MRCKB_HUMAN
Evidence for PS localization
Functions
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed, PubMed). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed). Phosphorylates PPP1R12A (PubMed). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MRCKB_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 61.7647 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 61.7647 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 58.8235 | 4 | yes |
| GO:0019900 | kinase binding | 35.2941 | 4 | no |
| GO:0019901 | protein kinase binding | 35.2941 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 32.3529 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 32.3529 | 5 | yes |
| GO:0005524 | ATP binding | 29.4118 | 5 | yes |
| GO:0046872 | metal ion binding | 29.4118 | 4 | yes |
| GO:0003924 | GTPase activity | 29.4118 | 7 | no |
| GO:0005525 | GTP binding | 29.4118 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 29.4118 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 29.4118 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 29.4118 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 29.4118 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 29.4118 | 5 | no |
| GO:0016301 | kinase activity | 26.4706 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 26.4706 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 23.5294 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 14.7059 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 11.7647 | 4 | yes |
| GO:0000287 | magnesium ion binding | 8.8235 | 5 | yes |
| GO:0031267 | small GTPase binding | 5.8824 | 5 | yes |
| GO:0051020 | GTPase binding | 5.8824 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MRCKB_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 76.4706 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 55.8824 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 55.8824 | 4 | no |
| GO:0006996 | organelle organization | 52.9412 | 4 | yes |
| GO:0010646 | regulation of cell communication | 52.9412 | 4 | no |
| GO:0007010 | cytoskeleton organization | 50.0000 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 50.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 47.0588 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 47.0588 | 5 | no |
| GO:0023056 | positive regulation of signaling | 47.0588 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 44.1176 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 41.1765 | 4 | yes |
| GO:0030155 | regulation of cell adhesion | 41.1765 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 41.1765 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 41.1765 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 41.1765 | 4 | no |
| GO:0036211 | protein modification process | 38.2353 | 4 | yes |
| GO:0043412 | macromolecule modification | 38.2353 | 4 | yes |
| GO:0010468 | regulation of gene expression | 38.2353 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 38.2353 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 38.2353 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 38.2353 | 5 | no |
| GO:0022607 | cellular component assembly | 38.2353 | 4 | no |
| GO:0030030 | cell projection organization | 38.2353 | 4 | no |
| GO:0051049 | regulation of transport | 38.2353 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 38.2353 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 35.2941 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 35.2941 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 35.2941 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 35.2941 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 35.2941 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 35.2941 | 4 | no |
| GO:0071310 | cellular response to organic substance | 35.2941 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 35.2941 | 6 | no |
| GO:0031399 | regulation of protein modification process | 32.3529 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 32.3529 | 8 | no |
| GO:0010941 | regulation of cell death | 32.3529 | 4 | no |
| GO:0045785 | positive regulation of cell adhesion | 32.3529 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 32.3529 | 5 | no |
| GO:0008284 | positive regulation of cell population proliferation | 32.3529 | 5 | no |
| GO:0006468 | protein phosphorylation | 29.4118 | 5 | yes |
| GO:0016310 | phosphorylation | 29.4118 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 29.4118 | 7 | no |
| GO:0009889 | regulation of biosynthetic process | 29.4118 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.4118 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 29.4118 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 29.4118 | 4 | no |
| GO:0030334 | regulation of cell migration | 29.4118 | 5 | no |
| GO:2000145 | regulation of cell motility | 29.4118 | 4 | no |
| GO:0007264 | small GTPase mediated signal transduction | 29.4118 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 29.4118 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 29.4118 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 29.4118 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.4118 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 29.4118 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.4118 | 6 | no |
| GO:0008104 | protein localization | 29.4118 | 4 | no |
| GO:0018193 | peptidyl-amino acid modification | 26.4706 | 5 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 26.4706 | 8 | no |
| GO:0009892 | negative regulation of metabolic process | 26.4706 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.4706 | 5 | no |
| GO:0007265 | Ras protein signal transduction | 26.4706 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 26.4706 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 26.4706 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 26.4706 | 4 | no |
| GO:0033043 | regulation of organelle organization | 26.4706 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.4706 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 26.4706 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 26.4706 | 6 | no |
| GO:0031175 | neuron projection development | 26.4706 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.5294 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.5294 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.5294 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 23.5294 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 23.5294 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 23.5294 | 4 | no |
| GO:0022604 | regulation of cell morphogenesis | 23.5294 | 5 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 23.5294 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.5294 | 4 | no |
| GO:0051050 | positive regulation of transport | 23.5294 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.5882 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.5882 | 5 | no |
| GO:0043549 | regulation of kinase activity | 20.5882 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.5882 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.5882 | 5 | no |
| GO:0051338 | regulation of transferase activity | 20.5882 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 20.5882 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.5882 | 6 | no |
| GO:0002694 | regulation of leukocyte activation | 20.5882 | 4 | no |
| GO:0007015 | actin filament organization | 20.5882 | 5 | no |
| GO:0008360 | regulation of cell shape | 20.5882 | 6 | no |
| GO:0010810 | regulation of cell-substrate adhesion | 20.5882 | 5 | no |
| GO:0022407 | regulation of cell-cell adhesion | 20.5882 | 5 | no |
| GO:0022409 | positive regulation of cell-cell adhesion | 20.5882 | 6 | no |
| GO:0030335 | positive regulation of cell migration | 20.5882 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 20.5882 | 4 | no |
| GO:0050865 | regulation of cell activation | 20.5882 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.5882 | 5 | no |
| GO:0051345 | positive regulation of hydrolase activity | 20.5882 | 5 | no |
| GO:0060548 | negative regulation of cell death | 20.5882 | 5 | no |
| GO:0061024 | membrane organization | 20.5882 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 20.5882 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 20.5882 | 5 | no |
| GO:0071702 | organic substance transport | 20.5882 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.5882 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 20.5882 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 20.5882 | 4 | no |
| GO:0050776 | regulation of immune response | 20.5882 | 4 | no |
| GO:0031346 | positive regulation of cell projection organization | 20.5882 | 6 | no |
| GO:0060341 | regulation of cellular localization | 20.5882 | 4 | no |
| GO:0031032 | actomyosin structure organization | 17.6471 | 4 | yes |
| GO:0018107 | peptidyl-threonine phosphorylation | 11.7647 | 6 | yes |
| GO:0018210 | peptidyl-threonine modification | 11.7647 | 6 | yes |
| GO:0031532 | actin cytoskeleton reorganization | 11.7647 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MRCKB_HUMAN |
|---|---|---|---|---|
| DOID:0111962 | combined immunodeficiency | 5.8824 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 5.8824 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ZO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LURA1_HUMAN | [view interactions] | Low throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MRCKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDKN3_HUMAN | [view interactions] | Low throughput | no | no |
| PPM1A_HUMAN | [view interactions] | Low throughput | no | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MRCKB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPR2_HUMAN | [view interactions] | High throughput | no | yes |
| RXRB_HUMAN | [view interactions] | High throughput | no | yes |
| KSR2_HUMAN | [view interactions] | High throughput | no | yes |
| LUR1L_HUMAN | [view interactions] | High throughput | no | no |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| GRPR_HUMAN | [view interactions] | High throughput | no | no |
| UBX2B_HUMAN | [view interactions] | High throughput | no | no |
| INKA2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STA5B_HUMAN | [view interactions] | High throughput | no | yes |
| KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLAP1_HUMAN | [view interactions] | High throughput | no | yes |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| STAT4_HUMAN | [view interactions] | High throughput | no | yes |
| K2C78_HUMAN | [view interactions] | High throughput | no | no |
| RL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRX1_HUMAN | [view interactions] | High throughput | no | no |
| DDX21_HUMAN | [view interactions] | High throughput | no | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCD_HUMAN | [view interactions] | High throughput | no | no |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ML12A_HUMAN | [view interactions] | High throughput | no | no |
| MP2K5_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| PYGM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPRG_HUMAN | [view interactions] | High throughput | no | no |
| CPNE4_HUMAN | [view interactions] | High throughput | no | no |
| SP1_HUMAN | [view interactions] | High throughput | no | yes |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR7_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| SET1A_HUMAN | [view interactions] | High throughput | no | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC9C_HUMAN | [view interactions] | High throughput | no | yes |
| BEX1_HUMAN | [view interactions] | High throughput | no | yes |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| SIKE1_HUMAN | [view interactions] | High throughput | no | yes |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| KCD17_HUMAN | [view interactions] | High throughput | no | yes |
| TRI35_HUMAN | [view interactions] | High throughput | no | yes |
| APBA3_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| FA89A_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE1_HUMAN | [view interactions] | High throughput | no | no |
| ORC2_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |