PTPRD_HUMAN
Evidence for PS localization
Functions
Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PTPRD_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 29.2683 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 29.2683 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 29.2683 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 29.2683 | 5 | no |
| GO:0005524 | ATP binding | 26.8293 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.8293 | 4 | no |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 21.9512 | 4 | no |
| GO:0016301 | kinase activity | 21.9512 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 21.9512 | 4 | no |
| GO:0004725 | protein tyrosine phosphatase activity | 9.7561 | 4 | yes |
| GO:0016791 | phosphatase activity | 9.7561 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 9.7561 | 4 | yes |
| GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity | 7.3171 | 5 | yes |
| GO:0019198 | transmembrane receptor protein phosphatase activity | 7.3171 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PTPRD_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 53.6585 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 53.6585 | 4 | yes |
| GO:0010646 | regulation of cell communication | 46.3415 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 39.0244 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 39.0244 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.5854 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.5854 | 4 | no |
| GO:0022607 | cellular component assembly | 34.1463 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 34.1463 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 34.1463 | 4 | yes |
| GO:0050807 | regulation of synapse organization | 34.1463 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 34.1463 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 34.1463 | 5 | yes |
| GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 34.1463 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 31.7073 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 31.7073 | 4 | no |
| GO:0036211 | protein modification process | 29.2683 | 4 | yes |
| GO:0043412 | macromolecule modification | 29.2683 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 29.2683 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 29.2683 | 5 | yes |
| GO:0051963 | regulation of synapse assembly | 29.2683 | 6 | yes |
| GO:1901888 | regulation of cell junction assembly | 29.2683 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 29.2683 | 4 | yes |
| GO:0030030 | cell projection organization | 29.2683 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.2683 | 5 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 26.8293 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 26.8293 | 4 | yes |
| GO:0051962 | positive regulation of nervous system development | 26.8293 | 5 | yes |
| GO:0099560 | synaptic membrane adhesion | 26.8293 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 26.8293 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.8293 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 24.3902 | 7 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.3902 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 24.3902 | 5 | yes |
| GO:0051965 | positive regulation of synapse assembly | 24.3902 | 6 | yes |
| GO:0099174 | regulation of presynapse organization | 24.3902 | 6 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.3902 | 6 | yes |
| GO:1901890 | positive regulation of cell junction assembly | 24.3902 | 6 | yes |
| GO:1905606 | regulation of presynapse assembly | 24.3902 | 7 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 24.3902 | 5 | no |
| GO:0033043 | regulation of organelle organization | 21.9512 | 5 | yes |
| GO:0051049 | regulation of transport | 21.9512 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.9512 | 5 | no |
| GO:0034330 | cell junction organization | 21.9512 | 4 | no |
| GO:0050808 | synapse organization | 21.9512 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.9512 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.9512 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 21.9512 | 5 | no |
| GO:0045597 | positive regulation of cell differentiation | 19.5122 | 5 | yes |
| GO:0099175 | regulation of postsynapse organization | 19.5122 | 6 | yes |
| GO:0048585 | negative regulation of response to stimulus | 17.0732 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 17.0732 | 5 | yes |
| GO:0060284 | regulation of cell development | 17.0732 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 17.0732 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 17.0732 | 4 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 14.6341 | 4 | yes |
| GO:0010720 | positive regulation of cell development | 14.6341 | 6 | yes |
| GO:0031346 | positive regulation of cell projection organization | 14.6341 | 6 | yes |
| GO:0050767 | regulation of neurogenesis | 14.6341 | 6 | yes |
| GO:0009968 | negative regulation of signal transduction | 12.1951 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 12.1951 | 5 | yes |
| GO:0022604 | regulation of cell morphogenesis | 12.1951 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 12.1951 | 4 | yes |
| GO:0050769 | positive regulation of neurogenesis | 12.1951 | 6 | yes |
| GO:0050776 | regulation of immune response | 12.1951 | 4 | yes |
| GO:0061024 | membrane organization | 12.1951 | 4 | yes |
| GO:0099150 | regulation of postsynaptic specialization assembly | 12.1951 | 6 | yes |
| GO:0099151 | regulation of postsynaptic density assembly | 12.1951 | 7 | yes |
| GO:1902115 | regulation of organelle assembly | 12.1951 | 5 | yes |
| GO:1904889 | regulation of excitatory synapse assembly | 12.1951 | 7 | yes |
| GO:1905874 | regulation of postsynaptic density organization | 12.1951 | 6 | yes |
| GO:0006470 | protein dephosphorylation | 9.7561 | 5 | yes |
| GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway | 9.7561 | 5 | yes |
| GO:0016311 | dephosphorylation | 9.7561 | 5 | yes |
| GO:0048814 | regulation of dendrite morphogenesis | 9.7561 | 5 | yes |
| GO:0050773 | regulation of dendrite development | 9.7561 | 4 | yes |
| GO:0071709 | membrane assembly | 9.7561 | 5 | yes |
| GO:0097090 | presynaptic membrane organization | 9.7561 | 5 | yes |
| GO:0097105 | presynaptic membrane assembly | 9.7561 | 6 | yes |
| GO:0099545 | trans-synaptic signaling by trans-synaptic complex | 9.7561 | 5 | yes |
| GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | 7.3171 | 5 | yes |
| GO:0010769 | regulation of cell morphogenesis involved in differentiation | 7.3171 | 6 | yes |
| GO:0010770 | positive regulation of cell morphogenesis involved in differentiation | 7.3171 | 7 | yes |
| GO:0030182 | neuron differentiation | 7.3171 | 4 | yes |
| GO:0050775 | positive regulation of dendrite morphogenesis | 7.3171 | 6 | yes |
| GO:0046425 | regulation of receptor signaling pathway via JAK-STAT | 4.8780 | 6 | yes |
| GO:0046426 | negative regulation of receptor signaling pathway via JAK-STAT | 4.8780 | 7 | yes |
| GO:1904892 | regulation of receptor signaling pathway via STAT | 4.8780 | 5 | yes |
| GO:1904893 | negative regulation of receptor signaling pathway via STAT | 4.8780 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PTPRD_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 4.8780 | 4 | no |
| DOID:331 | central nervous system disease | 4.8780 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GPC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SLIK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRFN5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SLIK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRFN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IRPL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AURKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRC4B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPRD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LIPA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LIPA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRA_HUMAN | [view interactions] | Low throughput | no | yes |
| NLGN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPRF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IL1AP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN2_HUMAN | [view interactions] | High throughput | no | yes |
| MTSS1_HUMAN | [view interactions] | High throughput | no | no |
| YTHD1_HUMAN | [view interactions] | High throughput | no | no |
| GSTT1_HUMAN | [view interactions] | High throughput | no | no |
| DSC3_HUMAN | [view interactions] | High throughput | no | no |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRPM7_HUMAN | [view interactions] | High throughput | no | no |
| ROS1_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| SLAI2_HUMAN | [view interactions] | High throughput | no | no |
| NEK1_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| TBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSSK2_HUMAN | [view interactions] | High throughput | no | no |
| SMTL2_HUMAN | [view interactions] | High throughput | no | no |
| PAK6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK2_HUMAN | [view interactions] | High throughput | no | no |
| NEK6_HUMAN | [view interactions] | High throughput | no | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMX_HUMAN | [view interactions] | High throughput | no | no |
| IRS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX54_HUMAN | [view interactions] | High throughput | no | yes |
| FERM2_HUMAN | [view interactions] | High throughput | no | yes |
| BIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDM2_HUMAN | [view interactions] | High throughput | no | yes |
| LIPA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LPAR6_HUMAN | [view interactions] | High throughput | no | no |
| IL2RG_HUMAN | [view interactions] | High throughput | no | no |
| SCN2B_HUMAN | [view interactions] | High throughput | no | no |
| LRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COPG2_HUMAN | [view interactions] | High throughput | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPP2_HUMAN | [view interactions] | High throughput | no | yes |
| LRRN1_HUMAN | [view interactions] | High throughput | no | yes |
| PCDBG_HUMAN | [view interactions] | High throughput | no | no |
| PIANP_HUMAN | [view interactions] | High throughput | no | yes |
| LITAF_HUMAN | [view interactions] | High throughput | no | yes |
| CD83_HUMAN | [view interactions] | High throughput | no | yes |
| ICOSL_HUMAN | [view interactions] | High throughput | no | yes |
| PMEL_HUMAN | [view interactions] | High throughput | no | no |
| PCD20_HUMAN | [view interactions] | High throughput | no | no |
| IZUM1_HUMAN | [view interactions] | High throughput | no | no |
| GPR37_HUMAN | [view interactions] | High throughput | no | no |
| ABCG8_HUMAN | [view interactions] | High throughput | no | yes |
| PCDGG_HUMAN | [view interactions] | High throughput | no | no |
| LIRB4_HUMAN | [view interactions] | High throughput | no | no |
| TEX45_HUMAN | [view interactions] | High throughput | no | no |
| RHG36_HUMAN | [view interactions] | High throughput | no | yes |
| I17RD_HUMAN | [view interactions] | High throughput | no | yes |
| LIGO2_HUMAN | [view interactions] | High throughput | no | yes |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STMN4_HUMAN | [view interactions] | High throughput | no | no |
| MILR1_HUMAN | [view interactions] | High throughput | no | no |
| TM52B_HUMAN | [view interactions] | High throughput | no | no |
| RL28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPC2_HUMAN | [view interactions] | High throughput | no | no |
| TM223_HUMAN | [view interactions] | High throughput | no | yes |
| I20RA_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRE_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGFA_HUMAN | [view interactions] | High throughput | no | yes |
| PCDB1_HUMAN | [view interactions] | High throughput | no | no |
| TR10A_HUMAN | [view interactions] | High throughput | no | no |
| KI2L1_HUMAN | [view interactions] | High throughput | no | no |
| TA2R_HUMAN | [view interactions] | High throughput | no | no |
| V1BR_HUMAN | [view interactions] | High throughput | no | no |
| NIPA3_HUMAN | [view interactions] | High throughput | no | no |
| IL3RA_HUMAN | [view interactions] | High throughput | no | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| IL32_HUMAN | [view interactions] | High throughput | no | no |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| PRRT3_HUMAN | [view interactions] | High throughput | no | yes |
| PCDB6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN133_HUMAN | [view interactions] | High throughput | no | no |
| MCLN2_HUMAN | [view interactions] | High throughput | no | no |
| KCNKI_HUMAN | [view interactions] | High throughput | no | no |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| RYK_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| POTEA_HUMAN | [view interactions] | High throughput | no | no |
| MARH2_HUMAN | [view interactions] | High throughput | no | yes |
| SO4C1_HUMAN | [view interactions] | High throughput | no | no |
| OX2R_HUMAN | [view interactions] | High throughput | no | no |
| PL8L1_HUMAN | [view interactions] | High throughput | no | no |
| LRRN2_HUMAN | [view interactions] | High throughput | no | yes |
| PIGN_HUMAN | [view interactions] | High throughput | no | yes |
| SE6L1_HUMAN | [view interactions] | High throughput | no | no |
| UD11_HUMAN | [view interactions] | High throughput | no | no |
| T150A_HUMAN | [view interactions] | High throughput | no | yes |
| CLDN1_HUMAN | [view interactions] | High throughput | no | yes |
| PCDG6_HUMAN | [view interactions] | High throughput | no | yes |
| MRAP2_HUMAN | [view interactions] | High throughput | no | no |
| TIGIT_HUMAN | [view interactions] | High throughput | no | no |
| ZDH11_HUMAN | [view interactions] | High throughput | no | no |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| KCNC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TR19L_HUMAN | [view interactions] | High throughput | no | no |
| DDX17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCEL_HUMAN | [view interactions] | High throughput | no | no |
| MATK_HUMAN | [view interactions] | High throughput | no | yes |
| SLIK3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LIPA4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LIPB1_HUMAN | [view interactions] | Computational | no | yes |
| LIPB2_HUMAN | [view interactions] | Computational | no | yes |