AKAP9_HUMAN
Evidence for PS localization
Functions
Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 55%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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AKAP9_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [AKAP9_HUMAN]
Isoform [A0A2R8Y590] alignment
Isoform [Q99996-1] alignment
Isoform [Q99996-3] alignment
Isoform [Q99996-4] alignment
Isoform [Q99996-5] alignment
Isoform [Q99996-6] alignment
Isoform [A0A7P0T9E2] alignment
Isoform [A0A7P0T928] alignment
Isoform [A0A7P0T8N5] alignment
Isoform [A0A7P0T939] alignment
Isoform [A0A7P0T8Z8] alignment
Isoform [A0A7P0T9A9] alignment
Isoform [A0A7P0TAX3] alignment
Isoform [A0A7P0TBH8] alignment
LOADING 20%
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 1570 | Ser | Leu | LongQTsyndrome11(LQT11) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AKAP9_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 35.2113 | 4 | no |
| GO:0000166 | nucleotide binding | 33.8028 | 4 | no |
| GO:0017076 | purine nucleotide binding | 32.3944 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 30.9859 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 30.9859 | 4 | no |
| GO:0019900 | kinase binding | 30.9859 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 29.5775 | 5 | no |
| GO:0019901 | protein kinase binding | 28.1690 | 5 | no |
| GO:0043169 | cation binding | 28.1690 | 4 | no |
| GO:0046872 | metal ion binding | 26.7606 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.9437 | 4 | no |
| GO:0005524 | ATP binding | 22.5352 | 5 | no |
| GO:0099106 | ion channel regulator activity | 9.8592 | 4 | yes |
| GO:0003677 | DNA binding | 7.0423 | 4 | yes |
| GO:0015459 | potassium channel regulator activity | 5.6338 | 5 | yes |
| GO:0034237 | protein kinase A regulatory subunit binding | 4.2254 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AKAP9_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 64.7887 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 63.3803 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 61.9718 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 61.9718 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 60.5634 | 4 | no |
| GO:0010646 | regulation of cell communication | 53.5211 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 52.1127 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 47.8873 | 4 | yes |
| GO:0006996 | organelle organization | 43.6620 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 40.8451 | 6 | yes |
| GO:0009966 | regulation of signal transduction | 40.8451 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.4366 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 39.4366 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 39.4366 | 5 | yes |
| GO:0008104 | protein localization | 39.4366 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 39.4366 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.0282 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 38.0282 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.0282 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 38.0282 | 5 | no |
| GO:0051049 | regulation of transport | 36.6197 | 4 | yes |
| GO:0022607 | cellular component assembly | 36.6197 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 36.6197 | 5 | no |
| GO:0010468 | regulation of gene expression | 36.6197 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 35.2113 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| AKAP9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATOH1_HUMAN | [view interactions] | High throughput | no | no |
| BEX2_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| CA087_HUMAN | [view interactions] | High throughput | no | no |
| CA094_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAD22_HUMAN | [view interactions] | Low throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |