PYR1_HUMAN
Evidence for PS localization
Functions
This protein is a fusion protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PYR1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 45.6311 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 44.6602 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 44.6602 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 36.8932 | 5 | yes |
| GO:0005524 | ATP binding | 35.9223 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 35.9223 | 5 | yes |
| GO:0019900 | kinase binding | 24.2718 | 4 | no |
| GO:0019901 | protein kinase binding | 22.3301 | 5 | no |
| GO:0046872 | metal ion binding | 21.3592 | 4 | yes |
| GO:0016301 | kinase activity | 16.5049 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 16.5049 | 4 | yes |
| GO:0046914 | transition metal ion binding | 6.7961 | 5 | yes |
| GO:0008270 | zinc ion binding | 4.8544 | 6 | yes |
| GO:0031406 | carboxylic acid binding | 3.8835 | 4 | yes |
| GO:0016597 | amino acid binding | 2.9126 | 4 | yes |
| GO:0004070 | aspartate carbamoyltransferase activity | 1.9417 | 5 | yes |
| GO:0004088 | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | 1.9417 | 5 | yes |
| GO:0004151 | dihydroorotase activity | 1.9417 | 5 | yes |
| GO:0016743 | carboxyl- or carbamoyltransferase activity | 1.9417 | 4 | yes |
| GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides | 1.9417 | 4 | yes |
| GO:0016884 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor | 1.9417 | 4 | yes |
| GO:0070335 | aspartate binding | 1.9417 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PYR1_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 62.1359 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 61.1650 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 59.2233 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 59.2233 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 56.3107 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 47.5728 | 4 | no |
| GO:0010646 | regulation of cell communication | 46.6019 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.6311 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 44.6602 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 43.6893 | 4 | no |
| GO:0009966 | regulation of signal transduction | 42.7184 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 42.7184 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 41.7476 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 41.7476 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 41.7476 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 40.7767 | 5 | no |
| GO:0010468 | regulation of gene expression | 39.8058 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.8350 | 5 | no |
| GO:0006996 | organelle organization | 36.8932 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.9515 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 34.9515 | 5 | no |
| GO:0031399 | regulation of protein modification process | 33.0097 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 32.0388 | 5 | no |
| GO:0023056 | positive regulation of signaling | 32.0388 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 32.0388 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 32.0388 | 6 | no |
| GO:0036211 | protein modification process | 32.0388 | 4 | yes |
| GO:0043412 | macromolecule modification | 32.0388 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 32.0388 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 31.0680 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 31.0680 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.0971 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 29.1262 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 29.1262 | 7 | no |
| GO:0022607 | cellular component assembly | 29.1262 | 4 | no |
| GO:0010941 | regulation of cell death | 29.1262 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.1553 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.1553 | 5 | no |
| GO:0033043 | regulation of organelle organization | 28.1553 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 27.1845 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 27.1845 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 27.1845 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 27.1845 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 27.1845 | 6 | no |
| GO:0051049 | regulation of transport | 27.1845 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.1845 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 27.1845 | 6 | no |
| GO:0071310 | cellular response to organic substance | 26.2136 | 4 | no |
| GO:0051338 | regulation of transferase activity | 26.2136 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 25.2427 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 25.2427 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.2427 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.2718 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 24.2718 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.2718 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.2718 | 7 | no |
| GO:0031401 | positive regulation of protein modification process | 24.2718 | 7 | no |
| GO:0007010 | cytoskeleton organization | 23.3010 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.3010 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 23.3010 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.3301 | 6 | no |
| GO:0080134 | regulation of response to stress | 22.3301 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.3301 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.3301 | 5 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.3592 | 6 | no |
| GO:0060548 | negative regulation of cell death | 21.3592 | 5 | no |
| GO:0009894 | regulation of catabolic process | 21.3592 | 4 | no |
| GO:0043549 | regulation of kinase activity | 21.3592 | 5 | no |
| GO:0043408 | regulation of MAPK cascade | 21.3592 | 6 | no |
| GO:0008104 | protein localization | 21.3592 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.3592 | 5 | no |
| GO:0032880 | regulation of protein localization | 21.3592 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.3592 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.3883 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.3883 | 6 | no |
| GO:0006468 | protein phosphorylation | 17.4757 | 5 | yes |
| GO:0016310 | phosphorylation | 17.4757 | 5 | yes |
| GO:0018193 | peptidyl-amino acid modification | 12.6214 | 5 | yes |
| GO:0019752 | carboxylic acid metabolic process | 12.6214 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 12.6214 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 9.7087 | 4 | yes |
| GO:0016053 | organic acid biosynthetic process | 8.7379 | 4 | yes |
| GO:0046394 | carboxylic acid biosynthetic process | 8.7379 | 5 | yes |
| GO:0046777 | protein autophosphorylation | 8.7379 | 6 | yes |
| GO:0009064 | glutamine family amino acid metabolic process | 7.7670 | 5 | yes |
| GO:1901605 | alpha-amino acid metabolic process | 7.7670 | 4 | yes |
| GO:0008652 | cellular amino acid biosynthetic process | 6.7961 | 4 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 6.7961 | 4 | yes |
| GO:1901607 | alpha-amino acid biosynthetic process | 6.7961 | 5 | yes |
| GO:0006541 | glutamine metabolic process | 4.8544 | 6 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 4.8544 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 4.8544 | 5 | yes |
| GO:0009141 | nucleoside triphosphate metabolic process | 4.8544 | 5 | yes |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 4.8544 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 4.8544 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 4.8544 | 4 | yes |
| GO:0018107 | peptidyl-threonine phosphorylation | 3.8835 | 6 | yes |
| GO:0018130 | heterocycle biosynthetic process | 3.8835 | 4 | yes |
| GO:0018210 | peptidyl-threonine modification | 3.8835 | 6 | yes |
| GO:0019438 | aromatic compound biosynthetic process | 3.8835 | 4 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 3.8835 | 4 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 3.8835 | 4 | yes |
| GO:0009132 | nucleoside diphosphate metabolic process | 2.9126 | 5 | yes |
| GO:0009185 | ribonucleoside diphosphate metabolic process | 2.9126 | 6 | yes |
| GO:0090407 | organophosphate biosynthetic process | 2.9126 | 4 | yes |
| GO:0000052 | citrulline metabolic process | 1.9417 | 5 | yes |
| GO:0006206 | pyrimidine nucleobase metabolic process | 1.9417 | 5 | yes |
| GO:0006207 | de novo pyrimidine nucleobase biosynthetic process | 1.9417 | 7 | yes |
| GO:0006220 | pyrimidine nucleotide metabolic process | 1.9417 | 5 | yes |
| GO:0006221 | pyrimidine nucleotide biosynthetic process | 1.9417 | 6 | yes |
| GO:0006222 | UMP biosynthetic process | 1.9417 | 8 | yes |
| GO:0006225 | UDP biosynthetic process | 1.9417 | 8 | yes |
| GO:0006228 | UTP biosynthetic process | 1.9417 | 8 | yes |
| GO:0009112 | nucleobase metabolic process | 1.9417 | 4 | yes |
| GO:0009123 | nucleoside monophosphate metabolic process | 1.9417 | 5 | yes |
| GO:0009124 | nucleoside monophosphate biosynthetic process | 1.9417 | 6 | yes |
| GO:0009129 | pyrimidine nucleoside monophosphate metabolic process | 1.9417 | 6 | yes |
| GO:0009130 | pyrimidine nucleoside monophosphate biosynthetic process | 1.9417 | 7 | yes |
| GO:0009133 | nucleoside diphosphate biosynthetic process | 1.9417 | 6 | yes |
| GO:0009138 | pyrimidine nucleoside diphosphate metabolic process | 1.9417 | 6 | yes |
| GO:0009139 | pyrimidine nucleoside diphosphate biosynthetic process | 1.9417 | 7 | yes |
| GO:0009142 | nucleoside triphosphate biosynthetic process | 1.9417 | 6 | yes |
| GO:0009147 | pyrimidine nucleoside triphosphate metabolic process | 1.9417 | 6 | yes |
| GO:0009148 | pyrimidine nucleoside triphosphate biosynthetic process | 1.9417 | 7 | yes |
| GO:0009156 | ribonucleoside monophosphate biosynthetic process | 1.9417 | 7 | yes |
| GO:0009161 | ribonucleoside monophosphate metabolic process | 1.9417 | 6 | yes |
| GO:0009165 | nucleotide biosynthetic process | 1.9417 | 6 | yes |
| GO:0009173 | pyrimidine ribonucleoside monophosphate metabolic process | 1.9417 | 7 | yes |
| GO:0009174 | pyrimidine ribonucleoside monophosphate biosynthetic process | 1.9417 | 8 | yes |
| GO:0009188 | ribonucleoside diphosphate biosynthetic process | 1.9417 | 7 | yes |
| GO:0009193 | pyrimidine ribonucleoside diphosphate metabolic process | 1.9417 | 7 | yes |
| GO:0009194 | pyrimidine ribonucleoside diphosphate biosynthetic process | 1.9417 | 8 | yes |
| GO:0009201 | ribonucleoside triphosphate biosynthetic process | 1.9417 | 7 | yes |
| GO:0009208 | pyrimidine ribonucleoside triphosphate metabolic process | 1.9417 | 7 | yes |
| GO:0009209 | pyrimidine ribonucleoside triphosphate biosynthetic process | 1.9417 | 8 | yes |
| GO:0009218 | pyrimidine ribonucleotide metabolic process | 1.9417 | 6 | yes |
| GO:0009220 | pyrimidine ribonucleotide biosynthetic process | 1.9417 | 7 | yes |
| GO:0009260 | ribonucleotide biosynthetic process | 1.9417 | 6 | yes |
| GO:0019240 | citrulline biosynthetic process | 1.9417 | 6 | yes |
| GO:0019856 | pyrimidine nucleobase biosynthetic process | 1.9417 | 6 | yes |
| GO:0044205 | de novo UMP biosynthetic process | 1.9417 | 9 | yes |
| GO:0046048 | UDP metabolic process | 1.9417 | 7 | yes |
| GO:0046049 | UMP metabolic process | 1.9417 | 7 | yes |
| GO:0046051 | UTP metabolic process | 1.9417 | 7 | yes |
| GO:0046112 | nucleobase biosynthetic process | 1.9417 | 5 | yes |
| GO:0046390 | ribose phosphate biosynthetic process | 1.9417 | 5 | yes |
| GO:0072527 | pyrimidine-containing compound metabolic process | 1.9417 | 4 | yes |
| GO:0072528 | pyrimidine-containing compound biosynthetic process | 1.9417 | 5 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 1.9417 | 4 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 1.9417 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PYR1_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 1.9417 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PYR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAD9A_HUMAN | [view interactions] | Low throughput | no | yes |
| KS6B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYSC_HUMAN | [view interactions] | High throughput | no | yes |
| PPE1_HUMAN | [view interactions] | High throughput | no | no |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B2L14_HUMAN | [view interactions] | High throughput | no | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| IRF7_HUMAN | [view interactions] | High throughput | no | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| DNJA4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EI2BA_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRK6_HUMAN | [view interactions] | High throughput | no | yes |
| SYEP_HUMAN | [view interactions] | High throughput | no | yes |
| IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| GFPT1_HUMAN | [view interactions] | High throughput | no | no |
| PRKX_HUMAN | [view interactions] | High throughput | no | yes |
| SYIC_HUMAN | [view interactions] | High throughput | no | yes |
| LIMK1_HUMAN | [view interactions] | High throughput | no | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMK2_HUMAN | [view interactions] | High throughput | no | yes |
| IPO4_HUMAN | [view interactions] | High throughput | no | no |
| PDK4_HUMAN | [view interactions] | High throughput | no | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ST32C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| CDK20_HUMAN | [view interactions] | High throughput | no | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| PRS10_HUMAN | [view interactions] | High throughput | no | yes |
| M4K1_HUMAN | [view interactions] | High throughput | no | no |
| PSD12_HUMAN | [view interactions] | High throughput | no | yes |
| TESK2_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSSK6_HUMAN | [view interactions] | High throughput | no | no |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| STK33_HUMAN | [view interactions] | High throughput | no | no |
| MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAK6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| YMEL1_HUMAN | [view interactions] | High throughput | no | yes |
| NRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| TBXT_HUMAN | [view interactions] | High throughput | no | no |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| SP7_HUMAN | [view interactions] | High throughput | no | no |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| SP1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR2_HUMAN | [view interactions] | High throughput | no | yes |
| RS9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IKBE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| M3K1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| NFKB2_HUMAN | [view interactions] | High throughput | no | yes |
| RELB_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK1_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK3_HUMAN | [view interactions] | High throughput | no | no |
| TAB2_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1B_HUMAN | [view interactions] | High throughput | no | no |
| TRADD_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| P5F1B_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT7R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| KATIP_HUMAN | [view interactions] | High throughput | no | yes |
| MKS1_HUMAN | [view interactions] | High throughput | no | no |
| AHI1_HUMAN | [view interactions] | High throughput | no | yes |
| POC1B_HUMAN | [view interactions] | High throughput | no | no |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| NCOA2_HUMAN | [view interactions] | High throughput | no | no |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| ERG_HUMAN | [view interactions] | High throughput | no | yes |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| NOS2_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| KS6B2_HUMAN | [view interactions] | High throughput | no | yes |
| SKI_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| CAF1A_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| NFAC1_HUMAN | [view interactions] | High throughput | no | no |
| NFAC2_HUMAN | [view interactions] | High throughput | no | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| MTMRB_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYLC_HUMAN | [view interactions] | High throughput | no | yes |
| DPOD1_HUMAN | [view interactions] | High throughput | no | yes |
| PPP6_HUMAN | [view interactions] | High throughput | no | yes |
| ARNT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B2CL1_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGFB1_HUMAN | [view interactions] | High throughput | no | no |
| TRIP4_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| RIOK1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| GRWD1_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCND1_HUMAN | [view interactions] | High throughput | no | yes |
| TM41B_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FBXW8_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| RMC1_HUMAN | [view interactions] | High throughput | no | no |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| P63_HUMAN | [view interactions] | High throughput | no | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| UBP10_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASXL1_HUMAN | [view interactions] | High throughput | no | no |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| UNKL_HUMAN | [view interactions] | High throughput | no | no |
| GBRAP_HUMAN | [view interactions] | High throughput | no | no |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| HDA11_HUMAN | [view interactions] | High throughput | no | no |
| PAGE4_HUMAN | [view interactions] | High throughput | no | no |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| TBX19_HUMAN | [view interactions] | High throughput | no | no |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| VWA2_HUMAN | [view interactions] | High throughput | no | no |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| I12R1_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LOXL4_HUMAN | [view interactions] | High throughput | no | no |
| GET4_HUMAN | [view interactions] | High throughput | no | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| TRI29_HUMAN | [view interactions] | High throughput | no | no |
| ZEB1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| RHBT1_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| ADIP_HUMAN | [view interactions] | High throughput | no | yes |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| RRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| MTA70_HUMAN | [view interactions] | High throughput | no | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| HMGN5_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| MRT4_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| ATG12_HUMAN | [view interactions] | High throughput | no | yes |
| FGR_HUMAN | [view interactions] | High throughput | no | no |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| SOCS1_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| MP2K3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| BAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| ELK1_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK07_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K14_HUMAN | [view interactions] | High throughput | no | yes |
| SMRC2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS7_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMCA4_HUMAN | [view interactions] | High throughput | no | yes |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| ACSA_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYDC_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3C_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AATC2_HUMAN | [view interactions] | Computational | no | no |
| GFPT2_HUMAN | [view interactions] | Computational | no | yes |
| ASNS_HUMAN | [view interactions] | Computational | no | yes |
| DCE1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PUR1_HUMAN | [view interactions] | Computational | no | yes |
| AATM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCE2_HUMAN | [view interactions] | Computational | no | yes |
| GLSK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACY2_HUMAN | [view interactions] | Computational | no | no |
| AATC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NAT8L_HUMAN | [view interactions] | Computational | no | no |
| GADL1_HUMAN | [view interactions] | Computational | no | no |
| GLSL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PYRD_HUMAN | [view interactions] | Computational | no | yes |
| PURA1_HUMAN | [view interactions] | Computational | no | no |
| OXLA_HUMAN | [view interactions] | Computational | no | no |
| GLNA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GUAA_HUMAN | [view interactions] | Computational | no | no |
| ASPD_HUMAN | [view interactions] | Computational | no | yes |
| OTC_HUMAN | [view interactions] | Computational | no | no |
| ASGL1_HUMAN | [view interactions] | Computational | no | yes |
| CPSM_HUMAN | [view interactions] | Computational | no | no |
| PURA2_HUMAN | [view interactions] | Computational | no | yes |
| UMPS_HUMAN | [view interactions] | Computational | no | no |
| FTCD_HUMAN | [view interactions] | Computational | no | no |
| ASSY_HUMAN | [view interactions] | Computational | no | yes |
| PUR4_HUMAN | [view interactions] | Computational | no | yes |