TRIO_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed, PubMed, PubMed). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed, PubMed). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses . May act as a regulator of adipogenesis . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 1080 | Asn | Ile | Intellectualdevelopmentaldisorder,autosomaldominant63,withmacrocephaly(MRD63) | - |
| 1428 | Arg | Gln | Intellectualdevelopmentaldisorder,autosomaldominant44,withmicrocephaly(MRD44) | - |
| 1461 | Pro | Thr | Intellectualdevelopmentaldisorder,autosomaldominant44,withmicrocephaly(MRD44) | - |
| 1075 | Thr | Ile | Intellectualdevelopmentaldisorder,autosomaldominant63,withmacrocephaly(MRD63) | - |
| 1078 | Arg | Gly | Intellectualdevelopmentaldisorder,autosomaldominant63,withmacrocephaly(MRD63) | - |
| 1078 | Arg | Gln | Intellectualdevelopmentaldisorder,autosomaldominant63,withmacrocephaly(MRD63) | - |
| 1078 | Arg | Trp | Intellectualdevelopmentaldisorder,autosomaldominant63,withmacrocephaly(MRD63) | - |
| 1299 | Glu | Lys | Intellectualdevelopmentaldisorder,autosomaldominant44,withmicrocephaly(MRD44) | - |
| 1461 | Pro | Leu | Intellectualdevelopmentaldisorder,autosomaldominant63,withmacrocephaly(MRD63) | - |
| 1469 | His | Arg | Intellectualdevelopmentaldisorder,autosomaldominant44,withmicrocephaly(MRD44) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TRIO_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 42.5926 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 40.7407 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.7407 | 4 | yes |
| GO:0019900 | kinase binding | 27.7778 | 4 | no |
| GO:0019901 | protein kinase binding | 25.9259 | 5 | no |
| GO:0003924 | GTPase activity | 24.0741 | 7 | no |
| GO:0016462 | pyrophosphatase activity | 24.0741 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 24.0741 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 24.0741 | 6 | no |
| GO:0030554 | adenyl nucleotide binding | 22.2222 | 5 | yes |
| GO:0005525 | GTP binding | 22.2222 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 22.2222 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 22.2222 | 5 | no |
| GO:0005524 | ATP binding | 20.3704 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 20.3704 | 5 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 18.5185 | 4 | yes |
| GO:0016301 | kinase activity | 18.5185 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 18.5185 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 18.5185 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 12.9630 | 5 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 11.1111 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 11.1111 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TRIO_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 61.1111 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 59.2593 | 4 | no |
| GO:0010646 | regulation of cell communication | 55.5556 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 55.5556 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 51.8519 | 4 | yes |
| GO:0030030 | cell projection organization | 50.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 46.2963 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 42.5926 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 42.5926 | 5 | yes |
| GO:0006996 | organelle organization | 42.5926 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 42.5926 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 40.7407 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 40.7407 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 40.7407 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.7407 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.7407 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 40.7407 | 6 | no |
| GO:0007010 | cytoskeleton organization | 38.8889 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 35.1852 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.1852 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 33.3333 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 33.3333 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0031175 | neuron projection development | 31.4815 | 6 | yes |
| GO:0051130 | positive regulation of cellular component organization | 31.4815 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 31.4815 | 5 | no |
| GO:0022607 | cellular component assembly | 31.4815 | 4 | no |
| GO:0023056 | positive regulation of signaling | 31.4815 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.4815 | 4 | no |
| GO:0008104 | protein localization | 31.4815 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.6296 | 5 | no |
| GO:0030334 | regulation of cell migration | 29.6296 | 5 | no |
| GO:2000145 | regulation of cell motility | 29.6296 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 29.6296 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 29.6296 | 7 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.6296 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.6296 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 27.7778 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.7778 | 6 | no |
| GO:0031399 | regulation of protein modification process | 27.7778 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 27.7778 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 27.7778 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.7778 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 27.7778 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.9259 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.9259 | 7 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.9259 | 6 | no |
| GO:0030155 | regulation of cell adhesion | 25.9259 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 25.9259 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 25.9259 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.9259 | 7 | no |
| GO:0051049 | regulation of transport | 25.9259 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 25.9259 | 6 | no |
| GO:2000026 | regulation of multicellular organismal development | 25.9259 | 4 | no |
| GO:0060284 | regulation of cell development | 25.9259 | 5 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 24.0741 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 24.0741 | 6 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 24.0741 | 8 | no |
| GO:0010941 | regulation of cell death | 24.0741 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 24.0741 | 5 | no |
| GO:0045785 | positive regulation of cell adhesion | 24.0741 | 5 | no |
| GO:0036211 | protein modification process | 24.0741 | 4 | no |
| GO:0043412 | macromolecule modification | 24.0741 | 4 | no |
| GO:0031346 | positive regulation of cell projection organization | 22.2222 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0007264 | small GTPase mediated signal transduction | 22.2222 | 4 | no |
| GO:0022604 | regulation of cell morphogenesis | 22.2222 | 5 | no |
| GO:0071702 | organic substance transport | 22.2222 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.2222 | 4 | no |
| GO:0032990 | cell part morphogenesis | 20.3704 | 4 | yes |
| GO:0048812 | neuron projection morphogenesis | 20.3704 | 7 | yes |
| GO:0048858 | cell projection morphogenesis | 20.3704 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 20.3704 | 6 | yes |
| GO:0030335 | positive regulation of cell migration | 20.3704 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 20.3704 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.3704 | 5 | no |
| GO:2000147 | positive regulation of cell motility | 20.3704 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 20.3704 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 20.3704 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.3704 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.3704 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.3704 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 20.3704 | 4 | no |
| GO:0051093 | negative regulation of developmental process | 18.5185 | 4 | yes |
| GO:0045596 | negative regulation of cell differentiation | 16.6667 | 5 | yes |
| GO:0097485 | neuron projection guidance | 16.6667 | 7 | yes |
| GO:0007411 | axon guidance | 14.8148 | 8 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 12.9630 | 6 | yes |
| GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway | 5.5556 | 5 | yes |
| GO:0007417 | central nervous system development | 5.5556 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in TRIO_HUMAN |
|---|---|---|---|---|
| DOID:0060038 | specific developmental disorder | 3.7037 | 3 | yes |
| DOID:0060307 | autosomal dominant intellectual developmental disorder | 3.7037 | 5 | yes |
| DOID:1059 | intellectual disability | 3.7037 | 4 | yes |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MARE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NLGN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPRF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NAV1_HUMAN | [view interactions] | Low throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN232_HUMAN | [view interactions] | High throughput | no | no |
| ZN785_HUMAN | [view interactions] | High throughput | no | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CBAR1_HUMAN | [view interactions] | High throughput | no | no |
| TTC23_HUMAN | [view interactions] | High throughput | no | yes |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| UGGG1_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL22L_HUMAN | [view interactions] | High throughput | no | no |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| LMO3_HUMAN | [view interactions] | High throughput | no | no |
| ADA2_HUMAN | [view interactions] | High throughput | no | no |
| RBTN1_HUMAN | [view interactions] | High throughput | no | no |
| GLHA_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PALS2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPF27_HUMAN | [view interactions] | High throughput | no | yes |
| CFA45_HUMAN | [view interactions] | High throughput | no | no |
| PPM1F_HUMAN | [view interactions] | High throughput | no | yes |
| RPE_HUMAN | [view interactions] | High throughput | no | yes |
| SSU72_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPRS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STMN1_HUMAN | [view interactions] | High throughput | no | yes |
| ZSC26_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| DOC10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPP2_HUMAN | [view interactions] | High throughput | no | yes |
| APOB_HUMAN | [view interactions] | High throughput | no | no |
| LIPB1_HUMAN | [view interactions] | High throughput | no | yes |
| PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| ITPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CORO6_HUMAN | [view interactions] | High throughput | no | no |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCAB1_HUMAN | [view interactions] | High throughput | no | no |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOME3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAKD2_HUMAN | [view interactions] | High throughput | no | yes |
| BLMH_HUMAN | [view interactions] | High throughput | no | yes |
| LIMS1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| CENPJ_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAV2_HUMAN | [view interactions] | High throughput | no | yes |
| NAV3_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCK1_HUMAN | [view interactions] | Computational | no | yes |
| GNA12_HUMAN | [view interactions] | Computational | no | no |
| GBB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GNAQ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG1_HUMAN | [view interactions] | Computational | no | no |
| GNA13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RHG05_HUMAN | [view interactions] | Computational | no | yes |
| NET1_HUMAN | [view interactions] | Computational | no | no |
| PAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DOCK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |