Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PTN11_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed, PubMed, PubMed, PubMed, PubMed). Positively regulates MAPK signal transduction pathway (PubMed). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed). Dephosphorylates ROCK2 at Tyr-722 resulting in stimulation of its RhoA binding activity (PubMed). Dephosphorylates CDC73 (PubMed). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI000815 LIG_SH2_GRB2like LIG 546 549 -
ELMI003696 LIG_SH2_GRB2like LIG 584 587 -
ELMI000815 LIG_SH2_GRB2like LIG 546 549 -
ELMI003696 LIG_SH2_GRB2like LIG 584 587 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PTN11_HUMAN
GO:0043168 anion binding 40.0000 4 no
GO:0000166 nucleotide binding 37.7778 4 no
GO:0017076 purine nucleotide binding 37.7778 5 no
GO:0032555 purine ribonucleotide binding 37.0370 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.0370 4 no
GO:0030554 adenyl nucleotide binding 34.0741 6 no
GO:0005524 ATP binding 33.3333 5 no
GO:0032559 adenyl ribonucleotide binding 33.3333 5 no
GO:0003723 RNA binding 31.8519 4 no
GO:0019900 kinase binding 28.1481 4 yes
GO:0019901 protein kinase binding 28.1481 5 yes
GO:0043169 cation binding 22.2222 4 no
GO:0046872 metal ion binding 22.2222 5 no
GO:0016301 kinase activity 20.7407 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 20.7407 4 no
GO:0045296 cadherin binding 17.0370 4 yes
GO:0045309 protein phosphorylated amino acid binding 11.1111 4 yes
GO:1990782 protein tyrosine kinase binding 11.1111 6 yes
GO:0001784 phosphotyrosine residue binding 9.6296 5 yes
GO:0030971 receptor tyrosine kinase binding 8.8889 4 yes
GO:0030159 signaling receptor complex adaptor activity 5.1852 4 yes
GO:0005158 insulin receptor binding 4.4444 4 yes
GO:0042578 phosphoric ester hydrolase activity 4.4444 4 yes
GO:0004725 protein tyrosine phosphatase activity 2.9630 4 yes
GO:0016791 phosphatase activity 2.9630 5 yes
GO:0051427 hormone receptor binding 2.2222 4 yes
GO:0051428 peptide hormone receptor binding 2.2222 5 yes
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 1.4815 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PTN11_HUMAN
GO:0048522 positive regulation of cellular process 67.4074 4 yes
GO:0060255 regulation of macromolecule metabolic process 63.7037 4 yes
GO:0080090 regulation of primary metabolic process 62.2222 4 yes
GO:0031323 regulation of cellular metabolic process 61.4815 4 yes
GO:0048523 negative regulation of cellular process 60.7407 4 yes
GO:0009889 regulation of biosynthetic process 55.5556 4 yes
GO:0010646 regulation of cell communication 54.0741 4 yes
GO:0031326 regulation of cellular biosynthetic process 54.0741 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 53.3333 5 yes
GO:0009966 regulation of signal transduction 51.8519 4 yes
GO:0009893 positive regulation of metabolic process 51.1111 4 yes
GO:0010468 regulation of gene expression 48.1481 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 48.1481 5 yes
GO:0051128 regulation of cellular component organization 45.9259 4 yes
GO:0031325 positive regulation of cellular metabolic process 45.9259 5 yes
GO:0051246 regulation of protein metabolic process 42.9630 5 yes
GO:0048584 positive regulation of response to stimulus 42.2222 4 yes
GO:1902531 regulation of intracellular signal transduction 42.2222 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.5185 5 no
GO:0022607 cellular component assembly 37.0370 4 no
GO:0009891 positive regulation of biosynthetic process 37.0370 5 yes
GO:0009892 negative regulation of metabolic process 37.0370 4 yes
GO:0023056 positive regulation of signaling 37.0370 4 yes
GO:0010647 positive regulation of cell communication 36.2963 5 yes
GO:0051247 positive regulation of protein metabolic process 35.5556 6 yes
GO:0043067 regulation of programmed cell death 35.5556 4 no
GO:0009967 positive regulation of signal transduction 35.5556 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 35.5556 6 yes
GO:0042981 regulation of apoptotic process 34.8148 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 34.8148 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 yes
GO:0042127 regulation of cell population proliferation 32.5926 4 no
GO:0031399 regulation of protein modification process 31.8519 6 yes
GO:0051240 positive regulation of multicellular organismal process 31.8519 4 yes
GO:0006996 organelle organization 31.8519 4 no
GO:0031324 negative regulation of cellular metabolic process 31.8519 5 yes
GO:0006796 phosphate-containing compound metabolic process 31.1111 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 31.1111 4 yes
GO:0051049 regulation of transport 30.3704 4 yes
GO:0051252 regulation of RNA metabolic process 30.3704 5 no
GO:0060341 regulation of cellular localization 29.6296 4 yes
GO:0071310 cellular response to organic substance 29.6296 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 29.6296 5 yes
GO:1902533 positive regulation of intracellular signal transduction 28.8889 6 yes
GO:0048585 negative regulation of response to stimulus 28.8889 4 no
GO:0045595 regulation of cell differentiation 28.1481 4 yes
GO:0051130 positive regulation of cellular component organization 28.1481 5 no
GO:0043412 macromolecule modification 27.4074 4 yes
GO:0051174 regulation of phosphorus metabolic process 27.4074 5 yes
GO:0008104 protein localization 27.4074 4 no
GO:0019220 regulation of phosphate metabolic process 27.4074 6 yes
GO:0036211 protein modification process 26.6667 4 yes
GO:0032880 regulation of protein localization 25.9259 5 yes
GO:0080134 regulation of response to stress 25.9259 4 yes
GO:2000026 regulation of multicellular organismal development 25.9259 4 yes
GO:0043069 negative regulation of programmed cell death 25.9259 5 no
GO:0006355 regulation of DNA-templated transcription 25.9259 7 no
GO:2001141 regulation of RNA biosynthetic process 25.9259 6 no
GO:0009890 negative regulation of biosynthetic process 25.9259 5 yes
GO:0032101 regulation of response to external stimulus 25.1852 4 yes
GO:0043066 negative regulation of apoptotic process 25.1852 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.1852 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 25.1852 6 yes
GO:0051094 positive regulation of developmental process 24.4444 4 no
GO:0033043 regulation of organelle organization 24.4444 5 no
GO:0002684 positive regulation of immune system process 24.4444 4 yes
GO:0031401 positive regulation of protein modification process 23.7037 7 yes
GO:0043933 protein-containing complex organization 23.7037 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.7037 5 no
GO:0010648 negative regulation of cell communication 23.7037 5 yes
GO:0023057 negative regulation of signaling 23.7037 4 yes
GO:0042325 regulation of phosphorylation 22.9630 7 yes
GO:0016310 phosphorylation 22.9630 5 no
GO:0008284 positive regulation of cell population proliferation 22.9630 5 no
GO:2000145 regulation of cell motility 22.9630 4 no
GO:0010628 positive regulation of gene expression 22.9630 7 yes
GO:0030155 regulation of cell adhesion 22.9630 4 yes
GO:0043408 regulation of MAPK cascade 22.2222 6 yes
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0030334 regulation of cell migration 22.2222 5 no
GO:0001932 regulation of protein phosphorylation 22.2222 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 21.4815 4 no
GO:0071702 organic substance transport 21.4815 4 no
GO:0009968 negative regulation of signal transduction 21.4815 5 no
GO:0043085 positive regulation of catalytic activity 21.4815 4 no
GO:0030030 cell projection organization 21.4815 4 yes
GO:0044087 regulation of cellular component biogenesis 20.7407 4 yes
GO:0045937 positive regulation of phosphate metabolic process 20.7407 7 yes
GO:0031344 regulation of cell projection organization 20.7407 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.7407 6 no
GO:0065003 protein-containing complex assembly 20.7407 5 no
GO:0071705 nitrogen compound transport 20.7407 4 no
GO:1901701 cellular response to oxygen-containing compound 20.7407 4 no
GO:0051248 negative regulation of protein metabolic process 20.7407 6 no
GO:0060284 regulation of cell development 20.7407 5 no
GO:0010562 positive regulation of phosphorus metabolic process 20.7407 6 yes
GO:0042327 positive regulation of phosphorylation 20.0000 8 yes
GO:0050776 regulation of immune response 20.0000 4 yes
GO:0120036 plasma membrane bounded cell projection organization 20.0000 5 yes
GO:0010629 negative regulation of gene expression 20.0000 7 yes
GO:0001934 positive regulation of protein phosphorylation 19.2593 8 yes
GO:0043410 positive regulation of MAPK cascade 17.0370 7 yes
GO:0045785 positive regulation of cell adhesion 17.0370 5 yes
GO:0051241 negative regulation of multicellular organismal process 17.0370 4 yes
GO:0051050 positive regulation of transport 16.2963 4 yes
GO:0071363 cellular response to growth factor stimulus 16.2963 4 yes
GO:0050865 regulation of cell activation 15.5556 4 yes
GO:0051249 regulation of lymphocyte activation 15.5556 5 yes
GO:0002694 regulation of leukocyte activation 15.5556 4 yes
GO:0022407 regulation of cell-cell adhesion 15.5556 5 yes
GO:0031347 regulation of defense response 15.5556 5 yes
GO:0050863 regulation of T cell activation 14.8148 6 yes
GO:0051726 regulation of cell cycle 14.8148 4 yes
GO:0051093 negative regulation of developmental process 14.0741 4 yes
GO:0070201 regulation of establishment of protein localization 13.3333 6 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 13.3333 7 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 13.3333 6 yes
GO:0001817 regulation of cytokine production 12.5926 4 yes
GO:0034762 regulation of transmembrane transport 11.8519 4 yes
GO:0038127 ERBB signaling pathway 11.8519 6 yes
GO:0043254 regulation of protein-containing complex assembly 11.8519 5 yes
GO:0045596 negative regulation of cell differentiation 11.8519 5 yes
GO:0007162 negative regulation of cell adhesion 11.8519 5 yes
GO:0050867 positive regulation of cell activation 11.1111 5 yes
GO:0051251 positive regulation of lymphocyte activation 11.1111 6 yes
GO:0002696 positive regulation of leukocyte activation 11.1111 5 yes
GO:0002831 regulation of response to biotic stimulus 11.1111 4 yes
GO:0022409 positive regulation of cell-cell adhesion 11.1111 6 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 10.3704 8 yes
GO:0050870 positive regulation of T cell activation 10.3704 7 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 10.3704 7 yes
GO:0001819 positive regulation of cytokine production 10.3704 5 yes
GO:0019221 cytokine-mediated signaling pathway 10.3704 4 yes
GO:0045088 regulation of innate immune response 9.6296 5 yes
GO:0048812 neuron projection morphogenesis 9.6296 5 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 9.6296 9 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 9.6296 4 yes
GO:0007173 epidermal growth factor receptor signaling pathway 9.6296 7 yes
GO:0010564 regulation of cell cycle process 9.6296 5 yes
GO:0032386 regulation of intracellular transport 8.8889 5 yes
GO:0045787 positive regulation of cell cycle 8.8889 5 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 8.8889 8 yes
GO:0044057 regulation of system process 8.1481 4 yes
GO:0051046 regulation of secretion 8.1481 5 yes
GO:0051051 negative regulation of transport 8.1481 4 yes
GO:1903530 regulation of secretion by cell 8.1481 4 yes
GO:0051223 regulation of protein transport 7.4074 5 yes
GO:1903828 negative regulation of protein localization 7.4074 5 yes
GO:0007507 heart development 7.4074 4 yes
GO:0010001 glial cell differentiation 7.4074 4 yes
GO:0034764 positive regulation of transmembrane transport 6.6667 5 yes
GO:0048013 ephrin receptor signaling pathway 6.6667 6 yes
GO:0007229 integrin-mediated signaling pathway 6.6667 4 yes
GO:0007346 regulation of mitotic cell cycle 6.6667 5 yes
GO:0030099 myeloid cell differentiation 6.6667 4 yes
GO:0045931 positive regulation of mitotic cell cycle 5.9259 6 yes
GO:0046883 regulation of hormone secretion 5.9259 4 yes
GO:0070849 response to epidermal growth factor 5.9259 4 yes
GO:0001667 ameboidal-type cell migration 5.9259 4 yes
GO:0006974 DNA damage response 5.9259 4 yes
GO:0032368 regulation of lipid transport 5.1852 5 yes
GO:0042593 glucose homeostasis 5.1852 4 yes
GO:0071364 cellular response to epidermal growth factor stimulus 5.1852 5 yes
GO:1905952 regulation of lipid localization 5.1852 4 yes
GO:0001894 tissue homeostasis 5.1852 4 yes
GO:0008543 fibroblast growth factor receptor signaling pathway 5.1852 6 yes
GO:0010631 epithelial cell migration 5.1852 5 yes
GO:0030097 hemopoiesis 5.1852 4 yes
GO:0032479 regulation of type I interferon production 4.4444 5 yes
GO:0032675 regulation of interleukin-6 production 4.4444 5 yes
GO:0033628 regulation of cell adhesion mediated by integrin 4.4444 5 yes
GO:0048008 platelet-derived growth factor receptor signaling pathway 4.4444 6 yes
GO:0048708 astrocyte differentiation 4.4444 5 yes
GO:0050708 regulation of protein secretion 4.4444 5 yes
GO:0051047 positive regulation of secretion 4.4444 5 yes
GO:0060759 regulation of response to cytokine stimulus 4.4444 4 yes
GO:0061515 myeloid cell development 4.4444 5 yes
GO:0090087 regulation of peptide transport 4.4444 5 yes
GO:0090276 regulation of peptide hormone secretion 4.4444 5 yes
GO:1903532 positive regulation of secretion by cell 4.4444 5 yes
GO:0001818 negative regulation of cytokine production 4.4444 5 yes
GO:0001959 regulation of cytokine-mediated signaling pathway 4.4444 5 yes
GO:0002791 regulation of peptide secretion 4.4444 6 yes
GO:0007409 axonogenesis 4.4444 6 yes
GO:0007420 brain development 4.4444 4 yes
GO:0032481 positive regulation of type I interferon production 3.7037 6 yes
GO:0032680 regulation of tumor necrosis factor production 3.7037 6 yes
GO:0032755 positive regulation of interleukin-6 production 3.7037 6 yes
GO:0033157 regulation of intracellular protein transport 3.7037 6 yes
GO:0042770 signal transduction in response to DNA damage 3.7037 4 yes
GO:0046486 glycerolipid metabolic process 3.7037 4 yes
GO:0046626 regulation of insulin receptor signaling pathway 3.7037 5 yes
GO:0046887 positive regulation of hormone secretion 3.7037 5 yes
GO:0050796 regulation of insulin secretion 3.7037 6 yes
GO:0051048 negative regulation of secretion 3.7037 5 yes
GO:0060020 Bergmann glial cell differentiation 3.7037 6 yes
GO:1900076 regulation of cellular response to insulin stimulus 3.7037 4 yes
GO:1901987 regulation of cell cycle phase transition 3.7037 6 yes
GO:1903531 negative regulation of secretion by cell 3.7037 5 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 3.7037 5 yes
GO:1904950 negative regulation of establishment of protein localization 3.7037 6 yes
GO:0010827 regulation of glucose transmembrane transport 3.7037 5 yes
GO:0032369 negative regulation of lipid transport 2.9630 5 yes
GO:0032760 positive regulation of tumor necrosis factor production 2.9630 7 yes
GO:0038179 neurotrophin signaling pathway 2.9630 4 yes
GO:0045786 negative regulation of cell cycle 2.9630 5 yes
GO:0046324 regulation of glucose import 2.9630 6 yes
GO:0046326 positive regulation of glucose import 2.9630 7 yes
GO:0046628 positive regulation of insulin receptor signaling pathway 2.9630 6 yes
GO:0046676 negative regulation of insulin secretion 2.9630 7 yes
GO:0046822 regulation of nucleocytoplasmic transport 2.9630 6 yes
GO:0046888 negative regulation of hormone secretion 2.9630 5 yes
GO:0048011 neurotrophin TRK receptor signaling pathway 2.9630 5 yes
GO:0048806 genitalia development 2.9630 4 yes
GO:0050709 negative regulation of protein secretion 2.9630 6 yes
GO:0051224 negative regulation of protein transport 2.9630 5 yes
GO:0090278 negative regulation of peptide hormone secretion 2.9630 6 yes
GO:1900078 positive regulation of cellular response to insulin stimulus 2.9630 5 yes
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 2.9630 6 yes
GO:1905953 negative regulation of lipid localization 2.9630 4 yes
GO:0002792 negative regulation of peptide secretion 2.9630 6 yes
GO:0010828 positive regulation of glucose transmembrane transport 2.9630 6 yes
GO:0030278 regulation of ossification 2.9630 4 yes
GO:0032330 regulation of chondrocyte differentiation 2.2222 5 yes
GO:0032331 negative regulation of chondrocyte differentiation 2.2222 6 yes
GO:0032480 negative regulation of type I interferon production 2.2222 6 yes
GO:0032528 microvillus organization 2.2222 6 yes
GO:0032648 regulation of interferon-beta production 2.2222 6 yes
GO:0035335 peptidyl-tyrosine dephosphorylation 2.2222 6 yes
GO:0035855 megakaryocyte development 2.2222 6 yes
GO:0044060 regulation of endocrine process 2.2222 5 yes
GO:0046825 regulation of protein export from nucleus 2.2222 7 yes
GO:0061035 regulation of cartilage development 2.2222 5 yes
GO:0061037 negative regulation of cartilage development 2.2222 5 yes
GO:0006470 protein dephosphorylation 2.2222 5 yes
GO:0006638 neutral lipid metabolic process 2.2222 4 yes
GO:0006639 acylglycerol metabolic process 2.2222 5 yes
GO:0006641 triglyceride metabolic process 2.2222 6 yes
GO:0016311 dephosphorylation 2.2222 5 yes
GO:0031570 DNA integrity checkpoint signaling 1.4815 5 yes
GO:0032728 positive regulation of interferon-beta production 1.4815 7 yes
GO:0033629 negative regulation of cell adhesion mediated by integrin 1.4815 6 yes
GO:0045778 positive regulation of ossification 1.4815 5 yes
GO:0048873 homeostasis of number of cells within a tissue 1.4815 4 yes
GO:0051462 regulation of cortisol secretion 1.4815 8 yes
GO:0051463 negative regulation of cortisol secretion 1.4815 8 yes
GO:0060123 regulation of growth hormone secretion 1.4815 6 yes
GO:0060125 negative regulation of growth hormone secretion 1.4815 7 yes
GO:0060338 regulation of type I interferon-mediated signaling pathway 1.4815 6 yes
GO:0061582 intestinal epithelial cell migration 1.4815 6 yes
GO:1901988 negative regulation of cell cycle phase transition 1.4815 7 yes
GO:2000831 regulation of steroid hormone secretion 1.4815 5 yes
GO:2000832 negative regulation of steroid hormone secretion 1.4815 5 yes
GO:2000846 regulation of corticosteroid hormone secretion 1.4815 6 yes
GO:2000847 negative regulation of corticosteroid hormone secretion 1.4815 6 yes
GO:2000849 regulation of glucocorticoid secretion 1.4815 7 yes
GO:2000850 negative regulation of glucocorticoid secretion 1.4815 7 yes
GO:0000075 cell cycle checkpoint signaling 1.4815 4 yes
GO:0000077 DNA damage checkpoint signaling 1.4815 5 yes
GO:0010948 negative regulation of cell cycle process 1.4815 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ROS1_HUMAN [view interactions] Low throughput no no
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
CSF3R_HUMAN [view interactions] Low throughput no yes
FCGRB_HUMAN [view interactions] Low throughput no no
SPY2_HUMAN [view interactions] Low throughput no yes
PAXI_HUMAN [view interactions] Low throughput no yes
MET_HUMAN [view interactions] Low throughput no yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
EPHA2_HUMAN [view interactions] Low throughput no no
NTRK2_HUMAN [view entry] [view interactions] Low throughput yes yes
FES_HUMAN [view entry] [view interactions] Low throughput yes no
TRAF6_HUMAN [view entry] [view interactions] Low throughput yes yes
CBL_HUMAN [view interactions] Low throughput no yes
SLAF7_HUMAN [view interactions] Low throughput no no
SLAF6_HUMAN [view interactions] Low throughput no no
CLM8_HUMAN [view interactions] Low throughput no no
LIRB2_HUMAN [view interactions] Low throughput no no
LIRB3_HUMAN [view interactions] Low throughput no no
LIRB5_HUMAN [view interactions] Low throughput no no
IRS2_HUMAN [view interactions] Low throughput no yes
P85A_HUMAN [view interactions] Low throughput no yes
SPY1_HUMAN [view interactions] Low throughput no yes
FINC_HUMAN [view interactions] Low throughput no yes
CD28_HUMAN [view interactions] Low throughput no no
STAT1_HUMAN [view entry] [view interactions] Low throughput yes no
TIE2_HUMAN [view interactions] Low throughput no no
VGFR2_HUMAN [view interactions] Low throughput no no
PGFRA_HUMAN [view interactions] Low throughput no no
HNRPQ_HUMAN [view entry] [view interactions] Low throughput yes yes
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
IL6RB_HUMAN [view interactions] Low throughput no no
JAK1_HUMAN [view interactions] Low throughput no yes
PLCG2_HUMAN [view interactions] Low throughput no yes
GAB3_HUMAN [view interactions] Low throughput no yes
BCAR1_HUMAN [view interactions] Low throughput no yes
CADH5_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
LAIR1_HUMAN [view interactions] Low throughput no no
PILRA_HUMAN [view interactions] Low throughput no yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
SLAF5_HUMAN [view interactions] Low throughput no no
LY9_HUMAN [view interactions] Low throughput no no
PRLR_HUMAN [view interactions] Low throughput no no
STA5A_HUMAN [view interactions] Low throughput no no
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
ITCH_HUMAN [view interactions] Low throughput no yes
SOCS1_HUMAN [view interactions] Low throughput no yes
CDC73_HUMAN [view interactions] Low throughput no yes
CBLB_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K5_HUMAN [view interactions] Low throughput no yes
FAS_HUMAN [view entry] [view interactions] Low throughput yes no
COP1_HUMAN [view interactions] Low throughput no no
DAB1_HUMAN [view interactions] Low throughput no yes
PD1L1_HUMAN [view interactions] Low throughput no no
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
SIG12_HUMAN [view interactions] Low throughput no no
SIGL9_HUMAN [view interactions] Low throughput no yes
SIGL7_HUMAN [view interactions] Low throughput no no
SIGL8_HUMAN [view interactions] Low throughput no yes
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
DYN2_HUMAN [view entry] [view interactions] Low throughput yes yes
GAB1_HUMAN [view interactions] Low throughput no yes
GARE2_HUMAN [view interactions] Low throughput no no
PRP19_HUMAN [view interactions] Low throughput no yes
FRS3_HUMAN [view interactions] Low throughput no no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
IGF1R_HUMAN [view entry] [view interactions] Low throughput yes yes
GRB7_HUMAN [view interactions] Low throughput no no
KI2L1_HUMAN [view interactions] Low throughput no no
DDR1_HUMAN [view interactions] Low throughput no yes
GAB2_HUMAN [view interactions] Low throughput no yes
GASR_HUMAN [view interactions] Low throughput no no
LEPR_HUMAN [view interactions] Low throughput no no
PK3CA_HUMAN [view entry] [view interactions] Low throughput yes yes
GRASP_HUMAN [view entry] [view interactions] Low throughput yes yes
PGFRB_HUMAN [view interactions] Low throughput no yes
SIG10_HUMAN [view interactions] Low throughput no no
HDAC6_HUMAN [view interactions] Low throughput no yes
SIG11_HUMAN [view interactions] Low throughput no no
FBXW7_HUMAN [view interactions] Low throughput no yes
RIGI_HUMAN [view interactions] Low throughput no yes
E2F1_HUMAN [view interactions] Low throughput no yes
PDCD1_HUMAN [view interactions] Low throughput no yes
PVR_HUMAN [view interactions] Low throughput no yes
SHC4_HUMAN [view entry] [view interactions] Low throughput yes no
IRS1_HUMAN [view entry] [view interactions] Low throughput yes yes
CASL_HUMAN [view interactions] Low throughput no yes
KIT_HUMAN [view interactions] Low throughput no no
FRS2_HUMAN [view interactions] Low throughput no no
SHPS1_HUMAN [view entry] [view interactions] Low throughput yes yes
PK3CG_HUMAN [view interactions] Low throughput no yes
RACK1_HUMAN [view interactions] Low throughput no yes
CAV1_HUMAN [view interactions] Low throughput no no
LRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
CD33_HUMAN [view interactions] Low throughput no no
ANXA2_HUMAN [view entry] [view interactions] Low throughput yes no
SIT1_HUMAN [view interactions] Low throughput no no
TYK2_HUMAN [view interactions] Low throughput no no
BTLA_HUMAN [view interactions] Low throughput no no
CL12A_HUMAN [view interactions] Low throughput no no
TRML1_HUMAN [view interactions] Low throughput no no
MPZL1_HUMAN [view interactions] Low throughput no yes
COASY_HUMAN [view entry] [view interactions] Low throughput yes yes
SLAF1_HUMAN [view interactions] Low throughput no no
G6B_HUMAN [view interactions] Low throughput no no
LYAM2_HUMAN [view interactions] Low throughput no no
B3AT_HUMAN [view entry] [view interactions] Low throughput yes no
FLT3_HUMAN [view interactions] Low throughput no no
ITB3_HUMAN [view entry] [view interactions] Low throughput yes no
DOK1_HUMAN [view interactions] Low throughput no yes
CATA_HUMAN [view entry] [view interactions] Low throughput yes no
EGFR_HUMAN [view interactions] Low throughput no no
ERBB4_HUMAN [view entry] [view interactions] Low throughput yes yes
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
INSR_HUMAN [view interactions] Low throughput no yes
FCG2B_HUMAN [view interactions] Low throughput no no
GHR_HUMAN [view interactions] Low throughput no yes
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
TNR1A_HUMAN [view interactions] Low throughput no yes
SOCS3_HUMAN [view interactions] Low throughput no yes
PECA1_HUMAN [view interactions] Low throughput no no
IL3RB_HUMAN [view interactions] Low throughput no no
AGTR1_HUMAN [view interactions] Low throughput no no
CEAM1_HUMAN [view interactions] Low throughput no no
KI2L3_HUMAN [view interactions] Low throughput no no
JAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
EPOR_HUMAN [view interactions] Low throughput no no
I23O1_HUMAN [view interactions] Low throughput no no
CTND1_HUMAN [view entry] [view interactions] Low throughput yes no
CD244_HUMAN [view interactions] Low throughput no no
CRK_HUMAN [view entry] [view interactions] Low throughput yes no
CRKL_HUMAN [view entry] [view interactions] Low throughput yes yes
SHIP1_HUMAN [view interactions] Low throughput no no
PML_HUMAN [view interactions] Low throughput no yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
RN183_HUMAN [view interactions] Low throughput no no
SOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] Low throughput yes no
HXA10_HUMAN [view interactions] Low throughput no no
STA5B_HUMAN [view interactions] Low throughput no yes
IL4RA_HUMAN [view interactions] Low throughput no no
FCRL3_HUMAN [view interactions] Low throughput no no
TXNIP_HUMAN [view interactions] Low throughput no no
SMC1A_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
STX18_HUMAN [view interactions] High throughput no yes
NOX4_HUMAN [view interactions] High throughput no no
NUMB_HUMAN [view entry] [view interactions] High throughput yes yes
CALR_HUMAN [view entry] [view interactions] High throughput yes yes
VGFR1_HUMAN [view interactions] High throughput no no
ZAP70_HUMAN [view interactions] High throughput no no
DUS3_HUMAN [view entry] [view interactions] High throughput yes no
RL5_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
APOB_HUMAN [view interactions] High throughput no no
PPIF_HUMAN [view interactions] High throughput no no
RS19_HUMAN [view entry] [view interactions] High throughput yes no
CHRC1_HUMAN [view interactions] High throughput no no
IN35_HUMAN [view interactions] High throughput no yes
EFHD2_HUMAN [view entry] [view interactions] High throughput yes no
RS7_HUMAN [view entry] [view interactions] High throughput yes yes
MK14_HUMAN [view interactions] High throughput no yes
RL39_HUMAN [view interactions] High throughput no no
SCOT1_HUMAN [view entry] [view interactions] High throughput yes yes
RS15_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K1_HUMAN [view entry] [view interactions] High throughput yes yes
TM223_HUMAN [view interactions] High throughput no yes
STABP_HUMAN [view interactions] High throughput no yes
RL35_HUMAN [view entry] [view interactions] High throughput yes yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
CCD93_HUMAN [view entry] [view interactions] High throughput yes yes
LIFR_HUMAN [view interactions] High throughput no no
RS13_HUMAN [view entry] [view interactions] High throughput yes yes
PTN2_HUMAN [view interactions] High throughput no yes
YBOX1_HUMAN [view interactions] High throughput no yes
RHG01_HUMAN [view entry] [view interactions] High throughput yes yes
5NT3B_HUMAN [view interactions] High throughput no yes
PTPRA_HUMAN [view interactions] High throughput no yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
HNRDL_HUMAN [view interactions] High throughput no yes
UAP1L_HUMAN [view interactions] High throughput no yes
E41L2_HUMAN [view entry] [view interactions] High throughput yes yes
VAV2_HUMAN [view entry] [view interactions] High throughput yes yes
OGA_HUMAN [view interactions] High throughput no yes
RS3A_HUMAN [view entry] [view interactions] High throughput yes yes
GGCT_HUMAN [view interactions] High throughput no yes
MBB1A_HUMAN [view interactions] High throughput no yes
WDHD1_HUMAN [view interactions] High throughput no no
FABPL_HUMAN [view interactions] High throughput no no
PAPS2_HUMAN [view interactions] High throughput no yes
RS18_HUMAN [view entry] [view interactions] High throughput yes yes
K1C18_HUMAN [view interactions] High throughput no no
ITPR2_HUMAN [view interactions] High throughput no yes
HNRPC_HUMAN [view interactions] High throughput no yes
RS4X_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
TIM44_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
BORG5_HUMAN [view interactions] High throughput no yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
IF2A_HUMAN [view entry] [view interactions] High throughput yes yes
C1TC_HUMAN [view entry] [view interactions] High throughput yes yes
RS14_HUMAN [view entry] [view interactions] High throughput yes yes
TPR_HUMAN [view interactions] High throughput no yes
TRIO_HUMAN [view entry] [view interactions] High throughput yes yes
GSTM3_HUMAN [view entry] [view interactions] High throughput yes yes
STAM2_HUMAN [view interactions] High throughput no yes
ATPA_HUMAN [view interactions] High throughput no yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
RFA1_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
UFO_HUMAN [view interactions] High throughput no no
AL1B1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
GPX4_HUMAN [view entry] [view interactions] High throughput yes no
HDGF_HUMAN [view interactions] High throughput no yes
ACLY_HUMAN [view entry] [view interactions] High throughput yes yes
COPZ1_HUMAN [view interactions] High throughput no no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RS28_HUMAN [view entry] [view interactions] High throughput yes yes
PLOD1_HUMAN [view interactions] High throughput no yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
PSME1_HUMAN [view interactions] High throughput no yes
ANXA1_HUMAN [view entry] [view interactions] High throughput yes no
ILF3_HUMAN [view interactions] High throughput no yes
SF3B2_HUMAN [view interactions] High throughput no yes
IPYR_HUMAN [view interactions] High throughput no yes
STXB2_HUMAN [view interactions] High throughput no no
BRE1A_HUMAN [view interactions] High throughput no yes
DNJC9_HUMAN [view interactions] High throughput no yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
CPPED_HUMAN [view interactions] High throughput no yes
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CAV3_HUMAN [view interactions] High throughput no no
TRI33_HUMAN [view interactions] High throughput no yes
TRI32_HUMAN [view entry] [view interactions] High throughput yes yes
GBF1_HUMAN [view interactions] High throughput no yes
DDI1_HUMAN [view interactions] High throughput no no
NAA40_HUMAN [view interactions] High throughput no no
BEX1_HUMAN [view interactions] High throughput no yes
RET_HUMAN [view interactions] High throughput no yes
BEX2_HUMAN [view interactions] High throughput no yes
KBTB4_HUMAN [view interactions] High throughput no yes
GO45_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
CF123_HUMAN [view interactions] High throughput no no
RAB25_HUMAN [view interactions] High throughput no no
CTDS1_HUMAN [view interactions] High throughput no no
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
DMRTC_HUMAN [view interactions] High throughput no no
RFA2_HUMAN [view interactions] High throughput no yes
GAR5A_HUMAN [view interactions] High throughput no no
RFA3_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
WWTR1_HUMAN [view interactions] High throughput no yes
T2AG_HUMAN [view interactions] High throughput no no
NSUN5_HUMAN [view interactions] High throughput no yes
NSN5C_HUMAN [view interactions] High throughput no no
ORML3_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
KCC1B_HUMAN [view interactions] High throughput no yes
OBF1_HUMAN [view interactions] High throughput no no
MOG1_HUMAN [view interactions] High throughput no yes
SERF2_HUMAN [view interactions] High throughput no no
PEDF_HUMAN [view interactions] High throughput no no
SRS10_HUMAN [view interactions] High throughput no yes
S38A1_HUMAN [view interactions] High throughput no yes
SARCO_HUMAN [view interactions] High throughput no no
TLK1_HUMAN [view interactions] High throughput no yes
TRM2B_HUMAN [view interactions] High throughput no yes
LMTK1_HUMAN [view interactions] High throughput no yes
ERBB3_HUMAN [view interactions] High throughput no yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
PTK7_HUMAN [view interactions] High throughput no yes
EPHA1_HUMAN [view interactions] High throughput no yes
FGFR2_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
P85B_HUMAN [view interactions] High throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
NEBU_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
SGCG_HUMAN [view interactions] High throughput no no
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
H2B1C_HUMAN [view interactions] High throughput no yes
CTR9_HUMAN [view interactions] High throughput no yes
PAF1_HUMAN [view interactions] High throughput no yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA5_HUMAN [view interactions] High throughput no no
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
FGFR3_HUMAN [view interactions] High throughput no yes
LTK_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
RYK_HUMAN [view entry] [view interactions] High throughput yes no
STYK1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
GEMI_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
LEO1_HUMAN [view interactions] High throughput no yes
RTF1_HUMAN [view interactions] High throughput no yes
SKI8_HUMAN [view interactions] High throughput no yes
SHC1_HUMAN [view entry] [view interactions] High throughput yes yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
CXCR4_HUMAN [view interactions] High throughput no no
OVCA2_HUMAN [view interactions] High throughput no no
LEG3_HUMAN [view interactions] High throughput no yes
FCG2A_HUMAN [view interactions] High throughput no no
FSD1_HUMAN [view entry] [view interactions] High throughput yes no
LEG9_HUMAN [view interactions] High throughput no yes
TCAL1_HUMAN [view interactions] High throughput no yes
CP1A1_HUMAN [view interactions] High throughput no yes
SMRC1_HUMAN [view interactions] High throughput no yes
HEAT6_HUMAN [view interactions] High throughput no no
DS13A_HUMAN [view interactions] High throughput no no
LC7L3_HUMAN [view interactions] High throughput no yes
SIGL5_HUMAN [view interactions] High throughput no no
NXT2_HUMAN [view interactions] High throughput no yes
GPX7_HUMAN [view interactions] High throughput no no
T2EB_HUMAN [view interactions] High throughput no yes
SNR27_HUMAN [view interactions] High throughput no yes
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
RPIA_HUMAN [view interactions] High throughput no yes
LUM_HUMAN [view interactions] High throughput no no
TM220_HUMAN [view interactions] High throughput no no
NOSIP_HUMAN [view interactions] High throughput no yes
MED21_HUMAN [view interactions] High throughput no yes
IQCB1_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
WRP73_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
LMO4_HUMAN [view interactions] High throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
SAHH2_HUMAN [view entry] [view interactions] High throughput yes yes
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
TCPE_HUMAN [view entry] [view interactions] High throughput yes yes
TCPW_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
DCAF7_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
PSA4_HUMAN [view entry] [view interactions] High throughput yes yes
PSA6_HUMAN [view interactions] High throughput no yes
PSB1_HUMAN [view interactions] High throughput no yes
PSB4_HUMAN [view interactions] High throughput no yes
PRS6A_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK1_HUMAN [view interactions] High throughput no yes
PRS10_HUMAN [view interactions] High throughput no yes
PSD12_HUMAN [view interactions] High throughput no yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP47_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
BACD3_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
CEBPA_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
ANR39_HUMAN [view interactions] High throughput no no
TECR_HUMAN [view interactions] High throughput no yes
MTPN_HUMAN [view interactions] High throughput no yes
MTSS2_HUMAN [view interactions] High throughput no yes
DAPP1_HUMAN [view interactions] High throughput no yes
CYTB_HUMAN [view interactions] High throughput no no
THMS1_HUMAN [view interactions] High throughput no no
CERS2_HUMAN [view interactions] High throughput no no
KI2L4_HUMAN [view interactions] High throughput no no
RM42_HUMAN [view interactions] High throughput no yes
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
FRM4B_HUMAN [view interactions] High throughput no no
MUS81_HUMAN [view interactions] High throughput no no
CSK_HUMAN [view interactions] High throughput no yes
SERB1_HUMAN [view interactions] High throughput no yes
SYT6_HUMAN [view entry] [view interactions] High throughput yes no
PTN6_HUMAN [view interactions] High throughput no no
HCK_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
GRAP_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
YES_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
PTPRC_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
BMX_HUMAN [view interactions] High throughput no no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
CSF1R_HUMAN [view interactions] High throughput no yes
MET14_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2H_HUMAN [view interactions] High throughput no yes
EMAL4_HUMAN [view interactions] High throughput no yes
LDLR_HUMAN [view interactions] High throughput no yes
SF3B1_HUMAN [view interactions] High throughput no yes
RIT1_HUMAN [view interactions] High throughput no yes
SH2B1_HUMAN [view interactions] High throughput no yes
DECR2_HUMAN [view entry] [view interactions] High throughput yes no
PECR_HUMAN [view interactions] High throughput no yes
MAAI_HUMAN [view interactions] High throughput no yes
WASL_HUMAN [view entry] [view interactions] High throughput yes yes
ILK_HUMAN [view interactions] High throughput no no
RCBT2_HUMAN [view interactions] High throughput no yes
TSC2_HUMAN [view entry] [view interactions] High throughput yes yes
CFAH_HUMAN [view interactions] High throughput no no
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
DDAH1_HUMAN [view entry] [view interactions] High throughput yes no
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
NHLC2_HUMAN [view interactions] High throughput no yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes