MTMR2_HUMAN
Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed, PubMed, PubMed, PubMed). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate . Stabilizes SBF2/MTMR13 at the membranes . Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
283 | Arg | Trp | Charcot-Marie-Toothdisease4B1(CMT4B1) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in MTMR2_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 26.6667 | 4 | no |
GO:0016791 | phosphatase activity | 16.6667 | 5 | yes |
GO:0042578 | phosphoric ester hydrolase activity | 16.6667 | 4 | yes |
GO:0004438 | phosphatidylinositol-3-phosphatase activity | 10.0000 | 8 | yes |
GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | 10.0000 | 4 | yes |
GO:0052744 | phosphatidylinositol monophosphate phosphatase activity | 10.0000 | 7 | yes |
GO:0052866 | phosphatidylinositol phosphate phosphatase activity | 10.0000 | 6 | yes |
GO:0004725 | protein tyrosine phosphatase activity | 6.6667 | 4 | yes |
GO:0034593 | phosphatidylinositol bisphosphate phosphatase activity | 6.6667 | 7 | yes |
GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | 6.6667 | 9 | yes |
GO:0106018 | phosphatidylinositol-3,5-bisphosphate phosphatase activity | 6.6667 | 8 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in MTMR2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 53.3333 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 46.6667 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 43.3333 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
GO:0022607 | cellular component assembly | 40.0000 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 36.6667 | 4 | yes |
GO:0051049 | regulation of transport | 33.3333 | 4 | yes |
GO:0008104 | protein localization | 33.3333 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.0000 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 30.0000 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 30.0000 | 5 | yes |
GO:0010646 | regulation of cell communication | 30.0000 | 4 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 26.6667 | 5 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 26.6667 | 5 | yes |
GO:2000026 | regulation of multicellular organismal development | 26.6667 | 4 | yes |
GO:0031399 | regulation of protein modification process | 26.6667 | 6 | no |
GO:0051247 | positive regulation of protein metabolic process | 26.6667 | 6 | no |
GO:0009889 | regulation of biosynthetic process | 26.6667 | 4 | no |
GO:0010468 | regulation of gene expression | 26.6667 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 26.6667 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.6667 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 26.6667 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 26.6667 | 5 | no |
GO:0006796 | phosphate-containing compound metabolic process | 26.6667 | 4 | yes |
GO:0009966 | regulation of signal transduction | 26.6667 | 4 | yes |
GO:0019220 | regulation of phosphate metabolic process | 26.6667 | 6 | yes |
GO:0044057 | regulation of system process | 23.3333 | 4 | yes |
GO:0048585 | negative regulation of response to stimulus | 23.3333 | 4 | yes |
GO:0051050 | positive regulation of transport | 23.3333 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 23.3333 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.3333 | 5 | no |
GO:0006996 | organelle organization | 23.3333 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 23.3333 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 23.3333 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 23.3333 | 6 | no |
GO:0031329 | regulation of cellular catabolic process | 20.0000 | 5 | yes |
GO:0036211 | protein modification process | 20.0000 | 4 | yes |
GO:0043412 | macromolecule modification | 20.0000 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 20.0000 | 5 | yes |
GO:0060341 | regulation of cellular localization | 20.0000 | 4 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 20.0000 | 4 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 20.0000 | 4 | yes |
GO:0009894 | regulation of catabolic process | 20.0000 | 4 | yes |
GO:0009968 | negative regulation of signal transduction | 20.0000 | 5 | yes |
GO:0010648 | negative regulation of cell communication | 20.0000 | 5 | yes |
GO:0023057 | negative regulation of signaling | 20.0000 | 4 | yes |
GO:0030100 | regulation of endocytosis | 16.6667 | 5 | yes |
GO:0051960 | regulation of nervous system development | 16.6667 | 5 | yes |
GO:0090407 | organophosphate biosynthetic process | 16.6667 | 4 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 16.6667 | 5 | yes |
GO:0008610 | lipid biosynthetic process | 16.6667 | 4 | yes |
GO:0030030 | cell projection organization | 16.6667 | 4 | yes |
GO:0032386 | regulation of intracellular transport | 13.3333 | 5 | yes |
GO:0035303 | regulation of dephosphorylation | 13.3333 | 7 | yes |
GO:0045017 | glycerolipid biosynthetic process | 13.3333 | 4 | yes |
GO:0046474 | glycerophospholipid biosynthetic process | 13.3333 | 5 | yes |
GO:0046486 | glycerolipid metabolic process | 13.3333 | 4 | yes |
GO:0046488 | phosphatidylinositol metabolic process | 13.3333 | 6 | yes |
GO:0051051 | negative regulation of transport | 13.3333 | 4 | yes |
GO:0051129 | negative regulation of cellular component organization | 13.3333 | 5 | yes |
GO:0006644 | phospholipid metabolic process | 13.3333 | 4 | yes |
GO:0006650 | glycerophospholipid metabolic process | 13.3333 | 5 | yes |
GO:0006661 | phosphatidylinositol biosynthetic process | 13.3333 | 6 | yes |
GO:0008654 | phospholipid biosynthetic process | 13.3333 | 4 | yes |
GO:0016311 | dephosphorylation | 13.3333 | 5 | yes |
GO:0019216 | regulation of lipid metabolic process | 13.3333 | 5 | yes |
GO:0030258 | lipid modification | 10.0000 | 4 | yes |
GO:0031330 | negative regulation of cellular catabolic process | 10.0000 | 6 | yes |
GO:0031641 | regulation of myelination | 10.0000 | 4 | yes |
GO:0031644 | regulation of nervous system process | 10.0000 | 5 | yes |
GO:0032388 | positive regulation of intracellular transport | 10.0000 | 5 | yes |
GO:0045806 | negative regulation of endocytosis | 10.0000 | 5 | yes |
GO:0046839 | phospholipid dephosphorylation | 10.0000 | 5 | yes |
GO:0046856 | phosphatidylinositol dephosphorylation | 10.0000 | 6 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 10.0000 | 4 | yes |
GO:1903649 | regulation of cytoplasmic transport | 10.0000 | 6 | yes |
GO:2000641 | regulation of early endosome to late endosome transport | 10.0000 | 5 | yes |
GO:0006470 | protein dephosphorylation | 10.0000 | 5 | yes |
GO:0009895 | negative regulation of catabolic process | 10.0000 | 5 | yes |
GO:0031642 | negative regulation of myelination | 6.6667 | 5 | yes |
GO:0031645 | negative regulation of nervous system process | 6.6667 | 5 | yes |
GO:0032288 | myelin assembly | 6.6667 | 4 | yes |
GO:0043647 | inositol phosphate metabolic process | 6.6667 | 4 | yes |
GO:0043954 | cellular component maintenance | 6.6667 | 4 | yes |
GO:0046164 | alcohol catabolic process | 6.6667 | 4 | yes |
GO:0046174 | polyol catabolic process | 6.6667 | 5 | yes |
GO:0046434 | organophosphate catabolic process | 6.6667 | 4 | yes |
GO:0046838 | phosphorylated carbohydrate dephosphorylation | 6.6667 | 4 | yes |
GO:0046855 | inositol phosphate dephosphorylation | 6.6667 | 5 | yes |
GO:0048259 | regulation of receptor-mediated endocytosis | 6.6667 | 6 | yes |
GO:0048261 | negative regulation of receptor-mediated endocytosis | 6.6667 | 6 | yes |
GO:0048666 | neuron development | 6.6667 | 4 | yes |
GO:0050805 | negative regulation of synaptic transmission | 6.6667 | 5 | yes |
GO:0060304 | regulation of phosphatidylinositol dephosphorylation | 6.6667 | 5 | yes |
GO:0071545 | inositol phosphate catabolic process | 6.6667 | 5 | yes |
GO:0090394 | negative regulation of excitatory postsynaptic potential | 6.6667 | 5 | yes |
GO:0097061 | dendritic spine organization | 6.6667 | 5 | yes |
GO:0097062 | dendritic spine maintenance | 6.6667 | 5 | yes |
GO:0098815 | modulation of excitatory postsynaptic potential | 6.6667 | 4 | yes |
GO:0099173 | postsynapse organization | 6.6667 | 4 | yes |
GO:0106027 | neuron projection organization | 6.6667 | 6 | yes |
GO:1901616 | organic hydroxy compound catabolic process | 6.6667 | 4 | yes |
GO:1903651 | positive regulation of cytoplasmic transport | 6.6667 | 6 | yes |
GO:1903725 | regulation of phospholipid metabolic process | 6.6667 | 6 | yes |
GO:2000643 | positive regulation of early endosome to late endosome transport | 6.6667 | 6 | yes |
GO:2000644 | regulation of receptor catabolic process | 6.6667 | 5 | yes |
GO:2000645 | negative regulation of receptor catabolic process | 6.6667 | 6 | yes |
GO:0002090 | regulation of receptor internalization | 6.6667 | 7 | yes |
GO:0002091 | negative regulation of receptor internalization | 6.6667 | 7 | yes |
GO:0019751 | polyol metabolic process | 6.6667 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in MTMR2_HUMAN |
---|---|---|---|---|
DOID:0050541 | Charcot-Marie-Tooth disease type 4 | 6.6667 | 7 | yes |
DOID:0110191 | Charcot-Marie-Tooth disease type 4B1 | 6.6667 | 8 | yes |
DOID:10595 | Charcot-Marie-Tooth disease | 6.6667 | 6 | yes |
DOID:440 | neuromuscular disease | 6.6667 | 5 | yes |
DOID:574 | peripheral nervous system disease | 6.6667 | 3 | yes |
DOID:870 | neuropathy | 6.6667 | 4 | yes |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NFL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MTMRC_HUMAN | [view interactions] | Low throughput | no | yes |
MTMR5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
MTMR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
MTMRD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NARF_HUMAN | [view interactions] | High throughput | no | no |
MTMRA_HUMAN | [view interactions] | High throughput | no | yes |
CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MTMR1_HUMAN | [view interactions] | High throughput | no | yes |
TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
MTMR9_HUMAN | [view interactions] | High throughput | no | no |
ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UNK_HUMAN | [view interactions] | High throughput | no | yes |
MTMRB_HUMAN | [view interactions] | High throughput | no | no |
EYA3_HUMAN | [view interactions] | High throughput | no | no |
SPCS_HUMAN | [view interactions] | High throughput | no | no |
NUD16_HUMAN | [view interactions] | High throughput | no | yes |
G45IP_HUMAN | [view interactions] | High throughput | no | yes |
AROS_HUMAN | [view interactions] | High throughput | no | yes |
MRT4_HUMAN | [view interactions] | High throughput | no | yes |
EBP2_HUMAN | [view interactions] | High throughput | no | yes |
RL3L_HUMAN | [view interactions] | High throughput | no | no |
CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MPP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LIN7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MPP7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
OTOL1_HUMAN | [view interactions] | High throughput | no | no |
RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMU1_HUMAN | [view interactions] | High throughput | no | yes |
SRSF3_HUMAN | [view interactions] | High throughput | no | yes |
SRSF5_HUMAN | [view interactions] | High throughput | no | yes |
OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
S10A2_HUMAN | [view interactions] | High throughput | no | no |
IQIP1_HUMAN | [view interactions] | High throughput | no | yes |
SCHI1_HUMAN | [view interactions] | High throughput | no | yes |
RF1M_HUMAN | [view interactions] | High throughput | no | yes |
LC7L3_HUMAN | [view interactions] | High throughput | no | yes |
G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
CX7A2_HUMAN | [view interactions] | High throughput | no | no |
RCAF1_HUMAN | [view interactions] | High throughput | no | yes |
NC2B_HUMAN | [view interactions] | High throughput | no | yes |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSK_HUMAN | [view interactions] | High throughput | no | yes |
SNTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RFC5_HUMAN | [view interactions] | High throughput | no | yes |
HSF1_HUMAN | [view interactions] | High throughput | no | yes |
SZRD1_HUMAN | [view interactions] | High throughput | no | yes |
PYRG2_HUMAN | [view interactions] | High throughput | no | yes |
EHD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LRSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
XPP1_HUMAN | [view interactions] | High throughput | no | yes |
CHIO_HUMAN | [view interactions] | High throughput | no | yes |
BICD2_HUMAN | [view interactions] | High throughput | no | yes |
S3TC2_HUMAN | [view interactions] | Computational | no | yes |
FIG4_HUMAN | [view interactions] | Computational | no | yes |
PK3C3_HUMAN | [view interactions] | Computational | no | yes |
FYV1_HUMAN | [view interactions] | Computational | no | no |
P3C2A_HUMAN | [view interactions] | Computational | no | yes |
SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
P3C2B_HUMAN | [view interactions] | Computational | no | no |
CDIPT_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SAC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |