Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

EP15R_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI000887 LIG_AP2alpha_2 LIG 599 601 -
ELMI000888 LIG_AP2alpha_2 LIG 618 620 -
ELMI000889 LIG_AP2alpha_2 LIG 624 626 -
ELMI000890 LIG_AP2alpha_2 LIG 629 631 -
ELMI000891 LIG_AP2alpha_2 LIG 640 642 -
ELMI000892 LIG_AP2alpha_2 LIG 645 647 -
ELMI000893 LIG_AP2alpha_2 LIG 656 658 -
ELMI000894 LIG_AP2alpha_2 LIG 661 663 -
ELMI000895 LIG_AP2alpha_2 LIG 667 669 -
ELMI000896 LIG_AP2alpha_2 LIG 685 687 -
ELMI000897 LIG_AP2alpha_2 LIG 690 692 -
ELMI000898 LIG_AP2alpha_2 LIG 703 705 -
ELMI000899 LIG_AP2alpha_2 LIG 709 711 -
ELMI000900 LIG_AP2alpha_2 LIG 722 724 -
ELMI000901 LIG_AP2alpha_2 LIG 728 730 -
ELMI000902 LIG_AP2alpha_2 LIG 768 770 -
ELMI000903 LIG_AP2alpha_2 LIG 812 814 -
ELMI000904 LIG_AP2alpha_2 LIG 823 825 -
ELMI000905 LIG_AP2alpha_2 LIG 833 835 -
ELMI000906 LIG_AP2alpha_2 LIG 839 841 -
ELMI003705 LIG_SH2_STAP1 LIG 564 568 -
ELMI000887 LIG_AP2alpha_2 LIG 599 601 -
ELMI000888 LIG_AP2alpha_2 LIG 618 620 -
ELMI000889 LIG_AP2alpha_2 LIG 624 626 -
ELMI000890 LIG_AP2alpha_2 LIG 629 631 -
ELMI000891 LIG_AP2alpha_2 LIG 640 642 -
ELMI000892 LIG_AP2alpha_2 LIG 645 647 -
ELMI000893 LIG_AP2alpha_2 LIG 656 658 -
ELMI000894 LIG_AP2alpha_2 LIG 661 663 -
ELMI000895 LIG_AP2alpha_2 LIG 667 669 -
ELMI000896 LIG_AP2alpha_2 LIG 685 687 -
ELMI000897 LIG_AP2alpha_2 LIG 690 692 -
ELMI000898 LIG_AP2alpha_2 LIG 703 705 -
ELMI000899 LIG_AP2alpha_2 LIG 709 711 -
ELMI000900 LIG_AP2alpha_2 LIG 722 724 -
ELMI000901 LIG_AP2alpha_2 LIG 728 730 -
ELMI000902 LIG_AP2alpha_2 LIG 768 770 -
ELMI000903 LIG_AP2alpha_2 LIG 812 814 -
ELMI000904 LIG_AP2alpha_2 LIG 823 825 -
ELMI000905 LIG_AP2alpha_2 LIG 833 835 -
ELMI000906 LIG_AP2alpha_2 LIG 839 841 -
ELMI003705 LIG_SH2_STAP1 LIG 564 568 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in EP15R_HUMAN
GO:0043169 cation binding 23.6364 4 yes
GO:0046872 metal ion binding 23.6364 5 yes
GO:0000166 nucleotide binding 23.6364 4 no
GO:0017076 purine nucleotide binding 23.6364 5 no
GO:0032555 purine ribonucleotide binding 23.6364 4 no
GO:0043168 anion binding 23.6364 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.8182 4 no
GO:0045296 cadherin binding 16.3636 4 yes
GO:0005509 calcium ion binding 12.7273 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in EP15R_HUMAN
GO:0048522 positive regulation of cellular process 52.7273 4 no
GO:0008104 protein localization 45.4545 4 no
GO:0051128 regulation of cellular component organization 45.4545 4 no
GO:0098657 import into cell 38.1818 4 yes
GO:0010646 regulation of cell communication 38.1818 4 no
GO:0048523 negative regulation of cellular process 38.1818 4 no
GO:0015031 protein transport 36.3636 4 no
GO:0071702 organic substance transport 36.3636 4 no
GO:0071705 nitrogen compound transport 36.3636 4 no
GO:0022607 cellular component assembly 34.5455 4 no
GO:0051049 regulation of transport 32.7273 4 no
GO:0060255 regulation of macromolecule metabolic process 32.7273 4 no
GO:0009966 regulation of signal transduction 30.9091 4 no
GO:0006886 intracellular protein transport 29.0909 4 no
GO:0006996 organelle organization 29.0909 4 no
GO:0080090 regulation of primary metabolic process 29.0909 4 no
GO:0031323 regulation of cellular metabolic process 27.2727 4 no
GO:0043933 protein-containing complex organization 25.4545 4 no
GO:0009893 positive regulation of metabolic process 23.6364 4 no
GO:0006898 receptor-mediated endocytosis 21.8182 4 no
GO:0009889 regulation of biosynthetic process 21.8182 4 no
GO:0010556 regulation of macromolecule biosynthetic process 21.8182 5 no
GO:0031326 regulation of cellular biosynthetic process 21.8182 5 no
GO:0031344 regulation of cell projection organization 21.8182 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.8182 6 no
GO:0032880 regulation of protein localization 21.8182 5 no
GO:0060341 regulation of cellular localization 21.8182 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
STON2_HUMAN [view interactions] Low throughput no yes
UBQL1_HUMAN [view interactions] Low throughput no yes
AGFG1_HUMAN [view interactions] Low throughput no yes
AGFG2_HUMAN [view interactions] Low throughput no yes
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
CAVN3_HUMAN [view interactions] Low throughput no no
EPN1_HUMAN [view entry] [view interactions] Low throughput yes yes
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
DAB2_HUMAN [view interactions] Low throughput no yes
NDC80_HUMAN [view interactions] High throughput no no
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
DCAF7_HUMAN [view interactions] High throughput no yes
PLK1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
MED4_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
SBNO1_HUMAN [view interactions] High throughput no yes
JIP4_HUMAN [view interactions] High throughput no yes
MCM4_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
HSF1_HUMAN [view interactions] High throughput no yes
SOX4_HUMAN [view interactions] High throughput no yes
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
MCM6_HUMAN [view interactions] High throughput no yes
GAPD1_HUMAN [view entry] [view interactions] High throughput yes yes
SMC1A_HUMAN [view interactions] High throughput no yes
TF3C4_HUMAN [view interactions] High throughput no no
CD11A_HUMAN [view interactions] High throughput no yes
SMC3_HUMAN [view entry] [view interactions] High throughput yes yes
UBP15_HUMAN [view entry] [view interactions] High throughput yes yes
NS1BP_HUMAN [view interactions] High throughput no yes
LRRC7_HUMAN [view entry] [view interactions] High throughput yes no
SIM2_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
BTBD8_HUMAN [view interactions] High throughput no yes
ODFP2_HUMAN [view interactions] High throughput no no
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD5_HUMAN [view interactions] High throughput no yes
RUN3A_HUMAN [view interactions] High throughput no yes
FCHO1_HUMAN [view entry] [view interactions] High throughput yes yes
SPN90_HUMAN [view entry] [view interactions] High throughput yes no
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
DVL2_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
SOS1_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
UBQL2_HUMAN [view interactions] High throughput no yes
CROCC_HUMAN [view interactions] High throughput no no
ASPP2_HUMAN [view interactions] High throughput no yes
CEP63_HUMAN [view interactions] High throughput no yes
SGIP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZCH10_HUMAN [view interactions] High throughput no yes
BFSP1_HUMAN [view interactions] High throughput no no
RNPS1_HUMAN [view interactions] High throughput no yes
SYCE1_HUMAN [view interactions] High throughput no no
INSY1_HUMAN [view entry] [view interactions] High throughput yes yes
GARE1_HUMAN [view interactions] High throughput no yes
AP1B1_HUMAN [view entry] [view interactions] High throughput yes yes
BRE1B_HUMAN [view interactions] High throughput no yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
KIFC1_HUMAN [view interactions] High throughput no yes
LUR1L_HUMAN [view interactions] High throughput no no
DRB5_HUMAN [view interactions] High throughput no no
LC7L2_HUMAN [view interactions] High throughput no yes
DEGS1_HUMAN [view interactions] High throughput no no
NECP2_HUMAN [view interactions] High throughput no yes
PDZD8_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
SMC5_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
NUMBL_HUMAN [view entry] [view interactions] High throughput yes yes
PRP17_HUMAN [view interactions] High throughput no no
EPN2_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC6_HUMAN [view entry] [view interactions] High throughput yes yes
GBF1_HUMAN [view interactions] High throughput no yes
CND3_HUMAN [view interactions] High throughput no yes
PRP4_HUMAN [view interactions] High throughput no yes
ZZEF1_HUMAN [view interactions] High throughput no no
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
AAK1_HUMAN [view entry] [view interactions] High throughput yes yes
MCES_HUMAN [view interactions] High throughput no yes
SC24A_HUMAN [view interactions] High throughput no no
HNRH3_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
TXNIP_HUMAN [view interactions] High throughput no no
DCA15_HUMAN [view interactions] High throughput no no
DC1L2_HUMAN [view entry] [view interactions] High throughput yes yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
RN183_HUMAN [view interactions] High throughput no no
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
UFO_HUMAN [view interactions] High throughput no no
PML_HUMAN [view interactions] High throughput no yes
ATG9A_HUMAN [view interactions] High throughput no yes
TRAF3_HUMAN [view entry] [view interactions] High throughput yes yes
PHLP1_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes
TRI23_HUMAN [view interactions] High throughput no yes
LRC4C_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
YAP1_HUMAN [view interactions] High throughput no yes
WWTR1_HUMAN [view interactions] High throughput no yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
GLUT4_HUMAN [view interactions] High throughput no no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NUMB_HUMAN [view entry] [view interactions] High throughput yes yes
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
SPC25_HUMAN [view interactions] High throughput no no
CDR2_HUMAN [view interactions] High throughput no yes
AP2S1_HUMAN [view entry] [view interactions] High throughput yes no
LSR_HUMAN [view interactions] High throughput no yes
RIN3_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
HYOU1_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA3_HUMAN [view interactions] High throughput no no
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
FCHO2_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
PGFRB_HUMAN [view interactions] High throughput no yes
CBL_HUMAN [view interactions] High throughput no yes
CBLB_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
TLK2_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
DYR1A_HUMAN [view interactions] High throughput no yes
TPC2A_HUMAN [view interactions] High throughput no yes
GBG5_HUMAN [view interactions] High throughput no no
CREB3_HUMAN [view interactions] High throughput no no
ZWINT_HUMAN [view entry] [view interactions] High throughput yes no