EP15R_HUMAN
Evidence for PS localization
Functions
Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI000887 | LIG_AP2alpha_2 | LIG | 599 | 601 | - |
| ELMI000888 | LIG_AP2alpha_2 | LIG | 618 | 620 | - |
| ELMI000889 | LIG_AP2alpha_2 | LIG | 624 | 626 | - |
| ELMI000890 | LIG_AP2alpha_2 | LIG | 629 | 631 | - |
| ELMI000891 | LIG_AP2alpha_2 | LIG | 640 | 642 | - |
| ELMI000892 | LIG_AP2alpha_2 | LIG | 645 | 647 | - |
| ELMI000893 | LIG_AP2alpha_2 | LIG | 656 | 658 | - |
| ELMI000894 | LIG_AP2alpha_2 | LIG | 661 | 663 | - |
| ELMI000895 | LIG_AP2alpha_2 | LIG | 667 | 669 | - |
| ELMI000896 | LIG_AP2alpha_2 | LIG | 685 | 687 | - |
| ELMI000897 | LIG_AP2alpha_2 | LIG | 690 | 692 | - |
| ELMI000898 | LIG_AP2alpha_2 | LIG | 703 | 705 | - |
| ELMI000899 | LIG_AP2alpha_2 | LIG | 709 | 711 | - |
| ELMI000900 | LIG_AP2alpha_2 | LIG | 722 | 724 | - |
| ELMI000901 | LIG_AP2alpha_2 | LIG | 728 | 730 | - |
| ELMI000902 | LIG_AP2alpha_2 | LIG | 768 | 770 | - |
| ELMI000903 | LIG_AP2alpha_2 | LIG | 812 | 814 | - |
| ELMI000904 | LIG_AP2alpha_2 | LIG | 823 | 825 | - |
| ELMI000905 | LIG_AP2alpha_2 | LIG | 833 | 835 | - |
| ELMI000906 | LIG_AP2alpha_2 | LIG | 839 | 841 | - |
| ELMI003705 | LIG_SH2_STAP1 | LIG | 564 | 568 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EP15R_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 22.9167 | 4 | yes |
| GO:0045296 | cadherin binding | 16.6667 | 4 | yes |
| GO:0005509 | calcium ion binding | 14.5833 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EP15R_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 54.1667 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 50.0000 | 4 | yes |
| GO:0006897 | endocytosis | 43.7500 | 5 | yes |
| GO:0008104 | protein localization | 39.5833 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 39.5833 | 4 | no |
| GO:0015031 | protein transport | 33.3333 | 4 | no |
| GO:0071702 | organic substance transport | 33.3333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 33.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0051049 | regulation of transport | 31.2500 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 31.2500 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 29.1667 | 4 | no |
| GO:0022607 | cellular component assembly | 29.1667 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 27.0833 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 27.0833 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 27.0833 | 4 | no |
| GO:0006996 | organelle organization | 27.0833 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.0833 | 4 | no |
| GO:0006886 | intracellular protein transport | 25.0000 | 4 | no |
| GO:0006898 | receptor-mediated endocytosis | 25.0000 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 22.9167 | 4 | no |
| GO:0036211 | protein modification process | 22.9167 | 4 | no |
| GO:0043412 | macromolecule modification | 22.9167 | 4 | no |
| GO:0010468 | regulation of gene expression | 20.8333 | 5 | no |
| GO:0016197 | endosomal transport | 10.4167 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UBQL1_HUMAN | [view interactions] | Low throughput | no | yes |
| AGFG1_HUMAN | [view interactions] | Low throughput | no | yes |
| AGFG2_HUMAN | [view interactions] | Low throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAVN3_HUMAN | [view interactions] | Low throughput | no | no |
| EPN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DAB2_HUMAN | [view interactions] | Low throughput | no | yes |
| STON2_HUMAN | [view interactions] | Low throughput | no | yes |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| MCM4_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| HSF1_HUMAN | [view interactions] | High throughput | no | yes |
| SOX4_HUMAN | [view interactions] | High throughput | no | yes |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM6_HUMAN | [view interactions] | High throughput | no | yes |
| GAPD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
| TF3C4_HUMAN | [view interactions] | High throughput | no | no |
| CD11A_HUMAN | [view interactions] | High throughput | no | yes |
| SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| LRRC7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| K1107_HUMAN | [view interactions] | High throughput | no | yes |
| ODFP2_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUD5_HUMAN | [view interactions] | High throughput | no | yes |
| RUN3A_HUMAN | [view interactions] | High throughput | no | yes |
| FCHO1_HUMAN | [view interactions] | High throughput | no | yes |
| SPN90_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| SOS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| CROCC_HUMAN | [view interactions] | High throughput | no | no |
| ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| SGIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
| BFSP1_HUMAN | [view interactions] | High throughput | no | no |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GARE1_HUMAN | [view interactions] | High throughput | no | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIFC1_HUMAN | [view interactions] | High throughput | no | yes |
| LUR1L_HUMAN | [view interactions] | High throughput | no | no |
| DRB5_HUMAN | [view interactions] | High throughput | no | no |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| DEGS1_HUMAN | [view interactions] | High throughput | no | no |
| NECP2_HUMAN | [view interactions] | High throughput | no | yes |
| PDZD8_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUMBL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP17_HUMAN | [view interactions] | High throughput | no | no |
| EPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| CND3_HUMAN | [view interactions] | High throughput | no | yes |
| PRP4_HUMAN | [view interactions] | High throughput | no | yes |
| ZZEF1_HUMAN | [view interactions] | High throughput | no | no |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TXNIP_HUMAN | [view interactions] | High throughput | no | no |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPC25_HUMAN | [view interactions] | High throughput | no | no |
| CDR2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LSR_HUMAN | [view interactions] | High throughput | no | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| IQGA3_HUMAN | [view interactions] | High throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| CBLB_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| GBG5_HUMAN | [view interactions] | High throughput | no | no |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| SBNO1_HUMAN | [view interactions] | High throughput | no | yes |
| HGS_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EPN3_HUMAN | [view interactions] | Computational | no | no |
| RAB28_HUMAN | [view interactions] | Computational | no | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UBB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NECP1_HUMAN | [view interactions] | Computational | no | no |
| EGFR_HUMAN | [view interactions] | Computational | no | no |
| CLH2_HUMAN | [view interactions] | Computational | no | no |
| PTN3_HUMAN | [view interactions] | Computational | no | yes |
| ENTD1_HUMAN | [view interactions] | Computational | no | no |
| DYN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |