Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LRRC7_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LRRC7_HUMAN
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0043168 anion binding 30.9524 4 no
GO:0019900 kinase binding 28.5714 4 no
GO:0000166 nucleotide binding 26.1905 4 no
GO:0017076 purine nucleotide binding 26.1905 5 no
GO:0030554 adenyl nucleotide binding 26.1905 6 no
GO:0032555 purine ribonucleotide binding 26.1905 4 no
GO:0032559 adenyl ribonucleotide binding 26.1905 5 no
GO:0005524 ATP binding 23.8095 5 no
GO:0016301 kinase activity 23.8095 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 23.8095 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.8095 4 no
GO:0019901 protein kinase binding 23.8095 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in LRRC7_HUMAN
GO:0048522 positive regulation of cellular process 69.0476 4 yes
GO:0010646 regulation of cell communication 69.0476 4 no
GO:0048523 negative regulation of cellular process 59.5238 4 no
GO:0009966 regulation of signal transduction 57.1429 4 no
GO:0051128 regulation of cellular component organization 54.7619 4 yes
GO:0031323 regulation of cellular metabolic process 54.7619 4 no
GO:0060255 regulation of macromolecule metabolic process 54.7619 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0008104 protein localization 47.6190 4 yes
GO:0022607 cellular component assembly 42.8571 4 no
GO:0051246 regulation of protein metabolic process 42.8571 5 no
GO:0050804 modulation of chemical synaptic transmission 42.8571 5 no
GO:0099177 regulation of trans-synaptic signaling 42.8571 4 no
GO:0009893 positive regulation of metabolic process 40.4762 4 no
GO:0010647 positive regulation of cell communication 40.4762 5 no
GO:0023056 positive regulation of signaling 40.4762 4 no
GO:0051049 regulation of transport 40.4762 4 no
GO:0006996 organelle organization 38.0952 4 no
GO:0009967 positive regulation of signal transduction 38.0952 5 no
GO:0048584 positive regulation of response to stimulus 38.0952 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.7143 5 no
GO:0022603 regulation of anatomical structure morphogenesis 35.7143 4 no
GO:0031325 positive regulation of cellular metabolic process 35.7143 5 no
GO:0031399 regulation of protein modification process 35.7143 6 no
GO:0031344 regulation of cell projection organization 33.3333 5 yes
GO:0030030 cell projection organization 33.3333 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.9524 6 yes
GO:0001932 regulation of protein phosphorylation 30.9524 7 no
GO:0019220 regulation of phosphate metabolic process 30.9524 6 no
GO:0042325 regulation of phosphorylation 30.9524 7 no
GO:0051174 regulation of phosphorus metabolic process 30.9524 5 no
GO:0034330 cell junction organization 30.9524 4 no
GO:0009889 regulation of biosynthetic process 30.9524 4 no
GO:0010975 regulation of neuron projection development 28.5714 7 yes
GO:0036211 protein modification process 28.5714 4 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0050890 cognition 28.5714 4 no
GO:0010468 regulation of gene expression 28.5714 6 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0072657 protein localization to membrane 26.1905 4 yes
GO:0031401 positive regulation of protein modification process 26.1905 7 no
GO:0120036 plasma membrane bounded cell projection organization 26.1905 5 no
GO:0051130 positive regulation of cellular component organization 23.8095 5 yes
GO:0006796 phosphate-containing compound metabolic process 23.8095 4 no
GO:0016310 phosphorylation 23.8095 5 no
GO:0051094 positive regulation of developmental process 23.8095 4 no
GO:2000026 regulation of multicellular organismal development 23.8095 4 no
GO:0009892 negative regulation of metabolic process 23.8095 4 no
GO:0010605 negative regulation of macromolecule metabolic process 23.8095 5 no
GO:1990778 protein localization to cell periphery 21.4286 5 yes
GO:0001934 positive regulation of protein phosphorylation 21.4286 8 no
GO:0007010 cytoskeleton organization 21.4286 5 no
GO:0010562 positive regulation of phosphorus metabolic process 21.4286 6 no
GO:0042327 positive regulation of phosphorylation 21.4286 8 no
GO:0043408 regulation of MAPK cascade 21.4286 6 no
GO:0045937 positive regulation of phosphate metabolic process 21.4286 7 no
GO:1902533 positive regulation of intracellular signal transduction 21.4286 6 no
GO:0010648 negative regulation of cell communication 21.4286 5 no
GO:0023057 negative regulation of signaling 21.4286 4 no
GO:0033043 regulation of organelle organization 21.4286 5 no
GO:0034329 cell junction assembly 21.4286 5 no
GO:0050808 synapse organization 21.4286 5 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0031175 neuron projection development 21.4286 6 no
GO:0042981 regulation of apoptotic process 21.4286 5 no
GO:0043067 regulation of programmed cell death 21.4286 4 no
GO:0045595 regulation of cell differentiation 21.4286 4 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0043269 regulation of monoatomic ion transport 21.4286 5 no
GO:0071702 organic substance transport 19.0476 4 yes
GO:0071705 nitrogen compound transport 19.0476 4 yes
GO:0033365 protein localization to organelle 14.2857 5 yes
GO:0015031 protein transport 11.9048 4 yes
GO:0031346 positive regulation of cell projection organization 11.9048 6 yes
GO:0035418 protein localization to synapse 11.9048 6 yes
GO:0043113 receptor clustering 11.9048 5 yes
GO:0072659 protein localization to plasma membrane 11.9048 5 yes
GO:1902414 protein localization to cell junction 11.9048 5 yes
GO:0062237 protein localization to postsynapse 9.5238 7 yes
GO:1903539 protein localization to postsynaptic membrane 9.5238 5 yes
GO:0010976 positive regulation of neuron projection development 7.1429 7 yes
GO:0035088 establishment or maintenance of apical/basal cell polarity 7.1429 4 yes
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 7.1429 5 yes
GO:0090150 establishment of protein localization to membrane 4.7619 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CTND2_HUMAN [view entry] [view interactions] Low throughput yes no
CNKR2_HUMAN [view entry] [view interactions] Low throughput yes no
SHAN1_HUMAN [view entry] [view interactions] Low throughput yes yes
TOR1A_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
GKAP1_HUMAN [view interactions] Low throughput no no
ACTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
SCN7A_HUMAN [view interactions] Low throughput no no
KCC2G_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN4_HUMAN [view entry] [view interactions] Low throughput yes yes
CADH2_HUMAN [view entry] [view interactions] Low throughput yes no
CYFP1_HUMAN [view entry] [view interactions] Low throughput yes yes
CAD10_HUMAN [view entry] [view interactions] Low throughput yes yes
CAC1D_HUMAN [view entry] [view interactions] Low throughput yes yes
PKP4_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ZNRD2_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
SATB2_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
ERBB3_HUMAN [view interactions] High throughput no yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
NQO2_HUMAN [view interactions] High throughput no yes
HOMEZ_HUMAN [view interactions] High throughput no no
HOME3_HUMAN [view entry] [view interactions] High throughput yes yes
EP15R_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
OTU7A_HUMAN [view interactions] High throughput no no
AGRB1_HUMAN [view entry] [view interactions] High throughput yes no
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
LGR5_HUMAN [view interactions] High throughput no no
LRCH1_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RNF43_HUMAN [view interactions] High throughput no yes
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
LRC4C_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
PTK7_HUMAN [view interactions] High throughput no yes
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
DET1_HUMAN [view interactions] High throughput no no
SHSA6_HUMAN [view entry] [view interactions] High throughput yes no