Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AGRB1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Inhibits angiogenesis. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AGRB1_HUMAN
GO:0019900 kinase binding 40.9091 4 no
GO:0019901 protein kinase binding 36.3636 5 no
GO:0030165 PDZ domain binding 27.2727 4 yes
GO:0004930 G protein-coupled receptor activity 13.6364 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AGRB1_HUMAN
GO:0048522 positive regulation of cellular process 72.7273 4 yes
GO:0010646 regulation of cell communication 59.0909 4 yes
GO:0051128 regulation of cellular component organization 59.0909 4 yes
GO:0031399 regulation of protein modification process 54.5455 6 yes
GO:0048523 negative regulation of cellular process 54.5455 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 54.5455 4 yes
GO:0051246 regulation of protein metabolic process 54.5455 5 yes
GO:0060255 regulation of macromolecule metabolic process 54.5455 4 yes
GO:0080090 regulation of primary metabolic process 54.5455 4 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 yes
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0051130 positive regulation of cellular component organization 45.4545 5 yes
GO:0051049 regulation of transport 45.4545 4 no
GO:0008104 protein localization 45.4545 4 no
GO:0009892 negative regulation of metabolic process 40.9091 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 40.9091 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 40.9091 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 40.9091 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 40.9091 6 no
GO:0010604 positive regulation of macromolecule metabolic process 40.9091 5 no
GO:0019220 regulation of phosphate metabolic process 40.9091 6 no
GO:0031401 positive regulation of protein modification process 40.9091 7 no
GO:0043085 positive regulation of catalytic activity 40.9091 4 no
GO:0045937 positive regulation of phosphate metabolic process 40.9091 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 40.9091 5 no
GO:0051174 regulation of phosphorus metabolic process 40.9091 5 no
GO:0051247 positive regulation of protein metabolic process 40.9091 6 no
GO:1902531 regulation of intracellular signal transduction 40.9091 5 no
GO:0031400 negative regulation of protein modification process 36.3636 7 yes
GO:0051094 positive regulation of developmental process 36.3636 4 yes
GO:0051248 negative regulation of protein metabolic process 36.3636 6 yes
GO:0001932 regulation of protein phosphorylation 36.3636 7 no
GO:0001934 positive regulation of protein phosphorylation 36.3636 8 no
GO:0042325 regulation of phosphorylation 36.3636 7 no
GO:0042327 positive regulation of phosphorylation 36.3636 8 no
GO:0043269 regulation of ion transport 36.3636 5 no
GO:0044057 regulation of system process 36.3636 4 no
GO:0051050 positive regulation of transport 36.3636 4 no
GO:0051336 regulation of hydrolase activity 36.3636 4 no
GO:0042127 regulation of cell population proliferation 31.8182 4 yes
GO:0050804 modulation of chemical synaptic transmission 31.8182 5 yes
GO:0099177 regulation of trans-synaptic signaling 31.8182 4 yes
GO:2000026 regulation of multicellular organismal development 31.8182 4 yes
GO:0010959 regulation of metal ion transport 31.8182 6 no
GO:0033674 positive regulation of kinase activity 31.8182 6 no
GO:0034762 regulation of transmembrane transport 31.8182 4 no
GO:0034765 regulation of ion transmembrane transport 31.8182 5 no
GO:0043549 regulation of kinase activity 31.8182 5 no
GO:0045859 regulation of protein kinase activity 31.8182 6 no
GO:0045860 positive regulation of protein kinase activity 31.8182 7 no
GO:0051338 regulation of transferase activity 31.8182 4 no
GO:0051347 positive regulation of transferase activity 31.8182 5 no
GO:1904062 regulation of cation transmembrane transport 31.8182 6 no
GO:0008285 negative regulation of cell population proliferation 27.2727 5 yes
GO:0009889 regulation of biosynthetic process 27.2727 4 yes
GO:0016192 vesicle-mediated transport 27.2727 4 yes
GO:0030030 cell projection organization 27.2727 4 yes
GO:0030334 regulation of cell migration 27.2727 5 yes
GO:0051240 positive regulation of multicellular organismal process 27.2727 4 yes
GO:0051960 regulation of nervous system development 27.2727 5 yes
GO:0061024 membrane organization 27.2727 4 yes
GO:2000145 regulation of cell motility 27.2727 4 yes
GO:0008016 regulation of heart contraction 27.2727 6 no
GO:0022898 regulation of transmembrane transporter activity 27.2727 4 no
GO:0031324 negative regulation of cellular metabolic process 27.2727 5 no
GO:0032412 regulation of ion transmembrane transporter activity 27.2727 5 no
GO:0043270 positive regulation of ion transport 27.2727 5 no
GO:0051345 positive regulation of hydrolase activity 27.2727 5 no
GO:1903522 regulation of blood circulation 27.2727 5 no
GO:2001257 regulation of cation channel activity 27.2727 6 no
GO:0022607 cellular component assembly 27.2727 4 no
GO:0031344 regulation of cell projection organization 27.2727 5 no
GO:0045595 regulation of cell differentiation 27.2727 4 no
GO:0072657 protein localization to membrane 27.2727 4 no
GO:0030100 regulation of endocytosis 22.7273 5 no
GO:0060627 regulation of vesicle-mediated transport 22.7273 4 no
GO:0009891 positive regulation of biosynthetic process 22.7273 5 yes
GO:0032990 cell part morphogenesis 22.7273 4 yes
GO:0048812 neuron projection morphogenesis 22.7273 7 yes
GO:0048858 cell projection morphogenesis 22.7273 5 yes
GO:0050807 regulation of synapse organization 22.7273 5 yes
GO:0051241 negative regulation of multicellular organismal process 22.7273 4 yes
GO:0051962 positive regulation of nervous system development 22.7273 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 22.7273 6 yes
GO:0001933 negative regulation of protein phosphorylation 22.7273 8 no
GO:0010038 response to metal ion 22.7273 4 no
GO:0010563 negative regulation of phosphorus metabolic process 22.7273 6 no
GO:0010564 regulation of cell cycle process 22.7273 5 no
GO:0010921 regulation of phosphatase activity 22.7273 5 no
GO:0035303 regulation of dephosphorylation 22.7273 7 no
GO:0035304 regulation of protein dephosphorylation 22.7273 7 no
GO:0042326 negative regulation of phosphorylation 22.7273 8 no
GO:0043666 regulation of phosphoprotein phosphatase activity 22.7273 6 no
GO:0045936 negative regulation of phosphate metabolic process 22.7273 7 no
GO:0051051 negative regulation of transport 22.7273 4 no
GO:0051726 regulation of cell cycle 22.7273 4 no
GO:0051924 regulation of calcium ion transport 22.7273 7 no
GO:0009967 positive regulation of signal transduction 22.7273 5 no
GO:0010647 positive regulation of cell communication 22.7273 5 no
GO:0023056 positive regulation of signaling 22.7273 4 no
GO:0031346 positive regulation of cell projection organization 22.7273 6 no
GO:0034330 cell junction organization 22.7273 4 no
GO:0045597 positive regulation of cell differentiation 22.7273 5 no
GO:0048584 positive regulation of response to stimulus 22.7273 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.7273 6 no
GO:0032880 regulation of protein localization 22.7273 5 no
GO:0060341 regulation of cellular localization 22.7273 4 no
GO:0007409 axonogenesis 18.1818 8 yes
GO:0030336 negative regulation of cell migration 18.1818 6 yes
GO:0040013 negative regulation of locomotion 18.1818 4 yes
GO:0044087 regulation of cellular component biogenesis 18.1818 4 yes
GO:0044089 positive regulation of cellular component biogenesis 18.1818 5 yes
GO:2000146 negative regulation of cell motility 18.1818 5 yes
GO:0006909 phagocytosis 13.6364 5 yes
GO:0006911 phagocytosis, engulfment 13.6364 7 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 13.6364 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 13.6364 5 yes
GO:0007422 peripheral nervous system development 13.6364 4 yes
GO:0010324 membrane invagination 13.6364 5 yes
GO:0010632 regulation of epithelial cell migration 13.6364 4 yes
GO:0031396 regulation of protein ubiquitination 13.6364 8 yes
GO:0031397 negative regulation of protein ubiquitination 13.6364 9 yes
GO:0045765 regulation of angiogenesis 13.6364 5 yes
GO:0051093 negative regulation of developmental process 13.6364 4 yes
GO:0099024 plasma membrane invagination 13.6364 6 yes
GO:1901342 regulation of vasculature development 13.6364 5 yes
GO:1903320 regulation of protein modification by small protein conjugation or removal 13.6364 7 yes
GO:1903321 negative regulation of protein modification by small protein conjugation or removal 13.6364 8 yes
GO:0007517 muscle organ development 9.0909 4 yes
GO:0009894 regulation of catabolic process 9.0909 4 yes
GO:0009895 negative regulation of catabolic process 9.0909 5 yes
GO:0010594 regulation of endothelial cell migration 9.0909 5 yes
GO:0010596 negative regulation of endothelial cell migration 9.0909 6 yes
GO:0010633 negative regulation of epithelial cell migration 9.0909 5 yes
GO:0016525 negative regulation of angiogenesis 9.0909 6 yes
GO:0042176 regulation of protein catabolic process 9.0909 5 yes
GO:0042177 negative regulation of protein catabolic process 9.0909 6 yes
GO:0042742 defense response to bacterium 9.0909 4 yes
GO:0043277 apoptotic cell clearance 9.0909 6 yes
GO:0043652 engulfment of apoptotic cell 9.0909 8 yes
GO:0050829 defense response to Gram-negative bacterium 9.0909 5 yes
GO:0051963 regulation of synapse assembly 9.0909 6 yes
GO:0051965 positive regulation of synapse assembly 9.0909 6 yes
GO:0060142 regulation of syncytium formation by plasma membrane fusion 9.0909 4 yes
GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 9.0909 5 yes
GO:1901343 negative regulation of vasculature development 9.0909 5 yes
GO:1901739 regulation of myoblast fusion 9.0909 5 yes
GO:1901741 positive regulation of myoblast fusion 9.0909 6 yes
GO:1901888 regulation of cell junction assembly 9.0909 5 yes
GO:1901890 positive regulation of cell junction assembly 9.0909 6 yes
GO:1903426 regulation of reactive oxygen species biosynthetic process 9.0909 5 yes
GO:1903428 positive regulation of reactive oxygen species biosynthetic process 9.0909 6 yes
GO:2000181 negative regulation of blood vessel morphogenesis 9.0909 5 yes
GO:2000377 regulation of reactive oxygen species metabolic process 9.0909 5 yes
GO:2000379 positive regulation of reactive oxygen species metabolic process 9.0909 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in AGRB1_HUMAN
DOID:0050700 cardiomyopathy 13.6364 4 no
DOID:0060036 intrinsic cardiomyopathy 13.6364 5 no
DOID:114 heart disease 13.6364 3 no
DOID:2843 long QT syndrome 13.6364 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MAGI3_HUMAN [view interactions] Low throughput no no
BAIP3_HUMAN [view interactions] Low throughput no yes
ELMO1_HUMAN [view interactions] Low throughput no no
DOCK1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI1_HUMAN [view interactions] Low throughput no no
BAIP2_HUMAN [view entry] [view interactions] Low throughput yes yes
PHYIP_HUMAN [view entry] [view interactions] Low throughput yes yes
AGRB1_HUMAN [view entry] [view interactions] Low throughput yes no
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
ELMO2_HUMAN [view entry] [view interactions] Low throughput yes no
RTN4R_HUMAN [view interactions] Low throughput no no
EIF3H_HUMAN [view interactions] High throughput no yes
NEK4_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
DRD2_HUMAN [view entry] [view interactions] High throughput yes no
GPR35_HUMAN [view interactions] High throughput no no
GPR37_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
RN123_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
RAB9A_HUMAN [view interactions] High throughput no yes
RAB3B_HUMAN [view interactions] High throughput no no
TPC10_HUMAN [view interactions] High throughput no no
AB17B_HUMAN [view entry] [view interactions] High throughput yes no
COT2_HUMAN [view interactions] High throughput no no
INADL_HUMAN [view interactions] High throughput no no
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
LIN7A_HUMAN [view entry] [view interactions] High throughput yes yes
LRRC7_HUMAN [view entry] [view interactions] High throughput yes no
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
SNTB1_HUMAN [view entry] [view interactions] High throughput yes yes
SNTB2_HUMAN [view entry] [view interactions] High throughput yes no
SNTG2_HUMAN [view interactions] High throughput no no
PDZD2_HUMAN [view interactions] High throughput no yes
AGRB2_HUMAN [view interactions] High throughput no no
TIAM1_HUMAN [view entry] [view interactions] Computational yes yes