Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KAP2_HUMAN

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in KAP2_HUMAN
GO:0043168 anion binding 40.4255 4 yes
GO:0000166 nucleotide binding 36.1702 4 yes
GO:0017076 purine nucleotide binding 34.0426 5 yes
GO:0032555 purine ribonucleotide binding 34.0426 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 29.7872 4 no
GO:0043169 cation binding 29.7872 4 no
GO:0046872 metal ion binding 28.7234 5 no
GO:0030554 adenyl nucleotide binding 26.5957 6 yes
GO:0032559 adenyl ribonucleotide binding 26.5957 5 yes
GO:0019900 kinase binding 24.4681 4 yes
GO:0019901 protein kinase binding 24.4681 5 yes
GO:0005524 ATP binding 22.3404 5 no
GO:0031625 ubiquitin protein ligase binding 18.0851 5 yes
GO:0044389 ubiquitin-like protein ligase binding 18.0851 4 yes
GO:0019887 protein kinase regulator activity 9.5745 4 yes
GO:0034236 protein kinase A catalytic subunit binding 7.4468 4 yes
GO:0004860 protein kinase inhibitor activity 6.3830 5 yes
GO:0019210 kinase inhibitor activity 6.3830 4 yes
GO:0030291 protein serine/threonine kinase inhibitor activity 5.3191 6 yes
GO:0004862 cAMP-dependent protein kinase inhibitor activity 4.2553 6 yes
GO:0008603 cAMP-dependent protein kinase regulator activity 4.2553 5 yes
GO:0030551 cyclic nucleotide binding 4.2553 5 yes
GO:0030552 cAMP binding 4.2553 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KAP2_HUMAN
GO:0048522 positive regulation of cellular process 61.7021 4 no
GO:0060255 regulation of macromolecule metabolic process 55.3191 4 yes
GO:0031323 regulation of cellular metabolic process 52.1277 4 yes
GO:0080090 regulation of primary metabolic process 51.0638 4 yes
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0006996 organelle organization 48.9362 4 no
GO:0048523 negative regulation of cellular process 46.8085 4 yes
GO:0051246 regulation of protein metabolic process 43.6170 5 yes
GO:0051128 regulation of cellular component organization 42.5532 4 no
GO:0009966 regulation of signal transduction 41.4894 4 no
GO:0009889 regulation of biosynthetic process 40.4255 4 no
GO:0009893 positive regulation of metabolic process 38.2979 4 no
GO:0010556 regulation of macromolecule biosynthetic process 38.2979 5 no
GO:0031326 regulation of cellular biosynthetic process 38.2979 5 no
GO:0008104 protein localization 37.2340 4 no
GO:0010604 positive regulation of macromolecule metabolic process 36.1702 5 no
GO:0022607 cellular component assembly 36.1702 4 no
GO:0010468 regulation of gene expression 35.1064 6 no
GO:0010647 positive regulation of cell communication 34.0426 5 no
GO:0023056 positive regulation of signaling 34.0426 4 no
GO:0043933 protein-containing complex organization 32.9787 4 no
GO:0051049 regulation of transport 31.9149 4 no
GO:0051174 regulation of phosphorus metabolic process 30.8511 5 yes
GO:0031325 positive regulation of cellular metabolic process 30.8511 5 no
GO:0048584 positive regulation of response to stimulus 30.8511 4 no
GO:1902531 regulation of intracellular signal transduction 30.8511 5 no
GO:0019220 regulation of phosphate metabolic process 30.8511 6 yes
GO:0031399 regulation of protein modification process 30.8511 6 yes
GO:0051247 positive regulation of protein metabolic process 29.7872 6 no
GO:0009892 negative regulation of metabolic process 29.7872 4 yes
GO:0031324 negative regulation of cellular metabolic process 28.7234 5 yes
GO:0009967 positive regulation of signal transduction 26.5957 5 no
GO:0009894 regulation of catabolic process 26.5957 4 no
GO:0033043 regulation of organelle organization 26.5957 5 no
GO:0060341 regulation of cellular localization 26.5957 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.5957 5 no
GO:0010605 negative regulation of macromolecule metabolic process 26.5957 5 yes
GO:0043067 regulation of programmed cell death 25.5319 4 no
GO:0044087 regulation of cellular component biogenesis 25.5319 4 no
GO:0071702 organic substance transport 25.5319 4 no
GO:0071705 nitrogen compound transport 25.5319 4 no
GO:0065003 protein-containing complex assembly 25.5319 5 no
GO:0042325 regulation of phosphorylation 24.4681 7 yes
GO:0032880 regulation of protein localization 24.4681 5 no
GO:0042981 regulation of apoptotic process 24.4681 5 no
GO:0051130 positive regulation of cellular component organization 24.4681 5 no
GO:0071310 cellular response to organic substance 24.4681 4 no
GO:0006796 phosphate-containing compound metabolic process 22.3404 4 no
GO:0015031 protein transport 22.3404 4 no
GO:0001932 regulation of protein phosphorylation 22.3404 7 yes
GO:0036211 protein modification process 21.2766 4 no
GO:0043412 macromolecule modification 21.2766 4 no
GO:0007005 mitochondrion organization 21.2766 5 no
GO:0051050 positive regulation of transport 21.2766 4 no
GO:0045936 negative regulation of phosphate metabolic process 20.2128 7 yes
GO:0051248 negative regulation of protein metabolic process 20.2128 6 yes
GO:0007010 cytoskeleton organization 20.2128 5 no
GO:0009891 positive regulation of biosynthetic process 20.2128 5 no
GO:0010638 positive regulation of organelle organization 20.2128 6 no
GO:0030162 regulation of proteolysis 20.2128 6 no
GO:0061024 membrane organization 20.2128 4 no
GO:0033365 protein localization to organelle 20.2128 5 no
GO:0051252 regulation of RNA metabolic process 20.2128 5 no
GO:0010563 negative regulation of phosphorus metabolic process 20.2128 6 yes
GO:0031400 negative regulation of protein modification process 20.2128 7 yes
GO:0051338 regulation of transferase activity 18.0851 4 yes
GO:0042326 negative regulation of phosphorylation 17.0213 8 yes
GO:0043549 regulation of kinase activity 15.9574 5 yes
GO:0001933 negative regulation of protein phosphorylation 14.8936 8 yes
GO:0045859 regulation of protein kinase activity 13.8298 6 yes
GO:0043086 negative regulation of catalytic activity 11.7021 4 yes
GO:0051348 negative regulation of transferase activity 10.6383 5 yes
GO:0071900 regulation of protein serine/threonine kinase activity 10.6383 7 yes
GO:0033673 negative regulation of kinase activity 9.5745 6 yes
GO:0006469 negative regulation of protein kinase activity 7.4468 7 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 5.3191 8 yes
GO:2000479 regulation of cAMP-dependent protein kinase activity 5.3191 8 yes
GO:2000480 negative regulation of cAMP-dependent protein kinase activity 4.2553 9 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RACK1_HUMAN [view interactions] Low throughput no yes
PLAK2_HUMAN [view interactions] Low throughput no no
AKAP4_HUMAN [view interactions] Low throughput no no
WASF1_HUMAN [view entry] [view interactions] Low throughput yes yes
INAR2_HUMAN [view interactions] Low throughput no no
AKAP6_HUMAN [view interactions] Low throughput no no
RYR2_HUMAN [view entry] [view interactions] Low throughput yes yes
AKA7G_HUMAN [view interactions] Low throughput no yes
NHRF3_HUMAN [view interactions] Low throughput no no
AKAP9_HUMAN [view entry] [view interactions] Low throughput yes yes
AKA10_HUMAN [view interactions] Low throughput no no
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
AKAP3_HUMAN [view interactions] Low throughput no no
AKAP5_HUMAN [view entry] [view interactions] Low throughput yes yes
CK5P2_HUMAN [view interactions] Low throughput no yes
AKAP1_HUMAN [view entry] [view interactions] Low throughput yes yes
CCND3_HUMAN [view interactions] Low throughput no no
CCNE1_HUMAN [view interactions] Low throughput no no
AKA28_HUMAN [view interactions] Low throughput no no
AKP13_HUMAN [view interactions] Low throughput no yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
AKAP8_HUMAN [view interactions] Low throughput no yes
CDK1_HUMAN [view interactions] Low throughput no no
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
AKA12_HUMAN [view entry] [view interactions] Low throughput yes no
AKA11_HUMAN [view interactions] Low throughput no yes
PJA2_HUMAN [view entry] [view interactions] Low throughput yes yes
CAV1_HUMAN [view interactions] Low throughput no no
INGR2_HUMAN [view interactions] Low throughput no yes
BIG2_HUMAN [view entry] [view interactions] Low throughput yes yes
MTG8_HUMAN [view interactions] Low throughput no yes
RAB32_HUMAN [view interactions] Low throughput no yes
KAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNQ1_HUMAN [view interactions] Low throughput no yes
MTG16_HUMAN [view interactions] Low throughput no yes
PDE4A_HUMAN [view interactions] Low throughput no no
GNA13_HUMAN [view entry] [view interactions] Low throughput yes yes
CENPE_HUMAN [view interactions] High throughput no no
CE170_HUMAN [view interactions] High throughput no yes
PTN22_HUMAN [view interactions] High throughput no yes
PPIE_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
WDR76_HUMAN [view interactions] High throughput no no
H4_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
NHLC2_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
HPT_HUMAN [view interactions] High throughput no no
H12_HUMAN [view interactions] High throughput no yes
TRFE_HUMAN [view interactions] High throughput no no
MTAP2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
CLIP1_HUMAN [view entry] [view interactions] High throughput yes yes
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
ERF3A_HUMAN [view interactions] High throughput no yes
HS12A_HUMAN [view entry] [view interactions] High throughput yes yes
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
AAPK1_HUMAN [view interactions] High throughput no no
TBB4B_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
KPCA_HUMAN [view entry] [view interactions] High throughput yes yes
DPTOR_HUMAN [view interactions] High throughput no no
MOB3C_HUMAN [view interactions] High throughput no no
CBL_HUMAN [view interactions] High throughput no yes
MET14_HUMAN [view interactions] High throughput no yes
MIDN_HUMAN [view interactions] High throughput no no
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
CIRBP_HUMAN [view interactions] High throughput no no
IMDH2_HUMAN [view interactions] High throughput no yes
CSRP1_HUMAN [view entry] [view interactions] High throughput yes yes
CSN1_HUMAN [view interactions] High throughput no no
IMA7_HUMAN [view interactions] High throughput no yes
PSD11_HUMAN [view entry] [view interactions] High throughput yes yes
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
JIP4_HUMAN [view interactions] High throughput no yes
SRS10_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
RINI_HUMAN [view interactions] High throughput no yes
GNS_HUMAN [view interactions] High throughput no yes
ML12A_HUMAN [view interactions] High throughput no no
TGM2_HUMAN [view interactions] High throughput no no
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
KINH_HUMAN [view entry] [view interactions] High throughput yes no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
PRS7_HUMAN [view interactions] High throughput no yes
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD7_HUMAN [view interactions] High throughput no yes
SNAA_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
PRS10_HUMAN [view interactions] High throughput no yes
ACACA_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD2_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA4_HUMAN [view interactions] High throughput no yes
CHD4_HUMAN [view interactions] High throughput no yes
GAPD1_HUMAN [view entry] [view interactions] High throughput yes yes
ADRM1_HUMAN [view interactions] High throughput no yes
PLCH1_HUMAN [view interactions] High throughput no no
GGYF2_HUMAN [view interactions] High throughput no yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
PSB7_HUMAN [view interactions] High throughput no yes
CND3_HUMAN [view interactions] High throughput no yes
NADAP_HUMAN [view interactions] High throughput no yes
GCP60_HUMAN [view interactions] High throughput no yes
VTA1_HUMAN [view entry] [view interactions] High throughput yes yes
SMC4_HUMAN [view interactions] High throughput no yes
DJB11_HUMAN [view interactions] High throughput no yes
BIG1_HUMAN [view interactions] High throughput no yes
STK24_HUMAN [view interactions] High throughput no yes
PTPRA_HUMAN [view interactions] High throughput no yes
RET_HUMAN [view interactions] High throughput no yes
EXD2_HUMAN [view interactions] High throughput no yes
FIS1_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
MARH5_HUMAN [view interactions] High throughput no no
MAVS_HUMAN [view interactions] High throughput no yes
MFN2_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH1_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
OCAD1_HUMAN [view interactions] High throughput no yes
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
RMD3_HUMAN [view entry] [view interactions] High throughput yes yes
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC5_HUMAN [view interactions] High throughput no yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
PEX14_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
PXMP2_HUMAN [view interactions] High throughput no no
TAXB1_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
RFA4_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
RHG05_HUMAN [view interactions] High throughput no yes
SAP_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
MK06_HUMAN [view interactions] High throughput no yes
CP135_HUMAN [view interactions] High throughput no no
CE120_HUMAN [view interactions] High throughput no no
CEP43_HUMAN [view interactions] High throughput no no
NEK2_HUMAN [view interactions] High throughput no no
C170L_HUMAN [view entry] [view interactions] High throughput yes no
OFD1_HUMAN [view interactions] High throughput no yes
FA83D_HUMAN [view interactions] High throughput no no
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
FLNB_HUMAN [view interactions] High throughput no no
KAPCB_HUMAN [view entry] [view interactions] High throughput yes yes
CP250_HUMAN [view interactions] High throughput no no
CEP72_HUMAN [view interactions] High throughput no yes
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes
SC24C_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
SC16A_HUMAN [view interactions] High throughput no yes
KAP3_HUMAN [view entry] [view interactions] High throughput yes yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
USO1_HUMAN [view entry] [view interactions] High throughput yes yes
PCNT_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC1_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
ERH_HUMAN [view interactions] High throughput no yes
MRCKB_HUMAN [view entry] [view interactions] High throughput yes yes
APOB_HUMAN [view interactions] High throughput no no
VPS53_HUMAN [view entry] [view interactions] High throughput yes yes
TPP2_HUMAN [view interactions] High throughput no yes
SYIM_HUMAN [view entry] [view interactions] High throughput yes yes
SRSF1_HUMAN [view interactions] High throughput no yes
TRIPB_HUMAN [view interactions] High throughput no yes
PLCG1_HUMAN [view entry] [view interactions] High throughput yes yes
ANKL2_HUMAN [view interactions] High throughput no yes
KAPCG_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
GRIA1_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
MYOME_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TX101_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
DYR1A_HUMAN [view interactions] High throughput no yes
CEP63_HUMAN [view interactions] High throughput no yes
POC5_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
PRDM4_HUMAN [view interactions] High throughput no no
SCLT1_HUMAN [view interactions] High throughput no yes
TOM20_HUMAN [view entry] [view interactions] High throughput yes yes
TOM22_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
KCNK3_HUMAN [view interactions] High throughput no no
LRIF1_HUMAN [view interactions] High throughput no yes
FOS_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
GCH1_HUMAN [view interactions] High throughput no no
SUZ12_HUMAN [view interactions] High throughput no no
ABCE1_HUMAN [view interactions] High throughput no yes
LRCC1_HUMAN [view interactions] High throughput no yes