Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MK10_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MK10_HUMAN
GO:0019900 kinase binding 44.8276 4 no
GO:0019901 protein kinase binding 41.3793 5 no
GO:0017076 purine nucleotide binding 37.9310 4 yes
GO:0032555 purine ribonucleotide binding 37.9310 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 37.9310 4 yes
GO:0005524 ATP binding 34.4828 5 yes
GO:0030554 adenyl nucleotide binding 34.4828 5 yes
GO:0032559 adenyl ribonucleotide binding 34.4828 5 yes
GO:0016462 pyrophosphatase activity 24.1379 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 24.1379 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 24.1379 6 no
GO:0046872 metal ion binding 20.6897 4 no
GO:0004674 protein serine/threonine kinase activity 10.3448 4 yes
GO:0004708 MAP kinase kinase activity 10.3448 5 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 10.3448 4 yes
GO:0016301 kinase activity 10.3448 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 10.3448 4 yes
GO:0106310 protein serine kinase activity 10.3448 4 yes
GO:0004705 JUN kinase activity 6.8966 6 yes
GO:0004707 MAP kinase activity 6.8966 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MK10_HUMAN
GO:0048522 positive regulation of cellular process 75.8621 4 no
GO:0051171 regulation of nitrogen compound metabolic process 68.9655 4 yes
GO:0060255 regulation of macromolecule metabolic process 68.9655 4 yes
GO:0080090 regulation of primary metabolic process 68.9655 4 yes
GO:0048523 negative regulation of cellular process 65.5172 4 no
GO:0031323 regulation of cellular metabolic process 62.0690 4 yes
GO:0010646 regulation of cell communication 58.6207 4 no
GO:0009893 positive regulation of metabolic process 55.1724 4 no
GO:0010604 positive regulation of macromolecule metabolic process 55.1724 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 55.1724 5 no
GO:0009966 regulation of signal transduction 55.1724 4 no
GO:0051246 regulation of protein metabolic process 51.7241 5 no
GO:0010468 regulation of gene expression 48.2759 5 yes
GO:0051128 regulation of cellular component organization 48.2759 4 no
GO:1902531 regulation of intracellular signal transduction 48.2759 5 no
GO:0009889 regulation of biosynthetic process 44.8276 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 44.8276 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 44.8276 5 yes
GO:0031326 regulation of cellular biosynthetic process 44.8276 5 yes
GO:0031325 positive regulation of cellular metabolic process 44.8276 5 no
GO:0051247 positive regulation of protein metabolic process 44.8276 6 no
GO:0031399 regulation of protein modification process 41.3793 6 no
GO:0033043 regulation of organelle organization 41.3793 5 no
GO:0080134 regulation of response to stress 41.3793 4 no
GO:0009967 positive regulation of signal transduction 41.3793 5 no
GO:0010647 positive regulation of cell communication 41.3793 5 no
GO:0023056 positive regulation of signaling 41.3793 4 no
GO:0048584 positive regulation of response to stimulus 41.3793 4 no
GO:0006355 regulation of DNA-templated transcription 37.9310 6 yes
GO:0051252 regulation of RNA metabolic process 37.9310 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 37.9310 7 yes
GO:2001141 regulation of RNA biosynthetic process 37.9310 6 yes
GO:0019220 regulation of phosphate metabolic process 37.9310 6 no
GO:0042325 regulation of phosphorylation 37.9310 7 no
GO:0051174 regulation of phosphorus metabolic process 37.9310 5 no
GO:0009892 negative regulation of metabolic process 37.9310 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.9310 5 no
GO:0051130 positive regulation of cellular component organization 37.9310 5 no
GO:0051049 regulation of transport 37.9310 4 no
GO:0001932 regulation of protein phosphorylation 34.4828 7 no
GO:0008104 protein localization 34.4828 4 no
GO:0051338 regulation of transferase activity 34.4828 4 no
GO:0010941 regulation of cell death 34.4828 4 no
GO:0032880 regulation of protein localization 34.4828 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 34.4828 5 no
GO:0060341 regulation of cellular localization 34.4828 4 no
GO:0080135 regulation of cellular response to stress 34.4828 4 no
GO:0016192 vesicle-mediated transport 34.4828 4 no
GO:0043408 regulation of MAPK cascade 34.4828 6 no
GO:1902533 positive regulation of intracellular signal transduction 34.4828 6 no
GO:0050776 regulation of immune response 31.0345 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 31.0345 6 no
GO:0042327 positive regulation of phosphorylation 31.0345 8 no
GO:0043549 regulation of kinase activity 31.0345 5 no
GO:0045937 positive regulation of phosphate metabolic process 31.0345 7 no
GO:1903829 positive regulation of protein localization 31.0345 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 31.0345 6 no
GO:0042981 regulation of apoptotic process 31.0345 6 no
GO:0043067 regulation of programmed cell death 31.0345 5 no
GO:0051050 positive regulation of transport 31.0345 4 no
GO:0010648 negative regulation of cell communication 31.0345 5 no
GO:0023057 negative regulation of signaling 31.0345 4 no
GO:0036211 protein modification process 27.5862 4 yes
GO:0043412 macromolecule modification 27.5862 4 yes
GO:0001934 positive regulation of protein phosphorylation 27.5862 8 no
GO:0031401 positive regulation of protein modification process 27.5862 7 no
GO:0043085 positive regulation of catalytic activity 27.5862 4 no
GO:0045859 regulation of protein kinase activity 27.5862 6 no
GO:0051347 positive regulation of transferase activity 27.5862 5 no
GO:0022607 cellular component assembly 27.5862 4 no
GO:0030030 cell projection organization 27.5862 4 no
GO:0031324 negative regulation of cellular metabolic process 27.5862 5 no
GO:0050804 modulation of chemical synaptic transmission 27.5862 5 no
GO:0051094 positive regulation of developmental process 27.5862 4 no
GO:0051240 positive regulation of multicellular organismal process 27.5862 4 no
GO:0099177 regulation of trans-synaptic signaling 27.5862 4 no
GO:0009891 positive regulation of biosynthetic process 27.5862 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 27.5862 6 no
GO:0031328 positive regulation of cellular biosynthetic process 27.5862 6 no
GO:0060548 negative regulation of cell death 27.5862 5 no
GO:0010628 positive regulation of gene expression 27.5862 6 no
GO:0060627 regulation of vesicle-mediated transport 27.5862 4 no
GO:0009968 negative regulation of signal transduction 27.5862 5 no
GO:0032872 regulation of stress-activated MAPK cascade 27.5862 6 no
GO:0048585 negative regulation of response to stimulus 27.5862 4 no
GO:0070302 regulation of stress-activated protein kinase signaling cascade 27.5862 5 no
GO:0043410 positive regulation of MAPK cascade 27.5862 7 no
GO:0033674 positive regulation of kinase activity 24.1379 6 no
GO:0042127 regulation of cell population proliferation 24.1379 4 no
GO:0006996 organelle organization 24.1379 4 no
GO:0009894 regulation of catabolic process 24.1379 4 no
GO:0010629 negative regulation of gene expression 24.1379 6 no
GO:0022603 regulation of anatomical structure morphogenesis 24.1379 4 no
GO:0031344 regulation of cell projection organization 24.1379 5 no
GO:0044087 regulation of cellular component biogenesis 24.1379 4 no
GO:0045595 regulation of cell differentiation 24.1379 4 no
GO:0051248 negative regulation of protein metabolic process 24.1379 6 no
GO:0070201 regulation of establishment of protein localization 24.1379 6 no
GO:0071310 cellular response to organic substance 24.1379 4 no
GO:0120036 plasma membrane bounded cell projection organization 24.1379 5 no
GO:0043066 negative regulation of apoptotic process 24.1379 7 no
GO:0043069 negative regulation of programmed cell death 24.1379 6 no
GO:0070372 regulation of ERK1 and ERK2 cascade 24.1379 7 no
GO:0046328 regulation of JNK cascade 24.1379 7 no
GO:0000165 MAPK cascade 20.6897 4 yes
GO:0006796 phosphate-containing compound metabolic process 20.6897 4 yes
GO:0045860 positive regulation of protein kinase activity 20.6897 7 no
GO:0010638 positive regulation of organelle organization 20.6897 6 no
GO:0031175 neuron projection development 20.6897 6 no
GO:0031400 negative regulation of protein modification process 20.6897 7 no
GO:0043086 negative regulation of catalytic activity 20.6897 4 no
GO:0050890 cognition 20.6897 4 no
GO:0051129 negative regulation of cellular component organization 20.6897 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.6897 6 no
GO:1901214 regulation of neuron death 20.6897 5 no
GO:1901701 cellular response to oxygen-containing compound 20.6897 4 no
GO:0042176 regulation of protein catabolic process 20.6897 5 no
GO:0071702 organic substance transport 20.6897 4 no
GO:0043269 regulation of ion transport 20.6897 5 no
GO:0001817 regulation of cytokine production 20.6897 4 no
GO:0006357 regulation of transcription by RNA polymerase II 20.6897 7 no
GO:0051241 negative regulation of multicellular organismal process 20.6897 4 no
GO:0032874 positive regulation of stress-activated MAPK cascade 20.6897 7 no
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 20.6897 6 no
GO:0051254 positive regulation of RNA metabolic process 20.6897 6 no
GO:0009416 response to light stimulus 17.2414 4 yes
GO:0016310 phosphorylation 17.2414 5 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 13.7931 4 yes
GO:0006468 protein phosphorylation 13.7931 5 yes
GO:0007254 JNK cascade 13.7931 6 yes
GO:0031098 stress-activated protein kinase signaling cascade 13.7931 4 yes
GO:0051403 stress-activated MAPK cascade 13.7931 5 yes
GO:0038093 Fc receptor signaling pathway 10.3448 5 yes
GO:0038095 Fc-epsilon receptor signaling pathway 10.3448 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
JIP3_HUMAN [view entry] [view interactions] Low throughput yes yes
JUND_HUMAN [view interactions] Low throughput no yes
GSTA4_HUMAN [view interactions] Low throughput no yes
PMYT1_HUMAN [view interactions] Low throughput no no
P53_HUMAN [view interactions] Low throughput no no
HDAC9_HUMAN [view interactions] Low throughput no yes
HDAC1_HUMAN [view interactions] Low throughput no no
MABP1_HUMAN [view interactions] Low throughput no yes
MK10_HUMAN [view entry] [view interactions] Low throughput yes yes
3BP5_HUMAN [view interactions] Low throughput no yes
JIP2_HUMAN [view entry] [view interactions] Low throughput yes no
CDN1B_HUMAN [view interactions] Low throughput no yes
ATF2_HUMAN [view interactions] Low throughput no yes
RARA_HUMAN [view interactions] Low throughput no no
CDN2C_HUMAN [view interactions] Low throughput no yes
MP2K4_HUMAN [view interactions] Low throughput no yes
DUS9_HUMAN [view interactions] Low throughput no no
MCL1_HUMAN [view interactions] Low throughput no yes
ELK1_HUMAN [view interactions] Low throughput no yes
MP2K7_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF5A_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
JIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
SYT4_HUMAN [view entry] [view interactions] Low throughput yes yes
JUN_HUMAN [view interactions] Low throughput no yes
ZW10_HUMAN [view interactions] High throughput no yes
C1TM_HUMAN [view entry] [view interactions] High throughput yes yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
WDR62_HUMAN [view interactions] High throughput no no
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
U119A_HUMAN [view interactions] High throughput no no
TF3C1_HUMAN [view interactions] High throughput no yes
CBP_HUMAN [view interactions] High throughput no yes
KI26A_HUMAN [view interactions] High throughput no no
CE290_HUMAN [view interactions] High throughput no no
UBE3A_HUMAN [view interactions] High throughput no yes
MK09_HUMAN [view interactions] High throughput no yes
IMDH2_HUMAN [view interactions] High throughput no yes
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
DUS1_HUMAN [view interactions] High throughput no no
DUS10_HUMAN [view entry] [view interactions] High throughput yes yes
DUS16_HUMAN [view interactions] High throughput no yes
GCH1_HUMAN [view interactions] High throughput no no
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
TCPW_HUMAN [view entry] [view interactions] High throughput yes yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
DDI1_HUMAN [view interactions] High throughput no no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP2_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
MTR1B_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
FBX7_HUMAN [view interactions] High throughput no yes
STMN2_HUMAN [view interactions] High throughput no no
FRIH_HUMAN [view entry] [view interactions] High throughput yes yes
PLIN2_HUMAN [view interactions] High throughput no no
TF65_HUMAN [view entry] [view interactions] High throughput yes yes
TNIP1_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no