LIN7B_HUMAN
Evidence for PS localization
Functions
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules . This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LIN7B_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 28.9474 | 4 | no |
| GO:0019901 | protein kinase binding | 26.3158 | 5 | no |
| GO:0046872 | metal ion binding | 23.6842 | 4 | no |
| GO:0030165 | PDZ domain binding | 15.7895 | 4 | yes |
| GO:0097016 | L27 domain binding | 13.1579 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LIN7B_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 60.5263 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 55.2632 | 4 | no |
| GO:0051049 | regulation of transport | 50.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 47.3684 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 47.3684 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.3684 | 4 | no |
| GO:0022607 | cellular component assembly | 44.7368 | 4 | no |
| GO:0008104 | protein localization | 42.1053 | 4 | yes |
| GO:0023061 | signal release | 42.1053 | 4 | yes |
| GO:0046903 | secretion | 42.1053 | 4 | yes |
| GO:0099643 | signal release from synapse | 42.1053 | 5 | yes |
| GO:0043269 | regulation of ion transport | 39.4737 | 5 | no |
| GO:0006887 | exocytosis | 34.2105 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 34.2105 | 4 | yes |
| GO:0006836 | neurotransmitter transport | 31.5789 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 31.5789 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 31.5789 | 5 | no |
| GO:0023056 | positive regulation of signaling | 31.5789 | 4 | no |
| GO:0043933 | protein-containing complex organization | 31.5789 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 31.5789 | 5 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 31.5789 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 31.5789 | 4 | no |
| GO:0034330 | cell junction organization | 31.5789 | 4 | no |
| GO:0007269 | neurotransmitter secretion | 28.9474 | 4 | yes |
| GO:0072657 | protein localization to membrane | 28.9474 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 28.9474 | 4 | no |
| GO:0009966 | regulation of signal transduction | 28.9474 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.9474 | 5 | no |
| GO:0051050 | positive regulation of transport | 28.9474 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 28.9474 | 4 | no |
| GO:0051046 | regulation of secretion | 28.9474 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 28.9474 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 28.9474 | 4 | no |
| GO:0015031 | protein transport | 26.3158 | 4 | yes |
| GO:0071702 | organic substance transport | 26.3158 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 26.3158 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 26.3158 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.3158 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 26.3158 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 26.3158 | 4 | no |
| GO:0033043 | regulation of organelle organization | 26.3158 | 5 | no |
| GO:1990778 | protein localization to cell periphery | 23.6842 | 5 | yes |
| GO:0010959 | regulation of metal ion transport | 23.6842 | 6 | no |
| GO:0031323 | regulation of cellular metabolic process | 23.6842 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 23.6842 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 23.6842 | 5 | no |
| GO:0043270 | positive regulation of ion transport | 23.6842 | 5 | no |
| GO:0044057 | regulation of system process | 23.6842 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 23.6842 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.6842 | 6 | no |
| GO:0060341 | regulation of cellular localization | 23.6842 | 4 | no |
| GO:0006996 | organelle organization | 23.6842 | 4 | no |
| GO:0045055 | regulated exocytosis | 23.6842 | 5 | no |
| GO:0050806 | positive regulation of synaptic transmission | 23.6842 | 5 | no |
| GO:0017157 | regulation of exocytosis | 23.6842 | 5 | no |
| GO:0046928 | regulation of neurotransmitter secretion | 23.6842 | 4 | no |
| GO:0051588 | regulation of neurotransmitter transport | 23.6842 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.0526 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.0526 | 4 | no |
| GO:1904062 | regulation of cation transmembrane transport | 21.0526 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.0526 | 4 | no |
| GO:0016079 | synaptic vesicle exocytosis | 21.0526 | 4 | no |
| GO:0032880 | regulation of protein localization | 21.0526 | 5 | no |
| GO:0061024 | membrane organization | 21.0526 | 4 | no |
| GO:0099003 | vesicle-mediated transport in synapse | 21.0526 | 5 | no |
| GO:0050808 | synapse organization | 21.0526 | 5 | no |
| GO:0035088 | establishment or maintenance of apical/basal cell polarity | 13.1579 | 4 | yes |
| GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 13.1579 | 5 | yes |
| GO:0035090 | maintenance of apical/basal cell polarity | 10.5263 | 4 | yes |
| GO:0045199 | maintenance of epithelial cell apical/basal polarity | 10.5263 | 5 | yes |
| GO:1903361 | protein localization to basolateral plasma membrane | 10.5263 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in LIN7B_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 5.2632 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 5.2632 | 5 | no |
| DOID:114 | heart disease | 5.2632 | 3 | no |
| DOID:2843 | long QT syndrome | 5.2632 | 6 | no |
| DOID:331 | central nervous system disease | 5.2632 | 3 | no |
| DOID:936 | brain disease | 5.2632 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ABCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| KCNJ4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BAIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSKP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ASIC3_HUMAN | [view interactions] | Low throughput | no | no |
| KCJ12_HUMAN | [view interactions] | Low throughput | no | no |
| LIN7B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPP7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PALS2_HUMAN | [view interactions] | High throughput | no | yes |
| PALS1_HUMAN | [view interactions] | High throughput | no | no |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| MAK16_HUMAN | [view interactions] | High throughput | no | yes |
| TPC12_HUMAN | [view interactions] | High throughput | no | yes |
| ENKD1_HUMAN | [view interactions] | High throughput | no | yes |
| PSB1_HUMAN | [view interactions] | High throughput | no | yes |
| MPP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEANC_HUMAN | [view interactions] | High throughput | no | no |
| APBA1_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| PXDC1_HUMAN | [view interactions] | High throughput | no | no |
| CEP20_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGQ_HUMAN | [view interactions] | High throughput | no | yes |
| KI26B_HUMAN | [view interactions] | High throughput | no | yes |
| INADL_HUMAN | [view interactions] | High throughput | no | no |
| DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPOE4_HUMAN | [view interactions] | High throughput | no | no |
| MPDZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UTRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTNB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| A1AT_HUMAN | [view interactions] | High throughput | no | no |
| RIMS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UN13B_HUMAN | [view interactions] | Computational | no | no |
| LIPA4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RTKN_HUMAN | [view interactions] | Computational | no | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LIN7A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYN2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SYN3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CPLX1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LIPA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYT1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RIMB1_HUMAN | [view interactions] | Computational | no | yes |
| SYN1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| STX1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LIPA2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LIPA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |