AAK1_HUMAN
Evidence for PS localization
Functions
(Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AAK1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 29.7872 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 27.6596 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 25.5319 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.5319 | 4 | yes |
| GO:0005524 | ATP binding | 23.4043 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 23.4043 | 5 | yes |
| GO:0003723 | RNA binding | 21.2766 | 4 | no |
| GO:0019900 | kinase binding | 21.2766 | 4 | no |
| GO:0019901 | protein kinase binding | 21.2766 | 5 | no |
| GO:0045296 | cadherin binding | 21.2766 | 4 | no |
| GO:0004674 | protein serine/threonine kinase activity | 8.5106 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 8.5106 | 4 | yes |
| GO:0016301 | kinase activity | 8.5106 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 8.5106 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 8.5106 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AAK1_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 53.1915 | 4 | yes |
| GO:0008104 | protein localization | 51.0638 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 46.8085 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 44.6809 | 4 | yes |
| GO:0022607 | cellular component assembly | 44.6809 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 44.6809 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.6809 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.6809 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 42.5532 | 4 | no |
| GO:0071702 | organic substance transport | 42.5532 | 4 | no |
| GO:0071705 | nitrogen compound transport | 40.4255 | 4 | no |
| GO:0015031 | protein transport | 38.2979 | 4 | no |
| GO:0006897 | endocytosis | 36.1702 | 5 | yes |
| GO:0006996 | organelle organization | 36.1702 | 4 | no |
| GO:0051049 | regulation of transport | 34.0426 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 34.0426 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 31.9149 | 5 | no |
| GO:0060341 | regulation of cellular localization | 29.7872 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 29.7872 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 29.7872 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.7872 | 5 | no |
| GO:0032880 | regulation of protein localization | 27.6596 | 5 | yes |
| GO:0006886 | intracellular protein transport | 27.6596 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 27.6596 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.6596 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.6596 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.6596 | 5 | no |
| GO:0010646 | regulation of cell communication | 25.5319 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 25.5319 | 5 | no |
| GO:0007010 | cytoskeleton organization | 25.5319 | 5 | no |
| GO:0009966 | regulation of signal transduction | 23.4043 | 4 | yes |
| GO:0006898 | receptor-mediated endocytosis | 23.4043 | 6 | no |
| GO:0051050 | positive regulation of transport | 23.4043 | 4 | no |
| GO:0071310 | cellular response to organic substance | 23.4043 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.4043 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.4043 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 23.4043 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.4043 | 6 | no |
| GO:0030030 | cell projection organization | 23.4043 | 4 | no |
| GO:0034330 | cell junction organization | 23.4043 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 23.4043 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.4043 | 5 | no |
| GO:0033043 | regulation of organelle organization | 21.2766 | 5 | no |
| GO:0072583 | clathrin-dependent endocytosis | 21.2766 | 7 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.2766 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.2766 | 4 | no |
| GO:0030100 | regulation of endocytosis | 17.0213 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 17.0213 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 14.8936 | 4 | yes |
| GO:0036211 | protein modification process | 14.8936 | 4 | yes |
| GO:0043412 | macromolecule modification | 14.8936 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 14.8936 | 4 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 12.7660 | 6 | yes |
| GO:0009967 | positive regulation of signal transduction | 10.6383 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 10.6383 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 10.6383 | 4 | yes |
| GO:0061024 | membrane organization | 10.6383 | 4 | yes |
| GO:0006468 | protein phosphorylation | 8.5106 | 5 | yes |
| GO:0016310 | phosphorylation | 8.5106 | 5 | yes |
| GO:0050821 | protein stabilization | 6.3830 | 4 | yes |
| GO:0046777 | protein autophosphorylation | 4.2553 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| I17RB_HUMAN | [view interactions] | Low throughput | no | no |
| AT132_HUMAN | [view interactions] | Low throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| DRC5_HUMAN | [view interactions] | High throughput | no | no |
| VIP2_HUMAN | [view interactions] | High throughput | no | yes |
| SC24B_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP88_HUMAN | [view interactions] | High throughput | no | yes |
| GRDN_HUMAN | [view interactions] | High throughput | no | no |
| EYA4_HUMAN | [view interactions] | High throughput | no | yes |
| QSER1_HUMAN | [view interactions] | High throughput | no | yes |
| LUZP1_HUMAN | [view interactions] | High throughput | no | yes |
| URGCP_HUMAN | [view interactions] | High throughput | no | yes |
| DVL3_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| REPS1_HUMAN | [view interactions] | High throughput | no | yes |
| RUN3A_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UTP25_HUMAN | [view interactions] | High throughput | no | yes |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| NECP2_HUMAN | [view interactions] | High throughput | no | yes |
| RBM12_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV2_HUMAN | [view interactions] | High throughput | no | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEA1_HUMAN | [view interactions] | High throughput | no | no |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WNK2_HUMAN | [view interactions] | High throughput | no | yes |
| ACOT9_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI7_HUMAN | [view interactions] | High throughput | no | no |
| WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RM02_HUMAN | [view interactions] | High throughput | no | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
| TPP2_HUMAN | [view interactions] | High throughput | no | yes |
| GYS1_HUMAN | [view interactions] | High throughput | no | yes |
| ODPX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBQL2_HUMAN | [view interactions] | Computational | no | yes |
| SGIP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARFG1_HUMAN | [view interactions] | Computational | no | no |
| EPS15_HUMAN | [view entry] [view interactions] | Computational | yes | yes |