TOM34_HUMAN
Evidence for PS localization
Functions
Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TOM34_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 34.7826 | 4 | no |
| GO:0000166 | nucleotide binding | 34.7826 | 4 | no |
| GO:0005524 | ATP binding | 34.7826 | 5 | no |
| GO:0017076 | purine nucleotide binding | 34.7826 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 34.7826 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 34.7826 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 34.7826 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 34.7826 | 4 | no |
| GO:0043168 | anion binding | 34.7826 | 4 | no |
| GO:0019900 | kinase binding | 30.4348 | 4 | no |
| GO:0019901 | protein kinase binding | 30.4348 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 26.0870 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 26.0870 | 4 | no |
| GO:0016887 | ATP hydrolysis activity | 26.0870 | 7 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 26.0870 | 6 | no |
| GO:0031625 | ubiquitin protein ligase binding | 26.0870 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 26.0870 | 4 | no |
| GO:0042826 | histone deacetylase binding | 21.7391 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TOM34_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.8696 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 56.5217 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 56.5217 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 56.5217 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 52.1739 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 52.1739 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 47.8261 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 47.8261 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 47.8261 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 43.4783 | 6 | no |
| GO:0009966 | regulation of signal transduction | 43.4783 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.4783 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 43.4783 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 39.1304 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 39.1304 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 39.1304 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 39.1304 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 39.1304 | 5 | no |
| GO:0031399 | regulation of protein modification process | 39.1304 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 39.1304 | 4 | no |
| GO:0051726 | regulation of cell cycle | 34.7826 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 34.7826 | 5 | no |
| GO:0009894 | regulation of catabolic process | 34.7826 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.7826 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.7826 | 5 | no |
| GO:0090304 | nucleic acid metabolic process | 34.7826 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 34.7826 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 34.7826 | 4 | no |
| GO:0051049 | regulation of transport | 30.4348 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.4348 | 5 | no |
| GO:0051338 | regulation of transferase activity | 30.4348 | 4 | no |
| GO:0010564 | regulation of cell cycle process | 30.4348 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 30.4348 | 4 | no |
| GO:0051345 | positive regulation of hydrolase activity | 30.4348 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 30.4348 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 30.4348 | 5 | no |
| GO:0023056 | positive regulation of signaling | 30.4348 | 4 | no |
| GO:0080134 | regulation of response to stress | 30.4348 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.4348 | 6 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 30.4348 | 6 | no |
| GO:0022607 | cellular component assembly | 30.4348 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 30.4348 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 30.4348 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.4348 | 6 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 26.0870 | 7 | no |
| GO:0051347 | positive regulation of transferase activity | 26.0870 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.0870 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 26.0870 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.0870 | 5 | no |
| GO:0071310 | cellular response to organic substance | 26.0870 | 4 | no |
| GO:0008104 | protein localization | 26.0870 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 26.0870 | 7 | no |
| GO:0043933 | protein-containing complex organization | 26.0870 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.0870 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.0870 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 26.0870 | 7 | no |
| GO:0006996 | organelle organization | 26.0870 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 26.0870 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 26.0870 | 7 | no |
| GO:0034605 | cellular response to heat | 26.0870 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 26.0870 | 7 | no |
| GO:0043549 | regulation of kinase activity | 26.0870 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 26.0870 | 6 | no |
| GO:0051050 | positive regulation of transport | 21.7391 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.7391 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.7391 | 4 | no |
| GO:0060341 | regulation of cellular localization | 21.7391 | 4 | no |
| GO:1901873 | regulation of post-translational protein modification | 21.7391 | 7 | no |
| GO:1903320 | regulation of protein modification by small protein conjugation or removal | 21.7391 | 8 | no |
| GO:0031400 | negative regulation of protein modification process | 21.7391 | 7 | no |
| GO:0034762 | regulation of transmembrane transport | 21.7391 | 4 | no |
| GO:0030162 | regulation of proteolysis | 21.7391 | 6 | no |
| GO:0033043 | regulation of organelle organization | 21.7391 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.7391 | 4 | no |
| GO:0036211 | protein modification process | 21.7391 | 4 | no |
| GO:0043412 | macromolecule modification | 21.7391 | 4 | no |
| GO:0080135 | regulation of cellular response to stress | 21.7391 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 21.7391 | 8 | no |
| GO:0010628 | positive regulation of gene expression | 21.7391 | 7 | no |
| GO:0016070 | RNA metabolic process | 21.7391 | 5 | no |
| GO:0051052 | regulation of DNA metabolic process | 21.7391 | 5 | no |
| GO:0051054 | positive regulation of DNA metabolic process | 21.7391 | 6 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 21.7391 | 8 | no |
| GO:0002684 | positive regulation of immune system process | 21.7391 | 4 | no |
| GO:0006986 | response to unfolded protein | 21.7391 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 21.7391 | 4 | no |
| GO:0009059 | macromolecule biosynthetic process | 21.7391 | 4 | no |
| GO:0009896 | positive regulation of catabolic process | 21.7391 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 21.7391 | 4 | no |
| GO:0032880 | regulation of protein localization | 21.7391 | 5 | no |
| GO:0033674 | positive regulation of kinase activity | 21.7391 | 6 | no |
| GO:0042176 | regulation of protein catabolic process | 21.7391 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.7391 | 8 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.7391 | 4 | no |
| GO:0045860 | positive regulation of protein kinase activity | 21.7391 | 7 | no |
| GO:0033365 | protein localization to organelle | 17.3913 | 5 | yes |
| GO:0070585 | protein localization to mitochondrion | 13.0435 | 6 | yes |
| GO:0072594 | establishment of protein localization to organelle | 13.0435 | 4 | yes |
| GO:0072655 | establishment of protein localization to mitochondrion | 13.0435 | 5 | yes |
| GO:0006605 | protein targeting | 8.6957 | 4 | yes |
| GO:0006626 | protein targeting to mitochondrion | 8.6957 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AAPK1_HUMAN | [view interactions] | Low throughput | no | no |
| DMAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| MND1_HUMAN | [view interactions] | High throughput | no | no |
| TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| BBS1_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| TAGAP_HUMAN | [view interactions] | High throughput | no | yes |
| CBCO1_HUMAN | [view interactions] | High throughput | no | no |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| TMM51_HUMAN | [view interactions] | High throughput | no | yes |
| RM38_HUMAN | [view interactions] | High throughput | no | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF2_HUMAN | [view interactions] | High throughput | no | yes |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| RT18C_HUMAN | [view interactions] | High throughput | no | yes |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEIS2_HUMAN | [view interactions] | High throughput | no | yes |
| MED17_HUMAN | [view interactions] | High throughput | no | no |
| VATC2_HUMAN | [view interactions] | High throughput | no | yes |
| ZIM2_HUMAN | [view interactions] | High throughput | no | no |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| PLD2_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| HOIL1_HUMAN | [view interactions] | High throughput | no | no |
| WDR12_HUMAN | [view interactions] | High throughput | no | yes |
| ZFAN5_HUMAN | [view interactions] | High throughput | no | yes |
| RBM33_HUMAN | [view interactions] | High throughput | no | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| TRI16_HUMAN | [view interactions] | High throughput | no | no |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYTC_HUMAN | [view interactions] | High throughput | no | yes |
| AIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNC_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RECQ1_HUMAN | [view interactions] | High throughput | no | yes |
| ES8L1_HUMAN | [view interactions] | High throughput | no | no |
| GGA1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| CD37L_HUMAN | [view interactions] | High throughput | no | yes |
| CHRD1_HUMAN | [view interactions] | High throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| GPR21_HUMAN | [view interactions] | High throughput | no | no |
| AKIR2_HUMAN | [view interactions] | High throughput | no | no |
| COAA1_HUMAN | [view interactions] | High throughput | no | no |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| ZN490_HUMAN | [view interactions] | High throughput | no | no |
| MEPE_HUMAN | [view interactions] | High throughput | no | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| FUCM_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| HLAA_HUMAN | [view interactions] | High throughput | no | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| ATOSB_HUMAN | [view interactions] | High throughput | no | yes |
| TINF2_HUMAN | [view interactions] | High throughput | no | no |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| ACD_HUMAN | [view interactions] | High throughput | no | no |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| CCD82_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| PEA15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FA24B_HUMAN | [view interactions] | High throughput | no | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLAL2_HUMAN | [view interactions] | High throughput | no | no |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| KPB2_HUMAN | [view interactions] | High throughput | no | yes |
| SERB1_HUMAN | [view interactions] | High throughput | no | yes |
| RPC10_HUMAN | [view interactions] | High throughput | no | yes |
| AHR_HUMAN | [view interactions] | High throughput | no | yes |
| UN45A_HUMAN | [view interactions] | High throughput | no | yes |
| TF2H1_HUMAN | [view interactions] | High throughput | no | yes |