C1TM_HUMAN
May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in C1TM_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 25.0000 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | yes |
GO:0003723 | RNA binding | 22.9167 | 4 | no |
GO:0046872 | metal ion binding | 20.8333 | 4 | no |
GO:0005524 | ATP binding | 14.5833 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 14.5833 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 14.5833 | 5 | yes |
GO:0042803 | protein homodimerization activity | 8.3333 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in C1TM_HUMAN |
---|---|---|---|---|
GO:0060255 | regulation of macromolecule metabolic process | 43.7500 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 41.6667 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 41.6667 | 4 | no |
GO:0048522 | positive regulation of cellular process | 41.6667 | 4 | no |
GO:0048523 | negative regulation of cellular process | 39.5833 | 4 | no |
GO:0006996 | organelle organization | 37.5000 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 35.4167 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 35.4167 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 35.4167 | 5 | no |
GO:0031323 | regulation of cellular metabolic process | 35.4167 | 4 | no |
GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.2500 | 5 | no |
GO:0051128 | regulation of cellular component organization | 31.2500 | 4 | no |
GO:0071702 | organic substance transport | 31.2500 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 29.1667 | 6 | no |
GO:0071705 | nitrogen compound transport | 29.1667 | 4 | no |
GO:0010646 | regulation of cell communication | 29.1667 | 4 | no |
GO:0022607 | cellular component assembly | 27.0833 | 4 | no |
GO:0008104 | protein localization | 27.0833 | 4 | no |
GO:0051049 | regulation of transport | 27.0833 | 4 | no |
GO:0015031 | protein transport | 25.0000 | 4 | no |
GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 22.9167 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 22.9167 | 4 | no |
GO:0051050 | positive regulation of transport | 20.8333 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 20.8333 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 20.8333 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.8333 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 20.8333 | 5 | no |
GO:0016192 | vesicle-mediated transport | 20.8333 | 4 | no |
GO:0019752 | carboxylic acid metabolic process | 10.4167 | 5 | yes |
GO:0043436 | oxoacid metabolic process | 10.4167 | 4 | yes |
GO:0044271 | cellular nitrogen compound biosynthetic process | 8.3333 | 4 | yes |
GO:0018130 | heterocycle biosynthetic process | 6.2500 | 4 | yes |
GO:0019438 | aromatic compound biosynthetic process | 6.2500 | 4 | yes |
GO:1901362 | organic cyclic compound biosynthetic process | 6.2500 | 4 | yes |
GO:1901566 | organonitrogen compound biosynthetic process | 6.2500 | 4 | yes |
GO:0016053 | organic acid biosynthetic process | 4.1667 | 4 | yes |
GO:0032787 | monocarboxylic acid metabolic process | 4.1667 | 6 | yes |
GO:0043648 | dicarboxylic acid metabolic process | 4.1667 | 6 | yes |
GO:0046394 | carboxylic acid biosynthetic process | 4.1667 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in C1TM_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 4.1667 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 4.1667 | 5 | no |
DOID:114 | heart disease | 4.1667 | 3 | no |
DOID:2843 | long QT syndrome | 4.1667 | 6 | no |
DOID:0060286 | combined oxidative phosphorylation deficiency | 4.1667 | 4 | no |
DOID:700 | mitochondrial metabolism disease | 4.1667 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
TNKS1_HUMAN | [view interactions] | High throughput | no | yes |
UBP50_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RIPK4_HUMAN | [view interactions] | High throughput | no | no |
SIR4_HUMAN | [view interactions] | High throughput | no | yes |
CND2_HUMAN | [view interactions] | High throughput | no | no |
LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KI67_HUMAN | [view interactions] | High throughput | no | no |
NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CEBPD_HUMAN | [view interactions] | High throughput | no | no |
5NT3A_HUMAN | [view interactions] | High throughput | no | yes |
TR10A_HUMAN | [view interactions] | High throughput | no | no |
MK10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IKKE_HUMAN | [view interactions] | High throughput | no | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WRP73_HUMAN | [view interactions] | High throughput | no | no |
MAGD1_HUMAN | [view interactions] | High throughput | no | no |
ILK_HUMAN | [view interactions] | High throughput | no | no |
PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
NEK6_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
CASP4_HUMAN | [view interactions] | High throughput | no | yes |
PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
T22D1_HUMAN | [view interactions] | High throughput | no | no |
MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSN5_HUMAN | [view interactions] | High throughput | no | yes |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB19_HUMAN | [view interactions] | High throughput | no | no |
RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
AKIP_HUMAN | [view interactions] | High throughput | no | yes |
CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDK1_HUMAN | [view interactions] | High throughput | no | yes |
TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TR61B_HUMAN | [view interactions] | High throughput | no | yes |
ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
VGFR1_HUMAN | [view interactions] | High throughput | no | no |
FLT3_HUMAN | [view interactions] | High throughput | no | no |
VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
SIR7_HUMAN | [view interactions] | High throughput | no | yes |
ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ASB12_HUMAN | [view interactions] | High throughput | no | no |
EED_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
NFAC1_HUMAN | [view interactions] | High throughput | no | no |
MTMR7_HUMAN | [view interactions] | High throughput | no | no |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
AAR2_HUMAN | [view interactions] | High throughput | no | no |
PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
WWOX_HUMAN | [view interactions] | High throughput | no | yes |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
TXNIP_HUMAN | [view interactions] | High throughput | no | no |
CDK9_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
TGFR2_HUMAN | [view interactions] | High throughput | no | no |
TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
NFX1_HUMAN | [view interactions] | High throughput | no | yes |
WWP2_HUMAN | [view interactions] | High throughput | no | no |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
ANR55_HUMAN | [view interactions] | High throughput | no | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
RMC1_HUMAN | [view interactions] | High throughput | no | no |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
UFL1_HUMAN | [view interactions] | High throughput | no | yes |
MARC2_HUMAN | [view interactions] | High throughput | no | no |
AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MASU1_HUMAN | [view interactions] | High throughput | no | yes |
SYMM_HUMAN | [view interactions] | High throughput | no | yes |
TPC6B_HUMAN | [view interactions] | High throughput | no | yes |
NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANGE1_HUMAN | [view interactions] | High throughput | no | yes |
FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
ACSM5_HUMAN | [view interactions] | High throughput | no | yes |
SYYM_HUMAN | [view interactions] | High throughput | no | no |
NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GATA_HUMAN | [view interactions] | High throughput | no | yes |
AMACR_HUMAN | [view interactions] | High throughput | no | yes |
SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
FBX32_HUMAN | [view interactions] | High throughput | no | no |
CLU_HUMAN | [view interactions] | High throughput | no | yes |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BPHL_HUMAN | [view interactions] | High throughput | no | no |
CNN1_HUMAN | [view interactions] | High throughput | no | no |
CNN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ISOC1_HUMAN | [view interactions] | High throughput | no | no |
TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PAPOA_HUMAN | [view interactions] | High throughput | no | yes |
PAPOB_HUMAN | [view interactions] | High throughput | no | no |
XPP1_HUMAN | [view interactions] | High throughput | no | yes |
CE152_HUMAN | [view interactions] | High throughput | no | yes |
MRM1_HUMAN | [view interactions] | High throughput | no | no |
HOOK1_HUMAN | [view interactions] | High throughput | no | no |
HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
MRES1_HUMAN | [view interactions] | High throughput | no | yes |
HINT2_HUMAN | [view interactions] | High throughput | no | yes |
MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MET17_HUMAN | [view interactions] | High throughput | no | yes |
MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RRFM_HUMAN | [view interactions] | High throughput | no | yes |
IF2M_HUMAN | [view interactions] | High throughput | no | yes |
FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
EFTS_HUMAN | [view interactions] | High throughput | no | no |
EXD2_HUMAN | [view interactions] | High throughput | no | yes |
CLPP_HUMAN | [view interactions] | High throughput | no | yes |
LEG9_HUMAN | [view interactions] | High throughput | no | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
DJC28_HUMAN | [view interactions] | High throughput | no | yes |
ATG5_HUMAN | [view interactions] | High throughput | no | no |
SYAM_HUMAN | [view interactions] | High throughput | no | yes |
COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX8A_HUMAN | [view interactions] | High throughput | no | yes |
CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DPP4_HUMAN | [view interactions] | High throughput | no | no |
TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
NBR1_HUMAN | [view interactions] | High throughput | no | yes |
OPTN_HUMAN | [view interactions] | High throughput | no | yes |