PEA15_HUMAN
Evidence for PS localization
Functions
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm . Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PEA15_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 29.4118 | 4 | no |
| GO:0004674 | protein serine/threonine kinase activity | 29.4118 | 4 | no |
| GO:0005524 | ATP binding | 29.4118 | 5 | no |
| GO:0016301 | kinase activity | 29.4118 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 29.4118 | 4 | no |
| GO:0017076 | purine nucleotide binding | 29.4118 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 29.4118 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 29.4118 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 29.4118 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.4118 | 4 | no |
| GO:0043168 | anion binding | 29.4118 | 4 | no |
| GO:0106310 | protein serine kinase activity | 29.4118 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PEA15_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.8235 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 58.8235 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 52.9412 | 4 | no |
| GO:0051049 | regulation of transport | 41.1765 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 41.1765 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 41.1765 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.1765 | 4 | no |
| GO:0080134 | regulation of response to stress | 41.1765 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.2941 | 4 | yes |
| GO:0032101 | regulation of response to external stimulus | 35.2941 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 35.2941 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 35.2941 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.2941 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 35.2941 | 5 | no |
| GO:0010646 | regulation of cell communication | 35.2941 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 35.2941 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 35.2941 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 29.4118 | 5 | yes |
| GO:0043066 | negative regulation of apoptotic process | 29.4118 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 29.4118 | 4 | yes |
| GO:0043069 | negative regulation of programmed cell death | 29.4118 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 29.4118 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 29.4118 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 29.4118 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.4118 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.4118 | 5 | no |
| GO:0016310 | phosphorylation | 29.4118 | 5 | no |
| GO:0030334 | regulation of cell migration | 29.4118 | 5 | no |
| GO:0030335 | positive regulation of cell migration | 29.4118 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.4118 | 5 | no |
| GO:0036211 | protein modification process | 29.4118 | 4 | no |
| GO:0040017 | positive regulation of locomotion | 29.4118 | 4 | no |
| GO:0043412 | macromolecule modification | 29.4118 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 29.4118 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 29.4118 | 4 | no |
| GO:2000145 | regulation of cell motility | 29.4118 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 29.4118 | 5 | no |
| GO:0010468 | regulation of gene expression | 29.4118 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.4118 | 5 | no |
| GO:0008104 | protein localization | 29.4118 | 4 | no |
| GO:0033043 | regulation of organelle organization | 29.4118 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.4118 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 29.4118 | 6 | no |
| GO:0009966 | regulation of signal transduction | 29.4118 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 23.5294 | 4 | yes |
| GO:0002684 | positive regulation of immune system process | 23.5294 | 4 | no |
| GO:0006468 | protein phosphorylation | 23.5294 | 5 | no |
| GO:0006996 | organelle organization | 23.5294 | 4 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 23.5294 | 4 | no |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 23.5294 | 5 | no |
| GO:0008284 | positive regulation of cell population proliferation | 23.5294 | 5 | no |
| GO:0018193 | peptidyl-amino acid modification | 23.5294 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.5294 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.5294 | 5 | no |
| GO:0031347 | regulation of defense response | 23.5294 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 23.5294 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.5294 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 23.5294 | 5 | no |
| GO:0051338 | regulation of transferase activity | 23.5294 | 4 | no |
| GO:0051347 | positive regulation of transferase activity | 23.5294 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.5294 | 4 | no |
| GO:0071310 | cellular response to organic substance | 23.5294 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.5294 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.5294 | 7 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 23.5294 | 8 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.5294 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.5294 | 6 | no |
| GO:0032103 | positive regulation of response to external stimulus | 23.5294 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 23.5294 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.5294 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.5294 | 6 | no |
| GO:0034097 | response to cytokine | 23.5294 | 4 | no |
| GO:0022607 | cellular component assembly | 23.5294 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.5294 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 23.5294 | 5 | no |
| GO:0034330 | cell junction organization | 23.5294 | 4 | no |
| GO:0034599 | cellular response to oxidative stress | 23.5294 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.5294 | 5 | no |
| GO:0062197 | cellular response to chemical stress | 23.5294 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.5294 | 4 | no |
| GO:0006915 | apoptotic process | 23.5294 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 23.5294 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 23.5294 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 23.5294 | 4 | yes |
| GO:0071702 | organic substance transport | 17.6471 | 4 | yes |
| GO:0000165 | MAPK cascade | 17.6471 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 17.6471 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 17.6471 | 4 | yes |
| GO:0043065 | positive regulation of apoptotic process | 11.7647 | 6 | yes |
| GO:0043068 | positive regulation of programmed cell death | 11.7647 | 5 | yes |
| GO:0051051 | negative regulation of transport | 11.7647 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HXK2_HUMAN | [view interactions] | Low throughput | no | yes |
| PLD1_HUMAN | [view interactions] | Low throughput | no | no |
| CSN5_HUMAN | [view interactions] | Low throughput | no | yes |
| KS6A3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLD2_HUMAN | [view interactions] | Low throughput | no | yes |
| FADD_HUMAN | [view interactions] | Low throughput | no | yes |
| CASP8_HUMAN | [view interactions] | Low throughput | no | yes |
| TNF10_HUMAN | [view interactions] | Low throughput | no | no |
| RSSA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNR6_HUMAN | [view interactions] | Low throughput | no | no |
| PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| SMYD5_HUMAN | [view interactions] | High throughput | no | yes |
| BCAT2_HUMAN | [view interactions] | High throughput | no | no |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| ABCD4_HUMAN | [view interactions] | High throughput | no | yes |
| L1CAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| KAD9_HUMAN | [view interactions] | High throughput | no | yes |
| PANK4_HUMAN | [view interactions] | High throughput | no | no |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| STIL_HUMAN | [view interactions] | High throughput | no | no |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| TPC13_HUMAN | [view interactions] | High throughput | no | yes |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE120_HUMAN | [view interactions] | High throughput | no | no |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| RAMAC_HUMAN | [view interactions] | High throughput | no | yes |
| KLH12_HUMAN | [view interactions] | High throughput | no | no |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| OSBL1_HUMAN | [view interactions] | High throughput | no | yes |
| PAPD5_HUMAN | [view interactions] | High throughput | no | no |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| PUS3_HUMAN | [view interactions] | High throughput | no | no |
| RLP24_HUMAN | [view interactions] | High throughput | no | yes |
| RUXG_HUMAN | [view interactions] | High throughput | no | yes |
| P4R3A_HUMAN | [view interactions] | High throughput | no | yes |
| SON_HUMAN | [view interactions] | High throughput | no | yes |
| TALDO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| TOM34_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX46_HUMAN | [view interactions] | High throughput | no | yes |
| PR38B_HUMAN | [view interactions] | High throughput | no | no |
| DCA13_HUMAN | [view interactions] | High throughput | no | yes |
| RMXL1_HUMAN | [view interactions] | High throughput | no | yes |
| ANR11_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3H4_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3HD_HUMAN | [view interactions] | High throughput | no | yes |
| PCF11_HUMAN | [view interactions] | High throughput | no | no |
| RBM26_HUMAN | [view interactions] | High throughput | no | yes |
| TDIF2_HUMAN | [view interactions] | High throughput | no | yes |
| HABP4_HUMAN | [view interactions] | High throughput | no | yes |
| ESF1_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2A_HUMAN | [view interactions] | High throughput | no | yes |
| PR38A_HUMAN | [view interactions] | High throughput | no | no |
| MFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| SLTM_HUMAN | [view interactions] | High throughput | no | yes |
| MAP9_HUMAN | [view interactions] | High throughput | no | no |
| SNIP1_HUMAN | [view interactions] | High throughput | no | no |
| CLAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DIDO1_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI5_HUMAN | [view interactions] | High throughput | no | yes |
| RRP36_HUMAN | [view interactions] | High throughput | no | yes |
| LS14A_HUMAN | [view interactions] | High throughput | no | yes |
| UTP11_HUMAN | [view interactions] | High throughput | no | yes |
| SAFB2_HUMAN | [view interactions] | High throughput | no | yes |
| WBP11_HUMAN | [view interactions] | High throughput | no | yes |
| SAFB1_HUMAN | [view interactions] | High throughput | no | yes |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| ELOA1_HUMAN | [view interactions] | High throughput | no | yes |
| OSTN_HUMAN | [view interactions] | High throughput | no | no |
| F133B_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |