CSKP_HUMAN
Evidence for PS localization
Functions
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules . [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 28%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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CSKP_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [CSKP_HUMAN]
Isoform [A0A2R8Y7X6] alignment
Isoform [A0A2R8Y472] alignment
Isoform [A0A2R8Y3B3] alignment
Isoform [A0A2R8Y6D8] alignment
Isoform [A0A2R8Y6F8] alignment
Isoform [A0A2R8Y4K4] alignment
Isoform [A0A7I2RJN6] alignment
Isoform [A0A2R8YE77] alignment
Isoform [A0A2R8YGH2] alignment
Isoform [A0A2R8YFN5] alignment
Isoform [A0A2R8YEJ7] alignment
Isoform [A0A2R8YEK3] alignment
Isoform [A0A2U3TZN6] alignment
Isoform [A0A2U3TZM1] alignment
Isoform [A0A2U3TZM4] alignment
Isoform [Q5JS79] alignment
Isoform [O14936-2] alignment
Isoform [O14936-3] alignment
Isoform [O14936-4] alignment
Isoform [O14936-5] alignment
Isoform [O14936-6] alignment
LOADING 5%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CSKP_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 33.3333 | 4 | yes |
| GO:0043168 | anion binding | 33.3333 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 32.4074 | 5 | yes |
| GO:0019900 | kinase binding | 32.4074 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 31.4815 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.5556 | 4 | yes |
| GO:0019901 | protein kinase binding | 29.6296 | 5 | no |
| GO:0043169 | cation binding | 25.0000 | 4 | no |
| GO:0046872 | metal ion binding | 24.0741 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 21.2963 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 20.3704 | 5 | yes |
| GO:0005524 | ATP binding | 19.4444 | 5 | yes |
| GO:0016301 | kinase activity | 13.8889 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 12.9630 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 7.4074 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 7.4074 | 4 | yes |
| GO:0004385 | guanylate kinase activity | 2.7778 | 6 | yes |
| GO:0016776 | phosphotransferase activity, phosphate group as acceptor | 2.7778 | 4 | yes |
| GO:0019205 | nucleobase-containing compound kinase activity | 2.7778 | 5 | yes |
| GO:0050145 | nucleoside monophosphate kinase activity | 2.7778 | 5 | yes |
| GO:0042043 | neurexin family protein binding | 1.8519 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CSKP_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 67.5926 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 49.0741 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 49.0741 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 48.1481 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.2963 | 4 | yes |
| GO:0010646 | regulation of cell communication | 45.3704 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 41.6667 | 4 | yes |
| GO:0006996 | organelle organization | 41.6667 | 4 | no |
| GO:0051049 | regulation of transport | 40.7407 | 4 | yes |
| GO:0022607 | cellular component assembly | 40.7407 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.1111 | 4 | yes |
| GO:0008104 | protein localization | 36.1111 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.1852 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 35.1852 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.2593 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | yes |
| GO:0010468 | regulation of gene expression | 32.4074 | 6 | yes |
| GO:0030030 | cell projection organization | 30.5556 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 29.6296 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.7037 | 5 | no |
| GO:0007010 | cytoskeleton organization | 28.7037 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.7778 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.8519 | 6 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADA1D_HUMAN | [view interactions] | High throughput | no | no |
| AF17_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANFB_HUMAN | [view interactions] | High throughput | no | no |
| APBA1_HUMAN | [view interactions] | Low throughput | no | no |
| APBA2_HUMAN | [view interactions] | High throughput | no | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARHG8_HUMAN | [view interactions] | Low throughput | no | yes |
| ARHGQ_HUMAN | [view interactions] | High throughput | no | yes |
| ARI1_HUMAN | [view interactions] | Low throughput | no | yes |
| ARL14_HUMAN | [view interactions] | High throughput | no | no |
| AT2B4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BC11A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| BNI3L_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1B_HUMAN | [view interactions] | Low throughput | no | yes |
| CADM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |