PTPRS_HUMAN
Evidence for PS localization
Functions
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 . Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases . Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PTPRS_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 30.7692 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.7692 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.7692 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 23.0769 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.0769 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.0769 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 20.5128 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 20.5128 | 5 | no |
| GO:0004725 | protein tyrosine phosphatase activity | 10.2564 | 4 | yes |
| GO:0016791 | phosphatase activity | 10.2564 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 10.2564 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PTPRS_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 61.5385 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 51.2821 | 4 | no |
| GO:0010646 | regulation of cell communication | 51.2821 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 48.7179 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 46.1538 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 38.4615 | 6 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 38.4615 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.4615 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 38.4615 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 35.8974 | 4 | no |
| GO:0033043 | regulation of organelle organization | 35.8974 | 5 | no |
| GO:0009966 | regulation of signal transduction | 35.8974 | 4 | yes |
| GO:0030030 | cell projection organization | 33.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 33.3333 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 30.7692 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 30.7692 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 30.7692 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 30.7692 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 30.7692 | 7 | yes |
| GO:0051129 | negative regulation of cellular component organization | 28.2051 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 28.2051 | 4 | yes |
| GO:0050807 | regulation of synapse organization | 28.2051 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.2051 | 5 | no |
| GO:0022607 | cellular component assembly | 28.2051 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.2051 | 5 | no |
| GO:0034330 | cell junction organization | 28.2051 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 28.2051 | 4 | yes |
| GO:0080134 | regulation of response to stress | 25.6410 | 4 | yes |
| GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 25.6410 | 4 | yes |
| GO:1901888 | regulation of cell junction assembly | 25.6410 | 5 | no |
| GO:0006996 | organelle organization | 25.6410 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 25.6410 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.6410 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.6410 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.6410 | 5 | no |
| GO:0050808 | synapse organization | 25.6410 | 5 | no |
| GO:0060284 | regulation of cell development | 23.0769 | 5 | yes |
| GO:0008104 | protein localization | 23.0769 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.0769 | 6 | no |
| GO:0031399 | regulation of protein modification process | 23.0769 | 6 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 23.0769 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 23.0769 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 23.0769 | 7 | no |
| GO:0045597 | positive regulation of cell differentiation | 23.0769 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.0769 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 23.0769 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.0769 | 5 | no |
| GO:0031175 | neuron projection development | 23.0769 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 23.0769 | 4 | yes |
| GO:0032101 | regulation of response to external stimulus | 23.0769 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 20.5128 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 20.5128 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 20.5128 | 5 | yes |
| GO:0080135 | regulation of cellular response to stress | 20.5128 | 4 | yes |
| GO:0099560 | synaptic membrane adhesion | 20.5128 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 20.5128 | 7 | no |
| GO:0007010 | cytoskeleton organization | 20.5128 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 20.5128 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.5128 | 6 | no |
| GO:0010941 | regulation of cell death | 20.5128 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.5128 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.5128 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.5128 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.5128 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.5128 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.5128 | 5 | yes |
| GO:0001817 | regulation of cytokine production | 17.9487 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 17.9487 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 17.9487 | 4 | yes |
| GO:0036211 | protein modification process | 17.9487 | 4 | yes |
| GO:0043412 | macromolecule modification | 17.9487 | 4 | yes |
| GO:0050767 | regulation of neurogenesis | 15.3846 | 6 | yes |
| GO:0051093 | negative regulation of developmental process | 15.3846 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 15.3846 | 5 | yes |
| GO:0045596 | negative regulation of cell differentiation | 15.3846 | 5 | yes |
| GO:0010629 | negative regulation of gene expression | 12.8205 | 6 | yes |
| GO:0031345 | negative regulation of cell projection organization | 12.8205 | 6 | yes |
| GO:0048679 | regulation of axon regeneration | 10.2564 | 5 | yes |
| GO:0050768 | negative regulation of neurogenesis | 10.2564 | 6 | yes |
| GO:0050776 | regulation of immune response | 10.2564 | 4 | yes |
| GO:0051961 | negative regulation of nervous system development | 10.2564 | 5 | yes |
| GO:0070570 | regulation of neuron projection regeneration | 10.2564 | 4 | yes |
| GO:1903034 | regulation of response to wounding | 10.2564 | 5 | yes |
| GO:0001558 | regulation of cell growth | 10.2564 | 4 | yes |
| GO:0001818 | negative regulation of cytokine production | 10.2564 | 5 | yes |
| GO:0006470 | protein dephosphorylation | 10.2564 | 5 | yes |
| GO:0010721 | negative regulation of cell development | 10.2564 | 6 | yes |
| GO:0010977 | negative regulation of neuron projection development | 10.2564 | 7 | yes |
| GO:0016311 | dephosphorylation | 10.2564 | 5 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 10.2564 | 5 | yes |
| GO:0050770 | regulation of axonogenesis | 7.6923 | 5 | yes |
| GO:0060998 | regulation of dendritic spine development | 7.6923 | 4 | yes |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | 7.6923 | 6 | yes |
| GO:0045926 | negative regulation of growth | 5.1282 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 5.1282 | 4 | yes |
| GO:0048640 | negative regulation of developmental growth | 5.1282 | 5 | yes |
| GO:0048670 | regulation of collateral sprouting | 5.1282 | 5 | yes |
| GO:0048671 | negative regulation of collateral sprouting | 5.1282 | 6 | yes |
| GO:0048681 | negative regulation of axon regeneration | 5.1282 | 6 | yes |
| GO:0050771 | negative regulation of axonogenesis | 5.1282 | 6 | yes |
| GO:0061000 | negative regulation of dendritic spine development | 5.1282 | 5 | yes |
| GO:0061387 | regulation of extent of cell growth | 5.1282 | 5 | yes |
| GO:0062207 | regulation of pattern recognition receptor signaling pathway | 5.1282 | 5 | yes |
| GO:0070571 | negative regulation of neuron projection regeneration | 5.1282 | 5 | yes |
| GO:1903035 | negative regulation of response to wounding | 5.1282 | 5 | yes |
| GO:0030308 | negative regulation of cell growth | 5.1282 | 5 | yes |
| GO:0030516 | regulation of axon extension | 5.1282 | 5 | yes |
| GO:0030517 | negative regulation of axon extension | 5.1282 | 6 | yes |
| GO:0032479 | regulation of type I interferon production | 5.1282 | 5 | yes |
| GO:0032480 | negative regulation of type I interferon production | 5.1282 | 6 | yes |
| GO:0032647 | regulation of interferon-alpha production | 5.1282 | 6 | yes |
| GO:0032648 | regulation of interferon-beta production | 5.1282 | 6 | yes |
| GO:0032687 | negative regulation of interferon-alpha production | 5.1282 | 7 | yes |
| GO:0032688 | negative regulation of interferon-beta production | 5.1282 | 7 | yes |
| GO:0034121 | regulation of toll-like receptor signaling pathway | 5.1282 | 6 | yes |
| GO:0034122 | negative regulation of toll-like receptor signaling pathway | 5.1282 | 6 | yes |
| GO:0034163 | regulation of toll-like receptor 9 signaling pathway | 5.1282 | 7 | yes |
| GO:0034164 | negative regulation of toll-like receptor 9 signaling pathway | 5.1282 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PTPRS_HUMAN |
|---|---|---|---|---|
| DOID:0060038 | specific developmental disorder | 5.1282 | 3 | no |
| DOID:0060307 | autosomal dominant intellectual developmental disorder | 5.1282 | 5 | no |
| DOID:1059 | intellectual disability | 5.1282 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| LIPA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPRA_HUMAN | [view interactions] | Low throughput | no | yes |
| NDKB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PKD1_HUMAN | [view interactions] | Low throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRRT4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GPC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GPC3_HUMAN | [view interactions] | Low throughput | no | no |
| GPC2_HUMAN | [view interactions] | Low throughput | no | no |
| GPC6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SLIK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IL1AP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRN_HUMAN | [view interactions] | Low throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE126_HUMAN | [view interactions] | High throughput | no | no |
| U119A_HUMAN | [view interactions] | High throughput | no | no |
| PTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHOCN_HUMAN | [view interactions] | High throughput | no | yes |
| KAT5_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBR1_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| FEZ1_HUMAN | [view interactions] | High throughput | no | no |
| PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UT14A_HUMAN | [view interactions] | High throughput | no | yes |
| SETB1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIPA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIPA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYK_HUMAN | [view interactions] | High throughput | no | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| DPA1_HUMAN | [view interactions] | High throughput | no | yes |
| CEA21_HUMAN | [view interactions] | High throughput | no | yes |
| TM231_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| GINM1_HUMAN | [view interactions] | High throughput | no | yes |
| MMP3_HUMAN | [view interactions] | High throughput | no | no |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| HECA2_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| SYSC_HUMAN | [view interactions] | High throughput | no | yes |
| PCD12_HUMAN | [view interactions] | High throughput | no | no |
| CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRIQ1_HUMAN | [view interactions] | High throughput | no | no |
| S39A5_HUMAN | [view interactions] | High throughput | no | no |
| PCDGD_HUMAN | [view interactions] | High throughput | no | no |
| FKBP9_HUMAN | [view interactions] | High throughput | no | yes |
| TNFL8_HUMAN | [view interactions] | High throughput | no | no |
| KLRG2_HUMAN | [view interactions] | High throughput | no | no |
| MRAP2_HUMAN | [view interactions] | High throughput | no | no |
| LIPE_HUMAN | [view interactions] | High throughput | no | no |
| FCGRN_HUMAN | [view interactions] | High throughput | no | yes |
| CRP_HUMAN | [view interactions] | High throughput | no | no |
| RUSF1_HUMAN | [view interactions] | High throughput | no | yes |
| MANS1_HUMAN | [view interactions] | High throughput | no | yes |
| I13R2_HUMAN | [view interactions] | High throughput | no | no |
| STX11_HUMAN | [view interactions] | High throughput | no | yes |
| ARRD3_HUMAN | [view interactions] | High throughput | no | no |
| CC50B_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| TISD_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRM_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRE_HUMAN | [view interactions] | High throughput | no | no |
| GCN1_HUMAN | [view interactions] | High throughput | no | yes |
| GET4_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| SMC4_HUMAN | [view interactions] | High throughput | no | yes |
| UGGG1_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRB_HUMAN | [view interactions] | High throughput | no | yes |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| CEAM8_HUMAN | [view interactions] | High throughput | no | no |
| OPT_HUMAN | [view interactions] | High throughput | no | no |
| TMM59_HUMAN | [view interactions] | High throughput | no | yes |
| PTC2_HUMAN | [view interactions] | High throughput | no | no |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| CTLA4_HUMAN | [view interactions] | High throughput | no | no |
| CGRE1_HUMAN | [view interactions] | High throughput | no | no |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| ST14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCL3_HUMAN | [view interactions] | High throughput | no | no |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| EPO_HUMAN | [view interactions] | High throughput | no | no |
| UD17_HUMAN | [view interactions] | High throughput | no | no |
| CSTL1_HUMAN | [view interactions] | High throughput | no | no |
| IL31_HUMAN | [view interactions] | High throughput | no | no |
| PCDG7_HUMAN | [view interactions] | High throughput | no | no |
| TMPSD_HUMAN | [view interactions] | High throughput | no | no |
| PRPH2_HUMAN | [view interactions] | High throughput | no | no |
| SG2A2_HUMAN | [view interactions] | High throughput | no | no |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EDAR_HUMAN | [view interactions] | High throughput | no | yes |
| SPXN4_HUMAN | [view interactions] | High throughput | no | no |
| CAD16_HUMAN | [view interactions] | High throughput | no | no |
| SMIM5_HUMAN | [view interactions] | High throughput | no | yes |
| CRLF1_HUMAN | [view interactions] | High throughput | no | no |
| SE6L1_HUMAN | [view interactions] | High throughput | no | no |
| MARH1_HUMAN | [view interactions] | High throughput | no | yes |
| INAR1_HUMAN | [view interactions] | High throughput | no | yes |
| SGCA_HUMAN | [view interactions] | High throughput | no | yes |
| KC1G2_HUMAN | [view interactions] | High throughput | no | yes |
| I20RB_HUMAN | [view interactions] | High throughput | no | no |
| GPC5B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYT11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLL1_HUMAN | [view interactions] | High throughput | no | no |
| KCNE4_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN13_HUMAN | [view interactions] | High throughput | no | yes |
| PTN14_HUMAN | [view interactions] | High throughput | no | yes |
| PTN2_HUMAN | [view interactions] | High throughput | no | yes |
| PTN6_HUMAN | [view interactions] | High throughput | no | no |
| PTPRG_HUMAN | [view interactions] | High throughput | no | no |
| PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRQ_HUMAN | [view interactions] | High throughput | no | no |
| PTN3_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRU_HUMAN | [view interactions] | High throughput | no | yes |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSKI2_HUMAN | [view interactions] | High throughput | no | yes |
| IKKA_HUMAN | [view interactions] | High throughput | no | yes |
| GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |