PAK6_HUMAN
Evidence for PS localization
Functions
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PAK6_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 45.2381 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 42.8571 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 40.4762 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.4762 | 4 | yes |
| GO:0043168 | anion binding | 40.4762 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 33.3333 | 6 | yes |
| GO:0005524 | ATP binding | 30.9524 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 30.9524 | 5 | yes |
| GO:0043169 | cation binding | 28.5714 | 4 | no |
| GO:0045296 | cadherin binding | 26.1905 | 4 | yes |
| GO:0019900 | kinase binding | 26.1905 | 4 | no |
| GO:0046872 | metal ion binding | 23.8095 | 5 | no |
| GO:0003723 | RNA binding | 21.4286 | 4 | no |
| GO:0019901 | protein kinase binding | 21.4286 | 5 | no |
| GO:0016301 | kinase activity | 19.0476 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 19.0476 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 11.9048 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 11.9048 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PAK6_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 64.2857 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 59.5238 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 59.5238 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 59.5238 | 4 | no |
| GO:0010646 | regulation of cell communication | 52.3810 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 52.3810 | 4 | no |
| GO:0008104 | protein localization | 50.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 47.6190 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 42.8571 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 42.8571 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 40.4762 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.4762 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.4762 | 5 | yes |
| GO:0051049 | regulation of transport | 40.4762 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.0952 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 38.0952 | 4 | no |
| GO:0006996 | organelle organization | 35.7143 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.7143 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 35.7143 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.7143 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 30.9524 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 30.9524 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 30.9524 | 5 | no |
| GO:0060341 | regulation of cellular localization | 30.9524 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.9524 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.9524 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.5714 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 28.5714 | 5 | no |
| GO:0032880 | regulation of protein localization | 28.5714 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 28.5714 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 28.5714 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.1905 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 26.1905 | 6 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.1905 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 26.1905 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 26.1905 | 7 | no |
| GO:0006915 | apoptotic process | 23.8095 | 4 | yes |
| GO:0030030 | cell projection organization | 23.8095 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 23.8095 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 23.8095 | 5 | no |
| GO:0016310 | phosphorylation | 21.4286 | 5 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 21.4286 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.4286 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.4286 | 6 | no |
| GO:0036211 | protein modification process | 21.4286 | 4 | no |
| GO:0043412 | macromolecule modification | 21.4286 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.4286 | 6 | no |
| GO:0034762 | regulation of transmembrane transport | 21.4286 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.4286 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.4286 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.4286 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.4286 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.4286 | 5 | no |
| GO:0051050 | positive regulation of transport | 21.4286 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.4286 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.4286 | 5 | no |
| GO:0051338 | regulation of transferase activity | 21.4286 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 19.0476 | 6 | yes |
| GO:0007612 | learning | 16.6667 | 4 | yes |
| GO:0050890 | cognition | 16.6667 | 4 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 16.6667 | 4 | yes |
| GO:0048812 | neuron projection morphogenesis | 14.2857 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 11.9048 | 5 | yes |
| GO:1990138 | neuron projection extension | 9.5238 | 4 | yes |
| GO:0007613 | memory | 4.7619 | 4 | yes |
| GO:0140058 | neuron projection arborization | 4.7619 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| ANDR_HUMAN | [view interactions] | Low throughput | no | no |
| LNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MDM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| PAK6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LIMK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK14_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
| ACACB_HUMAN | [view interactions] | High throughput | no | no |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK4_HUMAN | [view interactions] | High throughput | no | yes |
| C1TC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM4_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MP2K6_HUMAN | [view interactions] | High throughput | no | yes |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| AGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF8_HUMAN | [view interactions] | High throughput | no | yes |
| USP9X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| TTC28_HUMAN | [view interactions] | High throughput | no | no |
| SAHH3_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| APC1_HUMAN | [view interactions] | High throughput | no | no |
| CPVL_HUMAN | [view interactions] | High throughput | no | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPD53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEM3B_HUMAN | [view interactions] | High throughput | no | yes |
| NEK6_HUMAN | [view interactions] | High throughput | no | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIME_HUMAN | [view interactions] | High throughput | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TENX_HUMAN | [view interactions] | High throughput | no | no |
| CKAP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESRP1_HUMAN | [view interactions] | High throughput | no | yes |
| GIMA8_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC45_HUMAN | [view interactions] | High throughput | no | yes |
| MAK16_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |