AAK1_HUMAN
Evidence for PS localization
Functions
(Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AAK1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 26.1538 | 4 | no |
| GO:0019900 | kinase binding | 26.1538 | 4 | no |
| GO:0019901 | protein kinase binding | 26.1538 | 5 | no |
| GO:0045296 | cadherin binding | 24.6154 | 4 | no |
| GO:0043169 | cation binding | 24.6154 | 4 | no |
| GO:0046872 | metal ion binding | 24.6154 | 5 | no |
| GO:0043168 | anion binding | 23.0769 | 4 | yes |
| GO:0000166 | nucleotide binding | 21.5385 | 4 | yes |
| GO:0005524 | ATP binding | 21.5385 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 21.5385 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 21.5385 | 6 | yes |
| GO:0032555 | purine ribonucleotide binding | 21.5385 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 21.5385 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.5385 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 7.6923 | 4 | yes |
| GO:0016301 | kinase activity | 7.6923 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 7.6923 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 7.6923 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AAK1_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 58.4615 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 56.9231 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 53.8462 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 53.8462 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 53.8462 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.3077 | 4 | no |
| GO:0008104 | protein localization | 49.2308 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 47.6923 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 47.6923 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 47.6923 | 5 | no |
| GO:0022607 | cellular component assembly | 44.6154 | 4 | no |
| GO:0010468 | regulation of gene expression | 44.6154 | 6 | no |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0006996 | organelle organization | 38.4615 | 4 | no |
| GO:0051049 | regulation of transport | 33.8462 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 33.8462 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.8462 | 5 | no |
| GO:0009966 | regulation of signal transduction | 32.3077 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 32.3077 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.3077 | 4 | no |
| GO:0071702 | organic substance transport | 30.7692 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.7692 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.7692 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.2308 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.2308 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 29.2308 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.2308 | 5 | no |
| GO:0060341 | regulation of cellular localization | 27.6923 | 4 | yes |
| GO:0015031 | protein transport | 27.6923 | 4 | no |
| GO:0031399 | regulation of protein modification process | 27.6923 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 27.6923 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 26.1538 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.1538 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 26.1538 | 7 | no |
| GO:0051129 | negative regulation of cellular component organization | 26.1538 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.1538 | 6 | no |
| GO:0032880 | regulation of protein localization | 24.6154 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 24.6154 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 24.6154 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 24.6154 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.6154 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 23.0769 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.0769 | 4 | yes |
| GO:0098657 | import into cell | 23.0769 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 23.0769 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.0769 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 23.0769 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 23.0769 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 23.0769 | 6 | no |
| GO:0060284 | regulation of cell development | 21.5385 | 5 | no |
| GO:0009894 | regulation of catabolic process | 21.5385 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.5385 | 5 | no |
| GO:0034330 | cell junction organization | 21.5385 | 4 | no |
| GO:0036211 | protein modification process | 20.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 20.0000 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 18.4615 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 18.4615 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 15.3846 | 5 | yes |
| GO:0016310 | phosphorylation | 12.3077 | 5 | yes |
| GO:0030100 | regulation of endocytosis | 12.3077 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 12.3077 | 4 | yes |
| GO:0006468 | protein phosphorylation | 10.7692 | 5 | yes |
| GO:0061024 | membrane organization | 10.7692 | 4 | yes |
| GO:0050821 | protein stabilization | 7.6923 | 4 | yes |
| GO:0140238 | presynaptic endocytosis | 7.6923 | 4 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 6.1538 | 6 | yes |
| GO:0008593 | regulation of Notch signaling pathway | 3.0769 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AT132_HUMAN | [view interactions] | Low throughput | no | yes |
| I17RB_HUMAN | [view interactions] | Low throughput | no | no |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GYS1_HUMAN | [view interactions] | High throughput | no | yes |
| TPP2_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM02_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GEMI7_HUMAN | [view interactions] | High throughput | no | no |
| ACOT9_HUMAN | [view interactions] | High throughput | no | yes |
| WNK2_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| TLK2_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| DRC5_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIP2_HUMAN | [view interactions] | High throughput | no | yes |
| SC24B_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QSER1_HUMAN | [view interactions] | High throughput | no | no |
| EYA4_HUMAN | [view interactions] | High throughput | no | yes |
| GRDN_HUMAN | [view interactions] | High throughput | no | no |
| NUP88_HUMAN | [view interactions] | High throughput | no | yes |
| LUZP1_HUMAN | [view interactions] | High throughput | no | yes |
| URGCP_HUMAN | [view interactions] | High throughput | no | yes |
| DVL3_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| REPS1_HUMAN | [view interactions] | High throughput | no | yes |
| RUN3A_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UTP25_HUMAN | [view interactions] | High throughput | no | yes |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| NECP2_HUMAN | [view interactions] | High throughput | no | yes |
| RBM12_HUMAN | [view interactions] | High throughput | no | yes |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REPS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STON2_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPP2_HUMAN | [view interactions] | High throughput | no | no |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV2_HUMAN | [view interactions] | High throughput | no | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEA1_HUMAN | [view interactions] | High throughput | no | no |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |