C1TM_HUMAN
Evidence for PS localization
Functions
May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 55%
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
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C1TM_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [C1TM_HUMAN]
Isoform [B7ZM99] alignment
Isoform [Q5JYA3] alignment
Isoform [Q5JYA8] alignment
Isoform [H0Y327] alignment
Isoform [Q4VXV2] alignment
Isoform [Q4VXM0] alignment
Isoform [Q4VXM1] alignment
Isoform [Q6UB35-2] alignment
Isoform [A0A087WVM4] alignment
LOADING 29%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in C1TM_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 27.7778 | 4 | yes |
| GO:0043168 | anion binding | 27.7778 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 25.9259 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 25.9259 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.9259 | 4 | yes |
| GO:0003723 | RNA binding | 22.2222 | 4 | no |
| GO:0043169 | cation binding | 22.2222 | 4 | no |
| GO:0046872 | metal ion binding | 20.3704 | 5 | no |
| GO:0005524 | ATP binding | 16.6667 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 16.6667 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 16.6667 | 5 | yes |
| GO:0042803 | protein homodimerization activity | 7.4074 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in C1TM_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 42.5926 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 42.5926 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.5926 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.7407 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.8889 | 4 | no |
| GO:0006996 | organelle organization | 38.8889 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 35.1852 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:0071702 | organic substance transport | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.4815 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.4815 | 5 | no |
| GO:0010646 | regulation of cell communication | 31.4815 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 31.4815 | 5 | no |
| GO:0071705 | nitrogen compound transport | 31.4815 | 4 | no |
| GO:0051049 | regulation of transport | 29.6296 | 4 | no |
| GO:0022607 | cellular component assembly | 29.6296 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.7778 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.7778 | 5 | no |
| GO:0008104 | protein localization | 27.7778 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.9259 | 5 | no |
| GO:0015031 | protein transport | 25.9259 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.0741 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 5NT3A_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| ACSM5_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKIP_HUMAN | [view interactions] | High throughput | no | yes |
| AMACR_HUMAN | [view interactions] | High throughput | no | yes |
| ANGE1_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASB12_HUMAN | [view interactions] | High throughput | no | no |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| BPHL_HUMAN | [view interactions] | High throughput | no | no |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASP4_HUMAN | [view interactions] | High throughput | no | yes |