Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PEA15_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm . Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PEA15_HUMAN
GO:0004674 protein serine/threonine kinase activity 35.7143 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 35.7143 4 no
GO:0005524 ATP binding 35.7143 5 no
GO:0016301 kinase activity 35.7143 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 35.7143 4 no
GO:0017076 purine nucleotide binding 35.7143 4 no
GO:0030554 adenyl nucleotide binding 35.7143 5 no
GO:0032555 purine ribonucleotide binding 35.7143 4 no
GO:0032559 adenyl ribonucleotide binding 35.7143 5 no
GO:0035639 purine ribonucleoside triphosphate binding 35.7143 4 no
GO:0106310 protein serine kinase activity 35.7143 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in PEA15_HUMAN
GO:0048522 positive regulation of cellular process 57.1429 4 yes
GO:0051128 regulation of cellular component organization 57.1429 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0051049 regulation of transport 42.8571 4 yes
GO:0006796 phosphate-containing compound metabolic process 35.7143 4 no
GO:0030334 regulation of cell migration 35.7143 5 no
GO:0030335 positive regulation of cell migration 35.7143 6 no
GO:0031323 regulation of cellular metabolic process 35.7143 4 no
GO:0040017 positive regulation of locomotion 35.7143 4 no
GO:0051094 positive regulation of developmental process 35.7143 4 no
GO:0051171 regulation of nitrogen compound metabolic process 35.7143 4 no
GO:0060255 regulation of macromolecule metabolic process 35.7143 4 no
GO:0080090 regulation of primary metabolic process 35.7143 4 no
GO:2000145 regulation of cell motility 35.7143 4 no
GO:2000147 positive regulation of cell motility 35.7143 5 no
GO:0009966 regulation of signal transduction 28.5714 4 yes
GO:0010243 response to organonitrogen compound 28.5714 4 yes
GO:0010646 regulation of cell communication 28.5714 4 yes
GO:0010941 regulation of cell death 28.5714 4 yes
GO:0042981 regulation of apoptotic process 28.5714 6 yes
GO:0043066 negative regulation of apoptotic process 28.5714 7 yes
GO:0043067 regulation of programmed cell death 28.5714 5 yes
GO:0043069 negative regulation of programmed cell death 28.5714 6 yes
GO:0060548 negative regulation of cell death 28.5714 5 yes
GO:0006468 protein phosphorylation 28.5714 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 28.5714 4 no
GO:0008284 positive regulation of cell population proliferation 28.5714 5 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0016310 phosphorylation 28.5714 5 no
GO:0018193 peptidyl-amino acid modification 28.5714 5 no
GO:0022603 regulation of anatomical structure morphogenesis 28.5714 4 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0036211 protein modification process 28.5714 4 no
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:2000026 regulation of multicellular organismal development 28.5714 4 no
GO:0008104 protein localization 28.5714 4 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0045595 regulation of cell differentiation 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0051493 regulation of cytoskeleton organization 28.5714 6 no
GO:0080134 regulation of response to stress 28.5714 4 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0010468 regulation of gene expression 28.5714 5 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0000165 MAPK cascade 21.4286 4 yes
GO:0006915 apoptotic process 21.4286 4 yes
GO:0010647 positive regulation of cell communication 21.4286 5 yes
GO:0014070 response to organic cyclic compound 21.4286 4 yes
GO:0023056 positive regulation of signaling 21.4286 4 yes
GO:0048584 positive regulation of response to stimulus 21.4286 4 yes
GO:0048585 negative regulation of response to stimulus 21.4286 4 yes
GO:0071702 organic substance transport 21.4286 4 yes
GO:0001932 regulation of protein phosphorylation 21.4286 7 no
GO:0001934 positive regulation of protein phosphorylation 21.4286 8 no
GO:0002684 positive regulation of immune system process 21.4286 4 no
GO:0006996 organelle organization 21.4286 4 no
GO:0007010 cytoskeleton organization 21.4286 5 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 21.4286 5 no
GO:0009892 negative regulation of metabolic process 21.4286 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.4286 6 no
GO:0010605 negative regulation of macromolecule metabolic process 21.4286 5 no
GO:0018105 peptidyl-serine phosphorylation 21.4286 6 no
GO:0018209 peptidyl-serine modification 21.4286 6 no
GO:0019220 regulation of phosphate metabolic process 21.4286 6 no
GO:0031399 regulation of protein modification process 21.4286 6 no
GO:0031401 positive regulation of protein modification process 21.4286 7 no
GO:0042325 regulation of phosphorylation 21.4286 7 no
GO:0042327 positive regulation of phosphorylation 21.4286 8 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0045937 positive regulation of phosphate metabolic process 21.4286 7 no
GO:0050776 regulation of immune response 21.4286 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 21.4286 5 no
GO:0051174 regulation of phosphorus metabolic process 21.4286 5 no
GO:0051240 positive regulation of multicellular organismal process 21.4286 4 no
GO:0051247 positive regulation of protein metabolic process 21.4286 6 no
GO:0051338 regulation of transferase activity 21.4286 4 no
GO:0051347 positive regulation of transferase activity 21.4286 5 no
GO:0060341 regulation of cellular localization 21.4286 4 no
GO:0070848 response to growth factor 21.4286 4 no
GO:0071417 cellular response to organonitrogen compound 21.4286 4 no
GO:1901699 cellular response to nitrogen compound 21.4286 4 no
GO:1901701 cellular response to oxygen-containing compound 21.4286 4 no
GO:1902531 regulation of intracellular signal transduction 21.4286 5 no
GO:0022607 cellular component assembly 21.4286 4 no
GO:0001558 regulation of cell growth 21.4286 4 no
GO:0032101 regulation of response to external stimulus 21.4286 4 no
GO:0044087 regulation of cellular component biogenesis 21.4286 4 no
GO:0051129 negative regulation of cellular component organization 21.4286 5 no
GO:0034097 response to cytokine 21.4286 4 no
GO:0071345 cellular response to cytokine stimulus 21.4286 5 no
GO:0009891 positive regulation of biosynthetic process 21.4286 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0031328 positive regulation of cellular biosynthetic process 21.4286 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.4286 6 no
GO:0080135 regulation of cellular response to stress 21.4286 4 no
GO:0006355 regulation of DNA-templated transcription 21.4286 6 no
GO:0006357 regulation of transcription by RNA polymerase II 21.4286 7 no
GO:0051252 regulation of RNA metabolic process 21.4286 5 no
GO:1903506 regulation of nucleic acid-templated transcription 21.4286 7 no
GO:2001141 regulation of RNA biosynthetic process 21.4286 6 no
GO:0009967 positive regulation of signal transduction 14.2857 5 yes
GO:0009968 negative regulation of signal transduction 14.2857 5 yes
GO:0010648 negative regulation of cell communication 14.2857 5 yes
GO:0023057 negative regulation of signaling 14.2857 4 yes
GO:0034762 regulation of transmembrane transport 14.2857 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
HXK2_HUMAN [view interactions] Low throughput no yes
PLD1_HUMAN [view interactions] Low throughput no no
CSN5_HUMAN [view interactions] Low throughput no yes
KS6A3_HUMAN [view entry] [view interactions] Low throughput yes yes
PLD2_HUMAN [view interactions] Low throughput no yes
FADD_HUMAN [view interactions] Low throughput no yes
CASP8_HUMAN [view interactions] Low throughput no yes
TNF10_HUMAN [view interactions] Low throughput no no
RSSA_HUMAN [view entry] [view interactions] Low throughput yes yes
TNR6_HUMAN [view interactions] Low throughput no no
PDPK1_HUMAN [view entry] [view interactions] High throughput yes yes
IQCB1_HUMAN [view interactions] High throughput no no
BCAT2_HUMAN [view interactions] High throughput no no
SMYD5_HUMAN [view interactions] High throughput no yes
TE2IP_HUMAN [view interactions] High throughput no yes
ABCD4_HUMAN [view interactions] High throughput no yes
L1CAM_HUMAN [view entry] [view interactions] High throughput yes yes
LC7L2_HUMAN [view interactions] High throughput no yes
KAD9_HUMAN [view interactions] High throughput no yes
PANK4_HUMAN [view interactions] High throughput no no
FBF1_HUMAN [view interactions] High throughput no no
STIL_HUMAN [view interactions] High throughput no no
CE170_HUMAN [view interactions] High throughput no yes
AT1B3_HUMAN [view interactions] High throughput no yes
TPC13_HUMAN [view interactions] High throughput no yes
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
CE120_HUMAN [view interactions] High throughput no no
DNJB1_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
RAMAC_HUMAN [view interactions] High throughput no yes
KLH12_HUMAN [view interactions] High throughput no no
IF3M_HUMAN [view interactions] High throughput no yes
OSBL1_HUMAN [view interactions] High throughput no yes
PAPD5_HUMAN [view interactions] High throughput no no
MYOME_HUMAN [view interactions] High throughput no no
PGM1_HUMAN [view interactions] High throughput no no
PUS3_HUMAN [view interactions] High throughput no no
RLP24_HUMAN [view interactions] High throughput no yes
RUXG_HUMAN [view interactions] High throughput no yes
P4R3A_HUMAN [view interactions] High throughput no yes
SON_HUMAN [view interactions] High throughput no yes
TALDO_HUMAN [view entry] [view interactions] High throughput yes no
ZO1_HUMAN [view entry] [view interactions] High throughput yes no
LGR4_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
TOM34_HUMAN [view entry] [view interactions] High throughput yes yes
DDX46_HUMAN [view interactions] High throughput no yes
PR38B_HUMAN [view interactions] High throughput no no
DCA13_HUMAN [view interactions] High throughput no yes
RMXL1_HUMAN [view interactions] High throughput no yes
ANR11_HUMAN [view interactions] High throughput no yes
ZC3H4_HUMAN [view interactions] High throughput no yes
ZC3HD_HUMAN [view interactions] High throughput no yes
PCF11_HUMAN [view interactions] High throughput no no
RBM26_HUMAN [view interactions] High throughput no yes
TDIF2_HUMAN [view interactions] High throughput no yes
HABP4_HUMAN [view interactions] High throughput no yes
ESF1_HUMAN [view interactions] High throughput no yes
PRC2A_HUMAN [view interactions] High throughput no yes
PR38A_HUMAN [view interactions] High throughput no no
MFAP1_HUMAN [view interactions] High throughput no yes
SLTM_HUMAN [view interactions] High throughput no yes
MAP9_HUMAN [view interactions] High throughput no no
SNIP1_HUMAN [view interactions] High throughput no no
CLAP2_HUMAN [view entry] [view interactions] High throughput yes no
DIDO1_HUMAN [view interactions] High throughput no yes
GEMI5_HUMAN [view interactions] High throughput no yes
RRP36_HUMAN [view interactions] High throughput no yes
LS14A_HUMAN [view interactions] High throughput no yes
UTP11_HUMAN [view interactions] High throughput no yes
SAFB2_HUMAN [view interactions] High throughput no yes
WBP11_HUMAN [view interactions] High throughput no yes
SAFB1_HUMAN [view interactions] High throughput no yes
SNR27_HUMAN [view interactions] High throughput no yes
ELOA1_HUMAN [view interactions] High throughput no yes
OSTN_HUMAN [view interactions] High throughput no no
F133B_HUMAN [view interactions] High throughput no no
KCC2G_HUMAN [view entry] [view interactions] High throughput yes yes
HTRA2_HUMAN [view interactions] High throughput no yes
RET_HUMAN [view interactions] High throughput no yes