AAK1_HUMAN
Evidence for PS localization
Functions
(Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 46%
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Interacting regions
Canonical [AAK1_HUMAN]
Isoform [Q2M2I8-2] alignment
Isoform [A0A096LNZ0] alignment
Isoform [A0A096LP25] alignment
Isoform [A0A096LP60] alignment
Isoform [E9PG46] alignment
LOADING 39%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AAK1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 26.1538 | 4 | no |
| GO:0019900 | kinase binding | 26.1538 | 4 | no |
| GO:0019901 | protein kinase binding | 26.1538 | 5 | no |
| GO:0045296 | cadherin binding | 24.6154 | 4 | no |
| GO:0043169 | cation binding | 24.6154 | 4 | no |
| GO:0046872 | metal ion binding | 24.6154 | 5 | no |
| GO:0043168 | anion binding | 23.0769 | 4 | yes |
| GO:0000166 | nucleotide binding | 21.5385 | 4 | yes |
| GO:0005524 | ATP binding | 21.5385 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 21.5385 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 21.5385 | 6 | yes |
| GO:0032555 | purine ribonucleotide binding | 21.5385 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 21.5385 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.5385 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 7.6923 | 4 | yes |
| GO:0016301 | kinase activity | 7.6923 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 7.6923 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 7.6923 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AAK1_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 58.4615 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 56.9231 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 53.8462 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 53.8462 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 53.8462 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.3077 | 4 | no |
| GO:0008104 | protein localization | 49.2308 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 47.6923 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 47.6923 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 47.6923 | 5 | no |
| GO:0022607 | cellular component assembly | 44.6154 | 4 | no |
| GO:0010468 | regulation of gene expression | 44.6154 | 6 | no |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0006996 | organelle organization | 38.4615 | 4 | no |
| GO:0051049 | regulation of transport | 33.8462 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 33.8462 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.8462 | 5 | no |
| GO:0009966 | regulation of signal transduction | 32.3077 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 32.3077 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.3077 | 4 | no |
| GO:0071702 | organic substance transport | 30.7692 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.7692 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.7692 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.2308 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACOT9_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT132_HUMAN | [view interactions] | Low throughput | no | yes |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |