PTPRS_HUMAN
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 . Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases . Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PTPRS_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 32.0000 | 4 | no |
GO:0000166 | nucleotide binding | 30.0000 | 4 | no |
GO:0017076 | purine nucleotide binding | 30.0000 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 30.0000 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 28.0000 | 4 | no |
GO:0004725 | protein tyrosine phosphatase activity | 8.0000 | 4 | yes |
GO:0016791 | phosphatase activity | 8.0000 | 5 | yes |
GO:0042578 | phosphoric ester hydrolase activity | 8.0000 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PTPRS_HUMAN |
---|---|---|---|---|
GO:0051128 | regulation of cellular component organization | 58.0000 | 4 | yes |
GO:0010646 | regulation of cell communication | 54.0000 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 46.0000 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 46.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | yes |
GO:0031344 | regulation of cell projection organization | 38.0000 | 5 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 38.0000 | 6 | yes |
GO:0009966 | regulation of signal transduction | 36.0000 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 34.0000 | 4 | yes |
GO:0010975 | regulation of neuron projection development | 32.0000 | 7 | yes |
GO:0080090 | regulation of primary metabolic process | 32.0000 | 4 | no |
GO:0010468 | regulation of gene expression | 30.0000 | 6 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 30.0000 | 5 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 30.0000 | 5 | yes |
GO:0033043 | regulation of organelle organization | 30.0000 | 5 | yes |
GO:0044087 | regulation of cellular component biogenesis | 30.0000 | 4 | yes |
GO:0030030 | cell projection organization | 30.0000 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 30.0000 | 4 | yes |
GO:0045595 | regulation of cell differentiation | 28.0000 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 28.0000 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 28.0000 | 4 | yes |
GO:2000026 | regulation of multicellular organismal development | 28.0000 | 4 | yes |
GO:0022607 | cellular component assembly | 28.0000 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 28.0000 | 5 | no |
GO:0034330 | cell junction organization | 28.0000 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 28.0000 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 26.0000 | 4 | yes |
GO:0051129 | negative regulation of cellular component organization | 26.0000 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 26.0000 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 26.0000 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 26.0000 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 26.0000 | 5 | no |
GO:0050808 | synapse organization | 26.0000 | 5 | no |
GO:0050807 | regulation of synapse organization | 24.0000 | 5 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 24.0000 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 24.0000 | 5 | no |
GO:0031175 | neuron projection development | 24.0000 | 6 | no |
GO:0032101 | regulation of response to external stimulus | 22.0000 | 4 | yes |
GO:0060284 | regulation of cell development | 22.0000 | 5 | yes |
GO:0006996 | organelle organization | 22.0000 | 4 | no |
GO:0008104 | protein localization | 22.0000 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 22.0000 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 20.0000 | 4 | yes |
GO:0051960 | regulation of nervous system development | 20.0000 | 5 | yes |
GO:1901888 | regulation of cell junction assembly | 20.0000 | 5 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 20.0000 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 18.0000 | 4 | yes |
GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 18.0000 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 16.0000 | 5 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 16.0000 | 5 | yes |
GO:0036211 | protein modification process | 16.0000 | 4 | yes |
GO:0043412 | macromolecule modification | 16.0000 | 4 | yes |
GO:0045596 | negative regulation of cell differentiation | 16.0000 | 5 | yes |
GO:0050767 | regulation of neurogenesis | 16.0000 | 6 | yes |
GO:0051093 | negative regulation of developmental process | 16.0000 | 4 | yes |
GO:0001817 | regulation of cytokine production | 16.0000 | 4 | yes |
GO:0009968 | negative regulation of signal transduction | 14.0000 | 5 | yes |
GO:0010648 | negative regulation of cell communication | 14.0000 | 5 | yes |
GO:0010721 | negative regulation of cell development | 14.0000 | 6 | yes |
GO:0023057 | negative regulation of signaling | 14.0000 | 4 | yes |
GO:0051963 | regulation of synapse assembly | 14.0000 | 6 | yes |
GO:0080134 | regulation of response to stress | 14.0000 | 4 | yes |
GO:0099175 | regulation of postsynapse organization | 14.0000 | 6 | yes |
GO:0099560 | synaptic membrane adhesion | 14.0000 | 5 | yes |
GO:0009890 | negative regulation of biosynthetic process | 14.0000 | 5 | yes |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 12.0000 | 6 | yes |
GO:0010629 | negative regulation of gene expression | 12.0000 | 7 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 12.0000 | 6 | yes |
GO:0031345 | negative regulation of cell projection organization | 12.0000 | 6 | yes |
GO:0050768 | negative regulation of neurogenesis | 12.0000 | 6 | yes |
GO:0050770 | regulation of axonogenesis | 12.0000 | 5 | yes |
GO:0051961 | negative regulation of nervous system development | 12.0000 | 5 | yes |
GO:0099536 | synaptic signaling | 12.0000 | 4 | yes |
GO:0099537 | trans-synaptic signaling | 12.0000 | 5 | yes |
GO:1902115 | regulation of organelle assembly | 12.0000 | 5 | yes |
GO:0010977 | negative regulation of neuron projection development | 10.0000 | 7 | yes |
GO:0032102 | negative regulation of response to external stimulus | 10.0000 | 5 | yes |
GO:0048638 | regulation of developmental growth | 10.0000 | 4 | yes |
GO:0050771 | negative regulation of axonogenesis | 10.0000 | 6 | yes |
GO:0080135 | regulation of cellular response to stress | 10.0000 | 4 | yes |
GO:0099150 | regulation of postsynaptic specialization assembly | 10.0000 | 6 | yes |
GO:0099151 | regulation of postsynaptic density assembly | 10.0000 | 7 | yes |
GO:1904889 | regulation of excitatory synapse assembly | 10.0000 | 7 | yes |
GO:1905874 | regulation of postsynaptic density organization | 10.0000 | 6 | yes |
GO:0001558 | regulation of cell growth | 10.0000 | 4 | yes |
GO:0001818 | negative regulation of cytokine production | 10.0000 | 5 | yes |
GO:0016311 | dephosphorylation | 8.0000 | 5 | yes |
GO:0030308 | negative regulation of cell growth | 8.0000 | 5 | yes |
GO:0030516 | regulation of axon extension | 8.0000 | 5 | yes |
GO:0030517 | negative regulation of axon extension | 8.0000 | 6 | yes |
GO:0031347 | regulation of defense response | 8.0000 | 5 | yes |
GO:0045926 | negative regulation of growth | 8.0000 | 4 | yes |
GO:0048640 | negative regulation of developmental growth | 8.0000 | 5 | yes |
GO:0048679 | regulation of axon regeneration | 8.0000 | 5 | yes |
GO:0050776 | regulation of immune response | 8.0000 | 4 | yes |
GO:0061387 | regulation of extent of cell growth | 8.0000 | 5 | yes |
GO:0070570 | regulation of neuron projection regeneration | 8.0000 | 4 | yes |
GO:1903034 | regulation of response to wounding | 8.0000 | 5 | yes |
GO:0002683 | negative regulation of immune system process | 8.0000 | 4 | yes |
GO:0006470 | protein dephosphorylation | 8.0000 | 5 | yes |
GO:0035335 | peptidyl-tyrosine dephosphorylation | 6.0000 | 6 | yes |
GO:0060998 | regulation of dendritic spine development | 6.0000 | 4 | yes |
GO:0002831 | regulation of response to biotic stimulus | 6.0000 | 4 | yes |
GO:0032479 | regulation of type I interferon production | 4.0000 | 5 | yes |
GO:0032480 | negative regulation of type I interferon production | 4.0000 | 6 | yes |
GO:0032647 | regulation of interferon-alpha production | 4.0000 | 6 | yes |
GO:0032648 | regulation of interferon-beta production | 4.0000 | 6 | yes |
GO:0032687 | negative regulation of interferon-alpha production | 4.0000 | 7 | yes |
GO:0032688 | negative regulation of interferon-beta production | 4.0000 | 7 | yes |
GO:0034163 | regulation of toll-like receptor 9 signaling pathway | 4.0000 | 7 | yes |
GO:0034164 | negative regulation of toll-like receptor 9 signaling pathway | 4.0000 | 6 | yes |
GO:0039531 | regulation of cytoplasmic pattern recognition receptor signaling pathway | 4.0000 | 6 | yes |
GO:0039532 | negative regulation of cytoplasmic pattern recognition receptor signaling pathway | 4.0000 | 5 | yes |
GO:0045088 | regulation of innate immune response | 4.0000 | 5 | yes |
GO:0048670 | regulation of collateral sprouting | 4.0000 | 5 | yes |
GO:0048671 | negative regulation of collateral sprouting | 4.0000 | 6 | yes |
GO:0048681 | negative regulation of axon regeneration | 4.0000 | 6 | yes |
GO:0061000 | negative regulation of dendritic spine development | 4.0000 | 5 | yes |
GO:0061028 | establishment of endothelial barrier | 4.0000 | 6 | yes |
GO:0062207 | regulation of pattern recognition receptor signaling pathway | 4.0000 | 5 | yes |
GO:0070571 | negative regulation of neuron projection regeneration | 4.0000 | 5 | yes |
GO:0090557 | establishment of endothelial intestinal barrier | 4.0000 | 7 | yes |
GO:1903035 | negative regulation of response to wounding | 4.0000 | 5 | yes |
GO:0001885 | endothelial cell development | 4.0000 | 5 | yes |
GO:0002064 | epithelial cell development | 4.0000 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NDKB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PKD1_HUMAN | [view interactions] | Low throughput | no | yes |
CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
LRRT4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
GPC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GPC3_HUMAN | [view interactions] | Low throughput | no | no |
GPC2_HUMAN | [view interactions] | Low throughput | no | no |
GPC6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SLIK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IL1AP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PTPRN_HUMAN | [view interactions] | Low throughput | no | yes |
NTRK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LIPA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PTPRD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PTPRA_HUMAN | [view interactions] | Low throughput | no | yes |
FCGRN_HUMAN | [view interactions] | High throughput | no | yes |
CRP_HUMAN | [view interactions] | High throughput | no | no |
RUSF1_HUMAN | [view interactions] | High throughput | no | yes |
MANS1_HUMAN | [view interactions] | High throughput | no | yes |
I13R2_HUMAN | [view interactions] | High throughput | no | no |
STX11_HUMAN | [view interactions] | High throughput | no | yes |
ARRD3_HUMAN | [view interactions] | High throughput | no | no |
CC50B_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
TISD_HUMAN | [view interactions] | High throughput | no | no |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTPRM_HUMAN | [view interactions] | High throughput | no | yes |
PTPRE_HUMAN | [view interactions] | High throughput | no | no |
GCN1_HUMAN | [view interactions] | High throughput | no | yes |
GET4_HUMAN | [view interactions] | High throughput | no | yes |
PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
SMC2_HUMAN | [view interactions] | High throughput | no | yes |
SMC4_HUMAN | [view interactions] | High throughput | no | yes |
UGGG1_HUMAN | [view interactions] | High throughput | no | yes |
PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTPRB_HUMAN | [view interactions] | High throughput | no | yes |
NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
CEAM8_HUMAN | [view interactions] | High throughput | no | no |
OPT_HUMAN | [view interactions] | High throughput | no | no |
TMM59_HUMAN | [view interactions] | High throughput | no | yes |
PTC2_HUMAN | [view interactions] | High throughput | no | no |
KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
CTLA4_HUMAN | [view interactions] | High throughput | no | no |
CGRE1_HUMAN | [view interactions] | High throughput | no | no |
RN149_HUMAN | [view interactions] | High throughput | no | no |
ST14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCL3_HUMAN | [view interactions] | High throughput | no | no |
PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
EPO_HUMAN | [view interactions] | High throughput | no | no |
UD17_HUMAN | [view interactions] | High throughput | no | no |
CSTL1_HUMAN | [view interactions] | High throughput | no | no |
IL31_HUMAN | [view interactions] | High throughput | no | no |
PCDG7_HUMAN | [view interactions] | High throughput | no | no |
TMPSD_HUMAN | [view interactions] | High throughput | no | no |
PRPH2_HUMAN | [view interactions] | High throughput | no | no |
SG2A2_HUMAN | [view interactions] | High throughput | no | no |
FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EDAR_HUMAN | [view interactions] | High throughput | no | yes |
SPXN4_HUMAN | [view interactions] | High throughput | no | no |
CAD16_HUMAN | [view interactions] | High throughput | no | no |
SMIM5_HUMAN | [view interactions] | High throughput | no | yes |
CRLF1_HUMAN | [view interactions] | High throughput | no | no |
SE6L1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARH1_HUMAN | [view interactions] | High throughput | no | yes |
INAR1_HUMAN | [view interactions] | High throughput | no | yes |
SGCA_HUMAN | [view interactions] | High throughput | no | yes |
KC1G2_HUMAN | [view interactions] | High throughput | no | yes |
I20RB_HUMAN | [view interactions] | High throughput | no | no |
GPC5B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYT11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLL1_HUMAN | [view interactions] | High throughput | no | no |
KCNE4_HUMAN | [view interactions] | High throughput | no | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOC_HUMAN | [view interactions] | High throughput | no | no |
RND2_HUMAN | [view interactions] | High throughput | no | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TOP3B_HUMAN | [view interactions] | High throughput | no | no |
ASPM_HUMAN | [view interactions] | High throughput | no | no |
PTN13_HUMAN | [view interactions] | High throughput | no | yes |
PTN14_HUMAN | [view interactions] | High throughput | no | yes |
PTN2_HUMAN | [view interactions] | High throughput | no | yes |
PTN6_HUMAN | [view interactions] | High throughput | no | no |
PTPRG_HUMAN | [view interactions] | High throughput | no | no |
PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
PTPRQ_HUMAN | [view interactions] | High throughput | no | no |
PTN3_HUMAN | [view interactions] | High throughput | no | yes |
PTPRU_HUMAN | [view interactions] | High throughput | no | yes |
TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSKI2_HUMAN | [view interactions] | High throughput | no | yes |
STING_HUMAN | [view interactions] | High throughput | no | yes |
TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MUC18_HUMAN | [view interactions] | High throughput | no | yes |
IKKA_HUMAN | [view interactions] | High throughput | no | yes |
FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCD47_HUMAN | [view interactions] | High throughput | no | yes |
IF4A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCN2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CE126_HUMAN | [view interactions] | High throughput | no | no |
U119A_HUMAN | [view interactions] | High throughput | no | no |
PTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PHOCN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KAT5_HUMAN | [view interactions] | High throughput | no | yes |
SUMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBR1_HUMAN | [view interactions] | High throughput | no | yes |
CHD3_HUMAN | [view interactions] | High throughput | no | yes |
FEZ1_HUMAN | [view interactions] | High throughput | no | no |
PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UT14A_HUMAN | [view interactions] | High throughput | no | yes |
SETB1_HUMAN | [view interactions] | High throughput | no | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTPRS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LIPA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LIPA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RYK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FBX6_HUMAN | [view interactions] | High throughput | no | yes |
DPA1_HUMAN | [view interactions] | High throughput | no | yes |
CEA21_HUMAN | [view interactions] | High throughput | no | yes |
TM231_HUMAN | [view interactions] | High throughput | no | yes |
TGFR2_HUMAN | [view interactions] | High throughput | no | no |
GINM1_HUMAN | [view interactions] | High throughput | no | yes |
MMP3_HUMAN | [view interactions] | High throughput | no | no |
TNFA_HUMAN | [view interactions] | High throughput | no | no |
HECA2_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
SYSC_HUMAN | [view interactions] | High throughput | no | yes |
PCD12_HUMAN | [view interactions] | High throughput | no | no |
CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRIQ1_HUMAN | [view interactions] | High throughput | no | no |
S39A5_HUMAN | [view interactions] | High throughput | no | no |
PCDGD_HUMAN | [view interactions] | High throughput | no | no |
FKBP9_HUMAN | [view interactions] | High throughput | no | yes |
TNFL8_HUMAN | [view interactions] | High throughput | no | no |
KLRG2_HUMAN | [view interactions] | High throughput | no | no |
MRAP2_HUMAN | [view interactions] | High throughput | no | no |
LIPG_HUMAN | [view interactions] | High throughput | no | no |