Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PAK6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PAK6_HUMAN
GO:0017076 purine nucleotide binding 46.3415 4 yes
GO:0032555 purine ribonucleotide binding 46.3415 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 46.3415 4 yes
GO:0005524 ATP binding 34.1463 5 yes
GO:0030554 adenyl nucleotide binding 34.1463 5 yes
GO:0032559 adenyl ribonucleotide binding 34.1463 5 yes
GO:0019900 kinase binding 26.8293 4 no
GO:0045296 cadherin binding 24.3902 4 yes
GO:0019901 protein kinase binding 24.3902 5 no
GO:0016301 kinase activity 21.9512 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 21.9512 4 yes
GO:0004674 protein serine/threonine kinase activity 14.6341 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 14.6341 4 yes
GO:0106310 protein serine kinase activity 14.6341 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PAK6_HUMAN
GO:0031323 regulation of cellular metabolic process 63.4146 4 yes
GO:0060255 regulation of macromolecule metabolic process 60.9756 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 58.5366 4 yes
GO:0080090 regulation of primary metabolic process 58.5366 4 yes
GO:0048523 negative regulation of cellular process 56.0976 4 no
GO:0048522 positive regulation of cellular process 53.6585 4 no
GO:0010646 regulation of cell communication 51.2195 4 yes
GO:0009966 regulation of signal transduction 46.3415 4 yes
GO:0008104 protein localization 46.3415 4 no
GO:0010468 regulation of gene expression 41.4634 5 yes
GO:0051128 regulation of cellular component organization 41.4634 4 no
GO:0051049 regulation of transport 41.4634 4 no
GO:0009889 regulation of biosynthetic process 39.0244 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 39.0244 5 yes
GO:0031326 regulation of cellular biosynthetic process 39.0244 5 yes
GO:0051246 regulation of protein metabolic process 39.0244 5 no
GO:0009893 positive regulation of metabolic process 39.0244 4 no
GO:0010556 regulation of macromolecule biosynthetic process 36.5854 5 yes
GO:0009892 negative regulation of metabolic process 36.5854 4 no
GO:0010605 negative regulation of macromolecule metabolic process 36.5854 5 no
GO:0019220 regulation of phosphate metabolic process 36.5854 6 no
GO:0051174 regulation of phosphorus metabolic process 36.5854 5 no
GO:0010604 positive regulation of macromolecule metabolic process 36.5854 5 no
GO:0031325 positive regulation of cellular metabolic process 36.5854 5 no
GO:0006796 phosphate-containing compound metabolic process 34.1463 4 yes
GO:0006996 organelle organization 34.1463 4 yes
GO:1902531 regulation of intracellular signal transduction 34.1463 5 yes
GO:0031399 regulation of protein modification process 34.1463 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 34.1463 5 no
GO:0030030 cell projection organization 31.7073 4 yes
GO:0051252 regulation of RNA metabolic process 31.7073 5 yes
GO:0015031 protein transport 31.7073 4 no
GO:0042325 regulation of phosphorylation 31.7073 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 31.7073 5 no
GO:0071702 organic substance transport 31.7073 4 no
GO:0071705 nitrogen compound transport 31.7073 4 no
GO:0010941 regulation of cell death 31.7073 4 no
GO:0022607 cellular component assembly 31.7073 4 no
GO:0042981 regulation of apoptotic process 31.7073 6 no
GO:0043067 regulation of programmed cell death 31.7073 5 no
GO:0060341 regulation of cellular localization 31.7073 4 no
GO:0006355 regulation of DNA-templated transcription 29.2683 6 yes
GO:1903506 regulation of nucleic acid-templated transcription 29.2683 7 yes
GO:2001141 regulation of RNA biosynthetic process 29.2683 6 yes
GO:0001932 regulation of protein phosphorylation 29.2683 7 no
GO:0031324 negative regulation of cellular metabolic process 29.2683 5 no
GO:0036211 protein modification process 26.8293 4 yes
GO:0043412 macromolecule modification 26.8293 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.8293 6 no
GO:0048584 positive regulation of response to stimulus 26.8293 4 no
GO:0032880 regulation of protein localization 26.8293 5 no
GO:0051050 positive regulation of transport 26.8293 4 no
GO:0016310 phosphorylation 24.3902 5 yes
GO:0006886 intracellular protein transport 24.3902 4 no
GO:0043549 regulation of kinase activity 24.3902 5 no
GO:0045595 regulation of cell differentiation 24.3902 4 no
GO:0051338 regulation of transferase activity 24.3902 4 no
GO:0009967 positive regulation of signal transduction 24.3902 5 no
GO:0010647 positive regulation of cell communication 24.3902 5 no
GO:0023056 positive regulation of signaling 24.3902 4 no
GO:0044087 regulation of cellular component biogenesis 24.3902 4 no
GO:0051130 positive regulation of cellular component organization 24.3902 5 no
GO:0051247 positive regulation of protein metabolic process 24.3902 6 no
GO:1902533 positive regulation of intracellular signal transduction 24.3902 6 no
GO:0043085 positive regulation of catalytic activity 24.3902 4 no
GO:1903829 positive regulation of protein localization 24.3902 5 no
GO:0006468 protein phosphorylation 21.9512 5 yes
GO:0043408 regulation of MAPK cascade 21.9512 6 yes
GO:0045859 regulation of protein kinase activity 21.9512 6 no
GO:0051248 negative regulation of protein metabolic process 21.9512 6 no
GO:0009891 positive regulation of biosynthetic process 21.9512 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.9512 6 no
GO:0031328 positive regulation of cellular biosynthetic process 21.9512 6 no
GO:0033043 regulation of organelle organization 21.9512 5 no
GO:0042127 regulation of cell population proliferation 21.9512 4 no
GO:0120036 plasma membrane bounded cell projection organization 21.9512 5 no
GO:0010562 positive regulation of phosphorus metabolic process 21.9512 6 no
GO:0042327 positive regulation of phosphorylation 21.9512 8 no
GO:0045937 positive regulation of phosphate metabolic process 21.9512 7 no
GO:0060548 negative regulation of cell death 21.9512 5 no
GO:0031344 regulation of cell projection organization 21.9512 5 no
GO:0032386 regulation of intracellular transport 21.9512 5 no
GO:0051222 positive regulation of protein transport 21.9512 5 no
GO:0051223 regulation of protein transport 21.9512 5 no
GO:0070201 regulation of establishment of protein localization 21.9512 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.9512 6 no
GO:1904951 positive regulation of establishment of protein localization 21.9512 6 no
GO:0006915 apoptotic process 17.0732 4 yes
GO:0032990 cell part morphogenesis 17.0732 4 yes
GO:0048858 cell projection morphogenesis 17.0732 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 17.0732 6 yes
GO:0007010 cytoskeleton organization 14.6341 5 yes
GO:0048812 neuron projection morphogenesis 14.6341 7 yes
GO:1990138 neuron projection extension 12.1951 4 yes
GO:0007612 learning 9.7561 4 yes
GO:0050890 cognition 9.7561 4 yes
GO:0007613 memory 7.3171 4 yes
GO:0140058 neuron projection arborization 4.8780 8 yes

Disease

Term Name % Distance from top the of the tree Annotated in PAK6_HUMAN
DOID:0060038 specific developmental disorder 4.8780 3 no
DOID:1059 intellectual disability 4.8780 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
LRRK2_HUMAN [view interactions] Low throughput no yes
ANDR_HUMAN [view interactions] Low throughput no no
LNX1_HUMAN [view interactions] Low throughput no yes
MDM2_HUMAN [view interactions] Low throughput no yes
ESR1_HUMAN [view interactions] Low throughput no no
PAK6_HUMAN [view entry] [view interactions] Low throughput yes yes
LIMK1_HUMAN [view interactions] Low throughput no yes
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
MK14_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2G_HUMAN [view entry] [view interactions] High throughput yes yes
RHBT2_HUMAN [view interactions] High throughput no no
CPVL_HUMAN [view interactions] High throughput no no
APC1_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
SAHH3_HUMAN [view interactions] High throughput no yes
TTC28_HUMAN [view interactions] High throughput no no
UBP7_HUMAN [view interactions] High throughput no yes
USP9X_HUMAN [view entry] [view interactions] High throughput yes yes
DCAF8_HUMAN [view interactions] High throughput no yes
AGK_HUMAN [view entry] [view interactions] High throughput yes yes
DDB1_HUMAN [view interactions] High throughput no yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
RACK1_HUMAN [view interactions] High throughput no yes
DCAF7_HUMAN [view interactions] High throughput no yes
ACLY_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K6_HUMAN [view interactions] High throughput no yes
6PGD_HUMAN [view entry] [view interactions] High throughput yes no
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
MCM4_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
PYR1_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
C1TC_HUMAN [view entry] [view interactions] High throughput yes no
PAK4_HUMAN [view interactions] High throughput no yes
SAHH2_HUMAN [view entry] [view interactions] High throughput yes yes
AT2A1_HUMAN [view entry] [view interactions] High throughput yes no
ACACB_HUMAN [view interactions] High throughput no no
CNOT1_HUMAN [view interactions] High throughput no yes
KPYM_HUMAN [view interactions] High throughput no yes
CDK1_HUMAN [view interactions] High throughput no no
SNX2_HUMAN [view entry] [view interactions] High throughput yes no
TPD53_HUMAN [view entry] [view interactions] High throughput yes yes
SEM3B_HUMAN [view interactions] High throughput no yes
NEK6_HUMAN [view interactions] High throughput no yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOV_HUMAN [view interactions] High throughput no no
HSF2B_HUMAN [view interactions] High throughput no yes
LRRK1_HUMAN [view interactions] High throughput no yes
PTPRD_HUMAN [view entry] [view interactions] High throughput yes no
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
MIME_HUMAN [view interactions] High throughput no no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
TENX_HUMAN [view interactions] High throughput no no
CKAP2_HUMAN [view interactions] High throughput no yes
ESRP1_HUMAN [view interactions] High throughput no yes
GIMA8_HUMAN [view interactions] High throughput no yes
ANXA6_HUMAN [view entry] [view interactions] High throughput yes yes
LRC45_HUMAN [view interactions] High throughput no yes
MAK16_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
FBX7_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
AFAD_HUMAN [view interactions] High throughput no yes
NCK1_HUMAN [view interactions] Computational no yes
RAC2_HUMAN [view entry] [view interactions] Computational yes yes
ROBO1_HUMAN [view interactions] Computational no yes
NCK2_HUMAN [view entry] [view interactions] Computational yes yes
RAF1_HUMAN [view entry] [view interactions] Computational yes no
GBG12_HUMAN [view entry] [view interactions] Computational yes yes
ROBO2_HUMAN [view interactions] Computational no yes
MP2K1_HUMAN [view entry] [view interactions] Computational yes yes