ACTB_HUMAN
Evidence for PS localization
Functions
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed). [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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ACTB_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [ACTB_HUMAN]
Isoform [A0A2R8Y793] alignment
Isoform [A0A6Q8PFE4] alignment
Isoform [E7EVS6] alignment
Isoform [A0A6Q8PGD7] alignment
Isoform [A0A6Q8PH58] alignment
Isoform [A0A2R8YEA7] alignment
Isoform [A0A2R8YGF8] alignment
Isoform [C9JZR7] alignment
Isoform [A0A2R8YFE2] alignment
Isoform [C9JTX5] alignment
Isoform [C9JUM1] alignment
Isoform [G5E9R0] alignment
LOADING 60%
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 183 | Arg | Trp | Dystonia,juvenile-onset(DJO) | - |
| 12 | Asn | Asp | Baraitser-Wintersyndrome1(BRWS1) | - |
| 65 | Leu | Val | Baraitser-Wintersyndrome1(BRWS1) | - |
| 196 | Arg | Cys | Baraitser-Wintersyndrome1(BRWS1) | - |
| 196 | Arg | His | Baraitser-Wintersyndrome1(BRWS1) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
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Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACTB_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 28.7755 | 4 | no |
| GO:0043168 | anion binding | 26.1224 | 4 | yes |
| GO:0000166 | nucleotide binding | 24.8980 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 23.8776 | 5 | yes |
| GO:0003779 | actin binding | 23.8776 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 22.4490 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.0408 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 18.5714 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 17.1429 | 5 | yes |
| GO:0005524 | ATP binding | 16.7347 | 5 | yes |
| GO:0019900 | kinase binding | 13.8776 | 4 | yes |
| GO:0019901 | protein kinase binding | 12.6531 | 5 | yes |
| GO:0140297 | DNA-binding transcription factor binding | 4.8980 | 4 | yes |
| GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | 3.4694 | 5 | yes |
| GO:0048156 | tau protein binding | 2.6531 | 4 | yes |
| GO:0019894 | kinesin binding | 1.4286 | 4 | yes |
| GO:0030957 | Tat protein binding | 0.6122 | 6 | yes |
| GO:0050998 | nitric-oxide synthase binding | 0.4082 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACTB_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 50.6122 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 43.2653 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 41.6327 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 40.8163 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 40.4082 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 40.2041 | 4 | yes |
| GO:0006996 | organelle organization | 37.7551 | 4 | yes |
| GO:0022607 | cellular component assembly | 35.7143 | 4 | yes |
| GO:0010646 | regulation of cell communication | 33.6735 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 33.6735 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.2653 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 33.2653 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 31.2245 | 4 | yes |
| GO:0010468 | regulation of gene expression | 30.8163 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.5714 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 27.9592 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 26.3265 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 25.5102 | 5 | yes |
| GO:0008104 | protein localization | 25.3061 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.3061 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 24.8980 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 23.6735 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.4490 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.2449 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.0408 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT1E_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT6R_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT7R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| ABCG2_HUMAN | [view interactions] | High throughput | no | no |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABRA_HUMAN | [view interactions] | High throughput | no | no |
| ACD_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| ACE_HUMAN | [view interactions] | Low throughput | no | no |
| ACL6A_HUMAN | [view interactions] | High throughput | no | yes |