ZO1_HUMAN
Evidence for PS localization
Functions
TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed, PubMed). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation . Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ZO1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 31.7073 | 4 | no |
| GO:0000166 | nucleotide binding | 29.2683 | 4 | no |
| GO:0017076 | purine nucleotide binding | 29.2683 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 28.4553 | 4 | no |
| GO:0043169 | cation binding | 27.6423 | 4 | no |
| GO:0046872 | metal ion binding | 27.6423 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.0163 | 4 | no |
| GO:0045296 | cadherin binding | 25.2033 | 4 | yes |
| GO:0019900 | kinase binding | 23.5772 | 4 | no |
| GO:0003723 | RNA binding | 23.5772 | 4 | no |
| GO:0019901 | protein kinase binding | 22.7642 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 21.1382 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.3252 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ZO1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 59.3496 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 59.3496 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 52.0325 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 51.2195 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.4065 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 49.5935 | 4 | no |
| GO:0010646 | regulation of cell communication | 48.7805 | 4 | no |
| GO:0006996 | organelle organization | 44.7154 | 4 | yes |
| GO:0008104 | protein localization | 43.9024 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 42.2764 | 4 | no |
| GO:0022607 | cellular component assembly | 41.4634 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 40.6504 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.8374 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 39.8374 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.0244 | 5 | no |
| GO:0010468 | regulation of gene expression | 39.0244 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 39.0244 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 34.9593 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 32.5203 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 31.7073 | 4 | yes |
| GO:0051049 | regulation of transport | 31.7073 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 30.8943 | 5 | no |
| GO:0023056 | positive regulation of signaling | 30.8943 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.8943 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.0813 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.0813 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.0813 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 29.2683 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 29.2683 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 28.4553 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 28.4553 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.4553 | 5 | no |
| GO:0034330 | cell junction organization | 26.8293 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 26.8293 | 5 | no |
| GO:0031399 | regulation of protein modification process | 26.0163 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.0163 | 6 | no |
| GO:0033043 | regulation of organelle organization | 25.2033 | 5 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 25.2033 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.2033 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 24.3902 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.3902 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.5772 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.5772 | 6 | no |
| GO:0060341 | regulation of cellular localization | 23.5772 | 4 | no |
| GO:0030030 | cell projection organization | 22.7642 | 4 | no |
| GO:0071702 | organic substance transport | 22.7642 | 4 | no |
| GO:0032880 | regulation of protein localization | 22.7642 | 5 | no |
| GO:0036211 | protein modification process | 21.9512 | 4 | no |
| GO:0043412 | macromolecule modification | 21.9512 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.9512 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.9512 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 21.1382 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 21.1382 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 21.1382 | 5 | no |
| GO:0043933 | protein-containing complex organization | 21.1382 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 21.1382 | 4 | no |
| GO:0009894 | regulation of catabolic process | 21.1382 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.1382 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 20.3252 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 20.3252 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.3252 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.3252 | 6 | no |
| GO:0071705 | nitrogen compound transport | 20.3252 | 4 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.3252 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 19.5122 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 19.5122 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 19.5122 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 19.5122 | 6 | yes |
| GO:2000145 | regulation of cell motility | 18.6992 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 17.8862 | 4 | yes |
| GO:0034329 | cell junction assembly | 17.8862 | 5 | yes |
| GO:0030334 | regulation of cell migration | 16.2602 | 5 | yes |
| GO:0045216 | cell-cell junction organization | 16.2602 | 5 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 15.4472 | 5 | yes |
| GO:0030155 | regulation of cell adhesion | 14.6341 | 4 | yes |
| GO:0032970 | regulation of actin filament-based process | 13.0081 | 4 | yes |
| GO:0007043 | cell-cell junction assembly | 12.1951 | 6 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 12.1951 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 11.3821 | 6 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 10.5691 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 10.5691 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 10.5691 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 10.5691 | 5 | yes |
| GO:0001894 | tissue homeostasis | 9.7561 | 4 | yes |
| GO:1901888 | regulation of cell junction assembly | 9.7561 | 5 | yes |
| GO:0002064 | epithelial cell development | 8.9431 | 4 | yes |
| GO:0010639 | negative regulation of organelle organization | 8.1301 | 6 | yes |
| GO:0022407 | regulation of cell-cell adhesion | 8.1301 | 5 | yes |
| GO:0045785 | positive regulation of cell adhesion | 8.1301 | 5 | yes |
| GO:0034332 | adherens junction organization | 7.3171 | 6 | yes |
| GO:0032231 | regulation of actin filament bundle assembly | 6.5041 | 5 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 6.5041 | 7 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 6.5041 | 6 | yes |
| GO:0003018 | vascular process in circulatory system | 5.6911 | 4 | yes |
| GO:0022409 | positive regulation of cell-cell adhesion | 5.6911 | 6 | yes |
| GO:0035633 | maintenance of blood-brain barrier | 5.6911 | 5 | yes |
| GO:0051492 | regulation of stress fiber assembly | 5.6911 | 6 | yes |
| GO:0110020 | regulation of actomyosin structure organization | 5.6911 | 6 | yes |
| GO:1902414 | protein localization to cell junction | 5.6911 | 5 | yes |
| GO:0001885 | endothelial cell development | 4.8780 | 5 | yes |
| GO:0031032 | actomyosin structure organization | 4.8780 | 4 | yes |
| GO:0045765 | regulation of angiogenesis | 4.8780 | 5 | yes |
| GO:0061028 | establishment of endothelial barrier | 4.8780 | 6 | yes |
| GO:0150105 | protein localization to cell-cell junction | 4.8780 | 6 | yes |
| GO:1901342 | regulation of vasculature development | 4.8780 | 5 | yes |
| GO:0090557 | establishment of endothelial intestinal barrier | 4.0650 | 7 | yes |
| GO:0045766 | positive regulation of angiogenesis | 3.2520 | 6 | yes |
| GO:0071896 | protein localization to adherens junction | 3.2520 | 7 | yes |
| GO:1904018 | positive regulation of vasculature development | 3.2520 | 5 | yes |
| GO:2000047 | regulation of cell-cell adhesion mediated by cadherin | 3.2520 | 6 | yes |
| GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin | 3.2520 | 7 | yes |
| GO:0032232 | negative regulation of actin filament bundle assembly | 2.4390 | 6 | yes |
| GO:0043117 | positive regulation of vascular permeability | 2.4390 | 4 | yes |
| GO:0043954 | cellular component maintenance | 2.4390 | 4 | yes |
| GO:0051497 | negative regulation of stress fiber assembly | 2.4390 | 7 | yes |
| GO:1902396 | protein localization to bicellular tight junction | 2.4390 | 7 | yes |
| GO:1905603 | regulation of blood-brain barrier permeability | 2.4390 | 4 | yes |
| GO:1905605 | positive regulation of blood-brain barrier permeability | 2.4390 | 5 | yes |
| GO:2000810 | regulation of bicellular tight junction assembly | 2.4390 | 6 | yes |
| GO:0034331 | cell junction maintenance | 1.6260 | 5 | yes |
| GO:0034334 | adherens junction maintenance | 1.6260 | 7 | yes |
| GO:0045217 | cell-cell junction maintenance | 1.6260 | 6 | yes |
| GO:1903670 | regulation of sprouting angiogenesis | 1.6260 | 6 | yes |
| GO:1903672 | positive regulation of sprouting angiogenesis | 1.6260 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MIB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MALD2_HUMAN | [view interactions] | Low throughput | no | yes |
| CXG1_HUMAN | [view interactions] | Low throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MRCKB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VINC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KIRR1_HUMAN | [view interactions] | Low throughput | no | no |
| CING_HUMAN | [view interactions] | Low throughput | no | no |
| CLD1_HUMAN | [view interactions] | Low throughput | no | no |
| CLD2_HUMAN | [view interactions] | Low throughput | no | no |
| CLD3_HUMAN | [view interactions] | Low throughput | no | no |
| CLD5_HUMAN | [view interactions] | Low throughput | no | no |
| CLD4_HUMAN | [view interactions] | Low throughput | no | yes |
| CLD6_HUMAN | [view interactions] | Low throughput | no | no |
| CLD7_HUMAN | [view interactions] | Low throughput | no | no |
| CLD8_HUMAN | [view interactions] | Low throughput | no | no |
| CXB6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SSR3_HUMAN | [view interactions] | Low throughput | no | yes |
| CXD3_HUMAN | [view interactions] | Low throughput | no | no |
| WWTR1_HUMAN | [view interactions] | Low throughput | no | yes |
| MAGI3_HUMAN | [view interactions] | Low throughput | no | no |
| MPDZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| YBOX3_HUMAN | [view interactions] | Low throughput | no | yes |
| OCLN_HUMAN | [view interactions] | Low throughput | no | no |
| CADH5_HUMAN | [view interactions] | Low throughput | no | yes |
| VMP1_HUMAN | [view interactions] | Low throughput | no | yes |
| PVR_HUMAN | [view interactions] | Low throughput | no | yes |
| AFAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SCN7A_HUMAN | [view interactions] | Low throughput | no | no |
| TACD2_HUMAN | [view interactions] | Low throughput | no | no |
| ZO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| JAM1_HUMAN | [view interactions] | Low throughput | no | yes |
| PTN14_HUMAN | [view interactions] | Low throughput | no | yes |
| CXA8_HUMAN | [view interactions] | Low throughput | no | no |
| CXA3_HUMAN | [view interactions] | Low throughput | no | no |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| ZO3_HUMAN | [view interactions] | Low throughput | no | yes |
| STRN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DTNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| E41L5_HUMAN | [view interactions] | Low throughput | no | no |
| JAM2_HUMAN | [view interactions] | Low throughput | no | no |
| JAM3_HUMAN | [view interactions] | Low throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PAR6A_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PARD3_HUMAN | [view interactions] | Low throughput | no | yes |
| CAN5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBLB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSA5_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZPR1_HUMAN | [view interactions] | High throughput | no | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOTC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCO2_HUMAN | [view interactions] | High throughput | no | no |
| SUGP1_HUMAN | [view interactions] | High throughput | no | yes |
| GRHPR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THOC5_HUMAN | [view interactions] | High throughput | no | no |
| WDR3_HUMAN | [view interactions] | High throughput | no | no |
| BRSK2_HUMAN | [view interactions] | High throughput | no | no |
| MAGI1_HUMAN | [view interactions] | High throughput | no | no |
| MTM1_HUMAN | [view interactions] | High throughput | no | yes |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA1_HUMAN | [view interactions] | High throughput | no | no |
| RBM26_HUMAN | [view interactions] | High throughput | no | yes |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| DHX16_HUMAN | [view interactions] | High throughput | no | yes |
| RAE1_HUMAN | [view interactions] | High throughput | no | yes |
| SRS10_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| PCF11_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| ERCC3_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| PTBP1_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRE11_HUMAN | [view interactions] | High throughput | no | yes |
| CAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF7_HUMAN | [view interactions] | High throughput | no | yes |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| CPSF3_HUMAN | [view interactions] | High throughput | no | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRF2_HUMAN | [view interactions] | High throughput | no | yes |
| STK24_HUMAN | [view interactions] | High throughput | no | yes |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CC14A_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C10_HUMAN | [view interactions] | High throughput | no | no |
| ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
| AMOT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC85C_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR2_HUMAN | [view interactions] | High throughput | no | no |
| CGNL1_HUMAN | [view interactions] | High throughput | no | no |
| STAM2_HUMAN | [view interactions] | High throughput | no | yes |
| DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| DNMBP_HUMAN | [view interactions] | High throughput | no | no |
| CDKL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLYG_HUMAN | [view interactions] | High throughput | no | yes |
| JCAD_HUMAN | [view interactions] | High throughput | no | yes |
| K1671_HUMAN | [view interactions] | High throughput | no | yes |
| LMO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| NEBL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEAK1_HUMAN | [view interactions] | High throughput | no | yes |
| ASPP1_HUMAN | [view interactions] | High throughput | no | yes |
| RASF8_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| SI1L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN507_HUMAN | [view interactions] | High throughput | no | no |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENTR1_HUMAN | [view interactions] | High throughput | no | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| SH319_HUMAN | [view interactions] | High throughput | no | no |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| LN28A_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC3_HUMAN | [view interactions] | High throughput | no | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| COR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CBPZ_HUMAN | [view interactions] | High throughput | no | no |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| BACD1_HUMAN | [view interactions] | High throughput | no | no |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B9D2_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| CE104_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODFP2_HUMAN | [view interactions] | High throughput | no | no |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAS6_HUMAN | [view interactions] | High throughput | no | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
| CTDSL_HUMAN | [view interactions] | High throughput | no | no |
| DCAF4_HUMAN | [view interactions] | High throughput | no | yes |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| TLE2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEA15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB8B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAE1L_HUMAN | [view interactions] | High throughput | no | no |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C1_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| RPGF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| LUZP4_HUMAN | [view interactions] | High throughput | no | no |
| MAGIX_HUMAN | [view interactions] | High throughput | no | no |
| RN166_HUMAN | [view interactions] | High throughput | no | no |
| GILT_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPP9_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| C102B_HUMAN | [view interactions] | High throughput | no | yes |
| DEF1_HUMAN | [view interactions] | High throughput | no | no |
| CRBA4_HUMAN | [view interactions] | High throughput | no | no |
| QCR7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUN2_HUMAN | [view interactions] | High throughput | no | yes |
| RN168_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLC14_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIE_HUMAN | [view interactions] | High throughput | no | yes |
| TF7L2_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1B_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| PTN3_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| NOG2_HUMAN | [view interactions] | High throughput | no | yes |
| F168A_HUMAN | [view interactions] | High throughput | no | yes |
| SWAHB_HUMAN | [view interactions] | High throughput | no | yes |
| PPL13_HUMAN | [view interactions] | High throughput | no | no |
| PEN2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI68_HUMAN | [view interactions] | High throughput | no | yes |
| CP141_HUMAN | [view interactions] | High throughput | no | no |
| SUMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| SPT46_HUMAN | [view interactions] | High throughput | no | no |
| KIF2C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| ERLEC_HUMAN | [view interactions] | High throughput | no | yes |
| F133A_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANGP1_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OVOL2_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| MEN1_HUMAN | [view interactions] | High throughput | no | yes |
| AATF_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| CFAH_HUMAN | [view interactions] | High throughput | no | no |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| ARC1B_HUMAN | [view interactions] | High throughput | no | no |
| OTU7A_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |