MPP7_HUMAN
Evidence for PS localization
Functions
Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MPP7_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 48.7179 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 48.7179 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 48.7179 | 4 | no |
| GO:0003924 | GTPase activity | 35.8974 | 7 | no |
| GO:0005525 | GTP binding | 35.8974 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 35.8974 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 35.8974 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 35.8974 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 35.8974 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 35.8974 | 5 | no |
| GO:0019900 | kinase binding | 33.3333 | 4 | no |
| GO:0019901 | protein kinase binding | 33.3333 | 5 | no |
| GO:0019003 | GDP binding | 20.5128 | 4 | no |
| GO:0045296 | cadherin binding | 7.6923 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MPP7_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 74.3590 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 53.8462 | 4 | yes |
| GO:0010646 | regulation of cell communication | 53.8462 | 4 | no |
| GO:0009966 | regulation of signal transduction | 51.2821 | 4 | no |
| GO:0022607 | cellular component assembly | 48.7179 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.7179 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.1538 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.1538 | 4 | no |
| GO:0008104 | protein localization | 43.5897 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 43.5897 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 43.5897 | 5 | no |
| GO:0051049 | regulation of transport | 41.0256 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 41.0256 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.0256 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.0256 | 4 | no |
| GO:0030030 | cell projection organization | 38.4615 | 4 | no |
| GO:0006996 | organelle organization | 38.4615 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 38.4615 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 35.8974 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 35.8974 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.8974 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.8974 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 35.8974 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 35.8974 | 4 | no |
| GO:0071702 | organic substance transport | 35.8974 | 4 | no |
| GO:0071705 | nitrogen compound transport | 35.8974 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 33.3333 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 33.3333 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 33.3333 | 4 | no |
| GO:0030334 | regulation of cell migration | 33.3333 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 33.3333 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 33.3333 | 4 | no |
| GO:2000145 | regulation of cell motility | 33.3333 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.7692 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 30.7692 | 7 | no |
| GO:0007010 | cytoskeleton organization | 30.7692 | 5 | no |
| GO:0007264 | small GTPase mediated signal transduction | 30.7692 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 30.7692 | 5 | no |
| GO:0010468 | regulation of gene expression | 30.7692 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 30.7692 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 30.7692 | 5 | no |
| GO:0023056 | positive regulation of signaling | 30.7692 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 30.7692 | 5 | no |
| GO:0031399 | regulation of protein modification process | 30.7692 | 6 | no |
| GO:0032970 | regulation of actin filament-based process | 30.7692 | 4 | no |
| GO:0033043 | regulation of organelle organization | 30.7692 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 30.7692 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 30.7692 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 30.7692 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 30.7692 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.7692 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.7692 | 6 | no |
| GO:2000026 | regulation of multicellular organismal development | 28.2051 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 28.2051 | 8 | no |
| GO:0031401 | positive regulation of protein modification process | 28.2051 | 7 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 28.2051 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 28.2051 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 28.2051 | 6 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 28.2051 | 6 | no |
| GO:0031175 | neuron projection development | 28.2051 | 6 | no |
| GO:0097435 | supramolecular fiber organization | 25.6410 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 25.6410 | 4 | no |
| GO:0007265 | Ras protein signal transduction | 25.6410 | 5 | no |
| GO:0071310 | cellular response to organic substance | 25.6410 | 4 | no |
| GO:0015031 | protein transport | 25.6410 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 25.6410 | 5 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 23.0769 | 5 | yes |
| GO:0007015 | actin filament organization | 23.0769 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 23.0769 | 4 | no |
| GO:0051050 | positive regulation of transport | 23.0769 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 23.0769 | 4 | no |
| GO:0060341 | regulation of cellular localization | 23.0769 | 4 | no |
| GO:0010941 | regulation of cell death | 23.0769 | 4 | no |
| GO:0022407 | regulation of cell-cell adhesion | 23.0769 | 5 | no |
| GO:0030335 | positive regulation of cell migration | 23.0769 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 23.0769 | 4 | no |
| GO:0043549 | regulation of kinase activity | 23.0769 | 5 | no |
| GO:0045597 | positive regulation of cell differentiation | 23.0769 | 5 | no |
| GO:0045785 | positive regulation of cell adhesion | 23.0769 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.0769 | 4 | no |
| GO:0051338 | regulation of transferase activity | 23.0769 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 23.0769 | 5 | no |
| GO:0060284 | regulation of cell development | 23.0769 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.5128 | 5 | no |
| GO:0051960 | regulation of nervous system development | 20.5128 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.5128 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 20.5128 | 6 | no |
| GO:0022604 | regulation of cell morphogenesis | 20.5128 | 5 | no |
| GO:0030865 | cortical cytoskeleton organization | 20.5128 | 6 | no |
| GO:0033674 | positive regulation of kinase activity | 20.5128 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 20.5128 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.5128 | 5 | no |
| GO:0051093 | negative regulation of developmental process | 20.5128 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 20.5128 | 4 | no |
| GO:0051347 | positive regulation of transferase activity | 20.5128 | 5 | no |
| GO:0061024 | membrane organization | 20.5128 | 4 | no |
| GO:0032880 | regulation of protein localization | 20.5128 | 5 | no |
| GO:0043408 | regulation of MAPK cascade | 20.5128 | 6 | no |
| GO:0034330 | cell junction organization | 17.9487 | 4 | yes |
| GO:0034329 | cell junction assembly | 15.3846 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 15.3846 | 5 | yes |
| GO:0045216 | cell-cell junction organization | 15.3846 | 5 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 12.8205 | 6 | yes |
| GO:0007043 | cell-cell junction assembly | 10.2564 | 6 | yes |
| GO:1902414 | protein localization to cell junction | 7.6923 | 5 | yes |
| GO:0070830 | bicellular tight junction assembly | 5.1282 | 8 | yes |
| GO:0120192 | tight junction assembly | 5.1282 | 7 | yes |
| GO:0120193 | tight junction organization | 5.1282 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MPP7_HUMAN |
|---|---|---|---|---|
| DOID:0111962 | combined immunodeficiency | 5.1282 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 5.1282 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AMOT_HUMAN | [view interactions] | High throughput | no | no |
| LIN7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI26B_HUMAN | [view interactions] | High throughput | no | yes |
| EFNB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| GPC5B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN146_HUMAN | [view interactions] | High throughput | no | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN4_HUMAN | [view interactions] | High throughput | no | no |
| LIN7B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLGP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYSM1_HUMAN | [view interactions] | High throughput | no | yes |
| HSBP1_HUMAN | [view interactions] | High throughput | no | no |
| CLTR2_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM5_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTMR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| KCNA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANS4B_HUMAN | [view interactions] | High throughput | no | no |
| CADM4_HUMAN | [view interactions] | High throughput | no | yes |
| HDGR2_HUMAN | [view interactions] | High throughput | no | yes |
| KIBRA_HUMAN | [view interactions] | High throughput | no | yes |
| EFC11_HUMAN | [view interactions] | High throughput | no | no |
| BTNL9_HUMAN | [view interactions] | High throughput | no | no |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| MEIS2_HUMAN | [view interactions] | High throughput | no | yes |
| ATS1_HUMAN | [view interactions] | High throughput | no | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| BTK_HUMAN | [view interactions] | High throughput | no | no |
| AMOL1_HUMAN | [view interactions] | High throughput | no | no |
| GCYB1_HUMAN | [view interactions] | High throughput | no | yes |
| MPP4_HUMAN | [view interactions] | High throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| DLG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |