LRRC7_HUMAN
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. [View more on UniProt]
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No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in LRRC7_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 33.3333 | 4 | no |
GO:0019900 | kinase binding | 21.2121 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in LRRC7_HUMAN |
---|---|---|---|---|
GO:0010646 | regulation of cell communication | 72.7273 | 4 | no |
GO:0048522 | positive regulation of cellular process | 69.6970 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 63.6364 | 4 | no |
GO:0009966 | regulation of signal transduction | 60.6061 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 54.5455 | 4 | no |
GO:0051128 | regulation of cellular component organization | 48.4848 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 48.4848 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 48.4848 | 4 | no |
GO:0008104 | protein localization | 45.4545 | 4 | yes |
GO:0022607 | cellular component assembly | 45.4545 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 45.4545 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 45.4545 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 45.4545 | 4 | no |
GO:0051049 | regulation of transport | 45.4545 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 39.3939 | 5 | no |
GO:0030030 | cell projection organization | 39.3939 | 4 | no |
GO:0010647 | positive regulation of cell communication | 36.3636 | 5 | no |
GO:0023056 | positive regulation of signaling | 36.3636 | 4 | no |
GO:0034330 | cell junction organization | 36.3636 | 4 | no |
GO:0006996 | organelle organization | 36.3636 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 33.3333 | 5 | no |
GO:0031344 | regulation of cell projection organization | 30.3030 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 30.3030 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 30.3030 | 4 | no |
GO:0010468 | regulation of gene expression | 30.3030 | 5 | no |
GO:0031399 | regulation of protein modification process | 30.3030 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 30.3030 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 30.3030 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 30.3030 | 4 | no |
GO:0043269 | regulation of ion transport | 30.3030 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 30.3030 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 27.2727 | 6 | yes |
GO:0050890 | cognition | 27.2727 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.2727 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 27.2727 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 27.2727 | 5 | no |
GO:0031175 | neuron projection development | 27.2727 | 6 | no |
GO:0050808 | synapse organization | 27.2727 | 5 | no |
GO:0032880 | regulation of protein localization | 27.2727 | 5 | no |
GO:0060341 | regulation of cellular localization | 27.2727 | 4 | no |
GO:0010975 | regulation of neuron projection development | 24.2424 | 7 | yes |
GO:0072657 | protein localization to membrane | 24.2424 | 4 | yes |
GO:0043085 | positive regulation of catalytic activity | 24.2424 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 24.2424 | 6 | no |
GO:0034329 | cell junction assembly | 24.2424 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 24.2424 | 7 | no |
GO:0009892 | negative regulation of metabolic process | 24.2424 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 24.2424 | 5 | no |
GO:0010648 | negative regulation of cell communication | 24.2424 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.2424 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 24.2424 | 6 | no |
GO:0023057 | negative regulation of signaling | 24.2424 | 4 | no |
GO:0042325 | regulation of phosphorylation | 24.2424 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 24.2424 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 24.2424 | 5 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 24.2424 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 24.2424 | 6 | no |
GO:0051050 | positive regulation of transport | 24.2424 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 24.2424 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 21.2121 | 5 | yes |
GO:0010941 | regulation of cell death | 21.2121 | 4 | no |
GO:0051336 | regulation of hydrolase activity | 21.2121 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 21.2121 | 6 | no |
GO:0007010 | cytoskeleton organization | 21.2121 | 5 | no |
GO:0009968 | negative regulation of signal transduction | 21.2121 | 5 | no |
GO:0045595 | regulation of cell differentiation | 21.2121 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 21.2121 | 4 | no |
GO:0051094 | positive regulation of developmental process | 21.2121 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 21.2121 | 4 | no |
GO:0071310 | cellular response to organic substance | 21.2121 | 4 | no |
GO:0031401 | positive regulation of protein modification process | 21.2121 | 7 | no |
GO:0042127 | regulation of cell population proliferation | 21.2121 | 4 | no |
GO:0043113 | receptor clustering | 15.1515 | 5 | yes |
GO:0031346 | positive regulation of cell projection organization | 9.0909 | 6 | yes |
GO:0010976 | positive regulation of neuron projection development | 6.0606 | 7 | yes |
GO:0035088 | establishment or maintenance of apical/basal cell polarity | 6.0606 | 4 | yes |
GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 6.0606 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CTND2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CNKR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
TOR1A_HUMAN | [view interactions] | Low throughput | no | yes |
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SCN7A_HUMAN | [view interactions] | Low throughput | no | no |
KCC2G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CADH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SHAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CYFP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CAD10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CAC1D_HUMAN | [view interactions] | Low throughput | no | yes |
PKP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SATB2_HUMAN | [view interactions] | High throughput | no | yes |
ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NQO2_HUMAN | [view interactions] | High throughput | no | yes |
HOMEZ_HUMAN | [view interactions] | High throughput | no | no |
HOME3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
RN123_HUMAN | [view interactions] | High throughput | no | yes |
RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACK1_HUMAN | [view interactions] | High throughput | no | yes |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AGRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LGR5_HUMAN | [view interactions] | High throughput | no | no |
LRCH1_HUMAN | [view interactions] | High throughput | no | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RNF43_HUMAN | [view interactions] | High throughput | no | yes |
SHSA6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |