CNN3_HUMAN
Evidence for PS localization
Functions
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CNN3_HUMAN |
|---|---|---|---|---|
| GO:0005524 | ATP binding | 44.4444 | 5 | no |
| GO:0017076 | purine nucleotide binding | 44.4444 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 44.4444 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 44.4444 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 44.4444 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 44.4444 | 4 | no |
| GO:0045296 | cadherin binding | 33.3333 | 4 | yes |
| GO:0003723 | RNA binding | 22.2222 | 4 | no |
| GO:0046872 | metal ion binding | 22.2222 | 4 | no |
| GO:0003779 | actin binding | 16.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CNN3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 66.6667 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 66.6667 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 61.1111 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 61.1111 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 61.1111 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 61.1111 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 61.1111 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 55.5556 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 55.5556 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 55.5556 | 5 | no |
| GO:0010468 | regulation of gene expression | 55.5556 | 5 | no |
| GO:0033043 | regulation of organelle organization | 55.5556 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 50.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 50.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 50.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 50.0000 | 5 | no |
| GO:0006996 | organelle organization | 44.4444 | 4 | yes |
| GO:0051049 | regulation of transport | 44.4444 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 44.4444 | 5 | no |
| GO:0060341 | regulation of cellular localization | 44.4444 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 44.4444 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 44.4444 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 44.4444 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 44.4444 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 44.4444 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 44.4444 | 6 | no |
| GO:0010646 | regulation of cell communication | 44.4444 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 38.8889 | 6 | no |
| GO:0007010 | cytoskeleton organization | 38.8889 | 5 | yes |
| GO:0014070 | response to organic cyclic compound | 38.8889 | 4 | no |
| GO:0031399 | regulation of protein modification process | 38.8889 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 38.8889 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 38.8889 | 4 | no |
| GO:0071310 | cellular response to organic substance | 38.8889 | 4 | no |
| GO:0071407 | cellular response to organic cyclic compound | 38.8889 | 5 | no |
| GO:0080134 | regulation of response to stress | 38.8889 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 38.8889 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 38.8889 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 38.8889 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 38.8889 | 5 | no |
| GO:0009966 | regulation of signal transduction | 38.8889 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 33.3333 | 4 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0032880 | regulation of protein localization | 33.3333 | 5 | no |
| GO:0036211 | protein modification process | 33.3333 | 4 | no |
| GO:0043412 | macromolecule modification | 33.3333 | 4 | no |
| GO:0051726 | regulation of cell cycle | 33.3333 | 4 | no |
| GO:0080135 | regulation of cellular response to stress | 33.3333 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 33.3333 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 33.3333 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 33.3333 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 27.7778 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 27.7778 | 5 | no |
| GO:0023057 | negative regulation of signaling | 27.7778 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 27.7778 | 4 | no |
| GO:0050776 | regulation of immune response | 27.7778 | 4 | no |
| GO:0030030 | cell projection organization | 27.7778 | 4 | no |
| GO:0010629 | negative regulation of gene expression | 27.7778 | 6 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 27.7778 | 5 | no |
| GO:0030334 | regulation of cell migration | 27.7778 | 5 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 27.7778 | 6 | no |
| GO:2000145 | regulation of cell motility | 27.7778 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 27.7778 | 5 | no |
| GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway | 22.2222 | 6 | no |
| GO:0010941 | regulation of cell death | 22.2222 | 4 | no |
| GO:0016070 | RNA metabolic process | 22.2222 | 5 | no |
| GO:0034599 | cellular response to oxidative stress | 22.2222 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.2222 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 22.2222 | 5 | no |
| GO:0060759 | regulation of response to cytokine stimulus | 22.2222 | 4 | no |
| GO:0062197 | cellular response to chemical stress | 22.2222 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 22.2222 | 4 | no |
| GO:1902115 | regulation of organelle assembly | 22.2222 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.2222 | 6 | no |
| GO:2001233 | regulation of apoptotic signaling pathway | 22.2222 | 5 | no |
| GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 22.2222 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 22.2222 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.2222 | 6 | no |
| GO:0032101 | regulation of response to external stimulus | 22.2222 | 4 | no |
| GO:0032872 | regulation of stress-activated MAPK cascade | 22.2222 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 22.2222 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 22.2222 | 6 | no |
| GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 22.2222 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 22.2222 | 4 | no |
| GO:0034330 | cell junction organization | 22.2222 | 4 | no |
| GO:0043393 | regulation of protein binding | 22.2222 | 4 | no |
| GO:0051052 | regulation of DNA metabolic process | 22.2222 | 5 | no |
| GO:0071417 | cellular response to organonitrogen compound | 22.2222 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 22.2222 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 22.2222 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 22.2222 | 7 | no |
| GO:0008285 | negative regulation of cell population proliferation | 22.2222 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 22.2222 | 7 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.2222 | 5 | no |
| GO:0010639 | negative regulation of organelle organization | 22.2222 | 6 | no |
| GO:0031334 | positive regulation of protein-containing complex assembly | 22.2222 | 6 | no |
| GO:0032271 | regulation of protein polymerization | 22.2222 | 6 | no |
| GO:0032886 | regulation of microtubule-based process | 22.2222 | 4 | no |
| GO:0051495 | positive regulation of cytoskeleton organization | 22.2222 | 7 | no |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 22.2222 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.2222 | 5 | no |
| GO:1902905 | positive regulation of supramolecular fiber organization | 22.2222 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.2222 | 5 | no |
| GO:0009894 | regulation of catabolic process | 22.2222 | 4 | no |
| GO:0010038 | response to metal ion | 22.2222 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.2222 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.2222 | 6 | no |
| GO:0032386 | regulation of intracellular transport | 22.2222 | 5 | no |
| GO:0051223 | regulation of protein transport | 22.2222 | 5 | no |
| GO:0070201 | regulation of establishment of protein localization | 22.2222 | 6 | no |
| GO:0001817 | regulation of cytokine production | 22.2222 | 4 | no |
| GO:0001959 | regulation of cytokine-mediated signaling pathway | 22.2222 | 5 | no |
| GO:0009057 | macromolecule catabolic process | 22.2222 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| ATG5_HUMAN | [view interactions] | High throughput | no | no |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRAP_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| CNN2_HUMAN | [view interactions] | High throughput | no | no |
| CARM1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TEC_HUMAN | [view interactions] | High throughput | no | yes |
| PACE1_HUMAN | [view interactions] | High throughput | no | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| PLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VKOR1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOS7_HUMAN | [view interactions] | High throughput | no | yes |
| PRP6_HUMAN | [view interactions] | High throughput | no | yes |
| CSDE1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2B_HUMAN | [view interactions] | High throughput | no | no |
| SPAS2_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF7_HUMAN | [view interactions] | High throughput | no | yes |
| DMRTB_HUMAN | [view interactions] | High throughput | no | no |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEF1_HUMAN | [view interactions] | High throughput | no | no |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| CSTFT_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP2_HUMAN | [view interactions] | High throughput | no | no |
| EIF3G_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P5F1B_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| CLC14_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OST4_HUMAN | [view interactions] | High throughput | no | no |
| YLAT2_HUMAN | [view interactions] | High throughput | no | no |
| YKT6_HUMAN | [view interactions] | High throughput | no | yes |
| C1TM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIP30_HUMAN | [view interactions] | High throughput | no | yes |
| FTO_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MICU1_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPR1_HUMAN | [view interactions] | High throughput | no | no |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |