Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LCK_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
341 Leu Pro Immunodeficiency22(IMD22) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI000316 MOD_SPalmitoyl_4 MOD 1 7 -
ELMI000316 MOD_SPalmitoyl_4 MOD 1 7 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LCK_HUMAN
GO:0043168 anion binding 34.8958 4 yes
GO:0000166 nucleotide binding 33.8542 4 yes
GO:0017076 purine nucleotide binding 33.3333 5 yes
GO:0032555 purine ribonucleotide binding 33.3333 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 yes
GO:0005524 ATP binding 30.7292 5 yes
GO:0030554 adenyl nucleotide binding 30.7292 6 yes
GO:0032559 adenyl ribonucleotide binding 30.7292 5 yes
GO:0045296 cadherin binding 22.9167 4 no
GO:0003723 RNA binding 22.9167 4 no
GO:0019900 kinase binding 20.3125 4 yes
GO:0019901 protein kinase binding 18.2292 5 yes
GO:0016301 kinase activity 16.6667 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 16.1458 4 yes
GO:0004713 protein tyrosine kinase activity 6.7708 4 yes
GO:0019902 phosphatase binding 6.7708 4 yes
GO:0019903 protein phosphatase binding 5.7292 5 yes
GO:0042578 phosphoric ester hydrolase activity 5.2083 4 yes
GO:0004715 non-membrane spanning protein tyrosine kinase activity 4.6875 5 yes
GO:0016791 phosphatase activity 4.6875 5 yes
GO:0045309 protein phosphorylated amino acid binding 4.6875 4 yes
GO:0001784 phosphotyrosine residue binding 3.6458 5 yes
GO:0016004 phospholipase activator activity 2.0833 5 yes
GO:0042169 SH2 domain binding 2.0833 4 yes
GO:0043274 phospholipase binding 2.0833 4 yes
GO:0060229 lipase activator activity 2.0833 4 yes
GO:0004722 protein serine/threonine phosphatase activity 1.5625 4 yes
GO:0051117 ATPase binding 1.5625 4 yes
GO:0042609 CD4 receptor binding 1.0417 4 yes
GO:0042610 CD8 receptor binding 1.0417 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in LCK_HUMAN
GO:0048522 positive regulation of cellular process 56.7708 4 yes
GO:0060255 regulation of macromolecule metabolic process 48.9583 4 yes
GO:0031323 regulation of cellular metabolic process 47.3958 4 no
GO:0048523 negative regulation of cellular process 46.8750 4 yes
GO:0080090 regulation of primary metabolic process 45.8333 4 yes
GO:0051128 regulation of cellular component organization 41.6667 4 no
GO:0010646 regulation of cell communication 39.5833 4 yes
GO:0009889 regulation of biosynthetic process 38.5417 4 no
GO:0010556 regulation of macromolecule biosynthetic process 38.5417 5 no
GO:0031326 regulation of cellular biosynthetic process 38.5417 5 no
GO:0008104 protein localization 37.5000 4 no
GO:0009893 positive regulation of metabolic process 37.5000 4 yes
GO:0009966 regulation of signal transduction 36.9792 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 35.9375 5 yes
GO:0006996 organelle organization 33.8542 4 no
GO:0022607 cellular component assembly 32.8125 4 no
GO:0010468 regulation of gene expression 32.2917 6 no
GO:0031325 positive regulation of cellular metabolic process 31.7708 5 no
GO:0048584 positive regulation of response to stimulus 29.1667 4 yes
GO:0051246 regulation of protein metabolic process 29.1667 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.6042 5 no
GO:1902531 regulation of intracellular signal transduction 27.0833 5 yes
GO:0060341 regulation of cellular localization 26.0417 4 no
GO:0009891 positive regulation of biosynthetic process 25.5208 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.5208 6 no
GO:0031328 positive regulation of cellular biosynthetic process 25.5208 6 no
GO:0032880 regulation of protein localization 25.5208 5 no
GO:0042981 regulation of apoptotic process 25.0000 5 yes
GO:0043067 regulation of programmed cell death 25.0000 4 yes
GO:0009892 negative regulation of metabolic process 24.4792 4 no
GO:0071702 organic substance transport 24.4792 4 no
GO:0071705 nitrogen compound transport 24.4792 4 no
GO:0051049 regulation of transport 24.4792 4 no
GO:0006796 phosphate-containing compound metabolic process 24.4792 4 yes
GO:0031399 regulation of protein modification process 23.9583 6 no
GO:0010605 negative regulation of macromolecule metabolic process 23.4375 5 no
GO:0051240 positive regulation of multicellular organismal process 22.9167 4 yes
GO:0010647 positive regulation of cell communication 22.9167 5 yes
GO:0023056 positive regulation of signaling 22.9167 4 yes
GO:0051130 positive regulation of cellular component organization 22.3958 5 no
GO:0043412 macromolecule modification 22.3958 4 yes
GO:0051247 positive regulation of protein metabolic process 21.8750 6 yes
GO:0030030 cell projection organization 21.8750 4 no
GO:0036211 protein modification process 21.8750 4 yes
GO:0044087 regulation of cellular component biogenesis 21.3542 4 no
GO:0033043 regulation of organelle organization 21.3542 5 no
GO:0009967 positive regulation of signal transduction 21.3542 5 yes
GO:0015031 protein transport 20.8333 4 no
GO:0031324 negative regulation of cellular metabolic process 20.8333 5 no
GO:0002684 positive regulation of immune system process 18.7500 4 yes
GO:0030155 regulation of cell adhesion 18.7500 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 16.6667 4 yes
GO:0016310 phosphorylation 16.1458 5 yes
GO:0050776 regulation of immune response 15.1042 4 yes
GO:1902533 positive regulation of intracellular signal transduction 15.1042 6 yes
GO:0043085 positive regulation of catalytic activity 15.1042 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 14.5833 5 yes
GO:0022407 regulation of cell-cell adhesion 13.5417 5 yes
GO:0050778 positive regulation of immune response 13.0208 5 yes
GO:0006468 protein phosphorylation 12.5000 5 yes
GO:0045785 positive regulation of cell adhesion 11.9792 5 yes
GO:0050865 regulation of cell activation 11.9792 4 yes
GO:0030162 regulation of proteolysis 11.9792 6 yes
GO:0051249 regulation of lymphocyte activation 11.4583 5 yes
GO:0051336 regulation of hydrolase activity 11.4583 4 yes
GO:0002694 regulation of leukocyte activation 11.4583 4 yes
GO:0050863 regulation of T cell activation 10.9375 6 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 10.4167 6 yes
GO:0018193 peptidyl-amino acid modification 9.8958 5 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 9.3750 4 yes
GO:0043065 positive regulation of apoptotic process 9.3750 6 yes
GO:0043068 positive regulation of programmed cell death 9.3750 5 yes
GO:0045862 positive regulation of proteolysis 8.8542 7 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 8.8542 4 yes
GO:0022409 positive regulation of cell-cell adhesion 8.8542 6 yes
GO:2001233 regulation of apoptotic signaling pathway 8.3333 5 yes
GO:0050867 positive regulation of cell activation 7.8125 5 yes
GO:0051251 positive regulation of lymphocyte activation 7.8125 6 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 7.8125 7 yes
GO:0002696 positive regulation of leukocyte activation 7.8125 5 yes
GO:0050870 positive regulation of T cell activation 7.2917 7 yes
GO:0051345 positive regulation of hydrolase activity 7.2917 5 yes
GO:0052547 regulation of peptidase activity 6.7708 5 yes
GO:0052548 regulation of endopeptidase activity 6.7708 6 yes
GO:0006811 monoatomic ion transport 6.7708 4 yes
GO:0046777 protein autophosphorylation 6.2500 6 yes
GO:0055080 monoatomic cation homeostasis 5.7292 4 yes
GO:0006812 monoatomic cation transport 5.7292 5 yes
GO:0030001 metal ion transport 5.7292 6 yes
GO:0038093 Fc receptor signaling pathway 5.7292 5 yes
GO:0050851 antigen receptor-mediated signaling pathway 5.2083 5 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 5.2083 7 yes
GO:2001242 regulation of intrinsic apoptotic signaling pathway 5.2083 6 yes
GO:0006873 intracellular monoatomic ion homeostasis 5.2083 4 yes
GO:0018108 peptidyl-tyrosine phosphorylation 5.2083 6 yes
GO:0018212 peptidyl-tyrosine modification 5.2083 6 yes
GO:0030003 intracellular monoatomic cation homeostasis 5.2083 5 yes
GO:0140546 defense response to symbiont 4.6875 4 yes
GO:0002521 leukocyte differentiation 4.6875 4 yes
GO:0038094 Fc-gamma receptor signaling pathway 4.6875 6 yes
GO:0042110 T cell activation 4.6875 4 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 4.6875 8 yes
GO:1903131 mononuclear cell differentiation 4.1667 5 yes
GO:0010950 positive regulation of endopeptidase activity 4.1667 7 yes
GO:0010952 positive regulation of peptidase activity 4.1667 6 yes
GO:0050852 T cell receptor signaling pathway 3.6458 6 yes
GO:0050853 B cell receptor signaling pathway 3.1250 6 yes
GO:0050854 regulation of antigen receptor-mediated signaling pathway 3.1250 5 yes
GO:0051282 regulation of sequestering of calcium ion 3.1250 4 yes
GO:0098655 monoatomic cation transmembrane transport 3.1250 4 yes
GO:0098662 inorganic cation transmembrane transport 3.1250 4 yes
GO:2001235 positive regulation of apoptotic signaling pathway 3.1250 6 yes
GO:0006816 calcium ion transport 3.1250 7 yes
GO:0050856 regulation of T cell receptor signaling pathway 2.6042 6 yes
GO:2001056 positive regulation of cysteine-type endopeptidase activity 2.6042 8 yes
GO:0030097 hemopoiesis 2.6042 4 yes
GO:0030098 lymphocyte differentiation 2.6042 4 yes
GO:0034114 regulation of heterotypic cell-cell adhesion 2.6042 6 yes
GO:0070588 calcium ion transmembrane transport 2.0833 5 yes
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 2.0833 10 yes
GO:0034116 positive regulation of heterotypic cell-cell adhesion 2.0833 7 yes
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 2.0833 9 yes
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 1.5625 6 yes
GO:0050862 positive regulation of T cell receptor signaling pathway 1.5625 7 yes
GO:0030217 T cell differentiation 1.5625 5 yes
GO:0038083 peptidyl-tyrosine autophosphorylation 1.5625 7 yes
GO:0051209 release of sequestered calcium ion into cytosol 1.0417 6 yes
GO:0051283 negative regulation of sequestering of calcium ion 1.0417 5 yes
GO:0097553 calcium ion transmembrane import into cytosol 1.0417 6 yes
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 1.0417 7 yes
GO:0006882 intracellular zinc ion homeostasis 1.0417 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
WASP_HUMAN [view interactions] Low throughput no yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
VAV_HUMAN [view interactions] Low throughput no no
3BP2_HUMAN [view interactions] Low throughput no yes
CD3E_HUMAN [view interactions] Low throughput no no
EGFR_HUMAN [view interactions] Low throughput no no
HAVR2_HUMAN [view interactions] Low throughput no no
THMS1_HUMAN [view interactions] Low throughput no no
GCR_HUMAN [view entry] [view interactions] Low throughput yes yes
HCLS1_HUMAN [view interactions] Low throughput no no
LAT_HUMAN [view interactions] Low throughput no no
STK11_HUMAN [view interactions] Low throughput no yes
SLAF6_HUMAN [view interactions] Low throughput no no
TNR6_HUMAN [view interactions] Low throughput no no
LCK_HUMAN [view entry] [view interactions] Low throughput yes no
WASL_HUMAN [view entry] [view interactions] Low throughput yes yes
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN6_HUMAN [view interactions] Low throughput no no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
DOK2_HUMAN [view interactions] Low throughput no no
MED25_HUMAN [view interactions] Low throughput no yes
CD44_HUMAN [view entry] [view interactions] Low throughput yes yes
KIT_HUMAN [view interactions] Low throughput no no
UBE3A_HUMAN [view entry] [view interactions] Low throughput yes yes
SOCS6_HUMAN [view interactions] Low throughput no yes
AJUBA_HUMAN [view interactions] Low throughput no yes
U119A_HUMAN [view interactions] Low throughput no no
PK3CA_HUMAN [view entry] [view interactions] Low throughput yes yes
NOTC1_HUMAN [view entry] [view interactions] Low throughput yes yes
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
PAXI_HUMAN [view interactions] Low throughput no yes
SH2B3_HUMAN [view interactions] Low throughput no yes
CD20_HUMAN [view interactions] Low throughput no no
CASL_HUMAN [view interactions] Low throughput no yes
CD48_HUMAN [view interactions] Low throughput no no
CD38_HUMAN [view interactions] Low throughput no no
CTLA4_HUMAN [view interactions] Low throughput no no
TRPV4_HUMAN [view interactions] Low throughput no yes
SIT1_HUMAN [view interactions] Low throughput no no
THY1_HUMAN [view entry] [view interactions] Low throughput yes yes
RAF1_HUMAN [view entry] [view interactions] Low throughput yes no
CYLD_HUMAN [view entry] [view interactions] Low throughput yes yes
SKAP1_HUMAN [view interactions] Low throughput no no
CBLB_HUMAN [view entry] [view interactions] Low throughput yes yes
CD5_HUMAN [view interactions] Low throughput no no
IL2RB_HUMAN [view interactions] Low throughput no no
SOCS1_HUMAN [view interactions] Low throughput no yes
SOCS2_HUMAN [view interactions] Low throughput no yes
SOCS3_HUMAN [view interactions] Low throughput no yes
CISH_HUMAN [view interactions] Low throughput no yes
1433T_HUMAN [view entry] [view interactions] Low throughput yes yes
BAG6_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRF_HUMAN [view entry] [view interactions] Low throughput yes yes
FCG3A_HUMAN [view interactions] Low throughput no no
RHOH_HUMAN [view interactions] Low throughput no yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
TNFL6_HUMAN [view interactions] Low throughput no yes
SQSTM_HUMAN [view interactions] Low throughput no yes
SMAD2_HUMAN [view interactions] Low throughput no yes
ADA10_HUMAN [view entry] [view interactions] Low throughput yes yes
SMAD3_HUMAN [view interactions] Low throughput no yes
ADA15_HUMAN [view interactions] Low throughput no yes
CDC45_HUMAN [view interactions] Low throughput no no
CD4_HUMAN [view interactions] Low throughput no no
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
CD8A_HUMAN [view interactions] Low throughput no no
SH22A_HUMAN [view interactions] Low throughput no no
SH21A_HUMAN [view interactions] Low throughput no no
KSYK_HUMAN [view interactions] Low throughput no no
CTND1_HUMAN [view entry] [view interactions] Low throughput yes no
MED28_HUMAN [view interactions] Low throughput no yes
PECA1_HUMAN [view interactions] Low throughput no no
CSK_HUMAN [view interactions] Low throughput no yes
RASA1_HUMAN [view interactions] Low throughput no yes
CBL_HUMAN [view interactions] Low throughput no yes
UFO_HUMAN [view interactions] Low throughput no no
G3BP1_HUMAN [view interactions] Low throughput no yes
F174A_HUMAN [view interactions] Low throughput no yes
BCL3_HUMAN [view interactions] Low throughput no yes
SOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
ZAP70_HUMAN [view interactions] Low throughput no no
LCP2_HUMAN [view interactions] Low throughput no yes
KPCT_HUMAN [view interactions] Low throughput no no
PTCA_HUMAN [view interactions] Low throughput no no
PTPRC_HUMAN [view interactions] Low throughput no no
KHDR1_HUMAN [view interactions] Low throughput no yes
SKAP2_HUMAN [view interactions] Low throughput no no
FYB1_HUMAN [view interactions] Low throughput no no
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
CD3Z_HUMAN [view interactions] Low throughput no no
CD2_HUMAN [view interactions] Low throughput no no
P85A_HUMAN [view interactions] Low throughput no yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
BCAR1_HUMAN [view interactions] Low throughput no yes
PTN22_HUMAN [view interactions] Low throughput no yes
MYO1D_HUMAN [view entry] [view interactions] High throughput yes yes
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
NAV1_HUMAN [view interactions] High throughput no yes
NCK5L_HUMAN [view interactions] High throughput no yes
NISCH_HUMAN [view interactions] High throughput no yes
CAPON_HUMAN [view entry] [view interactions] High throughput yes yes
NOTC2_HUMAN [view entry] [view interactions] High throughput yes yes
NUDC_HUMAN [view interactions] High throughput no yes
EHD4_HUMAN [view entry] [view interactions] High throughput yes no
NUDC3_HUMAN [view interactions] High throughput no yes
PGM1_HUMAN [view interactions] High throughput no no
NUMBL_HUMAN [view entry] [view interactions] High throughput yes yes
PRP4B_HUMAN [view interactions] High throughput no yes
OCLN_HUMAN [view interactions] High throughput no no
XRN1_HUMAN [view interactions] High throughput no yes
PALM_HUMAN [view entry] [view interactions] High throughput yes yes
G6PI_HUMAN [view entry] [view interactions] High throughput yes yes
PLAK2_HUMAN [view interactions] High throughput no no
MA1A2_HUMAN [view interactions] High throughput no yes
PARD3_HUMAN [view interactions] High throughput no yes
NUMB_HUMAN [view entry] [view interactions] High throughput yes yes
PEAK1_HUMAN [view interactions] High throughput no yes
API5_HUMAN [view interactions] High throughput no no
PHAR4_HUMAN [view interactions] High throughput no yes
LACB2_HUMAN [view interactions] High throughput no yes
PHLB3_HUMAN [view interactions] High throughput no yes
AP3M1_HUMAN [view entry] [view interactions] High throughput yes yes
PIHD1_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
P85B_HUMAN [view interactions] High throughput no yes
RM45_HUMAN [view interactions] High throughput no no
PKN3_HUMAN [view interactions] High throughput no yes
UAP1L_HUMAN [view interactions] High throughput no yes
PKP2_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKP4_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
PLCH1_HUMAN [view interactions] High throughput no no
BLK_HUMAN [view interactions] High throughput no no
PKHA5_HUMAN [view entry] [view interactions] High throughput yes yes
HCK_HUMAN [view entry] [view interactions] High throughput yes no
PKHA6_HUMAN [view entry] [view interactions] High throughput yes no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
PKHA7_HUMAN [view interactions] High throughput no yes
LIPA1_HUMAN [view entry] [view interactions] High throughput yes yes
LIPB1_HUMAN [view interactions] High throughput no yes
PHAG1_HUMAN [view interactions] High throughput no yes
PPID_HUMAN [view entry] [view interactions] High throughput yes yes
ASPP1_HUMAN [view interactions] High throughput no yes
STAT3_HUMAN [view entry] [view interactions] High throughput yes yes
PSD3_HUMAN [view entry] [view interactions] High throughput yes yes
PTN13_HUMAN [view interactions] High throughput no yes
PTN14_HUMAN [view interactions] High throughput no yes
NGAP_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
RICTR_HUMAN [view interactions] High throughput no yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
RS11_HUMAN [view entry] [view interactions] High throughput yes yes
RS8_HUMAN [view entry] [view interactions] High throughput yes no
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
S12A2_HUMAN [view entry] [view interactions] High throughput yes yes
ZNT6_HUMAN [view interactions] High throughput no yes
RIN3_HUMAN [view interactions] High throughput no yes
SNP23_HUMAN [view entry] [view interactions] High throughput yes no
CDKAL_HUMAN [view interactions] High throughput no no
SNTB2_HUMAN [view entry] [view interactions] High throughput yes no
LZTS2_HUMAN [view interactions] High throughput no no
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
GATA3_HUMAN [view interactions] High throughput no no
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN2_HUMAN [view entry] [view interactions] High throughput yes yes
NEMO_HUMAN [view interactions] High throughput no yes
F10A1_HUMAN [view interactions] High throughput no yes
FLT3_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
SGT1_HUMAN [view interactions] High throughput no no
ANDR_HUMAN [view interactions] High throughput no no
TANC1_HUMAN [view entry] [view interactions] High throughput yes yes
GAB1_HUMAN [view interactions] High throughput no yes
SYTM_HUMAN [view interactions] High throughput no yes
TOM22_HUMAN [view interactions] High throughput no yes
MET_HUMAN [view interactions] High throughput no yes
TOM34_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRM_HUMAN [view interactions] High throughput no yes
TRIPB_HUMAN [view interactions] High throughput no yes
PTPRK_HUMAN [view interactions] High throughput no no
TTC1_HUMAN [view interactions] High throughput no yes
PTPRG_HUMAN [view interactions] High throughput no no
TTC4_HUMAN [view interactions] High throughput no yes
PTPRZ_HUMAN [view entry] [view interactions] High throughput yes yes
TTC9C_HUMAN [view interactions] High throughput no yes
PTPRB_HUMAN [view interactions] High throughput no yes
UN45A_HUMAN [view interactions] High throughput no yes
PTPRJ_HUMAN [view interactions] High throughput no yes
UBP54_HUMAN [view interactions] High throughput no yes
PTPRO_HUMAN [view entry] [view interactions] High throughput yes no
US6NL_HUMAN [view interactions] High throughput no yes
PTN12_HUMAN [view interactions] High throughput no yes
UTRN_HUMAN [view entry] [view interactions] High throughput yes yes
UHRF2_HUMAN [view interactions] High throughput no no
VANG1_HUMAN [view interactions] High throughput no no
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
WDR6_HUMAN [view entry] [view interactions] High throughput yes yes
DAF_HUMAN [view interactions] High throughput no no
S53A1_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT7_HUMAN [view entry] [view interactions] High throughput yes yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
STAP1_HUMAN [view interactions] High throughput no no
AHNK2_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
AMOT_HUMAN [view entry] [view interactions] High throughput yes no
FAK1_HUMAN [view entry] [view interactions] High throughput yes yes
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
ASB9_HUMAN [view interactions] High throughput no no
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
TRI35_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
UBAP2_HUMAN [view interactions] High throughput no yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
CTDS1_HUMAN [view interactions] High throughput no no
CARL1_HUMAN [view interactions] High throughput no yes
C1QT2_HUMAN [view interactions] High throughput no yes
CEP55_HUMAN [view interactions] High throughput no yes
IKBD_HUMAN [view interactions] High throughput no no
CHRD1_HUMAN [view interactions] High throughput no yes
CMI2B_HUMAN [view interactions] High throughput no no
CRBG3_HUMAN [view interactions] High throughput no no
CSTFT_HUMAN [view interactions] High throughput no yes
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
DEST_HUMAN [view entry] [view interactions] High throughput yes yes
EGLN1_HUMAN [view entry] [view interactions] High throughput yes yes
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC4_HUMAN [view entry] [view interactions] High throughput yes yes
FERM2_HUMAN [view interactions] High throughput no yes
GOGA5_HUMAN [view interactions] High throughput no yes
JPH1_HUMAN [view interactions] High throughput no no
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
MPRIP_HUMAN [view entry] [view interactions] High throughput yes yes
MYO5A_HUMAN [view entry] [view interactions] High throughput yes yes
OCRL_HUMAN [view interactions] High throughput no yes
PFKAL_HUMAN [view entry] [view interactions] High throughput yes yes
PFKAM_HUMAN [view entry] [view interactions] High throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
PFKAP_HUMAN [view entry] [view interactions] High throughput yes yes
RFIP1_HUMAN [view interactions] High throughput no yes
RAI14_HUMAN [view interactions] High throughput no yes
RL15_HUMAN [view entry] [view interactions] High throughput yes no
RL7A_HUMAN [view entry] [view interactions] High throughput yes no
RS9_HUMAN [view entry] [view interactions] High throughput yes yes
SI1L2_HUMAN [view entry] [view interactions] High throughput yes yes
4F2_HUMAN [view entry] [view interactions] High throughput yes no
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
SYNJ1_HUMAN [view entry] [view interactions] High throughput yes yes
TLE5_HUMAN [view interactions] High throughput no no
TB182_HUMAN [view interactions] High throughput no yes
MEN1_HUMAN [view interactions] High throughput no yes
TRIO_HUMAN [view entry] [view interactions] High throughput yes yes
SPAST_HUMAN [view interactions] High throughput no yes
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
CAMP2_HUMAN [view interactions] High throughput no yes
USO1_HUMAN [view entry] [view interactions] High throughput yes yes
NELFD_HUMAN [view interactions] High throughput no yes
SYYC_HUMAN [view interactions] High throughput no yes
ESCO1_HUMAN [view interactions] High throughput no yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
STIM1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
MOB2_HUMAN [view interactions] High throughput no no
LARP7_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
U119B_HUMAN [view interactions] High throughput no yes
MTDC_HUMAN [view interactions] High throughput no yes
AUP1_HUMAN [view interactions] High throughput no yes
UBP11_HUMAN [view interactions] High throughput no yes
UBP7_HUMAN [view interactions] High throughput no yes
MK12_HUMAN [view interactions] High throughput no no
P3C2B_HUMAN [view interactions] High throughput no no
AMHR2_HUMAN [view interactions] High throughput no no
M3K8_HUMAN [view interactions] High throughput no yes
ITB7_HUMAN [view interactions] High throughput no no
KCC2G_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K7_HUMAN [view entry] [view interactions] High throughput yes yes
CRBB1_HUMAN [view interactions] High throughput no no
MASP2_HUMAN [view interactions] High throughput no no
PTK6_HUMAN [view interactions] High throughput no yes
NOS2_HUMAN [view interactions] High throughput no yes
LT4R1_HUMAN [view interactions] High throughput no yes
EPHB4_HUMAN [view interactions] High throughput no yes
IFNL1_HUMAN [view interactions] High throughput no no
IL21R_HUMAN [view interactions] High throughput no no
IL6RA_HUMAN [view interactions] High throughput no no
RHG17_HUMAN [view interactions] High throughput no no
TRAT1_HUMAN [view interactions] High throughput no no
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
ERBB3_HUMAN [view interactions] High throughput no yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
SMUF1_HUMAN [view interactions] High throughput no yes
MBP_HUMAN [view entry] [view interactions] High throughput yes no
MTR1B_HUMAN [view interactions] High throughput no yes
GCP60_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
AIP_HUMAN [view entry] [view interactions] High throughput yes yes
ATP5I_HUMAN [view interactions] High throughput no yes
ANR26_HUMAN [view interactions] High throughput no yes
C2CD5_HUMAN [view interactions] High throughput no yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
NSE2_HUMAN [view interactions] High throughput no yes
AP3D1_HUMAN [view entry] [view interactions] High throughput yes no
F200C_HUMAN [view interactions] High throughput no yes
AP3S1_HUMAN [view entry] [view interactions] High throughput yes no
PHF5A_HUMAN [view interactions] High throughput no yes
ARAP2_HUMAN [view interactions] High throughput no no
YES_HUMAN [view entry] [view interactions] High throughput yes yes
RHG32_HUMAN [view entry] [view interactions] High throughput yes yes
APOE_HUMAN [view entry] [view interactions] High throughput yes yes
AR13B_HUMAN [view interactions] High throughput no yes
HPS5_HUMAN [view interactions] High throughput no yes
AT2B1_HUMAN [view entry] [view interactions] High throughput yes yes
CDK13_HUMAN [view interactions] High throughput no no
BASP1_HUMAN [view entry] [view interactions] High throughput yes yes
PRD16_HUMAN [view interactions] High throughput no no
CABL1_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
GHC2_HUMAN [view entry] [view interactions] High throughput yes no
CSKI2_HUMAN [view interactions] High throughput no yes
GHC1_HUMAN [view entry] [view interactions] High throughput yes yes
CCDC8_HUMAN [view interactions] High throughput no yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
GRDN_HUMAN [view interactions] High throughput no no
E2F7_HUMAN [view interactions] High throughput no no
MRCKA_HUMAN [view entry] [view interactions] High throughput yes yes
RL22L_HUMAN [view interactions] High throughput no no
MRCKB_HUMAN [view entry] [view interactions] High throughput yes yes
CDC37_HUMAN [view interactions] High throughput no yes
CDCA3_HUMAN [view interactions] High throughput no no
PTPS_HUMAN [view interactions] High throughput no yes
CDK3_HUMAN [view interactions] High throughput no no
RBM3_HUMAN [view interactions] High throughput no no
CEP89_HUMAN [view interactions] High throughput no no
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
CNO10_HUMAN [view interactions] High throughput no yes
IF4A1_HUMAN [view interactions] High throughput no no
CN37_HUMAN [view entry] [view interactions] High throughput yes no
SYRC_HUMAN [view interactions] High throughput no yes
COBL1_HUMAN [view interactions] High throughput no yes
BMX_HUMAN [view interactions] High throughput no no
COG1_HUMAN [view interactions] High throughput no yes
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
DDX54_HUMAN [view interactions] High throughput no yes
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
DIP2A_HUMAN [view entry] [view interactions] High throughput yes no
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
DIP2B_HUMAN [view entry] [view interactions] High throughput yes yes
TCPE_HUMAN [view entry] [view interactions] High throughput yes yes
DLG5_HUMAN [view entry] [view interactions] High throughput yes no
SYIC_HUMAN [view interactions] High throughput no yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC7_HUMAN [view interactions] High throughput no yes
METK2_HUMAN [view interactions] High throughput no no
DRG1_HUMAN [view interactions] High throughput no yes
EF1G_HUMAN [view entry] [view interactions] High throughput yes yes
DSC2_HUMAN [view interactions] High throughput no no
SYVC_HUMAN [view interactions] High throughput no yes
DSG2_HUMAN [view interactions] High throughput no no
EF1B_HUMAN [view entry] [view interactions] High throughput yes yes
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
NF1_HUMAN [view entry] [view interactions] High throughput yes no
DTNA_HUMAN [view entry] [view interactions] High throughput yes yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
EDRF1_HUMAN [view interactions] High throughput no no
DESP_HUMAN [view entry] [view interactions] High throughput yes no
EFNB2_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
EFR3A_HUMAN [view entry] [view interactions] High throughput yes yes
H90B3_HUMAN [view interactions] High throughput no no
EFR3B_HUMAN [view entry] [view interactions] High throughput yes no
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
CDK1_HUMAN [view interactions] High throughput no no
E41L5_HUMAN [view interactions] High throughput no no
CDCP1_HUMAN [view interactions] High throughput no yes
EPHA2_HUMAN [view interactions] High throughput no no
H2B1L_HUMAN [view interactions] High throughput no yes
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
H2B1N_HUMAN [view interactions] High throughput no yes
ETFA_HUMAN [view interactions] High throughput no yes
H2B1H_HUMAN [view interactions] High throughput no yes
EXOC3_HUMAN [view entry] [view interactions] High throughput yes no
H2B2F_HUMAN [view interactions] High throughput no yes
EXOC5_HUMAN [view entry] [view interactions] High throughput yes yes
H2B1C_HUMAN [view interactions] High throughput no yes
NIBA2_HUMAN [view interactions] High throughput no no
H2B1D_HUMAN [view interactions] High throughput no yes
F1711_HUMAN [view entry] [view interactions] High throughput yes yes
H2B1M_HUMAN [view interactions] High throughput no yes
F1712_HUMAN [view interactions] High throughput no no
RP9_HUMAN [view interactions] High throughput no yes
F171B_HUMAN [view interactions] High throughput no yes
SAFB1_HUMAN [view interactions] High throughput no yes
FARP1_HUMAN [view entry] [view interactions] High throughput yes no
STK38_HUMAN [view entry] [view interactions] High throughput yes yes
FGD1_HUMAN [view interactions] High throughput no no
NOLC1_HUMAN [view interactions] High throughput no yes
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4B_HUMAN [view interactions] High throughput no yes
FLII_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
RAN_HUMAN [view entry] [view interactions] High throughput yes no
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
LAP2A_HUMAN [view interactions] High throughput no yes
FMN2_HUMAN [view entry] [view interactions] High throughput yes no
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
FRS2_HUMAN [view interactions] High throughput no no
RMXL1_HUMAN [view interactions] High throughput no yes
GCC2_HUMAN [view interactions] High throughput no yes
RBMX_HUMAN [view entry] [view interactions] High throughput yes yes
GLMN_HUMAN [view interactions] High throughput no no
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
ATPA_HUMAN [view interactions] High throughput no yes
GOGA3_HUMAN [view interactions] High throughput no yes
HSP76_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA4_HUMAN [view interactions] High throughput no yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
GOGB1_HUMAN [view entry] [view interactions] High throughput yes yes
XRCC5_HUMAN [view interactions] High throughput no yes
GRIN1_HUMAN [view entry] [view interactions] High throughput yes yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
GRIN3_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
IRS4_HUMAN [view interactions] High throughput no no
TBB5_HUMAN [view interactions] High throughput no yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
SKT_HUMAN [view entry] [view interactions] High throughput yes yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
NHSL3_HUMAN [view interactions] High throughput no yes
QCR8_HUMAN [view interactions] High throughput no yes
K1549_HUMAN [view entry] [view interactions] High throughput yes yes
K1671_HUMAN [view interactions] High throughput no yes
KDIS_HUMAN [view entry] [view interactions] High throughput yes yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
KI16B_HUMAN [view interactions] High throughput no yes
L2GL1_HUMAN [view entry] [view interactions] High throughput yes yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
LMTK2_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
LSR_HUMAN [view interactions] High throughput no yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
MACF1_HUMAN [view entry] [view interactions] High throughput yes yes
MD2L2_HUMAN [view interactions] High throughput no yes
M3K21_HUMAN [view interactions] High throughput no yes
M4K4_HUMAN [view interactions] High throughput no yes
MARK2_HUMAN [view entry] [view interactions] High throughput yes yes
MARK3_HUMAN [view interactions] High throughput no yes
MINK1_HUMAN [view entry] [view interactions] High throughput yes yes
MPP7_HUMAN [view entry] [view interactions] High throughput yes no
MYO1B_HUMAN [view entry] [view interactions] High throughput yes no
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes