LIN7A_HUMAN
Evidence for PS localization
Functions
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules . This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LIN7A_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 23.5294 | 4 | no |
| GO:0097016 | L27 domain binding | 5.8824 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LIN7A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 70.5882 | 4 | no |
| GO:0010646 | regulation of cell communication | 58.8235 | 4 | no |
| GO:0022607 | cellular component assembly | 50.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 47.0588 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.0588 | 4 | no |
| GO:0009966 | regulation of signal transduction | 47.0588 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.0588 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.1176 | 4 | no |
| GO:0051049 | regulation of transport | 41.1765 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 38.2353 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 35.2941 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.2941 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 35.2941 | 5 | no |
| GO:0006996 | organelle organization | 32.3529 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.3529 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 32.3529 | 5 | no |
| GO:0044057 | regulation of system process | 32.3529 | 4 | no |
| GO:0008104 | protein localization | 29.4118 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 29.4118 | 5 | no |
| GO:0031399 | regulation of protein modification process | 29.4118 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 29.4118 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.4118 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 29.4118 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 29.4118 | 4 | no |
| GO:0043933 | protein-containing complex organization | 26.4706 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 26.4706 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 26.4706 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.4706 | 6 | no |
| GO:0023056 | positive regulation of signaling | 26.4706 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.4706 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.4706 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 26.4706 | 4 | no |
| GO:0007010 | cytoskeleton organization | 23.5294 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 23.5294 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.5294 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.5294 | 7 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.5294 | 4 | no |
| GO:0030030 | cell projection organization | 23.5294 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 23.5294 | 7 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 23.5294 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.5294 | 4 | no |
| GO:0043269 | regulation of monoatomic ion transport | 23.5294 | 5 | no |
| GO:0009894 | regulation of catabolic process | 20.5882 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.5882 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.5882 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 20.5882 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 20.5882 | 5 | no |
| GO:0033043 | regulation of organelle organization | 20.5882 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.5882 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.5882 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.5882 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.5882 | 4 | no |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 20.5882 | 5 | no |
| GO:0051050 | positive regulation of transport | 20.5882 | 4 | no |
| GO:0034330 | cell junction organization | 20.5882 | 4 | no |
| GO:0015031 | protein transport | 14.7059 | 4 | yes |
| GO:0071702 | organic substance transport | 14.7059 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 14.7059 | 4 | yes |
| GO:0035088 | establishment or maintenance of apical/basal cell polarity | 8.8235 | 4 | yes |
| GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 8.8235 | 5 | yes |
| GO:0072657 | protein localization to membrane | 8.8235 | 4 | yes |
| GO:1990778 | protein localization to cell periphery | 8.8235 | 5 | yes |
| GO:0023061 | signal release | 5.8824 | 4 | yes |
| GO:0046903 | secretion | 5.8824 | 4 | yes |
| GO:0051650 | establishment of vesicle localization | 5.8824 | 4 | yes |
| GO:0099643 | signal release from synapse | 5.8824 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ABCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| PALS2_HUMAN | [view interactions] | Low throughput | no | yes |
| CSKP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| INADL_HUMAN | [view interactions] | Low throughput | no | no |
| PALS1_HUMAN | [view interactions] | Low throughput | no | no |
| KCJ12_HUMAN | [view interactions] | Low throughput | no | no |
| MARHB_HUMAN | [view interactions] | Low throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MARH2_HUMAN | [view interactions] | Low throughput | no | yes |
| AMOT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPDZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PI42B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GCYB1_HUMAN | [view interactions] | High throughput | no | yes |
| E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S20A1_HUMAN | [view interactions] | High throughput | no | yes |
| MPP7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PXDC1_HUMAN | [view interactions] | High throughput | no | no |
| GCYA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDD_HUMAN | [view interactions] | High throughput | no | no |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| PTHD1_HUMAN | [view interactions] | High throughput | no | no |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| FAM9B_HUMAN | [view interactions] | High throughput | no | no |
| MPP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| ECM1_HUMAN | [view interactions] | High throughput | no | no |
| CHRD_HUMAN | [view interactions] | High throughput | no | no |
| ADA1D_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIPA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MINY3_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| APBA1_HUMAN | [view interactions] | High throughput | no | no |
| MAGA9_HUMAN | [view interactions] | High throughput | no | no |
| DLGP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| FXL19_HUMAN | [view interactions] | High throughput | no | no |
| E41L5_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |