MPP7_HUMAN
Evidence for PS localization
Functions
Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MPP7_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 50.0000 | 4 | no |
| GO:0000166 | nucleotide binding | 47.7273 | 4 | no |
| GO:0017076 | purine nucleotide binding | 47.7273 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 47.7273 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 47.7273 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 34.0909 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 34.0909 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 34.0909 | 6 | no |
| GO:0003924 | GTPase activity | 31.8182 | 7 | no |
| GO:0005525 | GTP binding | 31.8182 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 31.8182 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 31.8182 | 5 | no |
| GO:0019900 | kinase binding | 29.5455 | 4 | no |
| GO:0019901 | protein kinase binding | 27.2727 | 5 | no |
| GO:0045296 | cadherin binding | 4.5455 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MPP7_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 72.7273 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 52.2727 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 45.4545 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.4545 | 4 | no |
| GO:0022607 | cellular component assembly | 43.1818 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 43.1818 | 5 | no |
| GO:0008104 | protein localization | 40.9091 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 40.9091 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.9091 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.9091 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 38.6364 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.3636 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.3636 | 5 | no |
| GO:0030334 | regulation of cell migration | 36.3636 | 5 | no |
| GO:2000145 | regulation of cell motility | 36.3636 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 34.0909 | 5 | no |
| GO:0023056 | positive regulation of signaling | 34.0909 | 4 | no |
| GO:0051049 | regulation of transport | 34.0909 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 31.8182 | 5 | yes |
| GO:0006996 | organelle organization | 31.8182 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 31.8182 | 5 | no |
| GO:0030030 | cell projection organization | 31.8182 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.8182 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 31.8182 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 31.8182 | 5 | no |
| GO:0071702 | organic substance transport | 31.8182 | 4 | no |
| GO:0071705 | nitrogen compound transport | 31.8182 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 31.8182 | 6 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 31.8182 | 6 | no |
| GO:0141124 | intracellular signaling cassette | 31.8182 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 29.5455 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 29.5455 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.5455 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.5455 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 29.5455 | 6 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.5455 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 29.5455 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 29.5455 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 27.2727 | 7 | no |
| GO:0002684 | positive regulation of immune system process | 27.2727 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 27.2727 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 27.2727 | 6 | no |
| GO:0031399 | regulation of protein modification process | 27.2727 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 27.2727 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 27.2727 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 27.2727 | 7 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 27.2727 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.2727 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 27.2727 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 27.2727 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 27.2727 | 5 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 27.2727 | 5 | no |
| GO:0060341 | regulation of cellular localization | 27.2727 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 25.0000 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 25.0000 | 8 | no |
| GO:0045595 | regulation of cell differentiation | 25.0000 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.0000 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 22.7273 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 22.7273 | 4 | no |
| GO:0031175 | neuron projection development | 22.7273 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.7273 | 5 | no |
| GO:0007010 | cytoskeleton organization | 22.7273 | 5 | no |
| GO:0033043 | regulation of organelle organization | 22.7273 | 5 | no |
| GO:0015031 | protein transport | 22.7273 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.4545 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 20.4545 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.4545 | 5 | no |
| GO:0032101 | regulation of response to external stimulus | 20.4545 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.4545 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 20.4545 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.4545 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 20.4545 | 6 | no |
| GO:0045785 | positive regulation of cell adhesion | 20.4545 | 5 | no |
| GO:0051093 | negative regulation of developmental process | 20.4545 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 20.4545 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.4545 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 20.4545 | 4 | no |
| GO:0032880 | regulation of protein localization | 20.4545 | 5 | no |
| GO:0034330 | cell junction organization | 15.9091 | 4 | yes |
| GO:0034329 | cell junction assembly | 13.6364 | 5 | yes |
| GO:0045216 | cell-cell junction organization | 13.6364 | 5 | yes |
| GO:0007043 | cell-cell junction assembly | 11.3636 | 6 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 11.3636 | 5 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 9.0909 | 6 | yes |
| GO:1902414 | protein localization to cell junction | 4.5455 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AMOT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIN7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI26B_HUMAN | [view interactions] | High throughput | no | yes |
| EFNB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| GPC5B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN146_HUMAN | [view interactions] | High throughput | no | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN4_HUMAN | [view interactions] | High throughput | no | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIN7B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLGP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYSM1_HUMAN | [view interactions] | High throughput | no | yes |
| HSBP1_HUMAN | [view interactions] | High throughput | no | no |
| CLTR2_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TRIM5_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTMR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| KCNA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANS4B_HUMAN | [view interactions] | High throughput | no | no |
| CADM4_HUMAN | [view interactions] | High throughput | no | yes |
| HDGR2_HUMAN | [view interactions] | High throughput | no | yes |
| KIBRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFC11_HUMAN | [view interactions] | High throughput | no | no |
| BTNL9_HUMAN | [view interactions] | High throughput | no | no |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| MEIS2_HUMAN | [view interactions] | High throughput | no | yes |
| ATS1_HUMAN | [view interactions] | High throughput | no | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| BTK_HUMAN | [view interactions] | High throughput | no | no |
| AMOL1_HUMAN | [view interactions] | High throughput | no | no |
| GCYB1_HUMAN | [view interactions] | High throughput | no | yes |
| MPP4_HUMAN | [view interactions] | High throughput | no | no |
| RHG17_HUMAN | [view interactions] | High throughput | no | no |
| PALS1_HUMAN | [view interactions] | High throughput | no | no |
| INADL_HUMAN | [view interactions] | High throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |