MRCKB_HUMAN
Evidence for PS localization
Functions
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed, PubMed). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed). Phosphorylates PPP1R12A (PubMed). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MRCKB_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 56.8182 | 4 | yes |
| GO:0043168 | anion binding | 56.8182 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 54.5455 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 54.5455 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 50.0000 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 31.8182 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 31.8182 | 5 | yes |
| GO:0043169 | cation binding | 31.8182 | 4 | yes |
| GO:0046872 | metal ion binding | 31.8182 | 5 | yes |
| GO:0005524 | ATP binding | 27.2727 | 5 | yes |
| GO:0016301 | kinase activity | 25.0000 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 25.0000 | 4 | yes |
| GO:0019900 | kinase binding | 25.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
| GO:0003924 | GTPase activity | 22.7273 | 7 | no |
| GO:0005525 | GTP binding | 22.7273 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 22.7273 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.7273 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.7273 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 22.7273 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 22.7273 | 5 | no |
| GO:0004674 | protein serine/threonine kinase activity | 15.9091 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 13.6364 | 4 | yes |
| GO:0000287 | magnesium ion binding | 11.3636 | 6 | yes |
| GO:0031267 | small GTPase binding | 6.8182 | 5 | yes |
| GO:0051020 | GTPase binding | 6.8182 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MRCKB_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 70.4545 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 59.0909 | 4 | no |
| GO:0010646 | regulation of cell communication | 56.8182 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 56.8182 | 4 | no |
| GO:0009966 | regulation of signal transduction | 52.2727 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.2727 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 52.2727 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 47.7273 | 5 | no |
| GO:0023056 | positive regulation of signaling | 47.7273 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 47.7273 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 47.7273 | 4 | no |
| GO:0006996 | organelle organization | 45.4545 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 45.4545 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 45.4545 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.4545 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 45.4545 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 43.1818 | 5 | no |
| GO:0010468 | regulation of gene expression | 43.1818 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 43.1818 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 40.9091 | 5 | no |
| GO:0007010 | cytoskeleton organization | 38.6364 | 5 | yes |
| GO:0036211 | protein modification process | 38.6364 | 4 | yes |
| GO:0043412 | macromolecule modification | 38.6364 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 38.6364 | 5 | no |
| GO:0022607 | cellular component assembly | 38.6364 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.3636 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 36.3636 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 34.0909 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 34.0909 | 4 | no |
| GO:0031399 | regulation of protein modification process | 34.0909 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 34.0909 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 34.0909 | 4 | no |
| GO:0051049 | regulation of transport | 34.0909 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 34.0909 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 34.0909 | 6 | no |
| GO:0141124 | intracellular signaling cassette | 34.0909 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.8182 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 31.8182 | 5 | no |
| GO:0023057 | negative regulation of signaling | 31.8182 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 31.8182 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 31.8182 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 31.8182 | 5 | no |
| GO:0008104 | protein localization | 31.8182 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 29.5455 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 29.5455 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 29.5455 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.5455 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 29.5455 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 27.2727 | 7 | no |
| GO:0008284 | positive regulation of cell population proliferation | 27.2727 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 27.2727 | 5 | no |
| GO:0030030 | cell projection organization | 27.2727 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 27.2727 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 27.2727 | 4 | no |
| GO:0071310 | cellular response to organic substance | 27.2727 | 4 | no |
| GO:2000145 | regulation of cell motility | 27.2727 | 4 | no |
| GO:0006468 | protein phosphorylation | 25.0000 | 5 | yes |
| GO:0016310 | phosphorylation | 25.0000 | 5 | yes |
| GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 25.0000 | 4 | no |
| GO:0045785 | positive regulation of cell adhesion | 25.0000 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0002684 | positive regulation of immune system process | 22.7273 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.7273 | 6 | no |
| GO:0032101 | regulation of response to external stimulus | 22.7273 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.7273 | 7 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 22.7273 | 4 | no |
| GO:0071702 | organic substance transport | 22.7273 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 22.7273 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 22.7273 | 5 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 22.7273 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.7273 | 4 | no |
| GO:0033043 | regulation of organelle organization | 22.7273 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.7273 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.7273 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 20.4545 | 8 | no |
| GO:0010243 | response to organonitrogen compound | 20.4545 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.4545 | 8 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.4545 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.4545 | 6 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.4545 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.4545 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.4545 | 5 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.4545 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 20.4545 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.4545 | 7 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.4545 | 6 | no |
| GO:0043933 | protein-containing complex organization | 20.4545 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.4545 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.4545 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.4545 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.4545 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 20.4545 | 4 | no |
| GO:0031032 | actomyosin structure organization | 15.9091 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ZO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LURA1_HUMAN | [view interactions] | Low throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MRCKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDKN3_HUMAN | [view interactions] | Low throughput | no | no |
| PPM1A_HUMAN | [view interactions] | Low throughput | no | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MRCKB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPR2_HUMAN | [view interactions] | High throughput | no | yes |
| RXRB_HUMAN | [view interactions] | High throughput | no | yes |
| KSR2_HUMAN | [view interactions] | High throughput | no | yes |
| LUR1L_HUMAN | [view interactions] | High throughput | no | no |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| GRPR_HUMAN | [view interactions] | High throughput | no | no |
| UBX2B_HUMAN | [view interactions] | High throughput | no | no |
| INKA2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STA5B_HUMAN | [view interactions] | High throughput | no | yes |
| KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| SLAP1_HUMAN | [view interactions] | High throughput | no | yes |
| STAT4_HUMAN | [view interactions] | High throughput | no | yes |
| K2C78_HUMAN | [view interactions] | High throughput | no | no |
| RL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRX1_HUMAN | [view interactions] | High throughput | no | no |
| DDX21_HUMAN | [view interactions] | High throughput | no | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCD_HUMAN | [view interactions] | High throughput | no | no |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ML12A_HUMAN | [view interactions] | High throughput | no | no |
| MP2K5_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| PYGM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WDR4_HUMAN | [view interactions] | High throughput | no | no |
| PTPRG_HUMAN | [view interactions] | High throughput | no | no |
| CPNE4_HUMAN | [view interactions] | High throughput | no | no |
| SP1_HUMAN | [view interactions] | High throughput | no | yes |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR7_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| SET1A_HUMAN | [view interactions] | High throughput | no | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC9C_HUMAN | [view interactions] | High throughput | no | yes |
| BEX1_HUMAN | [view interactions] | High throughput | no | yes |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| SIKE1_HUMAN | [view interactions] | High throughput | no | yes |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| KCD17_HUMAN | [view interactions] | High throughput | no | yes |
| TRI35_HUMAN | [view interactions] | High throughput | no | yes |
| APBA3_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| FA89A_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| STK38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPNE1_HUMAN | [view interactions] | High throughput | no | no |
| ORC2_HUMAN | [view interactions] | High throughput | no | yes |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| ARL14_HUMAN | [view interactions] | High throughput | no | no |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |