CNN3_HUMAN
Evidence for PS localization
Functions
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CNN3_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 50.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 50.0000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 46.8750 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 40.6250 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.6250 | 4 | no |
| GO:0043168 | anion binding | 40.6250 | 4 | no |
| GO:0005524 | ATP binding | 37.5000 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 37.5000 | 5 | no |
| GO:0043169 | cation binding | 31.2500 | 4 | no |
| GO:0046872 | metal ion binding | 31.2500 | 5 | no |
| GO:0045296 | cadherin binding | 28.1250 | 4 | yes |
| GO:0003779 | actin binding | 25.0000 | 4 | yes |
| GO:0015631 | tubulin binding | 21.8750 | 4 | no |
| GO:0003723 | RNA binding | 21.8750 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 21.8750 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 21.8750 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CNN3_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 71.8750 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 68.7500 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 68.7500 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 65.6250 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 62.5000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 62.5000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 62.5000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 62.5000 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 62.5000 | 4 | no |
| GO:0010468 | regulation of gene expression | 56.2500 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 53.1250 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 53.1250 | 5 | no |
| GO:0033043 | regulation of organelle organization | 53.1250 | 5 | no |
| GO:0006996 | organelle organization | 50.0000 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 46.8750 | 5 | no |
| GO:0010646 | regulation of cell communication | 46.8750 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 46.8750 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 46.8750 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 46.8750 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 43.7500 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 43.7500 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 43.7500 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 40.6250 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 40.6250 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.6250 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 40.6250 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 40.6250 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 40.6250 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 40.6250 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 40.6250 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 40.6250 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 40.6250 | 6 | no |
| GO:0008104 | protein localization | 40.6250 | 4 | no |
| GO:0060341 | regulation of cellular localization | 40.6250 | 4 | no |
| GO:0080134 | regulation of response to stress | 40.6250 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 37.5000 | 5 | no |
| GO:0022607 | cellular component assembly | 37.5000 | 4 | no |
| GO:0051049 | regulation of transport | 37.5000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 34.3750 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 34.3750 | 5 | no |
| GO:0023056 | positive regulation of signaling | 34.3750 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 34.3750 | 4 | no |
| GO:0071310 | cellular response to organic substance | 34.3750 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 34.3750 | 6 | no |
| GO:0032880 | regulation of protein localization | 34.3750 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 34.3750 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 34.3750 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 31.2500 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 31.2500 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 31.2500 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 31.2500 | 5 | no |
| GO:0023057 | negative regulation of signaling | 31.2500 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 31.2500 | 5 | no |
| GO:0009894 | regulation of catabolic process | 28.1250 | 4 | no |
| GO:0010629 | negative regulation of gene expression | 28.1250 | 7 | no |
| GO:0036211 | protein modification process | 28.1250 | 4 | no |
| GO:0043412 | macromolecule modification | 28.1250 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 28.1250 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 28.1250 | 8 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 28.1250 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 28.1250 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 28.1250 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 28.1250 | 5 | no |
| GO:0010638 | positive regulation of organelle organization | 28.1250 | 6 | no |
| GO:0031399 | regulation of protein modification process | 28.1250 | 6 | no |
| GO:0032101 | regulation of response to external stimulus | 28.1250 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.1250 | 5 | no |
| GO:0062197 | cellular response to chemical stress | 28.1250 | 4 | no |
| GO:0043933 | protein-containing complex organization | 28.1250 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 25.0000 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010639 | negative regulation of organelle organization | 25.0000 | 6 | no |
| GO:0010038 | response to metal ion | 25.0000 | 4 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 25.0000 | 6 | no |
| GO:0002684 | positive regulation of immune system process | 25.0000 | 4 | no |
| GO:0031347 | regulation of defense response | 25.0000 | 5 | no |
| GO:0034599 | cellular response to oxidative stress | 25.0000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 21.8750 | 7 | no |
| GO:0030162 | regulation of proteolysis | 21.8750 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 21.8750 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 21.8750 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.8750 | 6 | no |
| GO:0030334 | regulation of cell migration | 21.8750 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 21.8750 | 4 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 21.8750 | 8 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 21.8750 | 7 | no |
| GO:2000145 | regulation of cell motility | 21.8750 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.8750 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.8750 | 5 | no |
| GO:0050776 | regulation of immune response | 21.8750 | 4 | no |
| GO:0080135 | regulation of cellular response to stress | 21.8750 | 4 | no |
| GO:0071702 | organic substance transport | 21.8750 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.8750 | 4 | no |
| GO:0007015 | actin filament organization | 12.5000 | 5 | yes |
| GO:0031032 | actomyosin structure organization | 6.2500 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK10_HUMAN | [view interactions] | High throughput | no | no |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TEC_HUMAN | [view interactions] | High throughput | no | yes |
| PACE1_HUMAN | [view interactions] | High throughput | no | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| LN28A_HUMAN | [view interactions] | High throughput | no | no |
| PLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VKOR1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOS7_HUMAN | [view interactions] | High throughput | no | yes |
| PRP6_HUMAN | [view interactions] | High throughput | no | yes |
| CSDE1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2B_HUMAN | [view interactions] | High throughput | no | no |
| SPAS2_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF7_HUMAN | [view interactions] | High throughput | no | yes |
| DMRTB_HUMAN | [view interactions] | High throughput | no | no |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEF1_HUMAN | [view interactions] | High throughput | no | no |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| CSTFT_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP2_HUMAN | [view interactions] | High throughput | no | no |
| EIF3G_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P5F1B_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| DS13A_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| CLC14_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OST4_HUMAN | [view interactions] | High throughput | no | no |
| YLAT2_HUMAN | [view interactions] | High throughput | no | no |
| TRI31_HUMAN | [view interactions] | High throughput | no | no |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| YKT6_HUMAN | [view interactions] | High throughput | no | yes |
| C1TM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIP30_HUMAN | [view interactions] | High throughput | no | yes |
| FTO_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MICU1_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPR1_HUMAN | [view interactions] | High throughput | no | no |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| CNN2_HUMAN | [view interactions] | High throughput | no | no |
| CARM1_HUMAN | [view interactions] | High throughput | no | yes |