Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LIN7A_HUMAN

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules . This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in LIN7A_HUMAN
GO:0019900 kinase binding 26.9231 4 no
GO:0019901 protein kinase binding 21.1538 5 no
GO:0097016 L27 domain binding 7.6923 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in LIN7A_HUMAN
GO:0048522 positive regulation of cellular process 61.5385 4 no
GO:0010646 regulation of cell communication 57.6923 4 no
GO:0051128 regulation of cellular component organization 46.1538 4 no
GO:0022607 cellular component assembly 42.3077 4 yes
GO:0050804 modulation of chemical synaptic transmission 42.3077 5 no
GO:0051049 regulation of transport 42.3077 4 no
GO:0099177 regulation of trans-synaptic signaling 42.3077 4 no
GO:0048523 negative regulation of cellular process 42.3077 4 no
GO:0008104 protein localization 38.4615 4 yes
GO:0060255 regulation of macromolecule metabolic process 38.4615 4 no
GO:0080090 regulation of primary metabolic process 36.5385 4 no
GO:0016192 vesicle-mediated transport 34.6154 4 yes
GO:0006996 organelle organization 34.6154 4 no
GO:0009966 regulation of signal transduction 32.6923 4 no
GO:0009893 positive regulation of metabolic process 32.6923 4 no
GO:0051171 regulation of nitrogen compound metabolic process 32.6923 4 no
GO:0046903 secretion 30.7692 4 yes
GO:0031323 regulation of cellular metabolic process 30.7692 4 no
GO:0051246 regulation of protein metabolic process 30.7692 5 no
GO:0023061 signal release 28.8462 4 yes
GO:0043933 protein-containing complex organization 28.8462 4 yes
GO:0065003 protein-containing complex assembly 28.8462 5 yes
GO:0099643 signal release from synapse 28.8462 5 yes
GO:0010647 positive regulation of cell communication 28.8462 5 no
GO:0023056 positive regulation of signaling 28.8462 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.8462 5 no
GO:0043269 regulation of ion transport 28.8462 5 no
GO:0071702 organic substance transport 26.9231 4 yes
GO:0071705 nitrogen compound transport 26.9231 4 yes
GO:0009892 negative regulation of metabolic process 26.9231 4 no
GO:0051050 positive regulation of transport 26.9231 4 no
GO:0015031 protein transport 25.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0006887 exocytosis 23.0769 4 yes
GO:0072657 protein localization to membrane 23.0769 4 yes
GO:0034330 cell junction organization 23.0769 4 no
GO:0044087 regulation of cellular component biogenesis 23.0769 4 no
GO:0007268 chemical synaptic transmission 23.0769 6 no
GO:0051046 regulation of secretion 23.0769 5 no
GO:0098916 anterograde trans-synaptic signaling 23.0769 5 no
GO:0099537 trans-synaptic signaling 23.0769 4 no
GO:0031399 regulation of protein modification process 23.0769 6 no
GO:0051247 positive regulation of protein metabolic process 23.0769 6 no
GO:0010605 negative regulation of macromolecule metabolic process 23.0769 5 no
GO:0006836 neurotransmitter transport 21.1538 4 yes
GO:0050806 positive regulation of synaptic transmission 21.1538 5 no
GO:0061024 membrane organization 21.1538 4 no
GO:1903530 regulation of secretion by cell 21.1538 4 no
GO:0019220 regulation of phosphate metabolic process 21.1538 6 no
GO:0051174 regulation of phosphorus metabolic process 21.1538 5 no
GO:0022603 regulation of anatomical structure morphogenesis 21.1538 4 no
GO:0007269 neurotransmitter secretion 19.2308 4 yes
GO:1990778 protein localization to cell periphery 15.3846 5 yes
GO:0035088 establishment or maintenance of apical/basal cell polarity 11.5385 4 yes
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 11.5385 5 yes
GO:0097479 synaptic vesicle localization 11.5385 4 yes
GO:0051650 establishment of vesicle localization 7.6923 4 yes
GO:0035090 maintenance of apical/basal cell polarity 5.7692 4 yes
GO:0045199 maintenance of epithelial cell apical/basal polarity 5.7692 5 yes
GO:0048489 synaptic vesicle transport 5.7692 4 yes
GO:1903361 protein localization to basolateral plasma membrane 5.7692 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in LIN7A_HUMAN
DOID:0050700 cardiomyopathy 5.7692 4 no
DOID:0060036 intrinsic cardiomyopathy 5.7692 5 no
DOID:114 heart disease 5.7692 3 no
DOID:2843 long QT syndrome 5.7692 6 no
DOID:10273 heart conduction disease 3.8462 4 no
DOID:331 central nervous system disease 3.8462 3 no
DOID:936 brain disease 3.8462 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
PALS2_HUMAN [view interactions] Low throughput no yes
KCJ12_HUMAN [view interactions] Low throughput no no
MARHB_HUMAN [view interactions] Low throughput no no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
MARH2_HUMAN [view interactions] Low throughput no yes
ABCA1_HUMAN [view interactions] Low throughput no yes
PALS1_HUMAN [view interactions] Low throughput no no
INADL_HUMAN [view interactions] Low throughput no no
GCYB1_HUMAN [view interactions] High throughput no yes
SNTB2_HUMAN [view entry] [view interactions] High throughput yes no
MPP2_HUMAN [view entry] [view interactions] High throughput yes yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
PI42B_HUMAN [view entry] [view interactions] High throughput yes no
CADM1_HUMAN [view entry] [view interactions] High throughput yes no
MPDZ_HUMAN [view entry] [view interactions] High throughput yes yes
CDD_HUMAN [view interactions] High throughput no no
NSUN2_HUMAN [view interactions] High throughput no yes
PTHD1_HUMAN [view interactions] High throughput no no
CD81_HUMAN [view interactions] High throughput no no
NT2NA_HUMAN [view interactions] High throughput no no
ZYX_HUMAN [view interactions] High throughput no no
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
FAM9B_HUMAN [view interactions] High throughput no no
MPP3_HUMAN [view entry] [view interactions] High throughput yes yes
MDFI_HUMAN [view interactions] High throughput no no
ECM1_HUMAN [view interactions] High throughput no no
CHRD_HUMAN [view interactions] High throughput no no
ADA1D_HUMAN [view interactions] High throughput no no
DNJC5_HUMAN [view interactions] High throughput no yes
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
KCNJ4_HUMAN [view entry] [view interactions] High throughput yes no
LIPA2_HUMAN [view entry] [view interactions] High throughput yes no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
MINY3_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
MTMR2_HUMAN [view entry] [view interactions] High throughput yes no
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
BCAR1_HUMAN [view interactions] High throughput no yes
APBA1_HUMAN [view interactions] High throughput no no
MAGA9_HUMAN [view interactions] High throughput no no
DLGP4_HUMAN [view entry] [view interactions] High throughput yes yes
OSGEP_HUMAN [view interactions] High throughput no yes
FXL19_HUMAN [view interactions] High throughput no no
E41L5_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
AGRB1_HUMAN [view entry] [view interactions] High throughput yes no
AMOT_HUMAN [view interactions] High throughput no no
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
GCYA2_HUMAN [view entry] [view interactions] High throughput yes yes
PXDC1_HUMAN [view interactions] High throughput no no
MPP7_HUMAN [view entry] [view interactions] High throughput yes no
S20A1_HUMAN [view interactions] High throughput no yes
E41L2_HUMAN [view entry] [view interactions] High throughput yes yes
LIPA4_HUMAN [view entry] [view interactions] Computational yes yes
SYN2_HUMAN [view entry] [view interactions] Computational yes no
SNP25_HUMAN [view entry] [view interactions] Computational yes yes
SYN3_HUMAN [view entry] [view interactions] Computational yes yes
CPLX1_HUMAN [view entry] [view interactions] Computational yes yes
CNTN2_HUMAN [view entry] [view interactions] Computational yes yes
RIMS1_HUMAN [view entry] [view interactions] Computational yes yes
RAB3A_HUMAN [view entry] [view interactions] Computational yes yes
STXB1_HUMAN [view entry] [view interactions] Computational yes yes
USH1C_HUMAN [view interactions] Computational no yes
DLG3_HUMAN [view entry] [view interactions] Computational yes yes
UN13B_HUMAN [view interactions] Computational no no
LIN7B_HUMAN [view entry] [view interactions] Computational yes no
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes
DLG2_HUMAN [view entry] [view interactions] Computational yes yes
LIPA1_HUMAN [view entry] [view interactions] Computational yes yes
AQP1_HUMAN [view entry] [view interactions] Computational yes no
TX1B3_HUMAN [view interactions] Computational no no
VAMP2_HUMAN [view entry] [view interactions] Computational yes no
KIF17_HUMAN [view interactions] Computational no no
LIN7C_HUMAN [view entry] [view interactions] Computational yes yes
LIPA3_HUMAN [view entry] [view interactions] Computational yes yes
S6A12_HUMAN [view interactions] Computational no no
SYT1_HUMAN [view entry] [view interactions] Computational yes no
RIMB1_HUMAN [view interactions] Computational no yes
SYN1_HUMAN [view entry] [view interactions] Computational yes no
STX1A_HUMAN [view entry] [view interactions] Computational yes yes