LIN7A_HUMAN
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules . This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in LIN7A_HUMAN |
---|---|---|---|---|
GO:0019900 | kinase binding | 26.9231 | 4 | no |
GO:0019901 | protein kinase binding | 21.1538 | 5 | no |
GO:0097016 | L27 domain binding | 7.6923 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in LIN7A_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 61.5385 | 4 | no |
GO:0010646 | regulation of cell communication | 57.6923 | 4 | no |
GO:0051128 | regulation of cellular component organization | 46.1538 | 4 | no |
GO:0022607 | cellular component assembly | 42.3077 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 42.3077 | 5 | no |
GO:0051049 | regulation of transport | 42.3077 | 4 | no |
GO:0099177 | regulation of trans-synaptic signaling | 42.3077 | 4 | no |
GO:0048523 | negative regulation of cellular process | 42.3077 | 4 | no |
GO:0008104 | protein localization | 38.4615 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 38.4615 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 36.5385 | 4 | no |
GO:0016192 | vesicle-mediated transport | 34.6154 | 4 | yes |
GO:0006996 | organelle organization | 34.6154 | 4 | no |
GO:0009966 | regulation of signal transduction | 32.6923 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 32.6923 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 32.6923 | 4 | no |
GO:0046903 | secretion | 30.7692 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 30.7692 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 30.7692 | 5 | no |
GO:0023061 | signal release | 28.8462 | 4 | yes |
GO:0043933 | protein-containing complex organization | 28.8462 | 4 | yes |
GO:0065003 | protein-containing complex assembly | 28.8462 | 5 | yes |
GO:0099643 | signal release from synapse | 28.8462 | 5 | yes |
GO:0010647 | positive regulation of cell communication | 28.8462 | 5 | no |
GO:0023056 | positive regulation of signaling | 28.8462 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 28.8462 | 5 | no |
GO:0043269 | regulation of ion transport | 28.8462 | 5 | no |
GO:0071702 | organic substance transport | 26.9231 | 4 | yes |
GO:0071705 | nitrogen compound transport | 26.9231 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 26.9231 | 4 | no |
GO:0051050 | positive regulation of transport | 26.9231 | 4 | no |
GO:0015031 | protein transport | 25.0000 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
GO:0044057 | regulation of system process | 25.0000 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 25.0000 | 4 | no |
GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
GO:0006887 | exocytosis | 23.0769 | 4 | yes |
GO:0072657 | protein localization to membrane | 23.0769 | 4 | yes |
GO:0034330 | cell junction organization | 23.0769 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 23.0769 | 4 | no |
GO:0007268 | chemical synaptic transmission | 23.0769 | 6 | no |
GO:0051046 | regulation of secretion | 23.0769 | 5 | no |
GO:0098916 | anterograde trans-synaptic signaling | 23.0769 | 5 | no |
GO:0099537 | trans-synaptic signaling | 23.0769 | 4 | no |
GO:0031399 | regulation of protein modification process | 23.0769 | 6 | no |
GO:0051247 | positive regulation of protein metabolic process | 23.0769 | 6 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 23.0769 | 5 | no |
GO:0006836 | neurotransmitter transport | 21.1538 | 4 | yes |
GO:0050806 | positive regulation of synaptic transmission | 21.1538 | 5 | no |
GO:0061024 | membrane organization | 21.1538 | 4 | no |
GO:1903530 | regulation of secretion by cell | 21.1538 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 21.1538 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 21.1538 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 21.1538 | 4 | no |
GO:0007269 | neurotransmitter secretion | 19.2308 | 4 | yes |
GO:1990778 | protein localization to cell periphery | 15.3846 | 5 | yes |
GO:0035088 | establishment or maintenance of apical/basal cell polarity | 11.5385 | 4 | yes |
GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 11.5385 | 5 | yes |
GO:0097479 | synaptic vesicle localization | 11.5385 | 4 | yes |
GO:0051650 | establishment of vesicle localization | 7.6923 | 4 | yes |
GO:0035090 | maintenance of apical/basal cell polarity | 5.7692 | 4 | yes |
GO:0045199 | maintenance of epithelial cell apical/basal polarity | 5.7692 | 5 | yes |
GO:0048489 | synaptic vesicle transport | 5.7692 | 4 | yes |
GO:1903361 | protein localization to basolateral plasma membrane | 5.7692 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in LIN7A_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 5.7692 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 5.7692 | 5 | no |
DOID:114 | heart disease | 5.7692 | 3 | no |
DOID:2843 | long QT syndrome | 5.7692 | 6 | no |
DOID:10273 | heart conduction disease | 3.8462 | 4 | no |
DOID:331 | central nervous system disease | 3.8462 | 3 | no |
DOID:936 | brain disease | 3.8462 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CSKP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PALS2_HUMAN | [view interactions] | Low throughput | no | yes |
KCJ12_HUMAN | [view interactions] | Low throughput | no | no |
MARHB_HUMAN | [view interactions] | Low throughput | no | no |
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
MARH2_HUMAN | [view interactions] | Low throughput | no | yes |
ABCA1_HUMAN | [view interactions] | Low throughput | no | yes |
PALS1_HUMAN | [view interactions] | Low throughput | no | no |
INADL_HUMAN | [view interactions] | Low throughput | no | no |
GCYB1_HUMAN | [view interactions] | High throughput | no | yes |
SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MPP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PI42B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CADM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MPDZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDD_HUMAN | [view interactions] | High throughput | no | no |
NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
PTHD1_HUMAN | [view interactions] | High throughput | no | no |
CD81_HUMAN | [view interactions] | High throughput | no | no |
NT2NA_HUMAN | [view interactions] | High throughput | no | no |
ZYX_HUMAN | [view interactions] | High throughput | no | no |
GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAM9B_HUMAN | [view interactions] | High throughput | no | no |
MPP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MDFI_HUMAN | [view interactions] | High throughput | no | no |
ECM1_HUMAN | [view interactions] | High throughput | no | no |
CHRD_HUMAN | [view interactions] | High throughput | no | no |
ADA1D_HUMAN | [view interactions] | High throughput | no | no |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCNJ4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LIPA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MINY3_HUMAN | [view interactions] | High throughput | no | yes |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
MTMR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
APBA1_HUMAN | [view interactions] | High throughput | no | no |
MAGA9_HUMAN | [view interactions] | High throughput | no | no |
DLGP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
FXL19_HUMAN | [view interactions] | High throughput | no | no |
E41L5_HUMAN | [view interactions] | High throughput | no | no |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AMOT_HUMAN | [view interactions] | High throughput | no | no |
GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GCYA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PXDC1_HUMAN | [view interactions] | High throughput | no | no |
MPP7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
S20A1_HUMAN | [view interactions] | High throughput | no | yes |
E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LIPA4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SYN2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SNP25_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SYN3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CPLX1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CNTN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RIMS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAB3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
STXB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
USH1C_HUMAN | [view interactions] | Computational | no | yes |
DLG3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
UN13B_HUMAN | [view interactions] | Computational | no | no |
LIN7B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CTNB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DLG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LIPA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AQP1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
TX1B3_HUMAN | [view interactions] | Computational | no | no |
VAMP2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KIF17_HUMAN | [view interactions] | Computational | no | no |
LIN7C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LIPA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
S6A12_HUMAN | [view interactions] | Computational | no | no |
SYT1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RIMB1_HUMAN | [view interactions] | Computational | no | yes |
SYN1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
STX1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |