TOM34_HUMAN
Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in TOM34_HUMAN |
---|---|---|---|---|
GO:0019900 | kinase binding | 35.0000 | 4 | no |
GO:0019901 | protein kinase binding | 35.0000 | 5 | no |
GO:0005524 | ATP binding | 35.0000 | 5 | no |
GO:0017076 | purine nucleotide binding | 35.0000 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 35.0000 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 35.0000 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 35.0000 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 35.0000 | 4 | no |
GO:0003723 | RNA binding | 30.0000 | 4 | no |
GO:0097718 | disordered domain specific binding | 25.0000 | 4 | no |
GO:0016462 | pyrophosphatase activity | 25.0000 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.0000 | 4 | no |
GO:0016887 | ATP hydrolysis activity | 25.0000 | 7 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.0000 | 6 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in TOM34_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 60.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 60.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 60.0000 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 55.0000 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 55.0000 | 5 | no |
GO:0031323 | regulation of cellular metabolic process | 55.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 55.0000 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 55.0000 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 50.0000 | 5 | no |
GO:0009966 | regulation of signal transduction | 45.0000 | 4 | no |
GO:0010646 | regulation of cell communication | 45.0000 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 45.0000 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 45.0000 | 6 | no |
GO:0008104 | protein localization | 40.0000 | 4 | yes |
GO:0043085 | positive regulation of catalytic activity | 40.0000 | 4 | no |
GO:0051049 | regulation of transport | 40.0000 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 35.0000 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 35.0000 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 35.0000 | 6 | no |
GO:0031324 | negative regulation of cellular metabolic process | 35.0000 | 5 | no |
GO:0031399 | regulation of protein modification process | 35.0000 | 6 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 35.0000 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 35.0000 | 5 | no |
GO:0051336 | regulation of hydrolase activity | 35.0000 | 4 | no |
GO:0051338 | regulation of transferase activity | 35.0000 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 35.0000 | 5 | no |
GO:0006996 | organelle organization | 35.0000 | 4 | no |
GO:0009894 | regulation of catabolic process | 35.0000 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.0000 | 5 | no |
GO:0022607 | cellular component assembly | 35.0000 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 35.0000 | 4 | no |
GO:0033365 | protein localization to organelle | 30.0000 | 5 | yes |
GO:0071702 | organic substance transport | 30.0000 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 30.0000 | 7 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 30.0000 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 30.0000 | 7 | no |
GO:0034762 | regulation of transmembrane transport | 30.0000 | 4 | no |
GO:0042325 | regulation of phosphorylation | 30.0000 | 7 | no |
GO:0043549 | regulation of kinase activity | 30.0000 | 5 | no |
GO:0045859 | regulation of protein kinase activity | 30.0000 | 6 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 30.0000 | 7 | no |
GO:0051050 | positive regulation of transport | 30.0000 | 4 | no |
GO:0051345 | positive regulation of hydrolase activity | 30.0000 | 5 | no |
GO:0051347 | positive regulation of transferase activity | 30.0000 | 5 | no |
GO:0051726 | regulation of cell cycle | 30.0000 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 30.0000 | 4 | no |
GO:0010941 | regulation of cell death | 30.0000 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 30.0000 | 5 | no |
GO:0042981 | regulation of apoptotic process | 30.0000 | 6 | no |
GO:0043067 | regulation of programmed cell death | 30.0000 | 5 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 30.0000 | 6 | no |
GO:0051128 | regulation of cellular component organization | 30.0000 | 4 | no |
GO:0090304 | nucleic acid metabolic process | 30.0000 | 4 | no |
GO:0010243 | response to organonitrogen compound | 30.0000 | 4 | no |
GO:0006886 | intracellular protein transport | 25.0000 | 4 | yes |
GO:0015031 | protein transport | 25.0000 | 4 | yes |
GO:0070585 | protein localization to mitochondrion | 25.0000 | 6 | yes |
GO:0071705 | nitrogen compound transport | 25.0000 | 4 | yes |
GO:0072594 | establishment of protein localization to organelle | 25.0000 | 4 | yes |
GO:0072655 | establishment of protein localization to mitochondrion | 25.0000 | 5 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 25.0000 | 8 | no |
GO:0022898 | regulation of transmembrane transporter activity | 25.0000 | 4 | no |
GO:0033674 | positive regulation of kinase activity | 25.0000 | 6 | no |
GO:0034763 | negative regulation of transmembrane transport | 25.0000 | 5 | no |
GO:0042327 | positive regulation of phosphorylation | 25.0000 | 8 | no |
GO:0043269 | regulation of ion transport | 25.0000 | 5 | no |
GO:0045860 | positive regulation of protein kinase activity | 25.0000 | 7 | no |
GO:0051051 | negative regulation of transport | 25.0000 | 4 | no |
GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
GO:0071900 | regulation of protein serine/threonine kinase activity | 25.0000 | 7 | no |
GO:0006986 | response to unfolded protein | 25.0000 | 4 | no |
GO:0009059 | macromolecule biosynthetic process | 25.0000 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
GO:0044271 | cellular nitrogen compound biosynthetic process | 25.0000 | 4 | no |
GO:0051052 | regulation of DNA metabolic process | 25.0000 | 5 | no |
GO:0051054 | positive regulation of DNA metabolic process | 25.0000 | 6 | no |
GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
GO:0080134 | regulation of response to stress | 25.0000 | 4 | no |
GO:0031329 | regulation of cellular catabolic process | 25.0000 | 5 | no |
GO:0014070 | response to organic cyclic compound | 25.0000 | 4 | no |
GO:0036211 | protein modification process | 25.0000 | 4 | no |
GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
GO:0006839 | mitochondrial transport | 20.0000 | 4 | yes |
GO:0006605 | protein targeting | 10.0000 | 5 | yes |
GO:0006626 | protein targeting to mitochondrion | 10.0000 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in TOM34_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 10.0000 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 10.0000 | 5 | no |
DOID:114 | heart disease | 10.0000 | 3 | no |
DOID:2843 | long QT syndrome | 10.0000 | 6 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VATD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AAPK1_HUMAN | [view interactions] | Low throughput | no | no |
DMAP1_HUMAN | [view interactions] | Low throughput | no | yes |
HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDC37_HUMAN | [view interactions] | High throughput | no | yes |
CD37L_HUMAN | [view interactions] | High throughput | no | yes |
CHRD1_HUMAN | [view interactions] | High throughput | no | yes |
HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
T2EB_HUMAN | [view interactions] | High throughput | no | yes |
SNR27_HUMAN | [view interactions] | High throughput | no | yes |
GPR21_HUMAN | [view interactions] | High throughput | no | no |
AKIR2_HUMAN | [view interactions] | High throughput | no | no |
COAA1_HUMAN | [view interactions] | High throughput | no | no |
UBP47_HUMAN | [view interactions] | High throughput | no | yes |
ZN490_HUMAN | [view interactions] | High throughput | no | no |
MEPE_HUMAN | [view interactions] | High throughput | no | no |
MOT11_HUMAN | [view interactions] | High throughput | no | no |
FUCM_HUMAN | [view interactions] | High throughput | no | yes |
SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
VCAM1_HUMAN | [view interactions] | High throughput | no | no |
F214B_HUMAN | [view interactions] | High throughput | no | yes |
TINF2_HUMAN | [view interactions] | High throughput | no | no |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IKKE_HUMAN | [view interactions] | High throughput | no | yes |
TERF1_HUMAN | [view interactions] | High throughput | no | no |
ACD_HUMAN | [view interactions] | High throughput | no | no |
POTE1_HUMAN | [view interactions] | High throughput | no | no |
FINC_HUMAN | [view interactions] | High throughput | no | yes |
ITA4_HUMAN | [view interactions] | High throughput | no | no |
HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MOV10_HUMAN | [view interactions] | High throughput | no | no |
NXF1_HUMAN | [view interactions] | High throughput | no | yes |
CCD82_HUMAN | [view interactions] | High throughput | no | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
MK06_HUMAN | [view interactions] | High throughput | no | yes |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
WDR5_HUMAN | [view interactions] | High throughput | no | no |
PEA15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FA24B_HUMAN | [view interactions] | High throughput | no | no |
RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PLAL2_HUMAN | [view interactions] | High throughput | no | no |
CENPM_HUMAN | [view interactions] | High throughput | no | yes |
KPB2_HUMAN | [view interactions] | High throughput | no | yes |
PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
RPC10_HUMAN | [view interactions] | High throughput | no | yes |
AHR_HUMAN | [view interactions] | High throughput | no | yes |
UN45A_HUMAN | [view interactions] | High throughput | no | yes |
TF2H1_HUMAN | [view interactions] | High throughput | no | yes |
MND1_HUMAN | [view interactions] | High throughput | no | no |
TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
NPAS1_HUMAN | [view interactions] | High throughput | no | no |
BBS1_HUMAN | [view interactions] | High throughput | no | no |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
TAGAP_HUMAN | [view interactions] | High throughput | no | yes |
CBCO1_HUMAN | [view interactions] | High throughput | no | no |
ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
TMM51_HUMAN | [view interactions] | High throughput | no | yes |
RM38_HUMAN | [view interactions] | High throughput | no | yes |
AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
YIPF2_HUMAN | [view interactions] | High throughput | no | yes |
GGH_HUMAN | [view interactions] | High throughput | no | yes |
RT18C_HUMAN | [view interactions] | High throughput | no | yes |
OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MEIS2_HUMAN | [view interactions] | High throughput | no | yes |
MED17_HUMAN | [view interactions] | High throughput | no | no |
VATC2_HUMAN | [view interactions] | High throughput | no | yes |
ZIM2_HUMAN | [view interactions] | High throughput | no | no |
NTNG1_HUMAN | [view interactions] | High throughput | no | no |
WDR12_HUMAN | [view interactions] | High throughput | no | yes |
ZFAN5_HUMAN | [view interactions] | High throughput | no | yes |
RBM33_HUMAN | [view interactions] | High throughput | no | yes |
ZYX_HUMAN | [view interactions] | High throughput | no | no |
MCM7_HUMAN | [view interactions] | High throughput | no | no |
TRI16_HUMAN | [view interactions] | High throughput | no | no |
DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYTC_HUMAN | [view interactions] | High throughput | no | yes |
AIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HSP74_HUMAN | [view entry] [view interactions] | Computational | yes | yes |