TRIO_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed, PubMed, PubMed). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed, PubMed). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses . May act as a regulator of adipogenesis . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 1080 | Asn | Ile | Intellectualdevelopmentaldisorder,autosomaldominant63,withmacrocephaly(MRD63) | - |
| 1428 | Arg | Gln | Intellectualdevelopmentaldisorder,autosomaldominant44,withmicrocephaly(MRD44) | - |
| 1461 | Pro | Thr | Intellectualdevelopmentaldisorder,autosomaldominant44,withmicrocephaly(MRD44) | - |
| 1075 | Thr | Ile | Intellectualdevelopmentaldisorder,autosomaldominant63,withmacrocephaly(MRD63) | - |
| 1078 | Arg | Gly | Intellectualdevelopmentaldisorder,autosomaldominant63,withmacrocephaly(MRD63) | - |
| 1078 | Arg | Gln | Intellectualdevelopmentaldisorder,autosomaldominant63,withmacrocephaly(MRD63) | - |
| 1078 | Arg | Trp | Intellectualdevelopmentaldisorder,autosomaldominant63,withmacrocephaly(MRD63) | - |
| 1299 | Glu | Lys | Intellectualdevelopmentaldisorder,autosomaldominant44,withmicrocephaly(MRD44) | - |
| 1461 | Pro | Leu | Intellectualdevelopmentaldisorder,autosomaldominant63,withmacrocephaly(MRD63) | - |
| 1469 | His | Arg | Intellectualdevelopmentaldisorder,autosomaldominant44,withmicrocephaly(MRD44) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TRIO_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 43.6364 | 4 | yes |
| GO:0000166 | nucleotide binding | 36.3636 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 36.3636 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 36.3636 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.3636 | 4 | yes |
| GO:0019900 | kinase binding | 27.2727 | 4 | no |
| GO:0019901 | protein kinase binding | 25.4545 | 5 | no |
| GO:0005524 | ATP binding | 20.0000 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 20.0000 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 20.0000 | 5 | yes |
| GO:0016301 | kinase activity | 18.1818 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 18.1818 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 14.5455 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 10.9091 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 10.9091 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 9.0909 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TRIO_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.6364 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 63.6364 | 4 | no |
| GO:0010646 | regulation of cell communication | 58.1818 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 58.1818 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 52.7273 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.9091 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 49.0909 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 47.2727 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 45.4545 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 45.4545 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 45.4545 | 6 | no |
| GO:0006996 | organelle organization | 43.6364 | 4 | no |
| GO:0030030 | cell projection organization | 41.8182 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 38.1818 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.1818 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.1818 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 38.1818 | 5 | no |
| GO:0008104 | protein localization | 38.1818 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 36.3636 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 36.3636 | 5 | no |
| GO:0022607 | cellular component assembly | 36.3636 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 36.3636 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 34.5455 | 5 | no |
| GO:0023056 | positive regulation of signaling | 34.5455 | 4 | no |
| GO:0051049 | regulation of transport | 34.5455 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 32.7273 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 32.7273 | 6 | no |
| GO:0007010 | cytoskeleton organization | 32.7273 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 30.9091 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.9091 | 5 | no |
| GO:0031399 | regulation of protein modification process | 30.9091 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 30.9091 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 30.9091 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 29.0909 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 29.0909 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 29.0909 | 7 | no |
| GO:0031401 | positive regulation of protein modification process | 29.0909 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 29.0909 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 29.0909 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 27.2727 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 27.2727 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 27.2727 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 27.2727 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 27.2727 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 27.2727 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 27.2727 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 27.2727 | 4 | no |
| GO:0033043 | regulation of organelle organization | 27.2727 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 27.2727 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.4545 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.4545 | 6 | no |
| GO:0030155 | regulation of cell adhesion | 25.4545 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.4545 | 5 | no |
| GO:0036211 | protein modification process | 25.4545 | 4 | no |
| GO:0043412 | macromolecule modification | 25.4545 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.4545 | 5 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 23.6364 | 4 | yes |
| GO:0031175 | neuron projection development | 23.6364 | 6 | yes |
| GO:0001932 | regulation of protein phosphorylation | 23.6364 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 23.6364 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 23.6364 | 6 | no |
| GO:0030334 | regulation of cell migration | 23.6364 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 23.6364 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 23.6364 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 23.6364 | 7 | no |
| GO:2000145 | regulation of cell motility | 23.6364 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 21.8182 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.8182 | 4 | no |
| GO:0031346 | positive regulation of cell projection organization | 21.8182 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 21.8182 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.8182 | 4 | no |
| GO:0045785 | positive regulation of cell adhesion | 21.8182 | 5 | no |
| GO:0060284 | regulation of cell development | 21.8182 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 21.8182 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.8182 | 5 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 21.8182 | 5 | no |
| GO:0016310 | phosphorylation | 20.0000 | 5 | yes |
| GO:0051093 | negative regulation of developmental process | 18.1818 | 4 | yes |
| GO:0045596 | negative regulation of cell differentiation | 16.3636 | 5 | yes |
| GO:0048812 | neuron projection morphogenesis | 16.3636 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 16.3636 | 4 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 14.5455 | 6 | yes |
| GO:0007411 | axon guidance | 7.2727 | 8 | yes |
| GO:0097485 | neuron projection guidance | 7.2727 | 7 | yes |
| GO:0007185 | cell surface receptor protein tyrosine phosphatase signaling pathway | 5.4545 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DISC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NLGN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPRF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NAV1_HUMAN | [view interactions] | Low throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STMN1_HUMAN | [view interactions] | High throughput | no | yes |
| ZSC26_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| DOC10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| APOB_HUMAN | [view interactions] | High throughput | no | no |
| TPP2_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| NAKD2_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOME3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCAB1_HUMAN | [view interactions] | High throughput | no | no |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CORO6_HUMAN | [view interactions] | High throughput | no | no |
| ITPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BLMH_HUMAN | [view interactions] | High throughput | no | yes |
| LIMS1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| DSCR9_HUMAN | [view interactions] | High throughput | no | no |
| CENPJ_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAV2_HUMAN | [view interactions] | High throughput | no | yes |
| NAV3_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN232_HUMAN | [view interactions] | High throughput | no | no |
| ZN785_HUMAN | [view interactions] | High throughput | no | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CBAR1_HUMAN | [view interactions] | High throughput | no | no |
| TTC23_HUMAN | [view interactions] | High throughput | no | yes |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| UGGG1_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL22L_HUMAN | [view interactions] | High throughput | no | no |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| LMO3_HUMAN | [view interactions] | High throughput | no | no |
| ADA2_HUMAN | [view interactions] | High throughput | no | no |
| RBTN1_HUMAN | [view interactions] | High throughput | no | no |
| GLHA_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PALS2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| MYO10_HUMAN | [view interactions] | High throughput | no | no |
| IF2G_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELOF1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPF27_HUMAN | [view interactions] | High throughput | no | yes |
| CFA45_HUMAN | [view interactions] | High throughput | no | no |
| PPM1F_HUMAN | [view interactions] | High throughput | no | yes |
| RPE_HUMAN | [view interactions] | High throughput | no | yes |
| SSU72_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPRS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |