MP2K7_HUMAN
Evidence for PS localization
Functions
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MP2K7_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 43.0380 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 43.0380 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 43.0380 | 4 | yes |
| GO:0005524 | ATP binding | 31.6456 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 31.6456 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 31.6456 | 5 | yes |
| GO:0019900 | kinase binding | 30.3797 | 4 | yes |
| GO:0019901 | protein kinase binding | 27.8481 | 5 | yes |
| GO:0046872 | metal ion binding | 25.3165 | 4 | yes |
| GO:0003723 | RNA binding | 22.7848 | 4 | no |
| GO:0016301 | kinase activity | 16.4557 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 16.4557 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 13.9241 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 10.1266 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 10.1266 | 4 | yes |
| GO:0019902 | phosphatase binding | 8.8608 | 4 | yes |
| GO:0019903 | protein phosphatase binding | 7.5949 | 5 | yes |
| GO:0004713 | protein tyrosine kinase activity | 5.0633 | 4 | yes |
| GO:0004708 | MAP kinase kinase activity | 3.7975 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MP2K7_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.8228 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 56.9620 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 55.6962 | 4 | yes |
| GO:0010646 | regulation of cell communication | 54.4304 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 54.4304 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 54.4304 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.8987 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 45.5696 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 44.3038 | 4 | yes |
| GO:0010468 | regulation of gene expression | 44.3038 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 43.0380 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 43.0380 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.5063 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.5063 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 37.9747 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 36.7089 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 36.7089 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 36.7089 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 36.7089 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 36.7089 | 6 | yes |
| GO:0010647 | positive regulation of cell communication | 35.4430 | 5 | yes |
| GO:0010941 | regulation of cell death | 35.4430 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 35.4430 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 34.1772 | 6 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.9114 | 5 | yes |
| GO:0043412 | macromolecule modification | 32.9114 | 4 | no |
| GO:0051049 | regulation of transport | 32.9114 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 31.6456 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 31.6456 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 31.6456 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 31.6456 | 5 | yes |
| GO:0036211 | protein modification process | 31.6456 | 4 | no |
| GO:0022607 | cellular component assembly | 31.6456 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 30.3797 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 30.3797 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 29.1139 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 29.1139 | 4 | no |
| GO:0006996 | organelle organization | 29.1139 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 27.8481 | 7 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 27.8481 | 6 | yes |
| GO:0043085 | positive regulation of catalytic activity | 26.5823 | 4 | yes |
| GO:0080134 | regulation of response to stress | 26.5823 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 26.5823 | 4 | no |
| GO:0060341 | regulation of cellular localization | 26.5823 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.3165 | 7 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 25.3165 | 6 | yes |
| GO:0031401 | positive regulation of protein modification process | 25.3165 | 7 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 25.3165 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 25.3165 | 6 | yes |
| GO:0033043 | regulation of organelle organization | 24.0506 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 24.0506 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 24.0506 | 4 | no |
| GO:0060548 | negative regulation of cell death | 24.0506 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.7848 | 6 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.7848 | 7 | yes |
| GO:0051338 | regulation of transferase activity | 22.7848 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 22.7848 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.7848 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.7848 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 22.7848 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 22.7848 | 6 | no |
| GO:0043408 | regulation of MAPK cascade | 21.5190 | 6 | yes |
| GO:0051130 | positive regulation of cellular component organization | 21.5190 | 5 | yes |
| GO:0080135 | regulation of cellular response to stress | 21.5190 | 4 | yes |
| GO:0008104 | protein localization | 21.5190 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.5190 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.2532 | 8 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.2532 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.2532 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.2532 | 4 | no |
| GO:0071702 | organic substance transport | 20.2532 | 4 | no |
| GO:0009894 | regulation of catabolic process | 20.2532 | 4 | no |
| GO:0030030 | cell projection organization | 20.2532 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 18.9873 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 18.9873 | 6 | yes |
| GO:0051347 | positive regulation of transferase activity | 18.9873 | 5 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 17.7215 | 8 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 17.7215 | 6 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 17.7215 | 7 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 17.7215 | 6 | yes |
| GO:0043549 | regulation of kinase activity | 16.4557 | 5 | yes |
| GO:0050776 | regulation of immune response | 16.4557 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 15.1899 | 4 | yes |
| GO:0045859 | regulation of protein kinase activity | 13.9241 | 6 | yes |
| GO:0010942 | positive regulation of cell death | 12.6582 | 5 | yes |
| GO:0033674 | positive regulation of kinase activity | 12.6582 | 6 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 12.6582 | 7 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 12.6582 | 6 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 12.6582 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 12.6582 | 8 | yes |
| GO:0000165 | MAPK cascade | 11.3924 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 11.3924 | 6 | yes |
| GO:0051052 | regulation of DNA metabolic process | 11.3924 | 5 | yes |
| GO:1901214 | regulation of neuron death | 11.3924 | 5 | yes |
| GO:0045860 | positive regulation of protein kinase activity | 10.1266 | 7 | yes |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 8.8608 | 4 | yes |
| GO:0006915 | apoptotic process | 8.8608 | 4 | yes |
| GO:0032872 | regulation of stress-activated MAPK cascade | 8.8608 | 6 | yes |
| GO:0034097 | response to cytokine | 8.8608 | 4 | yes |
| GO:0051054 | positive regulation of DNA metabolic process | 8.8608 | 6 | yes |
| GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 8.8608 | 5 | yes |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 8.8608 | 7 | yes |
| GO:0032874 | positive regulation of stress-activated MAPK cascade | 7.5949 | 7 | yes |
| GO:0043523 | regulation of neuron apoptotic process | 7.5949 | 6 | yes |
| GO:0046328 | regulation of JNK cascade | 7.5949 | 7 | yes |
| GO:0070304 | positive regulation of stress-activated protein kinase signaling cascade | 7.5949 | 6 | yes |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 7.5949 | 8 | yes |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 7.5949 | 7 | yes |
| GO:0031098 | stress-activated protein kinase signaling cascade | 6.3291 | 4 | yes |
| GO:0043065 | positive regulation of apoptotic process | 6.3291 | 7 | yes |
| GO:0043068 | positive regulation of programmed cell death | 6.3291 | 6 | yes |
| GO:0046330 | positive regulation of JNK cascade | 6.3291 | 8 | yes |
| GO:0051403 | stress-activated MAPK cascade | 6.3291 | 5 | yes |
| GO:0051972 | regulation of telomerase activity | 6.3291 | 5 | yes |
| GO:0051973 | positive regulation of telomerase activity | 6.3291 | 6 | yes |
| GO:1901216 | positive regulation of neuron death | 6.3291 | 6 | yes |
| GO:2000278 | regulation of DNA biosynthetic process | 6.3291 | 6 | yes |
| GO:2000573 | positive regulation of DNA biosynthetic process | 6.3291 | 7 | yes |
| GO:0007254 | JNK cascade | 5.0633 | 6 | yes |
| GO:0009743 | response to carbohydrate | 5.0633 | 4 | yes |
| GO:0033044 | regulation of chromosome organization | 5.0633 | 6 | yes |
| GO:0043405 | regulation of MAP kinase activity | 5.0633 | 8 | yes |
| GO:0071902 | positive regulation of protein serine/threonine kinase activity | 5.0633 | 8 | yes |
| GO:0009416 | response to light stimulus | 3.7975 | 4 | yes |
| GO:0032204 | regulation of telomere maintenance | 3.7975 | 6 | yes |
| GO:0032206 | positive regulation of telomere maintenance | 3.7975 | 7 | yes |
| GO:0032210 | regulation of telomere maintenance via telomerase | 3.7975 | 7 | yes |
| GO:0032212 | positive regulation of telomere maintenance via telomerase | 3.7975 | 8 | yes |
| GO:0034612 | response to tumor necrosis factor | 3.7975 | 5 | yes |
| GO:0038093 | Fc receptor signaling pathway | 3.7975 | 5 | yes |
| GO:0043406 | positive regulation of MAP kinase activity | 3.7975 | 8 | yes |
| GO:0043506 | regulation of JUN kinase activity | 3.7975 | 9 | yes |
| GO:1904356 | regulation of telomere maintenance via telomere lengthening | 3.7975 | 7 | yes |
| GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | 3.7975 | 8 | yes |
| GO:2001252 | positive regulation of chromosome organization | 3.7975 | 7 | yes |
| GO:0038095 | Fc-epsilon receptor signaling pathway | 2.5316 | 6 | yes |
| GO:0043507 | positive regulation of JUN kinase activity | 2.5316 | 9 | yes |
| GO:0043525 | positive regulation of neuron apoptotic process | 2.5316 | 7 | yes |
| GO:0071322 | cellular response to carbohydrate stimulus | 2.5316 | 5 | yes |
| GO:1904353 | regulation of telomere capping | 2.5316 | 7 | yes |
| GO:1904355 | positive regulation of telomere capping | 2.5316 | 8 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MP2K7_HUMAN |
|---|---|---|---|---|
| DOID:0111962 | combined immunodeficiency | 3.7975 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 3.7975 | 3 | no |
| DOID:0060038 | specific developmental disorder | 2.5316 | 3 | no |
| DOID:1059 | intellectual disability | 2.5316 | 4 | no |
| DOID:627 | severe combined immunodeficiency | 2.5316 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ZDH17_HUMAN | [view interactions] | Low throughput | no | yes |
| TP8L1_HUMAN | [view interactions] | Low throughput | no | no |
| M3K4_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K11_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K13_HUMAN | [view interactions] | Low throughput | no | yes |
| MK14_HUMAN | [view interactions] | Low throughput | no | yes |
| JUN_HUMAN | [view interactions] | Low throughput | no | yes |
| MK10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK09_HUMAN | [view interactions] | Low throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TRIB3_HUMAN | [view interactions] | Low throughput | no | yes |
| CFLAR_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K1_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K5_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K7_HUMAN | [view interactions] | Low throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| GA45B_HUMAN | [view interactions] | Low throughput | no | yes |
| VRK2_HUMAN | [view interactions] | Low throughput | no | no |
| JIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK08_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K20_HUMAN | [view interactions] | Low throughput | no | yes |
| DUS22_HUMAN | [view interactions] | Low throughput | no | yes |
| JIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DUS19_HUMAN | [view interactions] | Low throughput | no | yes |
| JIP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| M3K12_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| M3K2_HUMAN | [view interactions] | Low throughput | no | yes |
| MP2K4_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCT_HUMAN | [view interactions] | Low throughput | no | no |
| BCL10_HUMAN | [view interactions] | Low throughput | no | yes |
| WDR6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RASN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| BRAF_HUMAN | [view interactions] | Low throughput | no | yes |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| NK3R_HUMAN | [view interactions] | High throughput | no | no |
| CF062_HUMAN | [view interactions] | High throughput | no | yes |
| UGGG2_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| HNRC2_HUMAN | [view interactions] | High throughput | no | no |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| PP2BA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CANB2_HUMAN | [view interactions] | High throughput | no | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| FCN3_HUMAN | [view interactions] | High throughput | no | no |
| ERG28_HUMAN | [view interactions] | High throughput | no | yes |
| F174C_HUMAN | [view interactions] | High throughput | no | yes |
| APC11_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOC2B_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| DMPK_HUMAN | [view interactions] | High throughput | no | yes |
| PI2R_HUMAN | [view interactions] | High throughput | no | no |
| KCRM_HUMAN | [view interactions] | High throughput | no | no |
| PROD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITB7_HUMAN | [view interactions] | High throughput | no | no |
| FABP4_HUMAN | [view interactions] | High throughput | no | no |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| M3K10_HUMAN | [view interactions] | High throughput | no | yes |
| CDN1A_HUMAN | [view interactions] | High throughput | no | no |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| ILKAP_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| SMHD1_HUMAN | [view interactions] | High throughput | no | yes |
| EVPL_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF3C3_HUMAN | [view interactions] | High throughput | no | no |
| YTHD2_HUMAN | [view interactions] | High throughput | no | yes |
| RTCB_HUMAN | [view interactions] | High throughput | no | yes |
| RT23_HUMAN | [view interactions] | High throughput | no | yes |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKP8L_HUMAN | [view interactions] | High throughput | no | yes |
| RM16_HUMAN | [view interactions] | High throughput | no | yes |
| SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRABD_HUMAN | [view interactions] | High throughput | no | yes |
| CPVL_HUMAN | [view interactions] | High throughput | no | no |
| CLPB_HUMAN | [view interactions] | High throughput | no | yes |
| METH_HUMAN | [view interactions] | High throughput | no | yes |
| DJC10_HUMAN | [view interactions] | High throughput | no | yes |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCN1_HUMAN | [view interactions] | High throughput | no | yes |
| PCAT1_HUMAN | [view interactions] | High throughput | no | yes |
| RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NU188_HUMAN | [view interactions] | High throughput | no | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| RM49_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| ATPK_HUMAN | [view interactions] | High throughput | no | yes |
| KAD2_HUMAN | [view interactions] | High throughput | no | no |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F10A1_HUMAN | [view interactions] | High throughput | no | yes |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| RPAB1_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLU2B_HUMAN | [view interactions] | High throughput | no | yes |
| CN37_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACSL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACSL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALU_HUMAN | [view interactions] | High throughput | no | yes |
| PFD6_HUMAN | [view interactions] | High throughput | no | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| HACL2_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| ATF4_HUMAN | [view interactions] | High throughput | no | no |
| RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPXN_HUMAN | [view interactions] | High throughput | no | yes |
| ARRC_HUMAN | [view interactions] | High throughput | no | no |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNR5_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| C4BPB_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SACA1_HUMAN | [view interactions] | High throughput | no | no |
| ANTR1_HUMAN | [view interactions] | High throughput | no | no |
| DLK1_HUMAN | [view interactions] | High throughput | no | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| I13R2_HUMAN | [view interactions] | High throughput | no | no |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| PROZ_HUMAN | [view interactions] | High throughput | no | no |
| TPC2_HUMAN | [view interactions] | High throughput | no | no |
| ADA32_HUMAN | [view interactions] | High throughput | no | no |
| PCDG5_HUMAN | [view interactions] | High throughput | no | yes |
| LRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| SP100_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| SH3R3_HUMAN | [view interactions] | High throughput | no | yes |
| PCDB6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S39A7_HUMAN | [view interactions] | High throughput | no | yes |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| TNFA_HUMAN | [view interactions] | Computational | no | no |
| CASP2_HUMAN | [view interactions] | Computational | no | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IRAK2_HUMAN | [view interactions] | Computational | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LRP8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NOD1_HUMAN | [view interactions] | Computational | no | no |
| MK11_HUMAN | [view interactions] | Computational | no | yes |
| PPM1A_HUMAN | [view interactions] | Computational | no | yes |
| TRAF3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TNFL6_HUMAN | [view interactions] | Computational | no | yes |
| RIPK1_HUMAN | [view interactions] | Computational | no | yes |
| NOD2_HUMAN | [view interactions] | Computational | no | yes |
| DAB1_HUMAN | [view interactions] | Computational | no | yes |
| DAXX_HUMAN | [view interactions] | Computational | no | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PTEN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SHC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NEMO_HUMAN | [view interactions] | Computational | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TAB2_HUMAN | [view interactions] | Computational | no | yes |
| TRAF2_HUMAN | [view interactions] | Computational | no | yes |
| TAB1_HUMAN | [view interactions] | Computational | no | yes |
| M3K8_HUMAN | [view interactions] | Computational | no | yes |
| FADD_HUMAN | [view interactions] | Computational | no | yes |
| 2A5D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CRADD_HUMAN | [view interactions] | Computational | no | yes |
| IRAK1_HUMAN | [view interactions] | Computational | no | yes |
| TRAF1_HUMAN | [view interactions] | Computational | no | no |
| MK13_HUMAN | [view interactions] | Computational | no | yes |
| TRAF5_HUMAN | [view interactions] | Computational | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RASH_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TNR1A_HUMAN | [view interactions] | Computational | no | yes |
| RELN_HUMAN | [view interactions] | Computational | no | no |
| IQGA1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TAB3_HUMAN | [view interactions] | Computational | no | yes |
| MK12_HUMAN | [view interactions] | Computational | no | no |
| RIPK2_HUMAN | [view interactions] | Computational | no | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FYN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| UBE2N_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CASP8_HUMAN | [view interactions] | Computational | no | yes |
| BIRC3_HUMAN | [view interactions] | Computational | no | no |
| TRADD_HUMAN | [view interactions] | Computational | no | yes |
| BIEA_HUMAN | [view interactions] | Computational | no | yes |
| TRAF6_HUMAN | [view interactions] | Computational | no | yes |
| RAC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |