Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AP2M1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Component of the adaptor protein complex 2 (AP-2) (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis (PubMed). AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules . AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway (PubMed). During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed). The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs . The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Thr-156 in membrane-associated AP-2 (PubMed). The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (PubMed). Plays a role in endocytosis of frizzled family members upon Wnt signaling . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
170 Arg Trp Intellectualdevelopmentaldisorder,autosomaldominant60,withseizures(MRD60) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI004736 MOD_AAK1BIKe_LxxQxTG_1 MOD 151 157 -
ELMI004736 MOD_AAK1BIKe_LxxQxTG_1 MOD 151 157 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AP2M1_HUMAN
GO:0043168 anion binding 32.5967 4 no
GO:0000166 nucleotide binding 30.9392 4 no
GO:0017076 purine nucleotide binding 30.9392 5 no
GO:0032555 purine ribonucleotide binding 29.8343 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.7293 4 no
GO:0043169 cation binding 27.0718 4 no
GO:0046872 metal ion binding 25.9669 5 no
GO:0030554 adenyl nucleotide binding 23.2044 6 no
GO:0032559 adenyl ribonucleotide binding 22.0994 5 no
GO:0019900 kinase binding 22.0994 4 no
GO:0003723 RNA binding 21.5470 4 no
GO:0005524 ATP binding 20.9945 5 no
GO:0019901 protein kinase binding 20.9945 5 no
GO:0035615 clathrin adaptor activity 3.8674 4 yes
GO:0097718 disordered domain specific binding 3.8674 4 yes
GO:0050750 low-density lipoprotein particle receptor binding 2.7624 5 yes
GO:0070325 lipoprotein particle receptor binding 2.7624 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AP2M1_HUMAN
GO:0048522 positive regulation of cellular process 59.6685 4 yes
GO:0048523 negative regulation of cellular process 48.6188 4 yes
GO:0051128 regulation of cellular component organization 48.6188 4 yes
GO:0010646 regulation of cell communication 46.4088 4 no
GO:0060255 regulation of macromolecule metabolic process 45.3039 4 no
GO:0031323 regulation of cellular metabolic process 44.7514 4 no
GO:0080090 regulation of primary metabolic process 40.8840 4 no
GO:0006996 organelle organization 40.3315 4 yes
GO:0022607 cellular component assembly 40.3315 4 yes
GO:0009966 regulation of signal transduction 38.6740 4 no
GO:0009889 regulation of biosynthetic process 35.3591 4 no
GO:0009893 positive regulation of metabolic process 35.3591 4 no
GO:0010556 regulation of macromolecule biosynthetic process 34.2541 5 no
GO:0031326 regulation of cellular biosynthetic process 34.2541 5 no
GO:0008104 protein localization 33.1492 4 yes
GO:0051246 regulation of protein metabolic process 33.1492 5 no
GO:0051049 regulation of transport 32.5967 4 yes
GO:0010468 regulation of gene expression 32.0442 6 no
GO:0010604 positive regulation of macromolecule metabolic process 32.0442 5 no
GO:0048584 positive regulation of response to stimulus 30.9392 4 no
GO:0031325 positive regulation of cellular metabolic process 29.8343 5 no
GO:0023056 positive regulation of signaling 28.7293 4 no
GO:0010647 positive regulation of cell communication 28.1768 5 no
GO:0043933 protein-containing complex organization 28.1768 4 yes
GO:0098657 import into cell 28.1768 4 yes
GO:1902531 regulation of intracellular signal transduction 26.5193 5 no
GO:0009892 negative regulation of metabolic process 26.5193 4 no
GO:0010605 negative regulation of macromolecule metabolic process 25.4144 5 no
GO:0071702 organic substance transport 24.8619 4 yes
GO:0009967 positive regulation of signal transduction 24.8619 5 no
GO:0071705 nitrogen compound transport 24.3094 4 yes
GO:0031324 negative regulation of cellular metabolic process 23.7569 5 no
GO:0051130 positive regulation of cellular component organization 23.7569 5 yes
GO:0036211 protein modification process 23.7569 4 no
GO:0043412 macromolecule modification 23.7569 4 no
GO:0031399 regulation of protein modification process 23.2044 6 no
GO:0060341 regulation of cellular localization 22.6519 4 yes
GO:0009891 positive regulation of biosynthetic process 22.6519 5 no
GO:0051247 positive regulation of protein metabolic process 22.0994 6 no
GO:0065003 protein-containing complex assembly 22.0994 5 yes
GO:0042981 regulation of apoptotic process 22.0994 5 no
GO:0043067 regulation of programmed cell death 22.0994 4 no
GO:0033043 regulation of organelle organization 21.5470 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.5470 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.5470 6 no
GO:0007010 cytoskeleton organization 21.5470 5 no
GO:0032880 regulation of protein localization 20.9945 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 20.9945 6 no
GO:0044087 regulation of cellular component biogenesis 20.4420 4 no
GO:0051252 regulation of RNA metabolic process 20.4420 5 no
GO:0051240 positive regulation of multicellular organismal process 20.4420 4 no
GO:0015031 protein transport 19.3370 4 yes
GO:0060627 regulation of vesicle-mediated transport 17.1271 4 yes
GO:0051050 positive regulation of transport 15.4696 4 yes
GO:0006886 intracellular protein transport 14.9171 4 yes
GO:0006898 receptor-mediated endocytosis 14.9171 4 yes
GO:0061024 membrane organization 14.9171 4 yes
GO:0030100 regulation of endocytosis 12.7072 5 yes
GO:0072583 clathrin-dependent endocytosis 9.3923 5 yes
GO:1905475 regulation of protein localization to membrane 9.3923 6 yes
GO:1904375 regulation of protein localization to cell periphery 8.2873 6 yes
GO:0016050 vesicle organization 7.7348 5 yes
GO:0031623 receptor internalization 7.1823 5 yes
GO:0048259 regulation of receptor-mediated endocytosis 7.1823 6 yes
GO:0140238 presynaptic endocytosis 6.6298 4 yes
GO:0032535 regulation of cellular component size 6.0773 4 yes
GO:0048488 synaptic vesicle endocytosis 6.0773 5 yes
GO:1903076 regulation of protein localization to plasma membrane 6.0773 7 yes
GO:0045807 positive regulation of endocytosis 5.5249 5 yes
GO:1903828 negative regulation of protein localization 4.9724 5 yes
GO:0098884 postsynaptic neurotransmitter receptor internalization 3.8674 4 yes
GO:0140239 postsynaptic endocytosis 3.8674 4 yes
GO:0002090 regulation of receptor internalization 3.3149 7 yes
GO:0006900 vesicle budding from membrane 3.3149 5 yes
GO:0048260 positive regulation of receptor-mediated endocytosis 3.3149 6 yes
GO:1903421 regulation of synaptic vesicle recycling 3.3149 5 yes
GO:1900242 regulation of synaptic vesicle endocytosis 2.7624 6 yes
GO:1903077 negative regulation of protein localization to plasma membrane 2.7624 7 yes
GO:1904376 negative regulation of protein localization to cell periphery 2.7624 6 yes
GO:1905476 negative regulation of protein localization to membrane 2.7624 6 yes
GO:0002092 positive regulation of receptor internalization 2.2099 7 yes
GO:0097494 regulation of vesicle size 1.6575 5 yes
GO:1900244 positive regulation of synaptic vesicle endocytosis 1.1050 6 yes
GO:1903423 positive regulation of synaptic vesicle recycling 1.1050 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TBCD5_HUMAN [view interactions] Low throughput no yes
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA3_HUMAN [view entry] [view interactions] Low throughput yes yes
DVL2_HUMAN [view interactions] Low throughput no yes
ARFG1_HUMAN [view interactions] Low throughput no no
AP2A2_HUMAN [view entry] [view interactions] Low throughput yes yes
ITA2_HUMAN [view interactions] Low throughput no yes
SYT3_HUMAN [view entry] [view interactions] Low throughput yes no
ITA4_HUMAN [view interactions] Low throughput no no
AP2A_HUMAN [view interactions] Low throughput no no
MRP2_HUMAN [view interactions] Low throughput no no
AP2M1_HUMAN [view entry] [view interactions] Low throughput yes yes
NECP1_HUMAN [view interactions] Low throughput no no
NECP2_HUMAN [view interactions] Low throughput no yes
AP2S1_HUMAN [view entry] [view interactions] Low throughput yes no
AP1B1_HUMAN [view entry] [view interactions] Low throughput yes yes
EHD2_HUMAN [view interactions] Low throughput no no
FURIN_HUMAN [view interactions] Low throughput no yes
ABCBB_HUMAN [view interactions] Low throughput no no
P2RX4_HUMAN [view entry] [view interactions] Low throughput yes yes
CORO7_HUMAN [view interactions] Low throughput no no
TGON2_HUMAN [view entry] [view interactions] Low throughput yes yes
LY9_HUMAN [view interactions] Low throughput no no
CD22_HUMAN [view interactions] Low throughput no no
CTLA4_HUMAN [view interactions] Low throughput no no
AQP4_HUMAN [view entry] [view interactions] Low throughput yes no
ADA1B_HUMAN [view interactions] Low throughput no no
RN111_HUMAN [view interactions] Low throughput no yes
FAIM1_HUMAN [view interactions] Low throughput no yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
CLC4M_HUMAN [view interactions] Low throughput no no
AP1G1_HUMAN [view entry] [view interactions] Low throughput yes yes
INAR1_HUMAN [view interactions] Low throughput no yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
A16L1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMD3A_HUMAN [view entry] [view interactions] Low throughput yes no
ADA10_HUMAN [view entry] [view interactions] Low throughput yes yes
LYAM3_HUMAN [view interactions] Low throughput no no
CD4_HUMAN [view interactions] Low throughput no no
GBRG2_HUMAN [view entry] [view interactions] Low throughput yes no
PI51C_HUMAN [view entry] [view interactions] Low throughput yes yes
IRS1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNQ1_HUMAN [view interactions] Low throughput no yes
ATG9A_HUMAN [view interactions] Low throughput no yes
RBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
MEG10_HUMAN [view interactions] Low throughput no no
AP2B1_HUMAN [view entry] [view interactions] Low throughput yes yes
CD5_HUMAN [view interactions] Low throughput no no
SYNJ1_HUMAN [view entry] [view interactions] Low throughput yes yes
OCRL_HUMAN [view interactions] Low throughput no yes
CLD2_HUMAN [view interactions] Low throughput no no
GBRB3_HUMAN [view entry] [view interactions] Low throughput yes no
STON2_HUMAN [view interactions] Low throughput no yes
STON1_HUMAN [view interactions] Low throughput no yes
TMM59_HUMAN [view interactions] High throughput no yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD3_HUMAN [view interactions] High throughput no yes
MTX2_HUMAN [view entry] [view interactions] High throughput yes yes
CALL3_HUMAN [view interactions] High throughput no yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
FLNB_HUMAN [view interactions] High throughput no no
EFNB2_HUMAN [view entry] [view interactions] High throughput yes yes
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
ZN746_HUMAN [view interactions] High throughput no no
MB212_HUMAN [view interactions] High throughput no no
MTMR4_HUMAN [view interactions] High throughput no no
AMPH_HUMAN [view entry] [view interactions] High throughput yes yes
M3K9_HUMAN [view interactions] High throughput no yes
SNX9_HUMAN [view entry] [view interactions] High throughput yes yes
WNK3_HUMAN [view interactions] High throughput no no
REPS2_HUMAN [view entry] [view interactions] High throughput yes no
SPTCS_HUMAN [view interactions] High throughput no yes
GP156_HUMAN [view interactions] High throughput no no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
GPBL1_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
TNKS1_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
NDRG1_HUMAN [view entry] [view interactions] High throughput yes yes
TES_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
DX39B_HUMAN [view interactions] High throughput no no
LITD1_HUMAN [view interactions] High throughput no no
BMR1A_HUMAN [view interactions] High throughput no no
INSR_HUMAN [view interactions] High throughput no yes
RN138_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
B2CL1_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
DIM1_HUMAN [view interactions] High throughput no yes
LN28A_HUMAN [view interactions] High throughput no no
MEX3C_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
U5S1_HUMAN [view interactions] High throughput no yes
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
SOCS6_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
RIOK1_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
HEXI1_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
CEBPA_HUMAN [view interactions] High throughput no yes
SFRP4_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
RSP14_HUMAN [view interactions] High throughput no no
KDM1A_HUMAN [view interactions] High throughput no yes
H2B1C_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
PR38A_HUMAN [view interactions] High throughput no no
UBQL2_HUMAN [view interactions] High throughput no yes
F90A1_HUMAN [view interactions] High throughput no no
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
UTP25_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
H2B1L_HUMAN [view interactions] High throughput no yes
CC14A_HUMAN [view interactions] High throughput no yes
PTPS_HUMAN [view interactions] High throughput no yes
AUXI_HUMAN [view entry] [view interactions] High throughput yes yes
PRP18_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
MMTA2_HUMAN [view interactions] High throughput no yes
ZBT7B_HUMAN [view interactions] High throughput no no
MTURN_HUMAN [view interactions] High throughput no no
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
H2B2E_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
NKAP1_HUMAN [view interactions] High throughput no yes
BRD7_HUMAN [view interactions] High throughput no yes
RL22_HUMAN [view entry] [view interactions] High throughput yes no
TIF1B_HUMAN [view interactions] High throughput no yes
EM55_HUMAN [view entry] [view interactions] High throughput yes no
PKHA4_HUMAN [view interactions] High throughput no yes
NAA11_HUMAN [view interactions] High throughput no no
ZCH18_HUMAN [view interactions] High throughput no yes
EAF1_HUMAN [view interactions] High throughput no yes
PRR13_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
MB213_HUMAN [view interactions] High throughput no no
ECT2_HUMAN [view interactions] High throughput no no
MFAP1_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
TMA16_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
CX05B_HUMAN [view interactions] High throughput no no
NUPR1_HUMAN [view interactions] High throughput no no
ZN581_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
KNOP1_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
EIF1A_HUMAN [view interactions] High throughput no no
ISG15_HUMAN [view interactions] High throughput no no
HEXI2_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
MED4_HUMAN [view interactions] High throughput no yes
UBP15_HUMAN [view entry] [view interactions] High throughput yes yes
IKZF1_HUMAN [view interactions] High throughput no no
SGIP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT8A_HUMAN [view interactions] High throughput no yes
CLMN_HUMAN [view entry] [view interactions] High throughput yes no
RUN3A_HUMAN [view interactions] High throughput no yes
SHC2_HUMAN [view interactions] High throughput no yes
DPPA2_HUMAN [view interactions] High throughput no no
CCD32_HUMAN [view interactions] High throughput no yes
AGTR1_HUMAN [view interactions] High throughput no no
ZCH10_HUMAN [view interactions] High throughput no yes
BKRB2_HUMAN [view interactions] High throughput no yes
INSY1_HUMAN [view entry] [view interactions] High throughput yes yes
5HT6R_HUMAN [view interactions] High throughput no yes
PAAT_HUMAN [view interactions] High throughput no yes
LT4R2_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
EDC4_HUMAN [view interactions] High throughput no yes
RHOH_HUMAN [view interactions] High throughput no yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
EPS15_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
ANR28_HUMAN [view interactions] High throughput no no
RHOC_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
SOX2_HUMAN [view interactions] High throughput no yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
AHSA1_HUMAN [view entry] [view interactions] High throughput yes yes
MEA1_HUMAN [view interactions] High throughput no no
RHG18_HUMAN [view interactions] High throughput no yes
YJ005_HUMAN [view interactions] High throughput no no
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
CTND1_HUMAN [view entry] [view interactions] High throughput yes no
TLS1_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
FCHO2_HUMAN [view interactions] High throughput no yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
HDAC6_HUMAN [view interactions] High throughput no yes
UBB_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
BAP1_HUMAN [view interactions] High throughput no yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
PARPT_HUMAN [view interactions] High throughput no no
RL40_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP48_HUMAN [view interactions] High throughput no yes
SLX4_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
EZH2_HUMAN [view interactions] High throughput no no
REPS1_HUMAN [view interactions] High throughput no yes
MIDN_HUMAN [view interactions] High throughput no no
CADH3_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
MASP1_HUMAN [view interactions] High throughput no no
TNIP1_HUMAN [view interactions] High throughput no yes
EP15R_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LRRK2_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
PPAL_HUMAN [view interactions] High throughput no no
BI2L1_HUMAN [view interactions] High throughput no yes
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
TIAM1_HUMAN [view entry] [view interactions] High throughput yes yes
DGKI_HUMAN [view entry] [view interactions] High throughput yes no
SOX4_HUMAN [view interactions] High throughput no yes
OTU6B_HUMAN [view interactions] High throughput no yes
PLRG1_HUMAN [view interactions] High throughput no yes
LHX2_HUMAN [view interactions] High throughput no no
DDX47_HUMAN [view interactions] High throughput no yes
DDR2_HUMAN [view interactions] High throughput no no
HAT1_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
TBB2B_HUMAN [view entry] [view interactions] High throughput yes yes
LMTK1_HUMAN [view interactions] High throughput no yes
AP180_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
CNOT4_HUMAN [view interactions] High throughput no yes
SYEP_HUMAN [view interactions] High throughput no yes
G6PD_HUMAN [view entry] [view interactions] High throughput yes no
PCNA_HUMAN [view interactions] High throughput no no
AMRP_HUMAN [view interactions] High throughput no yes
METK2_HUMAN [view interactions] High throughput no no
NCOR2_HUMAN [view interactions] High throughput no yes
GARS_HUMAN [view interactions] High throughput no yes
SYRC_HUMAN [view interactions] High throughput no yes
ATX1L_HUMAN [view interactions] High throughput no no
RAN_HUMAN [view entry] [view interactions] High throughput yes no
CAP1_HUMAN [view entry] [view interactions] High throughput yes yes
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
CUL2_HUMAN [view interactions] High throughput no yes
SPAS2_HUMAN [view interactions] High throughput no yes
ACAP2_HUMAN [view interactions] High throughput no yes
LC7L2_HUMAN [view interactions] High throughput no yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
CD2B2_HUMAN [view interactions] High throughput no yes
PR38B_HUMAN [view interactions] High throughput no no
CLK2_HUMAN [view interactions] High throughput no yes
WDFY1_HUMAN [view interactions] High throughput no yes
PKHF2_HUMAN [view interactions] High throughput no yes
TRM1_HUMAN [view interactions] High throughput no yes
MAT2B_HUMAN [view interactions] High throughput no yes
PPM1H_HUMAN [view interactions] High throughput no yes
P5F1B_HUMAN [view interactions] High throughput no no
AGR2_HUMAN [view interactions] High throughput no no
PO5F1_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
KS6A1_HUMAN [view entry] [view interactions] High throughput yes yes
KS6A3_HUMAN [view entry] [view interactions] High throughput yes yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
KS6A2_HUMAN [view interactions] High throughput no yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
BMP2K_HUMAN [view interactions] High throughput no yes
CRDL1_HUMAN [view interactions] High throughput no no
K1C10_HUMAN [view interactions] High throughput no no
CTIF_HUMAN [view interactions] High throughput no yes
ACACA_HUMAN [view entry] [view interactions] High throughput yes yes
MEX3B_HUMAN [view interactions] High throughput no no
K22E_HUMAN [view interactions] High throughput no no
PATL1_HUMAN [view interactions] High throughput no yes
K2C1_HUMAN [view interactions] High throughput no no
TNR6A_HUMAN [view interactions] High throughput no yes
K1C9_HUMAN [view interactions] High throughput no no
TNR6B_HUMAN [view interactions] High throughput no yes
TBB5_HUMAN [view interactions] High throughput no yes
TNR6C_HUMAN [view interactions] High throughput no no
TBB4B_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
K1C14_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
TBA1C_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
K2C5_HUMAN [view entry] [view interactions] High throughput yes no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
TBB2A_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
BROMI_HUMAN [view interactions] High throughput no no
K2C6A_HUMAN [view entry] [view interactions] High throughput yes no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
K2C6B_HUMAN [view interactions] High throughput no no
IFM1_HUMAN [view interactions] High throughput no no
K1C16_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
KBTB4_HUMAN [view interactions] High throughput no yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
K2C79_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
K1C17_HUMAN [view interactions] High throughput no no
RFA2_HUMAN [view interactions] High throughput no yes
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
RFA3_HUMAN [view interactions] High throughput no yes
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes
SFPQ_HUMAN [view entry] [view interactions] High throughput yes yes
HS71L_HUMAN [view entry] [view interactions] High throughput yes no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
K2C73_HUMAN [view interactions] High throughput no no
HSP76_HUMAN [view entry] [view interactions] High throughput yes yes
K2C1B_HUMAN [view interactions] High throughput no yes
K2C3_HUMAN [view interactions] High throughput no no
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
MAP4_HUMAN [view entry] [view interactions] High throughput yes no
DDX6_HUMAN [view entry] [view interactions] High throughput yes yes
RUVB2_HUMAN [view interactions] High throughput no yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
MAGC2_HUMAN [view interactions] High throughput no no
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
SPB12_HUMAN [view interactions] High throughput no no
EPN4_HUMAN [view interactions] High throughput no yes
RARA_HUMAN [view interactions] High throughput no no
RNF11_HUMAN [view interactions] High throughput no yes
GLP1R_HUMAN [view interactions] High throughput no no
EPHA2_HUMAN [view interactions] High throughput no no
ADT1_HUMAN [view entry] [view interactions] High throughput yes yes
ADT2_HUMAN [view entry] [view interactions] High throughput yes yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
ATX2L_HUMAN [view interactions] High throughput no no
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
S2541_HUMAN [view interactions] High throughput no no
AP1S2_HUMAN [view interactions] High throughput no no
AP1S1_HUMAN [view entry] [view interactions] High throughput yes yes
AP1S3_HUMAN [view interactions] High throughput no yes
AMER1_HUMAN [view interactions] High throughput no yes
CYTSA_HUMAN [view interactions] High throughput no yes
AKA11_HUMAN [view interactions] High throughput no yes
NKAP_HUMAN [view interactions] High throughput no yes
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
MAGD4_HUMAN [view interactions] High throughput no no
TNKS2_HUMAN [view interactions] High throughput no no
PP6R2_HUMAN [view interactions] High throughput no no
COL12_HUMAN [view interactions] High throughput no no
APC_HUMAN [view entry] [view interactions] High throughput yes no
PER1_HUMAN [view interactions] High throughput no no
CACO1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX14_HUMAN [view interactions] High throughput no yes
PJA1_HUMAN [view interactions] High throughput no yes
PJA2_HUMAN [view entry] [view interactions] High throughput yes yes
DNM3B_HUMAN [view interactions] High throughput no yes
KI13A_HUMAN [view interactions] High throughput no yes
IRS2_HUMAN [view interactions] High throughput no yes
ANR52_HUMAN [view interactions] High throughput no yes
DCAF1_HUMAN [view interactions] High throughput no yes
RRP12_HUMAN [view interactions] High throughput no no
CRY2_HUMAN [view interactions] High throughput no yes
CRY1_HUMAN [view interactions] High throughput no yes
PPHLN_HUMAN [view interactions] High throughput no yes
STK11_HUMAN [view interactions] High throughput no yes
PEX5_HUMAN [view interactions] High throughput no yes
CAC1A_HUMAN [view entry] [view interactions] High throughput yes no
CHD8_HUMAN [view interactions] High throughput no no
CD11B_HUMAN [view interactions] High throughput no yes
SV2A_HUMAN [view entry] [view interactions] High throughput yes yes
RL38_HUMAN [view entry] [view interactions] High throughput yes yes
KBTB7_HUMAN [view interactions] High throughput no yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
KBTB6_HUMAN [view interactions] High throughput no yes
TASOR_HUMAN [view interactions] High throughput no yes
KAPCB_HUMAN [view entry] [view interactions] High throughput yes yes
F199X_HUMAN [view interactions] High throughput no yes
HOOK2_HUMAN [view interactions] High throughput no yes
REXO1_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
GULP1_HUMAN [view interactions] High throughput no no
ICT1_HUMAN [view interactions] High throughput no yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
NUMB_HUMAN [view entry] [view interactions] High throughput yes yes
STX8_HUMAN [view interactions] High throughput no yes
AAK1_HUMAN [view entry] [view interactions] High throughput yes yes
KSR1_HUMAN [view interactions] High throughput no yes
CAPON_HUMAN [view entry] [view interactions] High throughput yes yes
K0232_HUMAN [view interactions] High throughput no yes
NAC1_HUMAN [view entry] [view interactions] High throughput yes yes
RGPA1_HUMAN [view entry] [view interactions] High throughput yes yes
PRD16_HUMAN [view interactions] High throughput no no
CA226_HUMAN [view interactions] High throughput no yes
MECOM_HUMAN [view interactions] High throughput no yes
SNX29_HUMAN [view interactions] High throughput no yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
NAGPA_HUMAN [view interactions] High throughput no no
SHC1_HUMAN [view entry] [view interactions] High throughput yes yes
TSSC4_HUMAN [view interactions] High throughput no yes
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
AP1G2_HUMAN [view interactions] High throughput no yes
BCR_HUMAN [view entry] [view interactions] High throughput yes yes
INTU_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
NPC1_HUMAN [view interactions] High throughput no yes
MARK2_HUMAN [view entry] [view interactions] High throughput yes yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
GAK_HUMAN [view entry] [view interactions] High throughput yes yes
VCAM1_HUMAN [view interactions] High throughput no no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
FINC_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
PK1L3_HUMAN [view interactions] High throughput no no
PICAL_HUMAN [view entry] [view interactions] High throughput yes yes
CEP63_HUMAN [view interactions] High throughput no yes
PDLI7_HUMAN [view entry] [view interactions] High throughput yes no
LMBD2_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
GTSE1_HUMAN [view interactions] High throughput no no
EPN1_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
MYO19_HUMAN [view interactions] High throughput no yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
EVPL_HUMAN [view interactions] High throughput no yes
DAB2_HUMAN [view interactions] High throughput no yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes