Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ERBB4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
927 Arg Gln Amyotrophiclateralsclerosis19(ALS19) -
1275 Arg Trp Amyotrophiclateralsclerosis19(ALS19) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI003701 LIG_SH2_GRB2like LIG 1188 1191 -
ELMI003702 LIG_SH2_GRB2like LIG 1242 1245 -
ELMI002194 LIG_SH2_STAT5 LIG 1056 1059 -
ELMI002135 LIG_WW_1 LIG 1053 1056 -
ELMI003701 LIG_SH2_GRB2like LIG 1188 1191 -
ELMI003702 LIG_SH2_GRB2like LIG 1242 1245 -
ELMI002194 LIG_SH2_STAT5 LIG 1056 1059 -
ELMI002135 LIG_WW_1 LIG 1053 1056 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ERBB4_HUMAN
GO:0019900 kinase binding 38.0282 4 no
GO:0019901 protein kinase binding 32.3944 5 no
GO:0043168 anion binding 29.5775 4 yes
GO:0000166 nucleotide binding 26.7606 4 yes
GO:0017076 purine nucleotide binding 26.7606 5 yes
GO:0030554 adenyl nucleotide binding 26.7606 6 yes
GO:0005524 ATP binding 25.3521 5 yes
GO:0016301 kinase activity 25.3521 4 yes
GO:0032555 purine ribonucleotide binding 25.3521 4 yes
GO:0032559 adenyl ribonucleotide binding 25.3521 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 25.3521 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 22.5352 4 yes
GO:0045309 protein phosphorylated amino acid binding 21.1268 4 no
GO:0004713 protein tyrosine kinase activity 19.7183 4 yes
GO:0042803 protein homodimerization activity 9.8592 4 yes
GO:0070851 growth factor receptor binding 9.8592 4 yes
GO:0005154 epidermal growth factor receptor binding 7.0423 5 yes
GO:0003677 DNA binding 5.6338 4 yes
GO:0003690 double-stranded DNA binding 5.6338 5 yes
GO:0004714 transmembrane receptor protein tyrosine kinase activity 5.6338 5 yes
GO:0019199 transmembrane receptor protein kinase activity 5.6338 4 yes
GO:0043565 sequence-specific DNA binding 5.6338 5 yes
GO:1990837 sequence-specific double-stranded DNA binding 5.6338 6 yes
GO:0000976 transcription cis-regulatory region binding 4.2254 5 yes
GO:0001067 transcription regulatory region nucleic acid binding 4.2254 4 yes
GO:0050811 GABA receptor binding 4.2254 4 yes
GO:0005006 epidermal growth factor receptor activity 2.8169 6 yes
GO:0038131 neuregulin receptor activity 2.8169 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ERBB4_HUMAN
GO:0048522 positive regulation of cellular process 73.2394 4 yes
GO:0048523 negative regulation of cellular process 64.7887 4 yes
GO:0060255 regulation of macromolecule metabolic process 64.7887 4 yes
GO:0031323 regulation of cellular metabolic process 61.9718 4 yes
GO:0080090 regulation of primary metabolic process 61.9718 4 yes
GO:0010646 regulation of cell communication 60.5634 4 yes
GO:0009966 regulation of signal transduction 57.7465 4 yes
GO:0051128 regulation of cellular component organization 52.1127 4 no
GO:0048584 positive regulation of response to stimulus 50.7042 4 yes
GO:0009889 regulation of biosynthetic process 47.8873 4 yes
GO:0009893 positive regulation of metabolic process 47.8873 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 47.8873 5 yes
GO:0031326 regulation of cellular biosynthetic process 47.8873 5 yes
GO:0051246 regulation of protein metabolic process 47.8873 5 yes
GO:1902531 regulation of intracellular signal transduction 47.8873 5 yes
GO:0010468 regulation of gene expression 45.0704 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 43.6620 5 yes
GO:0009967 positive regulation of signal transduction 42.2535 5 yes
GO:0010647 positive regulation of cell communication 42.2535 5 yes
GO:0023056 positive regulation of signaling 42.2535 4 yes
GO:0009892 negative regulation of metabolic process 42.2535 4 no
GO:0010605 negative regulation of macromolecule metabolic process 42.2535 5 no
GO:0031325 positive regulation of cellular metabolic process 40.8451 5 yes
GO:0051049 regulation of transport 40.8451 4 no
GO:0036211 protein modification process 39.4366 4 yes
GO:0043412 macromolecule modification 39.4366 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 38.0282 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 38.0282 5 yes
GO:0042127 regulation of cell population proliferation 38.0282 4 yes
GO:0042981 regulation of apoptotic process 38.0282 5 yes
GO:0043067 regulation of programmed cell death 38.0282 4 yes
GO:0019220 regulation of phosphate metabolic process 36.6197 6 yes
GO:0022607 cellular component assembly 36.6197 4 yes
GO:0031399 regulation of protein modification process 36.6197 6 yes
GO:0051174 regulation of phosphorus metabolic process 36.6197 5 yes
GO:0051247 positive regulation of protein metabolic process 36.6197 6 yes
GO:0006796 phosphate-containing compound metabolic process 36.6197 4 yes
GO:0051240 positive regulation of multicellular organismal process 35.2113 4 yes
GO:1902533 positive regulation of intracellular signal transduction 35.2113 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.8028 5 yes
GO:0031324 negative regulation of cellular metabolic process 33.8028 5 no
GO:0006996 organelle organization 33.8028 4 yes
GO:0008104 protein localization 32.3944 4 yes
GO:0042325 regulation of phosphorylation 32.3944 7 yes
GO:0060341 regulation of cellular localization 32.3944 4 yes
GO:2000026 regulation of multicellular organismal development 32.3944 4 yes
GO:0048585 negative regulation of response to stimulus 32.3944 4 no
GO:0010648 negative regulation of cell communication 30.9859 5 no
GO:0023057 negative regulation of signaling 30.9859 4 no
GO:0001932 regulation of protein phosphorylation 30.9859 7 yes
GO:0051094 positive regulation of developmental process 29.5775 4 yes
GO:0051130 positive regulation of cellular component organization 29.5775 5 no
GO:0022603 regulation of anatomical structure morphogenesis 29.5775 4 no
GO:0008284 positive regulation of cell population proliferation 28.1690 5 yes
GO:0009891 positive regulation of biosynthetic process 28.1690 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 28.1690 6 yes
GO:0031401 positive regulation of protein modification process 28.1690 7 yes
GO:0032880 regulation of protein localization 28.1690 5 yes
GO:0043066 negative regulation of apoptotic process 28.1690 6 yes
GO:0043069 negative regulation of programmed cell death 28.1690 5 yes
GO:0045937 positive regulation of phosphate metabolic process 28.1690 7 yes
GO:0051252 regulation of RNA metabolic process 28.1690 5 yes
GO:0051248 negative regulation of protein metabolic process 28.1690 6 no
GO:0002684 positive regulation of immune system process 28.1690 4 no
GO:0031344 regulation of cell projection organization 28.1690 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 26.7606 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 26.7606 6 yes
GO:0042327 positive regulation of phosphorylation 26.7606 8 yes
GO:0043408 regulation of MAPK cascade 26.7606 6 yes
GO:2001141 regulation of RNA biosynthetic process 26.7606 6 yes
GO:0071310 cellular response to organic substance 26.7606 4 no
GO:0030155 regulation of cell adhesion 26.7606 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.7606 6 no
GO:0006355 regulation of DNA-templated transcription 26.7606 7 yes
GO:0071363 cellular response to growth factor stimulus 25.3521 4 yes
GO:2000145 regulation of cell motility 25.3521 4 yes
GO:0045595 regulation of cell differentiation 25.3521 4 no
GO:0009968 negative regulation of signal transduction 25.3521 5 no
GO:0080134 regulation of response to stress 25.3521 4 no
GO:0050776 regulation of immune response 25.3521 4 no
GO:0001934 positive regulation of protein phosphorylation 25.3521 8 yes
GO:0016310 phosphorylation 23.9437 5 yes
GO:0030334 regulation of cell migration 23.9437 5 yes
GO:0009890 negative regulation of biosynthetic process 23.9437 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.9437 6 no
GO:0031327 negative regulation of cellular biosynthetic process 23.9437 6 no
GO:0141124 intracellular signaling cassette 23.9437 4 no
GO:0030030 cell projection organization 22.5352 4 no
GO:0045785 positive regulation of cell adhesion 22.5352 5 no
GO:0018193 peptidyl-amino acid modification 21.1268 5 yes
GO:0033365 protein localization to organelle 21.1268 5 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 21.1268 7 yes
GO:1903829 positive regulation of protein localization 21.1268 5 yes
GO:0043933 protein-containing complex organization 21.1268 4 no
GO:0120036 plasma membrane bounded cell projection organization 21.1268 5 no
GO:0010243 response to organonitrogen compound 21.1268 4 no
GO:0010975 regulation of neuron projection development 21.1268 7 no
GO:0032101 regulation of response to external stimulus 21.1268 4 no
GO:0006468 protein phosphorylation 21.1268 5 yes
GO:0043410 positive regulation of MAPK cascade 19.7183 7 yes
GO:0008285 negative regulation of cell population proliferation 18.3099 5 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 18.3099 8 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 18.3099 9 yes
GO:0018108 peptidyl-tyrosine phosphorylation 16.9014 6 yes
GO:0018212 peptidyl-tyrosine modification 16.9014 6 yes
GO:0038127 ERBB signaling pathway 16.9014 6 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 16.9014 5 yes
GO:0034330 cell junction organization 15.4930 4 yes
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 15.4930 6 yes
GO:0072657 protein localization to membrane 15.4930 4 yes
GO:0046777 protein autophosphorylation 14.0845 6 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 14.0845 8 yes
GO:0034329 cell junction assembly 12.6761 5 yes
GO:0045893 positive regulation of DNA-templated transcription 12.6761 8 yes
GO:0051254 positive regulation of RNA metabolic process 12.6761 6 yes
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 12.6761 7 yes
GO:1902680 positive regulation of RNA biosynthetic process 12.6761 7 yes
GO:0030182 neuron differentiation 9.8592 4 yes
GO:0035418 protein localization to synapse 9.8592 6 yes
GO:0045927 positive regulation of growth 9.8592 4 yes
GO:0046903 secretion 9.8592 4 yes
GO:1902414 protein localization to cell junction 9.8592 5 yes
GO:0007399 nervous system development 8.4507 4 yes
GO:0007507 heart development 8.4507 4 yes
GO:0048638 regulation of developmental growth 8.4507 4 yes
GO:0050808 synapse organization 8.4507 5 yes
GO:0062237 protein localization to postsynapse 8.4507 7 yes
GO:1903539 protein localization to postsynaptic membrane 8.4507 5 yes
GO:1990778 protein localization to cell periphery 8.4507 5 yes
GO:0030855 epithelial cell differentiation 7.0423 4 yes
GO:0038128 ERBB2 signaling pathway 7.0423 7 yes
GO:0070849 response to epidermal growth factor 7.0423 4 yes
GO:0071364 cellular response to epidermal growth factor stimulus 7.0423 5 yes
GO:0099633 protein localization to postsynaptic specialization membrane 7.0423 6 yes
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 7.0423 4 yes
GO:0001667 ameboidal-type cell migration 7.0423 4 yes
GO:0007005 mitochondrion organization 7.0423 5 yes
GO:0022008 neurogenesis 5.6338 4 yes
GO:0038130 ERBB4 signaling pathway 5.6338 7 yes
GO:0038135 ERBB2-ERBB4 signaling pathway 5.6338 8 yes
GO:0042509 regulation of tyrosine phosphorylation of STAT protein 5.6338 9 yes
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 5.6338 10 yes
GO:2000008 regulation of protein localization to cell surface 5.6338 6 yes
GO:0007416 synapse assembly 4.2254 6 yes
GO:0007589 body fluid secretion 4.2254 4 yes
GO:0008637 apoptotic mitochondrial changes 4.2254 6 yes
GO:0038138 ERBB4-ERBB4 signaling pathway 4.2254 8 yes
GO:0046620 regulation of organ growth 4.2254 4 yes
GO:0046622 positive regulation of organ growth 4.2254 5 yes
GO:0048639 positive regulation of developmental growth 4.2254 5 yes
GO:0055021 regulation of cardiac muscle tissue growth 4.2254 6 yes
GO:0055023 positive regulation of cardiac muscle tissue growth 4.2254 7 yes
GO:0060043 regulation of cardiac muscle cell proliferation 4.2254 5 yes
GO:0060045 positive regulation of cardiac muscle cell proliferation 4.2254 6 yes
GO:0060420 regulation of heart growth 4.2254 5 yes
GO:0060421 positive regulation of heart growth 4.2254 6 yes
GO:1904892 regulation of receptor signaling pathway via STAT 4.2254 5 yes
GO:2000010 positive regulation of protein localization to cell surface 4.2254 6 yes
GO:0001736 establishment of planar polarity 4.2254 4 yes
GO:0007595 lactation 2.8169 5 yes
GO:0021889 olfactory bulb interneuron differentiation 2.8169 5 yes
GO:0043653 mitochondrial fragmentation involved in apoptotic process 2.8169 7 yes
GO:0046425 regulation of receptor signaling pathway via JAK-STAT 2.8169 6 yes
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 2.8169 7 yes
GO:0060644 mammary gland epithelial cell differentiation 2.8169 5 yes
GO:0061026 cardiac muscle tissue regeneration 2.8169 4 yes
GO:0072046 establishment of planar polarity involved in nephron morphogenesis 2.8169 5 yes
GO:0090497 mesenchymal cell migration 2.8169 5 yes
GO:1904894 positive regulation of receptor signaling pathway via STAT 2.8169 6 yes
GO:0001755 neural crest cell migration 2.8169 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
SNTB2_HUMAN [view entry] [view interactions] Low throughput yes no
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
WWOX_HUMAN [view interactions] Low throughput no yes
LRIG1_HUMAN [view interactions] Low throughput no yes
S10A4_HUMAN [view entry] [view interactions] Low throughput yes no
HBEGF_HUMAN [view interactions] Low throughput no no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
SHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
BYST_HUMAN [view interactions] Low throughput no yes
TROAP_HUMAN [view interactions] Low throughput no yes
GRB7_HUMAN [view interactions] Low throughput no no
EGFR_HUMAN [view interactions] Low throughput no no
ERBB2_HUMAN [view entry] [view interactions] Low throughput yes no
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
TROP_HUMAN [view interactions] Low throughput no no
ERBB4_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN6_HUMAN [view interactions] Low throughput no no
YAP1_HUMAN [view interactions] Low throughput no yes
TAB2_HUMAN [view interactions] Low throughput no yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
STA5A_HUMAN [view interactions] Low throughput no no
CD44_HUMAN [view entry] [view interactions] Low throughput yes yes
MUC1_HUMAN [view interactions] Low throughput no no
EREG_HUMAN [view interactions] Low throughput no no
ITCH_HUMAN [view interactions] Low throughput no yes
WWP1_HUMAN [view interactions] Low throughput no yes
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
NCOR1_HUMAN [view interactions] Low throughput no yes
PIAS3_HUMAN [view entry] [view interactions] Low throughput yes yes
PIAS4_HUMAN [view interactions] Low throughput no yes
TIF1B_HUMAN [view interactions] Low throughput no yes
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
P53_HUMAN [view interactions] Low throughput no no
UBP8_HUMAN [view entry] [view interactions] Low throughput yes no
CBL_HUMAN [view interactions] Low throughput no yes
AP2A_HUMAN [view interactions] Low throughput no no
AP2C_HUMAN [view interactions] Low throughput no no
PTPRZ_HUMAN [view entry] [view interactions] Low throughput yes yes
ESR1_HUMAN [view interactions] Low throughput no no
RNF41_HUMAN [view interactions] Low throughput no yes
VANG1_HUMAN [view interactions] Low throughput no no
XPO1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN21_HUMAN [view interactions] Low throughput no yes
ASAP2_HUMAN [view interactions] Low throughput no yes
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
NTRK2_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRG2_HUMAN [view entry] [view interactions] Low throughput yes no
KALRN_HUMAN [view entry] [view interactions] Low throughput yes yes
LRIG3_HUMAN [view interactions] Low throughput no yes
NRG1_HUMAN [view entry] [view interactions] Low throughput yes no
NRG2_HUMAN [view interactions] Low throughput no yes
FES_HUMAN [view entry] [view interactions] High throughput yes no
FGR_HUMAN [view interactions] High throughput no no
GRAP2_HUMAN [view interactions] High throughput no no
GRB10_HUMAN [view entry] [view interactions] High throughput yes yes
HCK_HUMAN [view entry] [view interactions] High throughput yes no
HSH2D_HUMAN [view interactions] High throughput no no
SHIP2_HUMAN [view interactions] High throughput no yes
ITK_HUMAN [view interactions] High throughput no no
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LCP2_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MATK_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
P55G_HUMAN [view interactions] High throughput no yes
PLCG1_HUMAN [view entry] [view interactions] High throughput yes yes
PLCG2_HUMAN [view interactions] High throughput no yes
PTK6_HUMAN [view interactions] High throughput no yes
SH2B1_HUMAN [view interactions] High throughput no yes
SH2B2_HUMAN [view interactions] High throughput no yes
SH2B3_HUMAN [view interactions] High throughput no yes
SH21A_HUMAN [view interactions] High throughput no no
SH21B_HUMAN [view interactions] High throughput no no
SH22A_HUMAN [view interactions] High throughput no no
SH2D3_HUMAN [view interactions] High throughput no no
3BP2_HUMAN [view interactions] High throughput no yes
SHB_HUMAN [view interactions] High throughput no yes
SHC2_HUMAN [view interactions] High throughput no yes
SHC3_HUMAN [view interactions] High throughput no yes
SHC4_HUMAN [view entry] [view interactions] High throughput yes no
SHD_HUMAN [view interactions] High throughput no no
SLAP1_HUMAN [view interactions] High throughput no yes
SLAP2_HUMAN [view interactions] High throughput no no
SOCS1_HUMAN [view interactions] High throughput no yes
SOCS2_HUMAN [view interactions] High throughput no yes
SOCS3_HUMAN [view interactions] High throughput no yes
SOCS5_HUMAN [view interactions] High throughput no yes
SOCS6_HUMAN [view interactions] High throughput no yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
STAP1_HUMAN [view interactions] High throughput no no
TEC_HUMAN [view interactions] High throughput no yes
TENS2_HUMAN [view interactions] High throughput no no
TENS1_HUMAN [view interactions] High throughput no no
TENS3_HUMAN [view interactions] High throughput no no
TENS4_HUMAN [view interactions] High throughput no no
TXK_HUMAN [view interactions] High throughput no no
VAV_HUMAN [view interactions] High throughput no no
VAV2_HUMAN [view entry] [view interactions] High throughput yes yes
VAV3_HUMAN [view interactions] High throughput no yes
ZAP70_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
NUDC1_HUMAN [view interactions] High throughput no no
GOLM1_HUMAN [view interactions] High throughput no yes
CH10_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
CRKL_HUMAN [view entry] [view interactions] High throughput yes yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
STA5B_HUMAN [view interactions] High throughput no yes
P85B_HUMAN [view interactions] High throughput no yes
HNRH3_HUMAN [view interactions] High throughput no no
YES_HUMAN [view entry] [view interactions] High throughput yes yes
NUCL_HUMAN [view interactions] High throughput no yes
IPO7_HUMAN [view entry] [view interactions] High throughput yes yes
STXB2_HUMAN [view interactions] High throughput no no
TRI47_HUMAN [view entry] [view interactions] High throughput yes yes
LANC1_HUMAN [view entry] [view interactions] High throughput yes yes
AHNK_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
BORG4_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB3_HUMAN [view interactions] High throughput no yes
CD9_HUMAN [view entry] [view interactions] High throughput yes no
HDAC6_HUMAN [view interactions] High throughput no yes
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
COF1_HUMAN [view entry] [view interactions] High throughput yes no
PTPRH_HUMAN [view interactions] High throughput no no
PTPRT_HUMAN [view entry] [view interactions] High throughput yes yes
DUS18_HUMAN [view interactions] High throughput no yes
MPIP3_HUMAN [view interactions] High throughput no yes
DUS10_HUMAN [view entry] [view interactions] High throughput yes yes
DUS14_HUMAN [view interactions] High throughput no yes
DUS16_HUMAN [view interactions] High throughput no yes
STYX_HUMAN [view interactions] High throughput no yes
PTPC1_HUMAN [view interactions] High throughput no yes
PPM1F_HUMAN [view interactions] High throughput no yes
PPM1B_HUMAN [view interactions] High throughput no yes
PPM1A_HUMAN [view interactions] High throughput no yes
MTMR9_HUMAN [view interactions] High throughput no no
MTMR6_HUMAN [view interactions] High throughput no no
MTMR2_HUMAN [view entry] [view interactions] High throughput yes no
ILKAP_HUMAN [view interactions] High throughput no yes
DUS6_HUMAN [view interactions] High throughput no yes
DUS21_HUMAN [view interactions] High throughput no no
DUS19_HUMAN [view interactions] High throughput no yes
PTN12_HUMAN [view interactions] High throughput no yes
PTPRR_HUMAN [view interactions] High throughput no yes
TAB1_HUMAN [view interactions] High throughput no yes
PTN7_HUMAN [view interactions] High throughput no no
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
F241B_HUMAN [view interactions] High throughput no yes
ERG28_HUMAN [view interactions] High throughput no yes
TM230_HUMAN [view interactions] High throughput no yes
SIM20_HUMAN [view interactions] High throughput no yes
TMA7_HUMAN [view interactions] High throughput no no
TV23B_HUMAN [view interactions] High throughput no no
FKB1A_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
I2BP2_HUMAN [view interactions] High throughput no yes
LRRC7_HUMAN [view entry] [view interactions] High throughput yes no
PIN4_HUMAN [view interactions] High throughput no yes
PRDX5_HUMAN [view entry] [view interactions] High throughput yes yes
TMG4_HUMAN [view interactions] High throughput no yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
S10AA_HUMAN [view interactions] High throughput no no
SELK_HUMAN [view interactions] High throughput no yes
AP180_HUMAN [view entry] [view interactions] High throughput yes yes
SYNEM_HUMAN [view entry] [view interactions] High throughput yes no
TM134_HUMAN [view interactions] High throughput no yes
TM14A_HUMAN [view interactions] High throughput no yes
THIO_HUMAN [view interactions] High throughput no yes
ZN532_HUMAN [view interactions] High throughput no yes
ABL2_HUMAN [view entry] [view interactions] High throughput yes yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
KSYK_HUMAN [view interactions] High throughput no no
RASA1_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1A_HUMAN [view interactions] High throughput no yes
PTN20_HUMAN [view interactions] High throughput no yes
MUC4_HUMAN [view interactions] High throughput no no
S10AB_HUMAN [view interactions] High throughput no no
CRK_HUMAN [view entry] [view interactions] High throughput yes no
NCK1_HUMAN [view interactions] High throughput no yes
TRI66_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
EDA_HUMAN [view interactions] High throughput no no
GRM2_HUMAN [view entry] [view interactions] High throughput yes yes
BCAR3_HUMAN [view interactions] High throughput no yes
BLK_HUMAN [view interactions] High throughput no no