Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PTPRS_HUMAN

Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 . Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases . Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PTPRS_HUMAN
GO:0043168 anion binding 32.0000 4 no
GO:0000166 nucleotide binding 30.0000 4 no
GO:0017076 purine nucleotide binding 30.0000 5 no
GO:0032555 purine ribonucleotide binding 30.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.0000 4 no
GO:0004725 protein tyrosine phosphatase activity 8.0000 4 yes
GO:0016791 phosphatase activity 8.0000 5 yes
GO:0042578 phosphoric ester hydrolase activity 8.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PTPRS_HUMAN
GO:0051128 regulation of cellular component organization 58.0000 4 yes
GO:0010646 regulation of cell communication 54.0000 4 yes
GO:0048523 negative regulation of cellular process 46.0000 4 yes
GO:0048522 positive regulation of cellular process 46.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 40.0000 4 yes
GO:0031344 regulation of cell projection organization 38.0000 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 38.0000 6 yes
GO:0009966 regulation of signal transduction 36.0000 4 yes
GO:0031323 regulation of cellular metabolic process 34.0000 4 yes
GO:0010975 regulation of neuron projection development 32.0000 7 yes
GO:0080090 regulation of primary metabolic process 32.0000 4 no
GO:0010468 regulation of gene expression 30.0000 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 30.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 30.0000 5 yes
GO:0033043 regulation of organelle organization 30.0000 5 yes
GO:0044087 regulation of cellular component biogenesis 30.0000 4 yes
GO:0030030 cell projection organization 30.0000 4 no
GO:0009889 regulation of biosynthetic process 30.0000 4 yes
GO:0045595 regulation of cell differentiation 28.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 28.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 28.0000 4 yes
GO:2000026 regulation of multicellular organismal development 28.0000 4 yes
GO:0022607 cellular component assembly 28.0000 4 no
GO:0051246 regulation of protein metabolic process 28.0000 5 no
GO:0034330 cell junction organization 28.0000 4 no
GO:0051130 positive regulation of cellular component organization 28.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 26.0000 4 yes
GO:0051129 negative regulation of cellular component organization 26.0000 5 yes
GO:0009893 positive regulation of metabolic process 26.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 26.0000 5 no
GO:0120036 plasma membrane bounded cell projection organization 26.0000 5 no
GO:1902531 regulation of intracellular signal transduction 26.0000 5 no
GO:0050808 synapse organization 26.0000 5 no
GO:0050807 regulation of synapse organization 24.0000 5 yes
GO:0051241 negative regulation of multicellular organismal process 24.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 24.0000 5 no
GO:0031175 neuron projection development 24.0000 6 no
GO:0032101 regulation of response to external stimulus 22.0000 4 yes
GO:0060284 regulation of cell development 22.0000 5 yes
GO:0006996 organelle organization 22.0000 4 no
GO:0008104 protein localization 22.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 22.0000 4 no
GO:0048585 negative regulation of response to stimulus 20.0000 4 yes
GO:0051960 regulation of nervous system development 20.0000 5 yes
GO:1901888 regulation of cell junction assembly 20.0000 5 yes
GO:0006796 phosphate-containing compound metabolic process 20.0000 4 yes
GO:0009892 negative regulation of metabolic process 18.0000 4 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 18.0000 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 16.0000 5 yes
GO:0031324 negative regulation of cellular metabolic process 16.0000 5 yes
GO:0036211 protein modification process 16.0000 4 yes
GO:0043412 macromolecule modification 16.0000 4 yes
GO:0045596 negative regulation of cell differentiation 16.0000 5 yes
GO:0050767 regulation of neurogenesis 16.0000 6 yes
GO:0051093 negative regulation of developmental process 16.0000 4 yes
GO:0001817 regulation of cytokine production 16.0000 4 yes
GO:0009968 negative regulation of signal transduction 14.0000 5 yes
GO:0010648 negative regulation of cell communication 14.0000 5 yes
GO:0010721 negative regulation of cell development 14.0000 6 yes
GO:0023057 negative regulation of signaling 14.0000 4 yes
GO:0051963 regulation of synapse assembly 14.0000 6 yes
GO:0080134 regulation of response to stress 14.0000 4 yes
GO:0099175 regulation of postsynapse organization 14.0000 6 yes
GO:0099560 synaptic membrane adhesion 14.0000 5 yes
GO:0009890 negative regulation of biosynthetic process 14.0000 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 12.0000 6 yes
GO:0010629 negative regulation of gene expression 12.0000 7 yes
GO:0031327 negative regulation of cellular biosynthetic process 12.0000 6 yes
GO:0031345 negative regulation of cell projection organization 12.0000 6 yes
GO:0050768 negative regulation of neurogenesis 12.0000 6 yes
GO:0050770 regulation of axonogenesis 12.0000 5 yes
GO:0051961 negative regulation of nervous system development 12.0000 5 yes
GO:0099536 synaptic signaling 12.0000 4 yes
GO:0099537 trans-synaptic signaling 12.0000 5 yes
GO:1902115 regulation of organelle assembly 12.0000 5 yes
GO:0010977 negative regulation of neuron projection development 10.0000 7 yes
GO:0032102 negative regulation of response to external stimulus 10.0000 5 yes
GO:0048638 regulation of developmental growth 10.0000 4 yes
GO:0050771 negative regulation of axonogenesis 10.0000 6 yes
GO:0080135 regulation of cellular response to stress 10.0000 4 yes
GO:0099150 regulation of postsynaptic specialization assembly 10.0000 6 yes
GO:0099151 regulation of postsynaptic density assembly 10.0000 7 yes
GO:1904889 regulation of excitatory synapse assembly 10.0000 7 yes
GO:1905874 regulation of postsynaptic density organization 10.0000 6 yes
GO:0001558 regulation of cell growth 10.0000 4 yes
GO:0001818 negative regulation of cytokine production 10.0000 5 yes
GO:0016311 dephosphorylation 8.0000 5 yes
GO:0030308 negative regulation of cell growth 8.0000 5 yes
GO:0030516 regulation of axon extension 8.0000 5 yes
GO:0030517 negative regulation of axon extension 8.0000 6 yes
GO:0031347 regulation of defense response 8.0000 5 yes
GO:0045926 negative regulation of growth 8.0000 4 yes
GO:0048640 negative regulation of developmental growth 8.0000 5 yes
GO:0048679 regulation of axon regeneration 8.0000 5 yes
GO:0050776 regulation of immune response 8.0000 4 yes
GO:0061387 regulation of extent of cell growth 8.0000 5 yes
GO:0070570 regulation of neuron projection regeneration 8.0000 4 yes
GO:1903034 regulation of response to wounding 8.0000 5 yes
GO:0002683 negative regulation of immune system process 8.0000 4 yes
GO:0006470 protein dephosphorylation 8.0000 5 yes
GO:0035335 peptidyl-tyrosine dephosphorylation 6.0000 6 yes
GO:0060998 regulation of dendritic spine development 6.0000 4 yes
GO:0002831 regulation of response to biotic stimulus 6.0000 4 yes
GO:0032479 regulation of type I interferon production 4.0000 5 yes
GO:0032480 negative regulation of type I interferon production 4.0000 6 yes
GO:0032647 regulation of interferon-alpha production 4.0000 6 yes
GO:0032648 regulation of interferon-beta production 4.0000 6 yes
GO:0032687 negative regulation of interferon-alpha production 4.0000 7 yes
GO:0032688 negative regulation of interferon-beta production 4.0000 7 yes
GO:0034163 regulation of toll-like receptor 9 signaling pathway 4.0000 7 yes
GO:0034164 negative regulation of toll-like receptor 9 signaling pathway 4.0000 6 yes
GO:0039531 regulation of cytoplasmic pattern recognition receptor signaling pathway 4.0000 6 yes
GO:0039532 negative regulation of cytoplasmic pattern recognition receptor signaling pathway 4.0000 5 yes
GO:0045088 regulation of innate immune response 4.0000 5 yes
GO:0048670 regulation of collateral sprouting 4.0000 5 yes
GO:0048671 negative regulation of collateral sprouting 4.0000 6 yes
GO:0048681 negative regulation of axon regeneration 4.0000 6 yes
GO:0061000 negative regulation of dendritic spine development 4.0000 5 yes
GO:0061028 establishment of endothelial barrier 4.0000 6 yes
GO:0062207 regulation of pattern recognition receptor signaling pathway 4.0000 5 yes
GO:0070571 negative regulation of neuron projection regeneration 4.0000 5 yes
GO:0090557 establishment of endothelial intestinal barrier 4.0000 7 yes
GO:1903035 negative regulation of response to wounding 4.0000 5 yes
GO:0001885 endothelial cell development 4.0000 5 yes
GO:0002064 epithelial cell development 4.0000 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NDKB_HUMAN [view entry] [view interactions] Low throughput yes yes
PKD1_HUMAN [view interactions] Low throughput no yes
CADH1_HUMAN [view entry] [view interactions] Low throughput yes no
LRRT4_HUMAN [view entry] [view interactions] Low throughput yes no
GPC4_HUMAN [view entry] [view interactions] Low throughput yes yes
GPC3_HUMAN [view interactions] Low throughput no no
GPC2_HUMAN [view interactions] Low throughput no no
GPC6_HUMAN [view entry] [view interactions] Low throughput yes yes
SLIK1_HUMAN [view entry] [view interactions] Low throughput yes yes
IL1AP_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRN_HUMAN [view interactions] Low throughput no yes
NTRK3_HUMAN [view entry] [view interactions] Low throughput yes yes
LIPA1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRD_HUMAN [view entry] [view interactions] Low throughput yes no
PTPRA_HUMAN [view interactions] Low throughput no yes
FCGRN_HUMAN [view interactions] High throughput no yes
CRP_HUMAN [view interactions] High throughput no no
RUSF1_HUMAN [view interactions] High throughput no yes
MANS1_HUMAN [view interactions] High throughput no yes
I13R2_HUMAN [view interactions] High throughput no no
STX11_HUMAN [view interactions] High throughput no yes
ARRD3_HUMAN [view interactions] High throughput no no
CC50B_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
TISD_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
PTPRF_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRM_HUMAN [view interactions] High throughput no yes
PTPRE_HUMAN [view interactions] High throughput no no
GCN1_HUMAN [view interactions] High throughput no yes
GET4_HUMAN [view interactions] High throughput no yes
PSMD1_HUMAN [view entry] [view interactions] High throughput yes yes
SMC1A_HUMAN [view interactions] High throughput no yes
SMC2_HUMAN [view interactions] High throughput no yes
SMC4_HUMAN [view interactions] High throughput no yes
UGGG1_HUMAN [view interactions] High throughput no yes
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRB_HUMAN [view interactions] High throughput no yes
NRSN1_HUMAN [view interactions] High throughput no yes
CEAM8_HUMAN [view interactions] High throughput no no
OPT_HUMAN [view interactions] High throughput no no
TMM59_HUMAN [view interactions] High throughput no yes
PTC2_HUMAN [view interactions] High throughput no no
KCNE3_HUMAN [view interactions] High throughput no yes
CTLA4_HUMAN [view interactions] High throughput no no
CGRE1_HUMAN [view interactions] High throughput no no
RN149_HUMAN [view interactions] High throughput no no
ST14_HUMAN [view entry] [view interactions] High throughput yes yes
CCL3_HUMAN [view interactions] High throughput no no
PGFRB_HUMAN [view interactions] High throughput no yes
EPO_HUMAN [view interactions] High throughput no no
UD17_HUMAN [view interactions] High throughput no no
CSTL1_HUMAN [view interactions] High throughput no no
IL31_HUMAN [view interactions] High throughput no no
PCDG7_HUMAN [view interactions] High throughput no no
TMPSD_HUMAN [view interactions] High throughput no no
PRPH2_HUMAN [view interactions] High throughput no no
SG2A2_HUMAN [view interactions] High throughput no no
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
EDAR_HUMAN [view interactions] High throughput no yes
SPXN4_HUMAN [view interactions] High throughput no no
CAD16_HUMAN [view interactions] High throughput no no
SMIM5_HUMAN [view interactions] High throughput no yes
CRLF1_HUMAN [view interactions] High throughput no no
SE6L1_HUMAN [view entry] [view interactions] High throughput yes no
MARH1_HUMAN [view interactions] High throughput no yes
INAR1_HUMAN [view interactions] High throughput no yes
SGCA_HUMAN [view interactions] High throughput no yes
KC1G2_HUMAN [view interactions] High throughput no yes
I20RB_HUMAN [view interactions] High throughput no no
GPC5B_HUMAN [view entry] [view interactions] High throughput yes no
SYT11_HUMAN [view entry] [view interactions] High throughput yes yes
DLL1_HUMAN [view interactions] High throughput no no
KCNE4_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
TOP3B_HUMAN [view interactions] High throughput no no
ASPM_HUMAN [view interactions] High throughput no no
PTN13_HUMAN [view interactions] High throughput no yes
PTN14_HUMAN [view interactions] High throughput no yes
PTN2_HUMAN [view interactions] High throughput no yes
PTN6_HUMAN [view interactions] High throughput no no
PTPRG_HUMAN [view interactions] High throughput no no
PTPRJ_HUMAN [view interactions] High throughput no yes
PTPRQ_HUMAN [view interactions] High throughput no no
PTN3_HUMAN [view interactions] High throughput no yes
PTPRU_HUMAN [view interactions] High throughput no yes
TRIO_HUMAN [view entry] [view interactions] High throughput yes yes
CSKI2_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
MUC18_HUMAN [view interactions] High throughput no yes
IKKA_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
GRID2_HUMAN [view entry] [view interactions] High throughput yes no
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CCD47_HUMAN [view interactions] High throughput no yes
IF4A2_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SCN2A_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
EF1G_HUMAN [view entry] [view interactions] High throughput yes yes
CE126_HUMAN [view interactions] High throughput no no
U119A_HUMAN [view interactions] High throughput no no
PTN_HUMAN [view entry] [view interactions] High throughput yes yes
PHOCN_HUMAN [view entry] [view interactions] High throughput yes yes
KAT5_HUMAN [view interactions] High throughput no yes
SUMO2_HUMAN [view entry] [view interactions] High throughput yes yes
TBB2A_HUMAN [view entry] [view interactions] High throughput yes yes
UBR1_HUMAN [view interactions] High throughput no yes
CHD3_HUMAN [view interactions] High throughput no yes
FEZ1_HUMAN [view interactions] High throughput no no
PROF2_HUMAN [view entry] [view interactions] High throughput yes yes
UT14A_HUMAN [view interactions] High throughput no yes
SETB1_HUMAN [view interactions] High throughput no yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRS_HUMAN [view entry] [view interactions] High throughput yes no
LIPA2_HUMAN [view entry] [view interactions] High throughput yes no
LIPA3_HUMAN [view entry] [view interactions] High throughput yes yes
RYK_HUMAN [view entry] [view interactions] High throughput yes no
FBX6_HUMAN [view interactions] High throughput no yes
DPA1_HUMAN [view interactions] High throughput no yes
CEA21_HUMAN [view interactions] High throughput no yes
TM231_HUMAN [view interactions] High throughput no yes
TGFR2_HUMAN [view interactions] High throughput no no
GINM1_HUMAN [view interactions] High throughput no yes
MMP3_HUMAN [view interactions] High throughput no no
TNFA_HUMAN [view interactions] High throughput no no
HECA2_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
SYSC_HUMAN [view interactions] High throughput no yes
PCD12_HUMAN [view interactions] High throughput no no
CLUS_HUMAN [view entry] [view interactions] High throughput yes yes
LRIQ1_HUMAN [view interactions] High throughput no no
S39A5_HUMAN [view interactions] High throughput no no
PCDGD_HUMAN [view interactions] High throughput no no
FKBP9_HUMAN [view interactions] High throughput no yes
TNFL8_HUMAN [view interactions] High throughput no no
KLRG2_HUMAN [view interactions] High throughput no no
MRAP2_HUMAN [view interactions] High throughput no no
LIPG_HUMAN [view interactions] High throughput no no