MTMR2_HUMAN
Evidence for PS localization
Functions
Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed, PubMed, PubMed, PubMed). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate . Stabilizes SBF2/MTMR13 at the membranes . Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 283 | Arg | Trp | Charcot-Marie-Toothdisease4B1(CMT4B1) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MTMR2_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 28.5714 | 4 | no |
| GO:0000166 | nucleotide binding | 21.4286 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.4286 | 5 | no |
| GO:0016791 | phosphatase activity | 14.2857 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 14.2857 | 4 | yes |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | 10.7143 | 4 | yes |
| GO:0004438 | phosphatidylinositol-3-phosphate phosphatase activity | 7.1429 | 8 | yes |
| GO:0034593 | phosphatidylinositol bisphosphate phosphatase activity | 7.1429 | 7 | yes |
| GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | 7.1429 | 9 | yes |
| GO:0052744 | phosphatidylinositol monophosphate phosphatase activity | 7.1429 | 7 | yes |
| GO:0052866 | phosphatidylinositol phosphate phosphatase activity | 7.1429 | 6 | yes |
| GO:0106018 | phosphatidylinositol-3,5-bisphosphate phosphatase activity | 7.1429 | 8 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MTMR2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 57.1429 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 46.4286 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 46.4286 | 4 | yes |
| GO:0022607 | cellular component assembly | 42.8571 | 4 | yes |
| GO:0008104 | protein localization | 42.8571 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 39.2857 | 4 | yes |
| GO:0010646 | regulation of cell communication | 35.7143 | 4 | yes |
| GO:0051049 | regulation of transport | 35.7143 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 35.7143 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 32.1429 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 32.1429 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 28.5714 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 28.5714 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 28.5714 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 28.5714 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 25.0000 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 25.0000 | 5 | yes |
| GO:0051050 | positive regulation of transport | 25.0000 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 25.0000 | 4 | yes |
| GO:0033365 | protein localization to organelle | 25.0000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 25.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.4286 | 6 | yes |
| GO:0036211 | protein modification process | 21.4286 | 4 | yes |
| GO:0043412 | macromolecule modification | 21.4286 | 4 | yes |
| GO:0044057 | regulation of system process | 21.4286 | 4 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 21.4286 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 21.4286 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 21.4286 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 21.4286 | 5 | no |
| GO:0071702 | organic substance transport | 21.4286 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.4286 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.4286 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.4286 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.4286 | 6 | no |
| GO:0031399 | regulation of protein modification process | 21.4286 | 6 | no |
| GO:0030030 | cell projection organization | 17.8571 | 4 | yes |
| GO:0030100 | regulation of endocytosis | 17.8571 | 5 | yes |
| GO:0051051 | negative regulation of transport | 17.8571 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 17.8571 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 17.8571 | 5 | yes |
| GO:0031329 | regulation of cellular catabolic process | 14.2857 | 5 | yes |
| GO:0032386 | regulation of intracellular transport | 14.2857 | 5 | yes |
| GO:0032388 | positive regulation of intracellular transport | 14.2857 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 14.2857 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 14.2857 | 4 | yes |
| GO:0006470 | protein dephosphorylation | 10.7143 | 5 | yes |
| GO:0008610 | lipid biosynthetic process | 10.7143 | 4 | yes |
| GO:0009895 | negative regulation of catabolic process | 10.7143 | 5 | yes |
| GO:0016311 | dephosphorylation | 10.7143 | 5 | yes |
| GO:0031641 | regulation of myelination | 10.7143 | 4 | yes |
| GO:0035303 | regulation of dephosphorylation | 10.7143 | 7 | yes |
| GO:0045806 | negative regulation of endocytosis | 10.7143 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 10.7143 | 4 | yes |
| GO:0002090 | regulation of receptor internalization | 7.1429 | 7 | yes |
| GO:0002091 | negative regulation of receptor internalization | 7.1429 | 7 | yes |
| GO:0006644 | phospholipid metabolic process | 7.1429 | 4 | yes |
| GO:0006650 | glycerophospholipid metabolic process | 7.1429 | 5 | yes |
| GO:0006661 | phosphatidylinositol biosynthetic process | 7.1429 | 6 | yes |
| GO:0008654 | phospholipid biosynthetic process | 7.1429 | 5 | yes |
| GO:0019216 | regulation of lipid metabolic process | 7.1429 | 5 | yes |
| GO:0030258 | lipid modification | 7.1429 | 4 | yes |
| GO:0031330 | negative regulation of cellular catabolic process | 7.1429 | 6 | yes |
| GO:0031642 | negative regulation of myelination | 7.1429 | 5 | yes |
| GO:0031644 | regulation of nervous system process | 7.1429 | 5 | yes |
| GO:0031645 | negative regulation of nervous system process | 7.1429 | 5 | yes |
| GO:0032288 | myelin assembly | 7.1429 | 4 | yes |
| GO:0043954 | cellular component maintenance | 7.1429 | 4 | yes |
| GO:0045017 | glycerolipid biosynthetic process | 7.1429 | 4 | yes |
| GO:0046474 | glycerophospholipid biosynthetic process | 7.1429 | 5 | yes |
| GO:0046486 | glycerolipid metabolic process | 7.1429 | 4 | yes |
| GO:0046488 | phosphatidylinositol metabolic process | 7.1429 | 6 | yes |
| GO:0046839 | phospholipid dephosphorylation | 7.1429 | 5 | yes |
| GO:0046856 | phosphatidylinositol dephosphorylation | 7.1429 | 6 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 7.1429 | 6 | yes |
| GO:0048261 | negative regulation of receptor-mediated endocytosis | 7.1429 | 6 | yes |
| GO:0048666 | neuron development | 7.1429 | 4 | yes |
| GO:0060304 | regulation of phosphatidylinositol dephosphorylation | 7.1429 | 5 | yes |
| GO:0090394 | negative regulation of excitatory postsynaptic potential | 7.1429 | 4 | yes |
| GO:0097061 | dendritic spine organization | 7.1429 | 5 | yes |
| GO:0097062 | dendritic spine maintenance | 7.1429 | 5 | yes |
| GO:0098815 | modulation of excitatory postsynaptic potential | 7.1429 | 4 | yes |
| GO:0099173 | postsynapse organization | 7.1429 | 4 | yes |
| GO:0106027 | neuron projection organization | 7.1429 | 6 | yes |
| GO:1903725 | regulation of phospholipid metabolic process | 7.1429 | 6 | yes |
| GO:2000641 | regulation of early endosome to late endosome transport | 7.1429 | 5 | yes |
| GO:2000643 | positive regulation of early endosome to late endosome transport | 7.1429 | 6 | yes |
| GO:2000644 | regulation of receptor catabolic process | 7.1429 | 5 | yes |
| GO:2000645 | negative regulation of receptor catabolic process | 7.1429 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NFL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTMRC_HUMAN | [view interactions] | Low throughput | no | yes |
| MTMR5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MTMR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MTMRA_HUMAN | [view interactions] | High throughput | no | yes |
| NARF_HUMAN | [view interactions] | High throughput | no | no |
| MTMRD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTMR1_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTMR9_HUMAN | [view interactions] | High throughput | no | no |
| ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RSPH1_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| MTMRB_HUMAN | [view interactions] | High throughput | no | no |
| EYA3_HUMAN | [view interactions] | High throughput | no | no |
| SPCS_HUMAN | [view interactions] | High throughput | no | no |
| NUD16_HUMAN | [view interactions] | High throughput | no | yes |
| G45IP_HUMAN | [view interactions] | High throughput | no | yes |
| AROS_HUMAN | [view interactions] | High throughput | no | yes |
| MRT4_HUMAN | [view interactions] | High throughput | no | yes |
| EBP2_HUMAN | [view interactions] | High throughput | no | yes |
| RL3L_HUMAN | [view interactions] | High throughput | no | no |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIN7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPP7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OTOL1_HUMAN | [view interactions] | High throughput | no | no |
| RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMU1_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF3_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF5_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| IQIP1_HUMAN | [view interactions] | High throughput | no | yes |
| SCHI1_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| LC7L3_HUMAN | [view interactions] | High throughput | no | yes |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| CX7A2_HUMAN | [view interactions] | High throughput | no | no |
| RCAF1_HUMAN | [view interactions] | High throughput | no | yes |
| NC2B_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| MTM1_HUMAN | [view interactions] | High throughput | no | yes |
| SNTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFC5_HUMAN | [view interactions] | High throughput | no | yes |
| HSF1_HUMAN | [view interactions] | High throughput | no | yes |
| SZRD1_HUMAN | [view interactions] | High throughput | no | yes |
| PYRG2_HUMAN | [view interactions] | High throughput | no | yes |
| EHD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| CHIO_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |