NMDZ1_HUMAN
Evidence for PS localization
Functions
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed, PubMed, PubMed, PubMed, PubMed). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002449 | LIG_PDZ_Class_1 | LIG | 917 | 922 | - |
| ELMI002147 | MOD_PKA_1 | MOD | 894 | 900 | - |
| ELMI002450 | TRG_ER_diArg_1 | TRG | 893 | 895 | - |
| ELMI002064 | TRG_ER_diArg_1 | TRG | 893 | 895 | - |
| ELMI002449 | LIG_PDZ_Class_1 | LIG | 917 | 922 | - |
| ELMI002147 | MOD_PKA_1 | MOD | 894 | 900 | - |
| ELMI002450 | TRG_ER_diArg_1 | TRG | 893 | 895 | - |
| ELMI002064 | TRG_ER_diArg_1 | TRG | 893 | 895 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NMDZ1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 40.9396 | 4 | yes |
| GO:0043169 | cation binding | 38.9262 | 4 | yes |
| GO:0046872 | metal ion binding | 36.2416 | 5 | yes |
| GO:0000166 | nucleotide binding | 33.5570 | 4 | no |
| GO:0017076 | purine nucleotide binding | 33.5570 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 32.2148 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.5436 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 28.1879 | 6 | no |
| GO:0019900 | kinase binding | 27.5168 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 26.8456 | 5 | no |
| GO:0005524 | ATP binding | 26.1745 | 5 | no |
| GO:0019901 | protein kinase binding | 23.4899 | 5 | no |
| GO:0016301 | kinase activity | 21.4765 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 20.1342 | 4 | no |
| GO:0005509 | calcium ion binding | 13.4228 | 6 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 11.4094 | 4 | yes |
| GO:0005216 | monoatomic ion channel activity | 10.7383 | 4 | yes |
| GO:0015267 | channel activity | 10.7383 | 4 | yes |
| GO:0008066 | glutamate receptor activity | 9.3960 | 4 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 9.3960 | 4 | yes |
| GO:0022836 | gated channel activity | 9.3960 | 5 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 9.3960 | 5 | yes |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 8.7248 | 4 | yes |
| GO:0004970 | glutamate-gated receptor activity | 8.0537 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 8.0537 | 6 | yes |
| GO:0005261 | monoatomic cation channel activity | 8.0537 | 5 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 8.0537 | 6 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 8.0537 | 5 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 8.0537 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 8.0537 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 8.0537 | 4 | yes |
| GO:0005262 | calcium channel activity | 7.3826 | 6 | yes |
| GO:0005244 | voltage-gated monoatomic ion channel activity | 6.7114 | 5 | yes |
| GO:0022832 | voltage-gated channel activity | 6.7114 | 6 | yes |
| GO:0031406 | carboxylic acid binding | 6.0403 | 4 | yes |
| GO:0004972 | NMDA glutamate receptor activity | 5.3691 | 5 | yes |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 4.6980 | 6 | yes |
| GO:0022849 | glutamate-gated calcium ion channel activity | 4.0268 | 5 | yes |
| GO:0099604 | ligand-gated calcium channel activity | 4.0268 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NMDZ1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 68.4564 | 4 | yes |
| GO:0010646 | regulation of cell communication | 63.0872 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 55.7047 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.3356 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 49.6644 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 48.3221 | 4 | yes |
| GO:0051049 | regulation of transport | 48.3221 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 47.6510 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.9799 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.2685 | 4 | yes |
| GO:0008104 | protein localization | 39.5973 | 4 | no |
| GO:0023056 | positive regulation of signaling | 39.5973 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.9262 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 38.2550 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 37.5839 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 37.5839 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 37.5839 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 36.9128 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 36.2416 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 34.8993 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 33.5570 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.5570 | 5 | yes |
| GO:0022607 | cellular component assembly | 33.5570 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 33.5570 | 5 | yes |
| GO:0010468 | regulation of gene expression | 32.2148 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 30.2013 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 30.2013 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 29.5302 | 4 | no |
| GO:0060341 | regulation of cellular localization | 28.8591 | 4 | yes |
| GO:0006996 | organelle organization | 28.8591 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 28.1879 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 28.1879 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.5168 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.5168 | 5 | no |
| GO:0036211 | protein modification process | 26.8456 | 4 | no |
| GO:0043412 | macromolecule modification | 26.8456 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 26.1745 | 7 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 26.1745 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 26.1745 | 7 | no |
| GO:0009892 | negative regulation of metabolic process | 25.5034 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.5034 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 25.5034 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.8322 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 24.8322 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 24.8322 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.8322 | 5 | yes |
| GO:0099536 | synaptic signaling | 24.1611 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 24.1611 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 24.1611 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 24.1611 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.1611 | 4 | no |
| GO:0071702 | organic substance transport | 24.1611 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.4899 | 4 | no |
| GO:0032880 | regulation of protein localization | 23.4899 | 5 | no |
| GO:0043269 | regulation of monoatomic ion transport | 23.4899 | 5 | yes |
| GO:0051050 | positive regulation of transport | 23.4899 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 22.8188 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.8188 | 4 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 22.1477 | 6 | yes |
| GO:0042981 | regulation of apoptotic process | 22.1477 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.1477 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 22.1477 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 22.1477 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 22.1477 | 7 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 22.1477 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 22.1477 | 4 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.1477 | 6 | yes |
| GO:0051252 | regulation of RNA metabolic process | 21.4765 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 21.4765 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 21.4765 | 7 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.4765 | 6 | no |
| GO:0033043 | regulation of organelle organization | 21.4765 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.4765 | 4 | no |
| GO:2000145 | regulation of cell motility | 21.4765 | 4 | no |
| GO:0034330 | cell junction organization | 21.4765 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.4765 | 6 | yes |
| GO:0044057 | regulation of system process | 21.4765 | 4 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 20.8054 | 6 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.8054 | 6 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.8054 | 7 | no |
| GO:0015031 | protein transport | 20.8054 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 20.8054 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.8054 | 7 | yes |
| GO:0016310 | phosphorylation | 20.1342 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 20.1342 | 8 | no |
| GO:0030030 | cell projection organization | 20.1342 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.1342 | 8 | no |
| GO:0043408 | regulation of MAPK cascade | 20.1342 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.1342 | 4 | no |
| GO:0030334 | regulation of cell migration | 20.1342 | 5 | no |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 19.4631 | 5 | yes |
| GO:0010959 | regulation of metal ion transport | 18.7919 | 6 | yes |
| GO:0050890 | cognition | 18.7919 | 4 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 18.1208 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 18.1208 | 4 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 17.4497 | 5 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 16.1074 | 5 | yes |
| GO:0065003 | protein-containing complex assembly | 15.4362 | 5 | yes |
| GO:0051924 | regulation of calcium ion transport | 14.7651 | 7 | yes |
| GO:0007612 | learning | 14.7651 | 4 | yes |
| GO:0006811 | monoatomic ion transport | 14.0940 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 14.0940 | 5 | yes |
| GO:0030001 | metal ion transport | 14.0940 | 6 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 13.4228 | 6 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 13.4228 | 8 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 12.7517 | 7 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 12.7517 | 5 | yes |
| GO:0043270 | positive regulation of monoatomic ion transport | 12.7517 | 5 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 12.7517 | 8 | yes |
| GO:0048168 | regulation of neuronal synaptic plasticity | 12.0805 | 4 | yes |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 11.4094 | 6 | yes |
| GO:0006816 | calcium ion transport | 11.4094 | 7 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 11.4094 | 4 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 10.7383 | 7 | yes |
| GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 10.7383 | 6 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 9.3960 | 7 | yes |
| GO:0031644 | regulation of nervous system process | 9.3960 | 5 | yes |
| GO:0098815 | modulation of excitatory postsynaptic potential | 8.7248 | 4 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 8.7248 | 9 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 8.0537 | 6 | yes |
| GO:0097305 | response to alcohol | 8.0537 | 4 | yes |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic | 7.3826 | 6 | yes |
| GO:0055080 | monoatomic cation homeostasis | 7.3826 | 4 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 7.3826 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 7.3826 | 4 | yes |
| GO:2000463 | positive regulation of excitatory postsynaptic potential | 7.3826 | 5 | yes |
| GO:0008306 | associative learning | 7.3826 | 5 | yes |
| GO:0009416 | response to light stimulus | 7.3826 | 4 | yes |
| GO:0035235 | ionotropic glutamate receptor signaling pathway | 7.3826 | 4 | yes |
| GO:0070588 | calcium ion transmembrane transport | 6.7114 | 5 | yes |
| GO:0097553 | calcium ion transmembrane import into cytosol | 6.7114 | 6 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 6.7114 | 7 | yes |
| GO:0007420 | brain development | 6.7114 | 4 | yes |
| GO:0008542 | visual learning | 6.0403 | 4 | yes |
| GO:0045471 | response to ethanol | 6.0403 | 5 | yes |
| GO:0051259 | protein complex oligomerization | 5.3691 | 6 | yes |
| GO:0055074 | calcium ion homeostasis | 5.3691 | 4 | yes |
| GO:0060078 | regulation of postsynaptic membrane potential | 5.3691 | 4 | yes |
| GO:0060079 | excitatory postsynaptic potential | 4.6980 | 5 | yes |
| GO:0043200 | response to amino acid | 4.6980 | 4 | yes |
| GO:0098976 | excitatory chemical synaptic transmission | 4.0268 | 8 | yes |
| GO:2000377 | regulation of reactive oxygen species metabolic process | 4.0268 | 5 | yes |
| GO:0051262 | protein tetramerization | 3.3557 | 7 | yes |
| GO:0051290 | protein heterotetramerization | 2.0134 | 8 | yes |
| GO:0051291 | protein heterooligomerization | 2.0134 | 7 | yes |
| GO:1903426 | regulation of reactive oxygen species biosynthetic process | 2.0134 | 5 | yes |
| GO:1905429 | response to glycine | 2.0134 | 4 | yes |
| GO:2000379 | positive regulation of reactive oxygen species metabolic process | 2.0134 | 6 | yes |
| GO:1900673 | olefin metabolic process | 1.3423 | 4 | yes |
| GO:1903428 | positive regulation of reactive oxygen species biosynthetic process | 1.3423 | 6 | yes |
| GO:0010524 | positive regulation of calcium ion transport into cytosol | 1.3423 | 4 | yes |
| GO:0018964 | propylene metabolic process | 1.3423 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APLP1_HUMAN | [view interactions] | Low throughput | no | yes |
| APLP2_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRR7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CA2D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PAGR1_HUMAN | [view interactions] | Low throughput | no | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCC2G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRIC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MPDZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PACN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAP1S_HUMAN | [view interactions] | Low throughput | no | no |
| IQEC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AT2B2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB11B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRFN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HOME1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CADH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTN5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DRD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SEM4B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LIN7B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NHRF3_HUMAN | [view interactions] | Low throughput | no | no |
| MAGI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ERBB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLCB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NETO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EPHB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NR1H4_HUMAN | [view interactions] | Low throughput | no | no |
| NU2M_HUMAN | [view interactions] | Low throughput | no | no |
| NMD3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NMD3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NUMB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHC3_HUMAN | [view interactions] | Low throughput | no | yes |
| EPS8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3R1_HUMAN | [view interactions] | Low throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPHRA_HUMAN | [view interactions] | High throughput | no | no |
| NOTC3_HUMAN | [view interactions] | High throughput | no | yes |
| MANEA_HUMAN | [view interactions] | High throughput | no | yes |
| AN13C_HUMAN | [view interactions] | High throughput | no | no |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISD2_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GPR88_HUMAN | [view interactions] | High throughput | no | no |
| BC11B_HUMAN | [view interactions] | High throughput | no | yes |
| ELMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANKK1_HUMAN | [view interactions] | High throughput | no | no |
| PTPRK_HUMAN | [view interactions] | High throughput | no | no |
| CDS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCAF6_HUMAN | [view interactions] | High throughput | no | no |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2BA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAP2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PA24A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NOS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| L1CAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IP3KA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VANG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIAM2_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BKRB1_HUMAN | [view interactions] | High throughput | no | yes |
| PTAFR_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| CTND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| SPTA1_HUMAN | [view interactions] | High throughput | no | no |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BSN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PFKAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A_HUMAN | [view interactions] | High throughput | no | no |