ZO1_HUMAN
Evidence for PS localization
Functions
TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed, PubMed). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation . Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ZO1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 30.5263 | 4 | no |
| GO:0045296 | cadherin binding | 28.4211 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 28.4211 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.3684 | 4 | no |
| GO:0019900 | kinase binding | 25.2632 | 4 | no |
| GO:0046872 | metal ion binding | 25.2632 | 4 | no |
| GO:0019901 | protein kinase binding | 24.2105 | 5 | no |
| GO:0003779 | actin binding | 22.1053 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ZO1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 53.6842 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 52.6316 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 48.4211 | 4 | yes |
| GO:0006996 | organelle organization | 47.3684 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 46.3158 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.2105 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.1579 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 43.1579 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.1053 | 4 | no |
| GO:0022607 | cellular component assembly | 42.1053 | 4 | yes |
| GO:0008104 | protein localization | 41.0526 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 38.9474 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.8947 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.7895 | 5 | no |
| GO:0007010 | cytoskeleton organization | 33.6842 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 32.6316 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 32.6316 | 5 | no |
| GO:0010468 | regulation of gene expression | 31.5789 | 5 | no |
| GO:0051049 | regulation of transport | 30.5263 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 29.4737 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.4737 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.4737 | 4 | no |
| GO:0034330 | cell junction organization | 29.4737 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 28.4211 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 28.4211 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.4211 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.3684 | 5 | no |
| GO:0010941 | regulation of cell death | 27.3684 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 26.3158 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.3158 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.3158 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.2632 | 6 | no |
| GO:0033043 | regulation of organelle organization | 25.2632 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 25.2632 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 25.2632 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 25.2632 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 24.2105 | 4 | no |
| GO:0030030 | cell projection organization | 24.2105 | 4 | no |
| GO:0051050 | positive regulation of transport | 23.1579 | 4 | no |
| GO:0071702 | organic substance transport | 23.1579 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.1579 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.1579 | 4 | no |
| GO:0045216 | cell-cell junction organization | 23.1579 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 22.1053 | 5 | no |
| GO:0060341 | regulation of cellular localization | 22.1053 | 4 | no |
| GO:0036211 | protein modification process | 22.1053 | 4 | no |
| GO:0043412 | macromolecule modification | 22.1053 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 22.1053 | 5 | no |
| GO:0034329 | cell junction assembly | 22.1053 | 5 | yes |
| GO:2000145 | regulation of cell motility | 21.0526 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.0526 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.0526 | 6 | no |
| GO:0032880 | regulation of protein localization | 21.0526 | 5 | no |
| GO:0071705 | nitrogen compound transport | 21.0526 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.0526 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.0000 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 20.0000 | 6 | yes |
| GO:0030334 | regulation of cell migration | 18.9474 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 17.8947 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 17.8947 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 16.8421 | 4 | yes |
| GO:0060548 | negative regulation of cell death | 16.8421 | 5 | yes |
| GO:0007043 | cell-cell junction assembly | 15.7895 | 6 | yes |
| GO:0030155 | regulation of cell adhesion | 15.7895 | 4 | yes |
| GO:0032970 | regulation of actin filament-based process | 15.7895 | 4 | yes |
| GO:0043066 | negative regulation of apoptotic process | 15.7895 | 7 | yes |
| GO:0043069 | negative regulation of programmed cell death | 15.7895 | 6 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 15.7895 | 4 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 14.7368 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 13.6842 | 4 | yes |
| GO:0060249 | anatomical structure homeostasis | 13.6842 | 4 | yes |
| GO:0110053 | regulation of actin filament organization | 13.6842 | 6 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 13.6842 | 5 | yes |
| GO:0001894 | tissue homeostasis | 12.6316 | 5 | yes |
| GO:2000147 | positive regulation of cell motility | 11.5789 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 11.5789 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 11.5789 | 4 | yes |
| GO:0034332 | adherens junction organization | 10.5263 | 6 | yes |
| GO:1901888 | regulation of cell junction assembly | 10.5263 | 5 | yes |
| GO:0002064 | epithelial cell development | 9.4737 | 4 | yes |
| GO:0010639 | negative regulation of organelle organization | 9.4737 | 6 | yes |
| GO:0031032 | actomyosin structure organization | 9.4737 | 4 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 8.4211 | 5 | yes |
| GO:0032231 | regulation of actin filament bundle assembly | 8.4211 | 5 | yes |
| GO:0035633 | maintenance of blood-brain barrier | 8.4211 | 6 | yes |
| GO:0045785 | positive regulation of cell adhesion | 8.4211 | 5 | yes |
| GO:0022407 | regulation of cell-cell adhesion | 7.3684 | 5 | yes |
| GO:0051492 | regulation of stress fiber assembly | 7.3684 | 6 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 7.3684 | 7 | yes |
| GO:0110020 | regulation of actomyosin structure organization | 7.3684 | 6 | yes |
| GO:0003018 | vascular process in circulatory system | 6.3158 | 4 | yes |
| GO:0150105 | protein localization to cell-cell junction | 6.3158 | 6 | yes |
| GO:1902414 | protein localization to cell junction | 6.3158 | 5 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 6.3158 | 6 | yes |
| GO:0001885 | endothelial cell development | 5.2632 | 5 | yes |
| GO:0022409 | positive regulation of cell-cell adhesion | 5.2632 | 6 | yes |
| GO:0045765 | regulation of angiogenesis | 5.2632 | 5 | yes |
| GO:0061028 | establishment of endothelial barrier | 5.2632 | 6 | yes |
| GO:1901342 | regulation of vasculature development | 5.2632 | 5 | yes |
| GO:1904018 | positive regulation of vasculature development | 4.2105 | 5 | yes |
| GO:0045766 | positive regulation of angiogenesis | 4.2105 | 6 | yes |
| GO:0071896 | protein localization to adherens junction | 4.2105 | 7 | yes |
| GO:0090557 | establishment of endothelial intestinal barrier | 4.2105 | 7 | yes |
| GO:1905603 | regulation of blood-brain barrier permeability | 3.1579 | 4 | yes |
| GO:1905605 | positive regulation of blood-brain barrier permeability | 3.1579 | 5 | yes |
| GO:2000047 | regulation of cell-cell adhesion mediated by cadherin | 3.1579 | 6 | yes |
| GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin | 3.1579 | 7 | yes |
| GO:2000249 | regulation of actin cytoskeleton reorganization | 3.1579 | 6 | yes |
| GO:2000810 | regulation of bicellular tight junction assembly | 3.1579 | 6 | yes |
| GO:0032232 | negative regulation of actin filament bundle assembly | 3.1579 | 6 | yes |
| GO:0043117 | positive regulation of vascular permeability | 3.1579 | 4 | yes |
| GO:0043954 | cellular component maintenance | 3.1579 | 4 | yes |
| GO:0051497 | negative regulation of stress fiber assembly | 3.1579 | 7 | yes |
| GO:1902396 | protein localization to bicellular tight junction | 3.1579 | 7 | yes |
| GO:2000250 | negative regulation of actin cytoskeleton reorganization | 2.1053 | 7 | yes |
| GO:0034331 | cell junction maintenance | 2.1053 | 5 | yes |
| GO:0034334 | adherens junction maintenance | 2.1053 | 7 | yes |
| GO:0045217 | cell-cell junction maintenance | 2.1053 | 6 | yes |
| GO:1903670 | regulation of sprouting angiogenesis | 2.1053 | 6 | yes |
| GO:1903672 | positive regulation of sprouting angiogenesis | 2.1053 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ZO1_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 5.2632 | 3 | no |
| DOID:0050700 | cardiomyopathy | 4.2105 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 4.2105 | 5 | no |
| DOID:0080000 | muscular disease | 2.1053 | 3 | no |
| DOID:423 | myopathy | 2.1053 | 5 | no |
| DOID:66 | muscle tissue disease | 2.1053 | 4 | no |
| DOID:0050155 | sensory system disease | 2.1053 | 3 | no |
| DOID:0050563 | nonsyndromic deafness | 2.1053 | 5 | no |
| DOID:0050564 | autosomal dominant nonsyndromic deafness | 2.1053 | 6 | no |
| DOID:2742 | auditory system disease | 2.1053 | 4 | no |
| DOID:331 | central nervous system disease | 2.1053 | 3 | no |
| DOID:1247 | blood coagulation disease | 2.1053 | 3 | no |
| DOID:2218 | blood platelet disease | 2.1053 | 4 | no |
| DOID:2843 | long QT syndrome | 2.1053 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| JAM2_HUMAN | [view interactions] | Low throughput | no | no |
| JAM3_HUMAN | [view interactions] | Low throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAR6A_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PARD3_HUMAN | [view interactions] | Low throughput | no | yes |
| CAN5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBLB_HUMAN | [view interactions] | Low throughput | no | yes |
| PSA5_HUMAN | [view interactions] | Low throughput | no | yes |
| MIB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MALD2_HUMAN | [view interactions] | Low throughput | no | yes |
| CXG1_HUMAN | [view interactions] | Low throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MRCKB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VINC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KIRR1_HUMAN | [view interactions] | Low throughput | no | no |
| CING_HUMAN | [view interactions] | Low throughput | no | no |
| CLD1_HUMAN | [view interactions] | Low throughput | no | no |
| CLD2_HUMAN | [view interactions] | Low throughput | no | no |
| CLD3_HUMAN | [view interactions] | Low throughput | no | no |
| CLD5_HUMAN | [view interactions] | Low throughput | no | no |
| CLD6_HUMAN | [view interactions] | Low throughput | no | no |
| CLD4_HUMAN | [view interactions] | Low throughput | no | yes |
| CLD7_HUMAN | [view interactions] | Low throughput | no | no |
| CLD8_HUMAN | [view interactions] | Low throughput | no | no |
| CXB6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTN1_HUMAN | [view interactions] | Low throughput | no | yes |
| SSR3_HUMAN | [view interactions] | Low throughput | no | yes |
| CXD3_HUMAN | [view interactions] | Low throughput | no | no |
| WWTR1_HUMAN | [view interactions] | Low throughput | no | yes |
| MAGI3_HUMAN | [view interactions] | Low throughput | no | no |
| MPDZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| YBOX3_HUMAN | [view interactions] | Low throughput | no | yes |
| OCLN_HUMAN | [view interactions] | Low throughput | no | no |
| CADH5_HUMAN | [view interactions] | Low throughput | no | yes |
| VMP1_HUMAN | [view interactions] | Low throughput | no | yes |
| ZO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PVR_HUMAN | [view interactions] | Low throughput | no | yes |
| AFAD_HUMAN | [view interactions] | Low throughput | no | yes |
| SCN7A_HUMAN | [view interactions] | Low throughput | no | no |
| TACD2_HUMAN | [view interactions] | Low throughput | no | no |
| ZO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| JAM1_HUMAN | [view interactions] | Low throughput | no | yes |
| PTN14_HUMAN | [view interactions] | Low throughput | no | yes |
| CXA8_HUMAN | [view interactions] | Low throughput | no | no |
| CXA3_HUMAN | [view interactions] | Low throughput | no | no |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| ZO3_HUMAN | [view interactions] | Low throughput | no | yes |
| STRN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DTNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| E41L5_HUMAN | [view interactions] | Low throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| NOG2_HUMAN | [view interactions] | High throughput | no | yes |
| F168A_HUMAN | [view interactions] | High throughput | no | yes |
| SWAHB_HUMAN | [view interactions] | High throughput | no | yes |
| PPL13_HUMAN | [view interactions] | High throughput | no | no |
| PEN2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI68_HUMAN | [view interactions] | High throughput | no | yes |
| CP141_HUMAN | [view interactions] | High throughput | no | no |
| SUMO1_HUMAN | [view interactions] | High throughput | no | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| SPT46_HUMAN | [view interactions] | High throughput | no | no |
| KIF2C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| ERLEC_HUMAN | [view interactions] | High throughput | no | yes |
| F133A_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANGP1_HUMAN | [view interactions] | High throughput | no | no |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZPR1_HUMAN | [view interactions] | High throughput | no | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOTC2_HUMAN | [view interactions] | High throughput | no | yes |
| SCO2_HUMAN | [view interactions] | High throughput | no | no |
| SUGP1_HUMAN | [view interactions] | High throughput | no | yes |
| GRHPR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THOC5_HUMAN | [view interactions] | High throughput | no | no |
| WDR3_HUMAN | [view interactions] | High throughput | no | no |
| BRSK2_HUMAN | [view interactions] | High throughput | no | no |
| MAGI1_HUMAN | [view interactions] | High throughput | no | no |
| MTM1_HUMAN | [view interactions] | High throughput | no | yes |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA1_HUMAN | [view interactions] | High throughput | no | no |
| RBM26_HUMAN | [view interactions] | High throughput | no | yes |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CC14A_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG5_HUMAN | [view interactions] | High throughput | no | no |
| ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMOT_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LATS1_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC85C_HUMAN | [view interactions] | High throughput | no | yes |
| CGNL1_HUMAN | [view interactions] | High throughput | no | no |
| DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNMBP_HUMAN | [view interactions] | High throughput | no | no |
| GLYG_HUMAN | [view interactions] | High throughput | no | yes |
| JCAD_HUMAN | [view interactions] | High throughput | no | yes |
| K1671_HUMAN | [view interactions] | High throughput | no | yes |
| LMO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| NEBL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEAK1_HUMAN | [view interactions] | High throughput | no | yes |
| ASPP1_HUMAN | [view interactions] | High throughput | no | yes |
| RASF8_HUMAN | [view interactions] | High throughput | no | yes |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAE1_HUMAN | [view interactions] | High throughput | no | yes |
| SI1L3_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN507_HUMAN | [view interactions] | High throughput | no | no |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| ENTR1_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SH319_HUMAN | [view interactions] | High throughput | no | no |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
| K1C10_HUMAN | [view interactions] | High throughput | no | no |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VGFR2_HUMAN | [view interactions] | High throughput | no | no |
| STAM2_HUMAN | [view interactions] | High throughput | no | yes |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| CDKL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| B9D2_HUMAN | [view interactions] | High throughput | no | yes |
| CE104_HUMAN | [view interactions] | High throughput | no | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| ODFP2_HUMAN | [view interactions] | High throughput | no | no |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| SAS6_HUMAN | [view interactions] | High throughput | no | no |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CTDSL_HUMAN | [view interactions] | High throughput | no | no |
| PEA15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB8B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAE1L_HUMAN | [view interactions] | High throughput | no | no |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C1_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| RPGF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| LUZP4_HUMAN | [view interactions] | High throughput | no | no |
| MAGIX_HUMAN | [view interactions] | High throughput | no | no |
| RN166_HUMAN | [view interactions] | High throughput | no | no |
| GILT_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPP9_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| C102B_HUMAN | [view interactions] | High throughput | no | yes |
| DEF1_HUMAN | [view interactions] | High throughput | no | no |
| CRBA4_HUMAN | [view interactions] | High throughput | no | no |
| QCR7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUN2_HUMAN | [view interactions] | High throughput | no | yes |
| RN168_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLC14_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIE_HUMAN | [view interactions] | High throughput | no | yes |
| TF7L2_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1B_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| PTN3_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| CLD10_HUMAN | [view interactions] | Computational | no | no |
| GNA12_HUMAN | [view interactions] | Computational | no | no |
| TBA1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAD17_HUMAN | [view interactions] | Computational | no | no |
| HSP74_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CLD11_HUMAN | [view interactions] | Computational | no | no |
| POPD1_HUMAN | [view interactions] | Computational | no | yes |
| CLD12_HUMAN | [view interactions] | Computational | no | yes |
| CLD16_HUMAN | [view interactions] | Computational | no | no |
| CTNA3_HUMAN | [view interactions] | Computational | no | no |
| CADH2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TBA4A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBA3E_HUMAN | [view interactions] | Computational | no | no |
| TBA3D_HUMAN | [view interactions] | Computational | no | no |
| TBA3C_HUMAN | [view interactions] | Computational | no | no |
| CLD15_HUMAN | [view interactions] | Computational | no | no |
| CTND1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CXD2_HUMAN | [view interactions] | Computational | no | no |
| NPHN_HUMAN | [view interactions] | Computational | no | no |
| HCLS1_HUMAN | [view interactions] | Computational | no | no |
| CASP3_HUMAN | [view interactions] | Computational | no | yes |
| TJAP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBA8_HUMAN | [view interactions] | Computational | no | yes |
| S10A8_HUMAN | [view interactions] | Computational | no | no |
| CLD9_HUMAN | [view interactions] | Computational | no | no |
| CTNA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RUNX1_HUMAN | [view interactions] | Computational | no | yes |
| NHRF1_HUMAN | [view interactions] | Computational | no | no |
| SHRM2_HUMAN | [view interactions] | Computational | no | yes |
| CD2AP_HUMAN | [view interactions] | Computational | no | no |
| YBOX1_HUMAN | [view interactions] | Computational | no | yes |
| PTPA_HUMAN | [view interactions] | Computational | no | yes |
| GIPC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBAL3_HUMAN | [view interactions] | Computational | no | no |
| SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CLD19_HUMAN | [view interactions] | Computational | no | no |
| PEBB_HUMAN | [view interactions] | Computational | no | no |
| IGSF5_HUMAN | [view interactions] | Computational | no | no |