GO:0019934 cGMP-mediated signaling 2.0833 5 yes
GO:1902931 negative regulation of alcohol biosynthetic process 2.0833 6 yes
GO:1902952 positive regulation of dendritic spine maintenance 2.0833 7 yes
GO:1902994 regulation of phospholipid efflux 2.0833 7 yes
GO:1902995 positive regulation of phospholipid efflux 2.0833 7 yes
GO:1903000 regulation of lipid transport across blood-brain barrier 2.0833 6 yes
GO:1903002 positive regulation of lipid transport across blood-brain barrier 2.0833 6 yes
GO:0030301 cholesterol transport 2.0833 7 yes
GO:1903365 regulation of fear response 2.0833 4 yes
GO:1905858 regulation of heparan sulfate proteoglycan binding 2.0833 5 yes
GO:1905860 positive regulation of heparan sulfate proteoglycan binding 2.0833 6 yes
GO:1905890 regulation of cellular response to very-low-density lipoprotein particle stimulus 2.0833 4 yes
GO:1905907 negative regulation of amyloid fibril formation 2.0833 7 yes
GO:2000644 regulation of receptor catabolic process 2.0833 5 yes
GO:2000646 positive regulation of receptor catabolic process 2.0833 6 yes
GO:2000822 regulation of behavioral fear response 2.0833 5 yes
GO:2001138 regulation of phospholipid transport 2.0833 6 yes
GO:2001140 positive regulation of phospholipid transport 2.0833 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TMCC2_HUMAN [view interactions] Low throughput no yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
CSTN3_HUMAN [view entry] [view interactions] Low throughput yes no
TREM2_HUMAN [view interactions] Low throughput no yes
TREM1_HUMAN [view interactions] Low throughput no yes
LRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
HPT_HUMAN [view interactions] Low throughput no no
LDLR_HUMAN [view interactions] Low throughput no yes
APOE_HUMAN [view entry] [view interactions] Low throughput yes yes
CFAH_HUMAN [view interactions] Low throughput no no
VLDLR_HUMAN [view interactions] Low throughput no yes
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
SORL_HUMAN [view interactions] Low throughput no yes
ECSIT_HUMAN [view interactions] Low throughput no yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
CLCF1_HUMAN [view interactions] Low throughput no yes
A2MG_HUMAN [view interactions] Low throughput no yes
LRP8_HUMAN [view entry] [view interactions] Low throughput yes no
ACHA7_HUMAN [view entry] [view interactions] Low throughput yes yes
NOS3_HUMAN [view interactions] Low throughput no no
PLTP_HUMAN [view interactions] Low throughput no no
SET_HUMAN [view interactions] Low throughput no yes
ITAM_HUMAN [view interactions] Low throughput no no
ACE2_HUMAN [view interactions] Low throughput no no
APOA1_HUMAN [view interactions] Low throughput no no
LRP2_HUMAN [view interactions] Low throughput no no
NFM_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
LCAT_HUMAN [view interactions] Low throughput no no
BCL2_HUMAN [view interactions] Low throughput no no
LIRA6_HUMAN [view interactions] Low throughput no no
F10A1_HUMAN [view interactions] High throughput no yes
ARFG1_HUMAN [view interactions] High throughput no no
LCK_HUMAN [view entry] [view interactions] High throughput yes no
DPA1_HUMAN [view interactions] High throughput no yes
MANS1_HUMAN [view interactions] High throughput no yes
IFNA8_HUMAN [view interactions] High throughput no no
MMRN1_HUMAN [view interactions] High throughput no yes
MMP10_HUMAN [view interactions] High throughput no no
CO9_HUMAN [view interactions] High throughput no no
MMP3_HUMAN [view interactions] High throughput no no
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
GRID2_HUMAN [view entry] [view interactions] High throughput yes no
VCAM1_HUMAN [view interactions] High throughput no no
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
SOST_HUMAN [view interactions] High throughput no no
ALBU_HUMAN [view interactions] High throughput no no
PDCD4_HUMAN [view interactions] High throughput no yes
CDC37_HUMAN [view interactions] High throughput no yes
CD81_HUMAN [view interactions] High throughput no no
PKHA7_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
GCDH_HUMAN [view interactions] High throughput no yes
CP2C8_HUMAN [view interactions] High throughput no no
IFIT3_HUMAN [view interactions] High throughput no yes
LOXL4_HUMAN [view interactions] High throughput no no
MAST1_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF32_HUMAN [view interactions] High throughput no no
CNTF_HUMAN [view interactions] High throughput no yes
LEG1_HUMAN [view interactions] High throughput no yes
MT2_HUMAN [view interactions] High throughput no no
BACD2_HUMAN [view interactions] High throughput no no
ZNF24_HUMAN [view interactions] High throughput no yes
UBA3_HUMAN [view interactions] High throughput no yes
RBM5_HUMAN [view interactions] High throughput no yes
MSRB2_HUMAN [view interactions] High throughput no no
TTC33_HUMAN [view interactions] High throughput no yes
HYPM_HUMAN [view interactions] High throughput no no
VPP4_HUMAN [view interactions] High throughput no no
KAD3_HUMAN [view entry] [view interactions] High throughput yes yes
UTP6_HUMAN [view interactions] High throughput no yes
DCR1B_HUMAN [view interactions] High throughput no no
LDH6B_HUMAN [view interactions] High throughput no no
SPA2L_HUMAN [view entry] [view interactions] High throughput yes yes
CT141_HUMAN [view interactions] High throughput no no
FX4L6_HUMAN [view interactions] High throughput no no
ACSL1_HUMAN [view interactions] High throughput no no
TOPRS_HUMAN [view interactions] High throughput no yes
PIAS3_HUMAN [view entry] [view interactions] High throughput yes yes
HIPK1_HUMAN [view interactions] High throughput no no
ZN451_HUMAN [view entry] [view interactions] High throughput yes no
PLAG1_HUMAN [view interactions] High throughput no no
RU17_HUMAN [view interactions] High throughput no yes
UBC9_HUMAN [view entry] [view interactions] High throughput yes yes
PIAS1_HUMAN [view entry] [view interactions] High throughput yes yes
PIAS2_HUMAN [view interactions] High throughput no yes
S100B_HUMAN [view entry] [view interactions] High throughput yes yes
APOA2_HUMAN [view interactions] High throughput no no
APOC2_HUMAN [view interactions] High throughput no no
TIM29_HUMAN [view interactions] High throughput no no
CP2CI_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
SYFA_HUMAN [view entry] [view interactions] High throughput yes yes
FXL12_HUMAN [view interactions] High throughput no yes
IFIT5_HUMAN [view interactions] High throughput no no
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
PRAM_HUMAN [view interactions] High throughput no no
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
RHEB_HUMAN [view entry] [view interactions] High throughput yes yes
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
ANKH_HUMAN [view interactions] High throughput no no
EPN2_HUMAN [view entry] [view interactions] High throughput yes yes
FOXG1_HUMAN [view interactions] High throughput no no
FXYD7_HUMAN [view interactions] High throughput no no
HTRA1_HUMAN [view interactions] High throughput no yes
IQEC1_HUMAN [view entry] [view interactions] High throughput yes yes
M1IP1_HUMAN [view interactions] High throughput no yes
PIMT_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA6_HUMAN [view entry] [view interactions] High throughput yes no
RL4_HUMAN [view entry] [view interactions] High throughput yes yes
TYRO3_HUMAN [view interactions] High throughput no yes
ZN558_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
OXDA_HUMAN [view interactions] High throughput no no
VDAC3_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
RS14_HUMAN [view entry] [view interactions] High throughput yes yes
RS7_HUMAN [view entry] [view interactions] High throughput yes yes
RL8_HUMAN [view entry] [view interactions] High throughput yes yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
RS26_HUMAN [view entry] [view interactions] High throughput yes yes
RL6_HUMAN [view entry] [view interactions] High throughput yes yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
RS28_HUMAN [view entry] [view interactions] High throughput yes yes
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
SENP2_HUMAN [view interactions] High throughput no yes
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
WDR5_HUMAN [view interactions] High throughput no no
CA2D3_HUMAN [view entry] [view interactions] High throughput yes no
CEAM8_HUMAN [view interactions] High throughput no no
MICB_HUMAN [view interactions] High throughput no no
FIMP_HUMAN [view interactions] High throughput no no
CSTL1_HUMAN [view interactions] High throughput no no
TMM59_HUMAN [view interactions] High throughput no yes
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
KLK10_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
ATPB_HUMAN [view interactions] High throughput no yes
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
ADAS_HUMAN [view interactions] High throughput no yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
NCPR_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
P4HA1_HUMAN [view interactions] High throughput no yes
ATPA_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
NNTM_HUMAN [view entry] [view interactions] High throughput yes yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
NB5R3_HUMAN [view interactions] High throughput no yes
HMOX2_HUMAN [view entry] [view interactions] High throughput yes yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
NB5R1_HUMAN [view entry] [view interactions] High throughput yes yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS8_HUMAN [view interactions] High throughput no yes
SCMC1_HUMAN [view interactions] High throughput no no
NIPS1_HUMAN [view entry] [view interactions] High throughput yes yes
PGES2_HUMAN [view interactions] High throughput no yes
EMC8_HUMAN [view interactions] High throughput no no
PRDX3_HUMAN [view interactions] High throughput no yes
ATPO_HUMAN [view interactions] High throughput no yes
QCR6_HUMAN [view interactions] High throughput no yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
TPP1_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
ODBA_HUMAN [view interactions] High throughput no yes
EMC2_HUMAN [view interactions] High throughput no yes
RCN2_HUMAN [view interactions] High throughput no yes
AT2A2_HUMAN [view entry] [view interactions] High throughput yes yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
ATPG_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
SCPDL_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
LETM1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB8_HUMAN [view entry] [view interactions] High throughput yes yes
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
MTAP2_HUMAN [view entry] [view interactions] High throughput yes yes
PCYOX_HUMAN [view interactions] High throughput no yes
SEPP1_HUMAN [view interactions] High throughput no yes
CATB_HUMAN [view interactions] High throughput no yes
FIBG_HUMAN [view entry] [view interactions] High throughput yes no
HEMO_HUMAN [view interactions] High throughput no no
APOH_HUMAN [view interactions] High throughput no no
FOXO1_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes