Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MK10_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MK10_HUMAN
GO:0019900 kinase binding 43.3333 4 no
GO:0043168 anion binding 40.0000 4 yes
GO:0000166 nucleotide binding 36.6667 4 yes
GO:0017076 purine nucleotide binding 36.6667 5 yes
GO:0032555 purine ribonucleotide binding 36.6667 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 36.6667 4 yes
GO:0019901 protein kinase binding 36.6667 5 no
GO:0005524 ATP binding 33.3333 5 yes
GO:0030554 adenyl nucleotide binding 33.3333 6 yes
GO:0032559 adenyl ribonucleotide binding 33.3333 5 yes
GO:0016462 pyrophosphatase activity 23.3333 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 23.3333 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 23.3333 6 no
GO:0043169 cation binding 23.3333 4 no
GO:0046872 metal ion binding 23.3333 5 no
GO:0004674 protein serine/threonine kinase activity 10.0000 4 yes
GO:0004707 MAP kinase activity 10.0000 5 yes
GO:0004708 MAP kinase kinase activity 10.0000 5 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 10.0000 4 yes
GO:0016301 kinase activity 10.0000 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 10.0000 4 yes
GO:0106310 protein serine kinase activity 10.0000 4 yes
GO:0004705 JUN kinase activity 6.6667 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MK10_HUMAN
GO:0048522 positive regulation of cellular process 76.6667 4 no
GO:0048523 negative regulation of cellular process 66.6667 4 no
GO:0031323 regulation of cellular metabolic process 63.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 63.3333 4 no
GO:0080090 regulation of primary metabolic process 63.3333 4 no
GO:0010646 regulation of cell communication 60.0000 4 no
GO:0009966 regulation of signal transduction 56.6667 4 no
GO:0009893 positive regulation of metabolic process 53.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 53.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 53.3333 5 no
GO:0051246 regulation of protein metabolic process 53.3333 5 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:1902531 regulation of intracellular signal transduction 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 46.6667 6 no
GO:0031399 regulation of protein modification process 43.3333 6 no
GO:0009967 positive regulation of signal transduction 43.3333 5 no
GO:0010468 regulation of gene expression 43.3333 6 no
GO:0010647 positive regulation of cell communication 43.3333 5 no
GO:0023056 positive regulation of signaling 43.3333 4 no
GO:0048584 positive regulation of response to stimulus 43.3333 4 no
GO:0009891 positive regulation of biosynthetic process 40.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 40.0000 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 40.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 40.0000 6 no
GO:0019220 regulation of phosphate metabolic process 36.6667 6 no
GO:0042325 regulation of phosphorylation 36.6667 7 no
GO:0051174 regulation of phosphorus metabolic process 36.6667 5 no
GO:0009892 negative regulation of metabolic process 36.6667 4 no
GO:0010605 negative regulation of macromolecule metabolic process 36.6667 5 no
GO:1902533 positive regulation of intracellular signal transduction 36.6667 6 no
GO:0051130 positive regulation of cellular component organization 36.6667 5 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0008104 protein localization 33.3333 4 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0006355 regulation of DNA-templated transcription 33.3333 7 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0043408 regulation of MAPK cascade 33.3333 6 no
GO:0141124 intracellular signaling cassette 30.0000 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 30.0000 6 no
GO:0031401 positive regulation of protein modification process 30.0000 7 no
GO:0042327 positive regulation of phosphorylation 30.0000 8 no
GO:0043549 regulation of kinase activity 30.0000 5 no
GO:0045937 positive regulation of phosphate metabolic process 30.0000 7 no
GO:0010648 negative regulation of cell communication 30.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 30.0000 4 no
GO:0023057 negative regulation of signaling 30.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 30.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 30.0000 4 no
GO:0000165 MAPK cascade 26.6667 5 yes
GO:0036211 protein modification process 26.6667 4 yes
GO:0043412 macromolecule modification 26.6667 4 yes
GO:0050776 regulation of immune response 26.6667 4 yes
GO:0001934 positive regulation of protein phosphorylation 26.6667 8 no
GO:0045859 regulation of protein kinase activity 26.6667 6 no
GO:0032880 regulation of protein localization 26.6667 5 no
GO:0045595 regulation of cell differentiation 26.6667 4 no
GO:0051094 positive regulation of developmental process 26.6667 4 no
GO:0060341 regulation of cellular localization 26.6667 4 no
GO:0009890 negative regulation of biosynthetic process 26.6667 5 no
GO:0009894 regulation of catabolic process 26.6667 4 no
GO:0009968 negative regulation of signal transduction 26.6667 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 26.6667 6 no
GO:0031327 negative regulation of cellular biosynthetic process 26.6667 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.6667 5 no
GO:0048585 negative regulation of response to stimulus 26.6667 4 no
GO:0051240 positive regulation of multicellular organismal process 26.6667 4 no
GO:0080134 regulation of response to stress 26.6667 4 no
GO:0043410 positive regulation of MAPK cascade 26.6667 7 no
GO:0030030 cell projection organization 26.6667 4 no
GO:0022607 cellular component assembly 26.6667 4 no
GO:0042127 regulation of cell population proliferation 23.3333 4 no
GO:0043085 positive regulation of catalytic activity 23.3333 4 no
GO:0051347 positive regulation of transferase activity 23.3333 5 no
GO:0006996 organelle organization 23.3333 4 no
GO:0050890 cognition 23.3333 4 no
GO:0051050 positive regulation of transport 23.3333 4 no
GO:0060627 regulation of vesicle-mediated transport 23.3333 4 no
GO:0006357 regulation of transcription by RNA polymerase II 23.3333 8 no
GO:0010628 positive regulation of gene expression 23.3333 7 no
GO:0042981 regulation of apoptotic process 23.3333 5 no
GO:0043067 regulation of programmed cell death 23.3333 4 no
GO:0051248 negative regulation of protein metabolic process 23.3333 6 no
GO:0010629 negative regulation of gene expression 23.3333 7 no
GO:0031344 regulation of cell projection organization 23.3333 5 no
GO:0044087 regulation of cellular component biogenesis 23.3333 4 no
GO:0046328 regulation of JNK cascade 23.3333 7 no
GO:0070372 regulation of ERK1 and ERK2 cascade 23.3333 7 no
GO:1903829 positive regulation of protein localization 23.3333 5 no
GO:0120036 plasma membrane bounded cell projection organization 23.3333 5 no
GO:0006796 phosphate-containing compound metabolic process 20.0000 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 16.6667 4 yes
GO:0007254 JNK cascade 16.6667 6 yes
GO:0009416 response to light stimulus 16.6667 4 yes
GO:0016310 phosphorylation 13.3333 5 yes
GO:0006468 protein phosphorylation 10.0000 5 yes
GO:0038093 Fc receptor signaling pathway 10.0000 5 yes
GO:0038095 Fc-epsilon receptor signaling pathway 10.0000 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
SYT4_HUMAN [view entry] [view interactions] Low throughput yes yes
JUN_HUMAN [view interactions] Low throughput no yes
JIP3_HUMAN [view entry] [view interactions] Low throughput yes yes
JUND_HUMAN [view interactions] Low throughput no yes
GSTA4_HUMAN [view interactions] Low throughput no yes
PMYT1_HUMAN [view interactions] Low throughput no no
P53_HUMAN [view interactions] Low throughput no no
HDAC9_HUMAN [view interactions] Low throughput no yes
HDAC1_HUMAN [view interactions] Low throughput no no
MABP1_HUMAN [view interactions] Low throughput no yes
MK10_HUMAN [view entry] [view interactions] Low throughput yes yes
3BP5_HUMAN [view interactions] Low throughput no yes
JIP2_HUMAN [view entry] [view interactions] Low throughput yes no
CDN1B_HUMAN [view interactions] Low throughput no yes
ATF2_HUMAN [view interactions] Low throughput no yes
RARA_HUMAN [view interactions] Low throughput no no
CDN2C_HUMAN [view interactions] Low throughput no yes
MP2K4_HUMAN [view interactions] Low throughput no yes
DUS9_HUMAN [view interactions] Low throughput no no
MCL1_HUMAN [view interactions] Low throughput no yes
ELK1_HUMAN [view interactions] Low throughput no yes
MP2K7_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF5A_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
JIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
PLIN2_HUMAN [view interactions] High throughput no no
TF65_HUMAN [view entry] [view interactions] High throughput yes yes
TNIP1_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
ZW10_HUMAN [view interactions] High throughput no yes
WDR62_HUMAN [view interactions] High throughput no no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
MOES_HUMAN [view entry] [view interactions] High throughput yes no
C1TM_HUMAN [view entry] [view interactions] High throughput yes yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
TF3C1_HUMAN [view interactions] High throughput no yes
U119A_HUMAN [view interactions] High throughput no no
CBP_HUMAN [view interactions] High throughput no yes
KI26A_HUMAN [view interactions] High throughput no no
CE290_HUMAN [view interactions] High throughput no no
UBE3A_HUMAN [view entry] [view interactions] High throughput yes yes
MK09_HUMAN [view interactions] High throughput no yes
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
IMDH2_HUMAN [view interactions] High throughput no yes
DUS1_HUMAN [view interactions] High throughput no no
DUS10_HUMAN [view entry] [view interactions] High throughput yes yes
DUS16_HUMAN [view interactions] High throughput no yes
GCH1_HUMAN [view interactions] High throughput no no
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
TCPW_HUMAN [view entry] [view interactions] High throughput yes yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
DDI1_HUMAN [view interactions] High throughput no no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP2_HUMAN [view interactions] High throughput no no
MK14_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
MTR1B_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
FBX7_HUMAN [view interactions] High throughput no yes
STMN2_HUMAN [view interactions] High throughput no no
FRIH_HUMAN [view entry] [view interactions] High throughput yes yes