Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ERBB4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
927 Arg Gln Amyotrophiclateralsclerosis19(ALS19) -
1275 Arg Trp Amyotrophiclateralsclerosis19(ALS19) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI003701 LIG_SH2_GRB2like LIG 1188 1191 -
ELMI003702 LIG_SH2_GRB2like LIG 1242 1245 -
ELMI002194 LIG_SH2_STAT5 LIG 1056 1059 -
ELMI002135 LIG_WW_1 LIG 1053 1056 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ERBB4_HUMAN
GO:0017076 purine nucleotide binding 32.5000 4 yes
GO:0032555 purine ribonucleotide binding 32.5000 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 32.5000 4 yes
GO:0019900 kinase binding 32.5000 4 no
GO:0019901 protein kinase binding 30.0000 5 no
GO:0005524 ATP binding 28.7500 5 yes
GO:0016301 kinase activity 28.7500 4 yes
GO:0030554 adenyl nucleotide binding 28.7500 5 yes
GO:0032559 adenyl ribonucleotide binding 28.7500 5 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 26.2500 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 26.2500 4 yes
GO:0004713 protein tyrosine kinase activity 18.7500 4 yes
GO:0070851 growth factor receptor binding 12.5000 4 yes
GO:0042803 protein homodimerization activity 11.2500 4 yes
GO:0003677 DNA binding 6.2500 4 yes
GO:0005154 epidermal growth factor receptor binding 6.2500 5 yes
GO:0003690 double-stranded DNA binding 5.0000 5 yes
GO:0004714 transmembrane receptor protein tyrosine kinase activity 5.0000 5 yes
GO:0019199 transmembrane receptor protein kinase activity 5.0000 4 yes
GO:0043565 sequence-specific DNA binding 5.0000 5 yes
GO:1990837 sequence-specific double-stranded DNA binding 5.0000 6 yes
GO:0000976 transcription cis-regulatory region binding 3.7500 5 yes
GO:0001067 transcription regulatory region nucleic acid binding 3.7500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ERBB4_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0010646 regulation of cell communication 67.5000 4 yes
GO:0060255 regulation of macromolecule metabolic process 67.5000 4 yes
GO:0080090 regulation of primary metabolic process 66.2500 4 yes
GO:0009966 regulation of signal transduction 63.7500 4 yes
GO:0048523 negative regulation of cellular process 62.5000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 62.5000 4 yes
GO:0031323 regulation of cellular metabolic process 61.2500 4 yes
GO:1902531 regulation of intracellular signal transduction 56.2500 5 yes
GO:0051246 regulation of protein metabolic process 53.7500 5 yes
GO:0048584 positive regulation of response to stimulus 52.5000 4 yes
GO:0009893 positive regulation of metabolic process 52.5000 4 yes
GO:0010647 positive regulation of cell communication 51.2500 5 yes
GO:0023056 positive regulation of signaling 51.2500 4 yes
GO:0010468 regulation of gene expression 50.0000 5 yes
GO:0051128 regulation of cellular component organization 48.7500 4 no
GO:0010604 positive regulation of macromolecule metabolic process 47.5000 5 yes
GO:0009967 positive regulation of signal transduction 46.2500 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 43.7500 5 yes
GO:0019220 regulation of phosphate metabolic process 42.5000 6 yes
GO:0031325 positive regulation of cellular metabolic process 42.5000 5 yes
GO:0042127 regulation of cell population proliferation 42.5000 4 yes
GO:0051174 regulation of phosphorus metabolic process 42.5000 5 yes
GO:0051247 positive regulation of protein metabolic process 42.5000 6 yes
GO:0051049 regulation of transport 42.5000 4 no
GO:0010941 regulation of cell death 41.2500 4 yes
GO:1902533 positive regulation of intracellular signal transduction 41.2500 6 yes
GO:0031399 regulation of protein modification process 40.0000 6 yes
GO:0042325 regulation of phosphorylation 40.0000 7 yes
GO:0043085 positive regulation of catalytic activity 40.0000 4 yes
GO:0071310 cellular response to organic substance 40.0000 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 40.0000 4 yes
GO:0036211 protein modification process 38.7500 4 yes
GO:0042981 regulation of apoptotic process 38.7500 6 yes
GO:0043067 regulation of programmed cell death 38.7500 5 yes
GO:0043412 macromolecule modification 38.7500 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 38.7500 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 yes
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 yes
GO:0009892 negative regulation of metabolic process 37.5000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.5000 5 no
GO:0001932 regulation of protein phosphorylation 37.5000 7 yes
GO:0006796 phosphate-containing compound metabolic process 37.5000 4 yes
GO:0009889 regulation of biosynthetic process 37.5000 4 yes
GO:0022607 cellular component assembly 36.2500 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 36.2500 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 35.0000 6 yes
GO:0045937 positive regulation of phosphate metabolic process 35.0000 7 yes
GO:0006996 organelle organization 35.0000 4 yes
GO:0031401 positive regulation of protein modification process 33.7500 7 yes
GO:0042327 positive regulation of phosphorylation 33.7500 8 yes
GO:0008284 positive regulation of cell population proliferation 33.7500 5 yes
GO:0051338 regulation of transferase activity 32.5000 4 yes
GO:0051240 positive regulation of multicellular organismal process 31.2500 4 yes
GO:0051252 regulation of RNA metabolic process 31.2500 5 yes
GO:0051130 positive regulation of cellular component organization 31.2500 5 no
GO:0001934 positive regulation of protein phosphorylation 31.2500 8 yes
GO:0043408 regulation of MAPK cascade 30.0000 6 yes
GO:0051094 positive regulation of developmental process 30.0000 4 yes
GO:0060341 regulation of cellular localization 30.0000 4 yes
GO:0060548 negative regulation of cell death 30.0000 5 yes
GO:2000145 regulation of cell motility 30.0000 4 yes
GO:0002684 positive regulation of immune system process 30.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 30.0000 5 no
GO:0048585 negative regulation of response to stimulus 30.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 30.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 30.0000 4 no
GO:0016310 phosphorylation 28.7500 5 yes
GO:0043066 negative regulation of apoptotic process 28.7500 7 yes
GO:0043069 negative regulation of programmed cell death 28.7500 6 yes
GO:0043549 regulation of kinase activity 28.7500 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 28.7500 7 yes
GO:2001141 regulation of RNA biosynthetic process 28.7500 6 yes
GO:0080134 regulation of response to stress 28.7500 4 no
GO:0050776 regulation of immune response 28.7500 4 no
GO:0006355 regulation of DNA-templated transcription 28.7500 6 yes
GO:0030334 regulation of cell migration 27.5000 5 yes
GO:2000026 regulation of multicellular organismal development 27.5000 4 yes
GO:0008104 protein localization 27.5000 4 no
GO:0010648 negative regulation of cell communication 27.5000 5 no
GO:0023057 negative regulation of signaling 27.5000 4 no
GO:0030030 cell projection organization 27.5000 4 no
GO:0031344 regulation of cell projection organization 27.5000 5 no
GO:0010243 response to organonitrogen compound 27.5000 4 no
GO:0051347 positive regulation of transferase activity 26.2500 5 yes
GO:0030155 regulation of cell adhesion 26.2500 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.2500 6 no
GO:0045595 regulation of cell differentiation 26.2500 4 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0006468 protein phosphorylation 25.0000 5 yes
GO:0009891 positive regulation of biosynthetic process 25.0000 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 23.7500 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 23.7500 6 yes
GO:0032880 regulation of protein localization 23.7500 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.7500 6 yes
GO:0045859 regulation of protein kinase activity 23.7500 6 no
GO:0010628 positive regulation of gene expression 23.7500 6 no
GO:0051248 negative regulation of protein metabolic process 23.7500 6 no
GO:1901701 cellular response to oxygen-containing compound 23.7500 4 no
GO:0018193 peptidyl-amino acid modification 22.5000 5 yes
GO:0033674 positive regulation of kinase activity 22.5000 6 yes
GO:0043410 positive regulation of MAPK cascade 22.5000 7 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 22.5000 7 yes
GO:0070848 response to growth factor 22.5000 4 yes
GO:0009968 negative regulation of signal transduction 22.5000 5 no
GO:0050865 regulation of cell activation 22.5000 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.5000 5 no
GO:0032101 regulation of response to external stimulus 22.5000 4 no
GO:0033043 regulation of organelle organization 21.2500 5 no
GO:0044087 regulation of cellular component biogenesis 21.2500 4 no
GO:0045785 positive regulation of cell adhesion 21.2500 5 no
GO:0007010 cytoskeleton organization 21.2500 5 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 20.0000 8 yes
GO:0071363 cellular response to growth factor stimulus 20.0000 5 yes
GO:0034330 cell junction organization 18.7500 4 yes
GO:0045893 positive regulation of DNA-templated transcription 18.7500 7 yes
GO:0051254 positive regulation of RNA metabolic process 18.7500 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 18.7500 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 18.7500 8 yes
GO:0008285 negative regulation of cell population proliferation 18.7500 5 yes
GO:0018108 peptidyl-tyrosine phosphorylation 17.5000 6 yes
GO:0018212 peptidyl-tyrosine modification 17.5000 6 yes
GO:0046777 protein autophosphorylation 16.2500 6 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 16.2500 9 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 16.2500 8 yes
GO:0034329 cell junction assembly 15.0000 5 yes
GO:1903829 positive regulation of protein localization 15.0000 5 yes
GO:0050808 synapse organization 11.2500 5 yes
GO:0019216 regulation of lipid metabolic process 10.0000 5 yes
GO:0048638 regulation of developmental growth 10.0000 4 yes
GO:0045834 positive regulation of lipid metabolic process 8.7500 5 yes
GO:0046903 secretion 8.7500 4 yes
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 7.5000 6 yes
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 7.5000 7 yes
GO:0030182 neuron differentiation 7.5000 4 yes
GO:0043550 regulation of lipid kinase activity 7.5000 6 yes
GO:0043551 regulation of phosphatidylinositol 3-kinase activity 7.5000 7 yes
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 7.5000 7 yes
GO:0045927 positive regulation of growth 7.5000 4 yes
GO:0090218 positive regulation of lipid kinase activity 7.5000 6 yes
GO:0001667 ameboidal-type cell migration 7.5000 4 yes
GO:0007399 nervous system development 7.5000 4 yes
GO:0007507 heart development 7.5000 4 yes
GO:0030855 epithelial cell differentiation 6.2500 4 yes
GO:0042509 regulation of tyrosine phosphorylation of STAT protein 6.2500 9 yes
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 6.2500 10 yes
GO:0071364 cellular response to epidermal growth factor stimulus 6.2500 4 yes
GO:0007416 synapse assembly 6.2500 6 yes
GO:1904892 regulation of receptor signaling pathway via STAT 5.0000 5 yes
GO:2000008 regulation of protein localization to cell surface 5.0000 6 yes
GO:0007005 mitochondrion organization 5.0000 5 yes
GO:0046425 regulation of receptor signaling pathway via JAK-STAT 3.7500 6 yes
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 3.7500 7 yes
GO:0046620 regulation of organ growth 3.7500 4 yes
GO:0046622 positive regulation of organ growth 3.7500 5 yes
GO:0048639 positive regulation of developmental growth 3.7500 5 yes
GO:0055021 regulation of cardiac muscle tissue growth 3.7500 6 yes
GO:0055023 positive regulation of cardiac muscle tissue growth 3.7500 7 yes
GO:0060043 regulation of cardiac muscle cell proliferation 3.7500 5 yes
GO:0060045 positive regulation of cardiac muscle cell proliferation 3.7500 6 yes
GO:0060420 regulation of heart growth 3.7500 5 yes
GO:0060421 positive regulation of heart growth 3.7500 6 yes
GO:1904894 positive regulation of receptor signaling pathway via STAT 3.7500 6 yes
GO:2000010 positive regulation of protein localization to cell surface 3.7500 6 yes
GO:0001736 establishment of planar polarity 3.7500 4 yes
GO:0007589 body fluid secretion 3.7500 4 yes
GO:0021889 olfactory bulb interneuron differentiation 2.5000 5 yes
GO:0043653 mitochondrial fragmentation involved in apoptotic process 2.5000 7 yes
GO:0060644 mammary gland epithelial cell differentiation 2.5000 5 yes
GO:0061026 cardiac muscle tissue regeneration 2.5000 4 yes
GO:0072046 establishment of planar polarity involved in nephron morphogenesis 2.5000 5 yes
GO:0090497 mesenchymal cell migration 2.5000 5 yes
GO:0001755 neural crest cell migration 2.5000 6 yes
GO:0007595 lactation 2.5000 5 yes
GO:0008637 apoptotic mitochondrial changes 2.5000 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in ERBB4_HUMAN
DOID:331 central nervous system disease 5.0000 3 yes
DOID:1289 neurodegenerative disease 3.7500 4 yes
DOID:0060210 amyotrophic lateral sclerosis type 19 2.5000 7 yes
DOID:231 motor neuron disease 2.5000 5 yes
DOID:332 amyotrophic lateral sclerosis 2.5000 6 yes
DOID:0050686 organ system cancer 2.5000 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ESR1_HUMAN [view interactions] Low throughput no no
RNF41_HUMAN [view interactions] Low throughput no yes
VANG1_HUMAN [view interactions] Low throughput no no
XPO1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN21_HUMAN [view interactions] Low throughput no yes
ASAP2_HUMAN [view interactions] Low throughput no yes
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
NTRK2_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRG2_HUMAN [view entry] [view interactions] Low throughput yes no
KALRN_HUMAN [view entry] [view interactions] Low throughput yes yes
LRIG3_HUMAN [view interactions] Low throughput no yes
NRG1_HUMAN [view entry] [view interactions] Low throughput yes no
NRG2_HUMAN [view interactions] Low throughput no yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
YAP1_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
SNTB2_HUMAN [view entry] [view interactions] Low throughput yes no
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
WWOX_HUMAN [view interactions] Low throughput no yes
LRIG1_HUMAN [view interactions] Low throughput no yes
S10A4_HUMAN [view entry] [view interactions] Low throughput yes no
HBEGF_HUMAN [view interactions] Low throughput no no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
SHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
BYST_HUMAN [view interactions] Low throughput no yes
TROAP_HUMAN [view interactions] Low throughput no yes
GRB7_HUMAN [view interactions] Low throughput no no
EGFR_HUMAN [view interactions] Low throughput no no
ERBB2_HUMAN [view entry] [view interactions] Low throughput yes no
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
TROP_HUMAN [view interactions] Low throughput no no
ERBB4_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN6_HUMAN [view interactions] Low throughput no no
TAB2_HUMAN [view interactions] Low throughput no yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
STA5A_HUMAN [view interactions] Low throughput no no
CD44_HUMAN [view interactions] Low throughput no yes
MUC1_HUMAN [view interactions] Low throughput no no
EREG_HUMAN [view interactions] Low throughput no no
ITCH_HUMAN [view interactions] Low throughput no yes
WWP1_HUMAN [view interactions] Low throughput no yes
NCOR1_HUMAN [view interactions] Low throughput no yes
PIAS3_HUMAN [view interactions] Low throughput no yes
PIAS4_HUMAN [view interactions] Low throughput no yes
TIF1B_HUMAN [view interactions] Low throughput no yes
MDM2_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
UBP8_HUMAN [view entry] [view interactions] Low throughput yes no
CBL_HUMAN [view interactions] Low throughput no yes
AP2A_HUMAN [view interactions] Low throughput no no
AP2C_HUMAN [view interactions] Low throughput no no
PTPRZ_HUMAN [view entry] [view interactions] Low throughput yes yes
TRI66_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
EDA_HUMAN [view interactions] High throughput no no
GRM2_HUMAN [view entry] [view interactions] High throughput yes yes
BCAR3_HUMAN [view interactions] High throughput no yes
BLK_HUMAN [view interactions] High throughput no no
FES_HUMAN [view entry] [view interactions] High throughput yes no
FGR_HUMAN [view interactions] High throughput no no
GRAP2_HUMAN [view interactions] High throughput no no
GRB10_HUMAN [view entry] [view interactions] High throughput yes yes
HCK_HUMAN [view entry] [view interactions] High throughput yes no
HSH2D_HUMAN [view interactions] High throughput no no
SHIP2_HUMAN [view interactions] High throughput no yes
ITK_HUMAN [view interactions] High throughput no no
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LCP2_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MATK_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
P55G_HUMAN [view interactions] High throughput no yes
PLCG1_HUMAN [view entry] [view interactions] High throughput yes yes
PLCG2_HUMAN [view interactions] High throughput no yes
PTK6_HUMAN [view interactions] High throughput no yes
SH2B1_HUMAN [view interactions] High throughput no yes
SH2B2_HUMAN [view interactions] High throughput no no
SH2B3_HUMAN [view interactions] High throughput no yes
SH21A_HUMAN [view interactions] High throughput no no
SH21B_HUMAN [view interactions] High throughput no no
SH22A_HUMAN [view interactions] High throughput no no
SH2D3_HUMAN [view interactions] High throughput no no
3BP2_HUMAN [view interactions] High throughput no yes
SHB_HUMAN [view interactions] High throughput no yes
SHC2_HUMAN [view interactions] High throughput no yes
SHC3_HUMAN [view interactions] High throughput no yes
SHC4_HUMAN [view entry] [view interactions] High throughput yes no
SHD_HUMAN [view interactions] High throughput no no
SLAP1_HUMAN [view interactions] High throughput no yes
SLAP2_HUMAN [view interactions] High throughput no no
SOCS1_HUMAN [view interactions] High throughput no yes
SOCS2_HUMAN [view interactions] High throughput no yes
SOCS3_HUMAN [view interactions] High throughput no yes
SOCS5_HUMAN [view interactions] High throughput no yes
SOCS6_HUMAN [view interactions] High throughput no yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
STAP1_HUMAN [view interactions] High throughput no no
TEC_HUMAN [view interactions] High throughput no yes
TNS2_HUMAN [view interactions] High throughput no no
TENS1_HUMAN [view interactions] High throughput no no
TENS3_HUMAN [view interactions] High throughput no no
TENS4_HUMAN [view interactions] High throughput no no
TXK_HUMAN [view interactions] High throughput no no
VAV_HUMAN [view interactions] High throughput no no
VAV2_HUMAN [view entry] [view interactions] High throughput yes yes
VAV3_HUMAN [view interactions] High throughput no yes
ZAP70_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
NUDC1_HUMAN [view interactions] High throughput no no
GOLM1_HUMAN [view interactions] High throughput no yes
CH10_HUMAN [view interactions] High throughput no yes
CRKL_HUMAN [view entry] [view interactions] High throughput yes yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
STA5B_HUMAN [view interactions] High throughput no yes
P85B_HUMAN [view interactions] High throughput no yes
LANC1_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
BORG4_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
AHNK_HUMAN [view entry] [view interactions] High throughput yes yes
TRI47_HUMAN [view interactions] High throughput no yes
STXB2_HUMAN [view interactions] High throughput no no
IPO7_HUMAN [view entry] [view interactions] High throughput yes yes
NUCL_HUMAN [view interactions] High throughput no yes
YES_HUMAN [view entry] [view interactions] High throughput yes yes
SYCM_HUMAN [view interactions] High throughput no yes
HNRH3_HUMAN [view interactions] High throughput no no
ERBB3_HUMAN [view interactions] High throughput no yes
CD9_HUMAN [view entry] [view interactions] High throughput yes no
HDAC6_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
COF1_HUMAN [view entry] [view interactions] High throughput yes no
PTPRH_HUMAN [view interactions] High throughput no no
PTPRT_HUMAN [view entry] [view interactions] High throughput yes yes
DUS14_HUMAN [view interactions] High throughput no yes
DUS10_HUMAN [view entry] [view interactions] High throughput yes yes
MPIP3_HUMAN [view interactions] High throughput no yes
DUS18_HUMAN [view interactions] High throughput no yes
DUS16_HUMAN [view interactions] High throughput no yes
PTN12_HUMAN [view interactions] High throughput no yes
DUS21_HUMAN [view interactions] High throughput no no
DUS6_HUMAN [view interactions] High throughput no yes
ILKAP_HUMAN [view interactions] High throughput no yes
MTMR2_HUMAN [view entry] [view interactions] High throughput yes no
MTMR6_HUMAN [view interactions] High throughput no no
MTMR9_HUMAN [view interactions] High throughput no no
PPM1A_HUMAN [view interactions] High throughput no yes
PPM1B_HUMAN [view interactions] High throughput no yes
PPM1F_HUMAN [view interactions] High throughput no yes
PTPC1_HUMAN [view interactions] High throughput no yes
DUS19_HUMAN [view interactions] High throughput no yes
PTPRR_HUMAN [view interactions] High throughput no yes
STYX_HUMAN [view interactions] High throughput no yes
TAB1_HUMAN [view interactions] High throughput no yes
PTN7_HUMAN [view interactions] High throughput no no
ZN532_HUMAN [view interactions] High throughput no yes
THIO_HUMAN [view interactions] High throughput no yes
TM14A_HUMAN [view interactions] High throughput no yes
TM134_HUMAN [view interactions] High throughput no yes
SYNEM_HUMAN [view entry] [view interactions] High throughput yes no
AP180_HUMAN [view entry] [view interactions] High throughput yes yes
SELK_HUMAN [view interactions] High throughput no yes
S10AA_HUMAN [view interactions] High throughput no no
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
TMG4_HUMAN [view interactions] High throughput no yes
PRDX5_HUMAN [view entry] [view interactions] High throughput yes yes
PIN4_HUMAN [view interactions] High throughput no yes
LRRC7_HUMAN [view entry] [view interactions] High throughput yes no
I2BP2_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
FKB1A_HUMAN [view interactions] High throughput no yes
TV23B_HUMAN [view interactions] High throughput no no
TMA7_HUMAN [view interactions] High throughput no no
SIM20_HUMAN [view interactions] High throughput no yes
TM230_HUMAN [view interactions] High throughput no yes
ERG28_HUMAN [view interactions] High throughput no yes
F241B_HUMAN [view interactions] High throughput no yes
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
ABL2_HUMAN [view entry] [view interactions] High throughput yes yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
KSYK_HUMAN [view interactions] High throughput no no
RASA1_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1A_HUMAN [view interactions] High throughput no yes
PTN20_HUMAN [view interactions] High throughput no yes
MUC4_HUMAN [view interactions] High throughput no no
S10AB_HUMAN [view interactions] High throughput no no
CRK_HUMAN [view entry] [view interactions] High throughput yes no
NCK1_HUMAN [view interactions] High throughput no yes
TGFA_HUMAN [view interactions] Computational no yes
BTC_HUMAN [view interactions] Computational no no
NICA_HUMAN [view interactions] Computational no yes
PK3CA_HUMAN [view entry] [view interactions] Computational yes yes
PSN2_HUMAN [view entry] [view interactions] Computational yes no
ERBIN_HUMAN [view entry] [view interactions] Computational yes yes
SDF1_HUMAN [view interactions] Computational no no
NMDE3_HUMAN [view entry] [view interactions] Computational yes no
PRGR_HUMAN [view interactions] Computational no no
PRLR_HUMAN [view interactions] Computational no no
S100B_HUMAN [view entry] [view interactions] Computational yes yes
RASK_HUMAN [view entry] [view interactions] Computational yes no
APH1A_HUMAN [view interactions] Computational no yes
PEN2_HUMAN [view interactions] Computational no yes
PRL_HUMAN [view interactions] Computational no no
KPCA_HUMAN [view entry] [view interactions] Computational yes yes
JAK2_HUMAN [view entry] [view interactions] Computational yes yes
PGS2_HUMAN [view interactions] Computational no no
MAD4_HUMAN [view interactions] Computational no no
AREG_HUMAN [view interactions] Computational no no
RASH_HUMAN [view entry] [view interactions] Computational yes no
MK03_HUMAN [view entry] [view interactions] Computational yes yes
PSN1_HUMAN [view entry] [view interactions] Computational yes yes
NMDE1_HUMAN [view entry] [view interactions] Computational yes yes
NRG3_HUMAN [view interactions] Computational no no
EGF_HUMAN [view interactions] Computational no no
MTG16_HUMAN [view interactions] Computational no yes
NRG4_HUMAN [view interactions] Computational no no
ADAP1_HUMAN [view interactions] Computational no yes
CASB_HUMAN [view interactions] Computational no no
CDC37_HUMAN [view interactions] Computational no yes
SPRC_HUMAN [view interactions] Computational no yes
MK01_HUMAN [view entry] [view interactions] Computational yes yes
APH1B_HUMAN [view interactions] Computational no no
APOE_HUMAN [view entry] [view interactions] Computational yes yes
RASN_HUMAN [view entry] [view interactions] Computational yes no
NMDE2_HUMAN [view entry] [view interactions] Computational yes no
PK3CB_HUMAN [view interactions] Computational no yes
ADA17_HUMAN [view interactions] Computational no yes
STMN1_HUMAN [view interactions] Computational no yes