EAA3_HUMAN
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed, PubMed, PubMed, PubMed, PubMed). Can also transport L-cysteine (PubMed). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed, PubMed, PubMed). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed, PubMed). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate . Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport . Negatively regulated by ARL6IP5 . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in EAA3_HUMAN |
---|---|---|---|---|
GO:0008324 | cation transmembrane transporter activity | 30.2326 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 27.9070 | 4 | yes |
GO:0046872 | metal ion binding | 25.5814 | 4 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 23.2558 | 5 | yes |
GO:0008509 | anion transmembrane transporter activity | 18.6047 | 4 | yes |
GO:0008514 | organic anion transmembrane transporter activity | 18.6047 | 5 | yes |
GO:0005216 | ion channel activity | 16.2791 | 4 | yes |
GO:0015171 | amino acid transmembrane transporter activity | 16.2791 | 5 | yes |
GO:0015267 | channel activity | 16.2791 | 4 | yes |
GO:0015291 | secondary active transmembrane transporter activity | 16.2791 | 4 | yes |
GO:0022853 | active ion transmembrane transporter activity | 16.2791 | 4 | yes |
GO:0046943 | carboxylic acid transmembrane transporter activity | 16.2791 | 4 | yes |
GO:0005416 | amino acid:cation symporter activity | 13.9535 | 6 | yes |
GO:0015293 | symporter activity | 13.9535 | 5 | yes |
GO:0015294 | solute:cation symporter activity | 13.9535 | 5 | yes |
GO:0005283 | amino acid:sodium symporter activity | 11.6279 | 5 | yes |
GO:0005313 | L-glutamate transmembrane transporter activity | 11.6279 | 6 | yes |
GO:0005343 | organic acid:sodium symporter activity | 11.6279 | 4 | yes |
GO:0015081 | sodium ion transmembrane transporter activity | 11.6279 | 6 | yes |
GO:0015172 | acidic amino acid transmembrane transporter activity | 11.6279 | 6 | yes |
GO:0015175 | neutral amino acid transmembrane transporter activity | 11.6279 | 6 | yes |
GO:0015179 | L-amino acid transmembrane transporter activity | 11.6279 | 6 | yes |
GO:0015370 | solute:sodium symporter activity | 11.6279 | 6 | yes |
GO:0016595 | glutamate binding | 11.6279 | 5 | yes |
GO:0016597 | amino acid binding | 11.6279 | 4 | yes |
GO:0031406 | carboxylic acid binding | 11.6279 | 4 | yes |
GO:0005310 | dicarboxylic acid transmembrane transporter activity | 9.3023 | 5 | yes |
GO:0005314 | high-affinity L-glutamate transmembrane transporter activity | 9.3023 | 7 | yes |
GO:0015183 | L-aspartate transmembrane transporter activity | 9.3023 | 6 | yes |
GO:0015501 | glutamate:sodium symporter activity | 9.3023 | 6 | yes |
GO:0015556 | C4-dicarboxylate transmembrane transporter activity | 9.3023 | 6 | yes |
GO:0015103 | inorganic anion transmembrane transporter activity | 6.9767 | 4 | yes |
GO:0015108 | chloride transmembrane transporter activity | 6.9767 | 5 | yes |
GO:0000099 | sulfur amino acid transmembrane transporter activity | 4.6512 | 4 | yes |
GO:0005253 | anion channel activity | 4.6512 | 5 | yes |
GO:0033229 | cysteine transmembrane transporter activity | 4.6512 | 5 | yes |
GO:0042943 | D-amino acid transmembrane transporter activity | 4.6512 | 6 | yes |
GO:0140010 | D-aspartate transmembrane transporter activity | 4.6512 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in EAA3_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 55.8140 | 4 | yes |
GO:0010646 | regulation of cell communication | 48.8372 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 46.5116 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 44.1860 | 4 | yes |
GO:0071702 | organic substance transport | 41.8605 | 4 | yes |
GO:0051049 | regulation of transport | 41.8605 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 41.8605 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 39.5349 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 39.5349 | 4 | yes |
GO:0071705 | nitrogen compound transport | 37.2093 | 4 | yes |
GO:0022607 | cellular component assembly | 37.2093 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 37.2093 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 34.8837 | 4 | no |
GO:0006996 | organelle organization | 34.8837 | 4 | no |
GO:0060341 | regulation of cellular localization | 32.5581 | 4 | yes |
GO:0008104 | protein localization | 32.5581 | 4 | yes |
GO:0010647 | positive regulation of cell communication | 32.5581 | 5 | yes |
GO:0023056 | positive regulation of signaling | 32.5581 | 4 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 32.5581 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 32.5581 | 5 | yes |
GO:0006811 | ion transport | 30.2326 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 30.2326 | 5 | yes |
GO:0032880 | regulation of protein localization | 30.2326 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 30.2326 | 6 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 27.9070 | 4 | yes |
GO:0009966 | regulation of signal transduction | 27.9070 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 27.9070 | 5 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 27.9070 | 5 | yes |
GO:0061024 | membrane organization | 25.5814 | 4 | no |
GO:0010243 | response to organonitrogen compound | 25.5814 | 4 | yes |
GO:0010941 | regulation of cell death | 25.5814 | 4 | yes |
GO:0043085 | positive regulation of catalytic activity | 25.5814 | 4 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 23.2558 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 23.2558 | 4 | yes |
GO:0043933 | protein-containing complex organization | 23.2558 | 4 | no |
GO:0065003 | protein-containing complex assembly | 23.2558 | 5 | no |
GO:0006812 | cation transport | 23.2558 | 5 | yes |
GO:0007268 | chemical synaptic transmission | 23.2558 | 6 | yes |
GO:0015031 | protein transport | 23.2558 | 4 | yes |
GO:0015849 | organic acid transport | 23.2558 | 5 | yes |
GO:0016192 | vesicle-mediated transport | 23.2558 | 4 | yes |
GO:0034330 | cell junction organization | 23.2558 | 4 | yes |
GO:0043067 | regulation of programmed cell death | 23.2558 | 5 | yes |
GO:0060548 | negative regulation of cell death | 20.9302 | 5 | yes |
GO:0070201 | regulation of establishment of protein localization | 20.9302 | 6 | yes |
GO:0072657 | protein localization to membrane | 20.9302 | 4 | yes |
GO:0098655 | cation transmembrane transport | 20.9302 | 4 | yes |
GO:0098656 | anion transmembrane transport | 20.9302 | 4 | yes |
GO:1990778 | protein localization to cell periphery | 20.9302 | 5 | yes |
GO:0051130 | positive regulation of cellular component organization | 20.9302 | 5 | no |
GO:0051050 | positive regulation of transport | 20.9302 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 20.9302 | 4 | no |
GO:0009894 | regulation of catabolic process | 20.9302 | 4 | no |
GO:0006820 | anion transport | 20.9302 | 5 | yes |
GO:0015711 | organic anion transport | 20.9302 | 5 | yes |
GO:0019220 | regulation of phosphate metabolic process | 20.9302 | 6 | yes |
GO:0030001 | metal ion transport | 20.9302 | 6 | yes |
GO:0030162 | regulation of proteolysis | 20.9302 | 6 | yes |
GO:0042981 | regulation of apoptotic process | 20.9302 | 6 | yes |
GO:0044057 | regulation of system process | 20.9302 | 4 | yes |
GO:0045862 | positive regulation of proteolysis | 20.9302 | 7 | yes |
GO:0050890 | cognition | 20.9302 | 4 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 20.9302 | 5 | yes |
GO:0051223 | regulation of protein transport | 20.9302 | 5 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 20.9302 | 4 | yes |
GO:0071310 | cellular response to organic substance | 18.6047 | 4 | yes |
GO:0098660 | inorganic ion transmembrane transport | 18.6047 | 4 | yes |
GO:0098662 | inorganic cation transmembrane transport | 18.6047 | 5 | yes |
GO:0098771 | inorganic ion homeostasis | 18.6047 | 6 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 18.6047 | 4 | yes |
GO:1905039 | carboxylic acid transmembrane transport | 18.6047 | 4 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 18.6047 | 4 | yes |
GO:0006865 | amino acid transport | 18.6047 | 5 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 18.6047 | 6 | yes |
GO:0010950 | positive regulation of endopeptidase activity | 18.6047 | 7 | yes |
GO:0010952 | positive regulation of peptidase activity | 18.6047 | 6 | yes |
GO:0031399 | regulation of protein modification process | 18.6047 | 6 | yes |
GO:0031401 | positive regulation of protein modification process | 18.6047 | 7 | yes |
GO:0043069 | negative regulation of programmed cell death | 18.6047 | 6 | yes |
GO:0045937 | positive regulation of phosphate metabolic process | 18.6047 | 7 | yes |
GO:0046942 | carboxylic acid transport | 18.6047 | 6 | yes |
GO:0048878 | chemical homeostasis | 18.6047 | 4 | yes |
GO:0050801 | ion homeostasis | 18.6047 | 5 | yes |
GO:0051336 | regulation of hydrolase activity | 18.6047 | 4 | yes |
GO:0051345 | positive regulation of hydrolase activity | 18.6047 | 5 | yes |
GO:0052547 | regulation of peptidase activity | 18.6047 | 5 | yes |
GO:0052548 | regulation of endopeptidase activity | 18.6047 | 6 | yes |
GO:0055080 | cation homeostasis | 18.6047 | 6 | yes |
GO:0071417 | cellular response to organonitrogen compound | 16.2791 | 4 | yes |
GO:0098657 | import into cell | 16.2791 | 4 | yes |
GO:0098876 | vesicle-mediated transport to the plasma membrane | 16.2791 | 4 | yes |
GO:1901699 | cellular response to nitrogen compound | 16.2791 | 4 | yes |
GO:2000116 | regulation of cysteine-type endopeptidase activity | 16.2791 | 7 | yes |
GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 16.2791 | 8 | yes |
GO:0001932 | regulation of protein phosphorylation | 16.2791 | 7 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 16.2791 | 8 | yes |
GO:0003333 | amino acid transmembrane transport | 16.2791 | 5 | yes |
GO:0006873 | cellular ion homeostasis | 16.2791 | 4 | yes |
GO:0007612 | learning | 16.2791 | 4 | yes |
GO:0015800 | acidic amino acid transport | 16.2791 | 6 | yes |
GO:0030003 | cellular cation homeostasis | 16.2791 | 5 | yes |
GO:0033674 | positive regulation of kinase activity | 16.2791 | 6 | yes |
GO:0036211 | protein modification process | 16.2791 | 4 | yes |
GO:0042325 | regulation of phosphorylation | 16.2791 | 7 | yes |
GO:0042327 | positive regulation of phosphorylation | 16.2791 | 8 | yes |
GO:0043066 | negative regulation of apoptotic process | 16.2791 | 7 | yes |
GO:0043412 | macromolecule modification | 16.2791 | 4 | yes |
GO:0043549 | regulation of kinase activity | 16.2791 | 5 | yes |
GO:0045859 | regulation of protein kinase activity | 16.2791 | 6 | yes |
GO:0045860 | positive regulation of protein kinase activity | 16.2791 | 7 | yes |
GO:0050806 | positive regulation of synaptic transmission | 16.2791 | 5 | yes |
GO:0051338 | regulation of transferase activity | 16.2791 | 4 | yes |
GO:0051347 | positive regulation of transferase activity | 16.2791 | 5 | yes |
GO:0055065 | metal ion homeostasis | 16.2791 | 7 | yes |
GO:0072507 | divalent inorganic cation homeostasis | 13.9535 | 7 | yes |
GO:1901566 | organonitrogen compound biosynthetic process | 13.9535 | 4 | yes |
GO:1902475 | L-alpha-amino acid transmembrane transport | 13.9535 | 6 | yes |
GO:1905475 | regulation of protein localization to membrane | 13.9535 | 6 | yes |
GO:0006835 | dicarboxylic acid transport | 13.9535 | 7 | yes |
GO:0006875 | cellular metal ion homeostasis | 13.9535 | 6 | yes |
GO:0006915 | apoptotic process | 13.9535 | 4 | yes |
GO:0007215 | glutamate receptor signaling pathway | 13.9535 | 4 | yes |
GO:0007613 | memory | 13.9535 | 4 | yes |
GO:0008306 | associative learning | 13.9535 | 5 | yes |
GO:0014070 | response to organic cyclic compound | 13.9535 | 4 | yes |
GO:0015807 | L-amino acid transport | 13.9535 | 5 | yes |
GO:0015813 | L-glutamate transmembrane transport | 13.9535 | 5 | yes |
GO:0050808 | synapse organization | 13.9535 | 5 | yes |
GO:0051938 | L-glutamate import | 13.9535 | 6 | yes |
GO:0072503 | cellular divalent inorganic cation homeostasis | 11.6279 | 6 | yes |
GO:0089718 | amino acid import across plasma membrane | 11.6279 | 4 | yes |
GO:0090150 | establishment of protein localization to membrane | 11.6279 | 4 | yes |
GO:0098712 | L-glutamate import across plasma membrane | 11.6279 | 5 | yes |
GO:1901214 | regulation of neuron death | 11.6279 | 5 | yes |
GO:0006468 | protein phosphorylation | 11.6279 | 5 | yes |
GO:0006836 | neurotransmitter transport | 11.6279 | 4 | yes |
GO:0007420 | brain development | 11.6279 | 4 | yes |
GO:0010038 | response to metal ion | 11.6279 | 4 | yes |
GO:0015740 | C4-dicarboxylate transport | 11.6279 | 8 | yes |
GO:0016310 | phosphorylation | 11.6279 | 5 | yes |
GO:0018193 | peptidyl-amino acid modification | 11.6279 | 5 | yes |
GO:0043279 | response to alkaloid | 11.6279 | 5 | yes |
GO:0043603 | cellular amide metabolic process | 11.6279 | 4 | yes |
GO:0060291 | long-term synaptic potentiation | 9.3023 | 4 | yes |
GO:0071241 | cellular response to inorganic substance | 9.3023 | 4 | yes |
GO:0071248 | cellular response to metal ion | 9.3023 | 5 | yes |
GO:0071407 | cellular response to organic cyclic compound | 9.3023 | 5 | yes |
GO:0098661 | inorganic anion transmembrane transport | 9.3023 | 5 | yes |
GO:0098877 | neurotransmitter receptor transport to plasma membrane | 9.3023 | 4 | yes |
GO:0150104 | transport across blood-brain barrier | 9.3023 | 5 | yes |
GO:1901215 | negative regulation of neuron death | 9.3023 | 6 | yes |
GO:1902476 | chloride transmembrane transport | 9.3023 | 6 | yes |
GO:1903522 | regulation of blood circulation | 9.3023 | 5 | yes |
GO:0003018 | vascular process in circulatory system | 9.3023 | 4 | yes |
GO:0006821 | chloride transport | 9.3023 | 7 | yes |
GO:0010232 | vascular transport | 9.3023 | 4 | yes |
GO:0015698 | inorganic anion transport | 9.3023 | 6 | yes |
GO:0032386 | regulation of intracellular transport | 9.3023 | 5 | yes |
GO:0042220 | response to cocaine | 9.3023 | 4 | yes |
GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 9.3023 | 9 | yes |
GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 9.3023 | 8 | yes |
GO:0043523 | regulation of neuron apoptotic process | 9.3023 | 6 | yes |
GO:0043604 | amide biosynthetic process | 9.3023 | 5 | yes |
GO:0044271 | cellular nitrogen compound biosynthetic process | 9.3023 | 4 | yes |
GO:0044272 | sulfur compound biosynthetic process | 9.3023 | 4 | yes |
GO:0051402 | neuron apoptotic process | 9.3023 | 4 | yes |
GO:0070633 | transepithelial transport | 6.9767 | 4 | yes |
GO:0070777 | D-aspartate transport | 6.9767 | 7 | yes |
GO:0070778 | L-aspartate transmembrane transport | 6.9767 | 5 | yes |
GO:0070779 | D-aspartate import across plasma membrane | 6.9767 | 5 | yes |
GO:0071312 | cellular response to alkaloid | 6.9767 | 5 | yes |
GO:0071314 | cellular response to cocaine | 6.9767 | 5 | yes |
GO:0140009 | L-aspartate import across plasma membrane | 6.9767 | 5 | yes |
GO:0001894 | tissue homeostasis | 6.9767 | 5 | yes |
GO:0001975 | response to amphetamine | 6.9767 | 6 | yes |
GO:0006518 | peptide metabolic process | 6.9767 | 4 | yes |
GO:0006576 | cellular biogenic amine metabolic process | 6.9767 | 5 | yes |
GO:0006584 | catecholamine metabolic process | 6.9767 | 6 | yes |
GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 6.9767 | 10 | yes |
GO:0008016 | regulation of heart contraction | 6.9767 | 6 | yes |
GO:0009308 | amine metabolic process | 6.9767 | 4 | yes |
GO:0009712 | catechol-containing compound metabolic process | 6.9767 | 5 | yes |
GO:0014075 | response to amine | 6.9767 | 5 | yes |
GO:0015804 | neutral amino acid transport | 6.9767 | 6 | yes |
GO:0018105 | peptidyl-serine phosphorylation | 6.9767 | 6 | yes |
GO:0018209 | peptidyl-serine modification | 6.9767 | 6 | yes |
GO:0018958 | phenol-containing compound metabolic process | 6.9767 | 4 | yes |
GO:0019221 | cytokine-mediated signaling pathway | 6.9767 | 4 | yes |
GO:0022008 | neurogenesis | 6.9767 | 4 | yes |
GO:0032147 | activation of protein kinase activity | 6.9767 | 8 | yes |
GO:0033157 | regulation of intracellular protein transport | 6.9767 | 6 | yes |
GO:0036293 | response to decreased oxygen levels | 6.9767 | 4 | yes |
GO:0042417 | dopamine metabolic process | 6.9767 | 7 | yes |
GO:0042940 | D-amino acid transport | 6.9767 | 6 | yes |
GO:0043524 | negative regulation of neuron apoptotic process | 6.9767 | 7 | yes |
GO:0044106 | cellular amine metabolic process | 6.9767 | 4 | yes |
GO:0046916 | cellular transition metal ion homeostasis | 6.9767 | 7 | yes |
GO:0055076 | transition metal ion homeostasis | 6.9767 | 8 | yes |
GO:0060249 | anatomical structure homeostasis | 6.9767 | 4 | yes |
GO:0060359 | response to ammonium ion | 4.6512 | 4 | yes |
GO:0071242 | cellular response to ammonium ion | 4.6512 | 5 | yes |
GO:0071288 | cellular response to mercury ion | 4.6512 | 6 | yes |
GO:0071577 | zinc ion transmembrane transport | 4.6512 | 6 | yes |
GO:0072348 | sulfur compound transport | 4.6512 | 4 | yes |
GO:0080144 | amino acid homeostasis | 4.6512 | 5 | yes |
GO:0090313 | regulation of protein targeting to membrane | 4.6512 | 7 | yes |
GO:0090461 | glutamate homeostasis | 4.6512 | 6 | yes |
GO:0097049 | motor neuron apoptotic process | 4.6512 | 5 | yes |
GO:1903524 | positive regulation of blood circulation | 4.6512 | 5 | yes |
GO:1903533 | regulation of protein targeting | 4.6512 | 7 | yes |
GO:1903925 | response to bisphenol A | 4.6512 | 4 | yes |
GO:1903926 | cellular response to bisphenol A | 4.6512 | 5 | yes |
GO:1990708 | conditioned place preference | 4.6512 | 6 | yes |
GO:0000041 | transition metal ion transport | 4.6512 | 7 | yes |
GO:0000101 | sulfur amino acid transport | 4.6512 | 5 | yes |
GO:0001662 | behavioral fear response | 4.6512 | 4 | yes |
GO:0003015 | heart process | 4.6512 | 4 | yes |
GO:0006749 | glutathione metabolic process | 4.6512 | 4 | yes |
GO:0006750 | glutathione biosynthetic process | 4.6512 | 5 | yes |
GO:0006801 | superoxide metabolic process | 4.6512 | 4 | yes |
GO:0006829 | zinc ion transport | 4.6512 | 8 | yes |
GO:0006882 | cellular zinc ion homeostasis | 4.6512 | 7 | yes |
GO:0010460 | positive regulation of heart rate | 4.6512 | 4 | yes |
GO:0010467 | gene expression | 4.6512 | 4 | yes |
GO:0014072 | response to isoquinoline alkaloid | 4.6512 | 5 | yes |
GO:0019184 | nonribosomal peptide biosynthetic process | 4.6512 | 6 | yes |
GO:0032148 | activation of protein kinase B activity | 4.6512 | 9 | yes |
GO:0035633 | maintenance of blood-brain barrier | 4.6512 | 6 | yes |
GO:0036475 | neuron death in response to oxidative stress | 4.6512 | 4 | yes |
GO:0042398 | cellular modified amino acid biosynthetic process | 4.6512 | 4 | yes |
GO:0042883 | cysteine transport | 4.6512 | 6 | yes |
GO:0043043 | peptide biosynthetic process | 4.6512 | 5 | yes |
GO:0043278 | response to morphine | 4.6512 | 6 | yes |
GO:0045823 | positive regulation of heart contraction | 4.6512 | 6 | yes |
GO:0046689 | response to mercury ion | 4.6512 | 5 | yes |
GO:0048514 | blood vessel morphogenesis | 4.6512 | 4 | yes |
GO:0048678 | response to axon injury | 4.6512 | 4 | yes |
GO:0055069 | zinc ion homeostasis | 4.6512 | 8 | yes |
GO:0055081 | anion homeostasis | 4.6512 | 6 | yes |
GO:0060013 | righting reflex | 4.6512 | 4 | yes |
GO:0060047 | heart contraction | 4.6512 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in EAA3_HUMAN |
---|---|---|---|---|
DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 4.6512 | 7 | no |
DOID:10595 | Charcot-Marie-Tooth disease | 4.6512 | 6 | no |
DOID:440 | neuromuscular disease | 4.6512 | 5 | no |
DOID:574 | peripheral nervous system disease | 4.6512 | 3 | no |
DOID:870 | neuropathy | 4.6512 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CCHL_HUMAN | [view interactions] | Low throughput | no | yes |
EAA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PRAF3_HUMAN | [view interactions] | Low throughput | no | yes |
ECM29_HUMAN | [view interactions] | High throughput | no | no |
VRK2_HUMAN | [view interactions] | High throughput | no | no |
S1PR4_HUMAN | [view interactions] | High throughput | no | no |
GRAH_HUMAN | [view interactions] | High throughput | no | no |
DPOD3_HUMAN | [view interactions] | High throughput | no | yes |
UBXN8_HUMAN | [view interactions] | High throughput | no | yes |
SYRM_HUMAN | [view interactions] | High throughput | no | yes |
HLAB_HUMAN | [view interactions] | High throughput | no | yes |
KCT2_HUMAN | [view interactions] | High throughput | no | yes |
STX17_HUMAN | [view interactions] | High throughput | no | yes |
GPAT4_HUMAN | [view interactions] | High throughput | no | yes |
COQ8B_HUMAN | [view interactions] | High throughput | no | yes |
SCMC2_HUMAN | [view interactions] | High throughput | no | yes |
UPK2_HUMAN | [view interactions] | High throughput | no | no |
AL3B1_HUMAN | [view interactions] | High throughput | no | yes |
FFAR1_HUMAN | [view interactions] | High throughput | no | no |
ASPH_HUMAN | [view interactions] | High throughput | no | yes |
TMEM9_HUMAN | [view interactions] | High throughput | no | no |
JIP4_HUMAN | [view interactions] | High throughput | no | yes |
DHC24_HUMAN | [view interactions] | High throughput | no | yes |
JAK1_HUMAN | [view interactions] | High throughput | no | yes |
KLRB1_HUMAN | [view interactions] | High throughput | no | yes |
PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
P2RY8_HUMAN | [view interactions] | High throughput | no | no |
T126A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LEG8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PXMP2_HUMAN | [view interactions] | High throughput | no | no |
MIC27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYTM_HUMAN | [view interactions] | High throughput | no | no |
EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUMBL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CD320_HUMAN | [view interactions] | High throughput | no | yes |
NFIP1_HUMAN | [view interactions] | High throughput | no | yes |
FMC1_HUMAN | [view interactions] | High throughput | no | no |
TIM14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHPT1_HUMAN | [view interactions] | High throughput | no | yes |
MICU2_HUMAN | [view interactions] | High throughput | no | yes |
GOGA7_HUMAN | [view interactions] | High throughput | no | yes |
HACD2_HUMAN | [view interactions] | High throughput | no | yes |
SNX17_HUMAN | [view interactions] | High throughput | no | yes |
RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MPC2_HUMAN | [view interactions] | High throughput | no | yes |
SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PM34_HUMAN | [view interactions] | High throughput | no | yes |
SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
SBSN_HUMAN | [view interactions] | High throughput | no | no |
NRN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LRAD1_HUMAN | [view interactions] | High throughput | no | no |
RNF5_HUMAN | [view interactions] | High throughput | no | yes |
F209A_HUMAN | [view interactions] | High throughput | no | no |
S35A1_HUMAN | [view interactions] | High throughput | no | no |
ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
T179B_HUMAN | [view interactions] | High throughput | no | no |
SYNPR_HUMAN | [view interactions] | High throughput | no | no |
PAGE1_HUMAN | [view interactions] | High throughput | no | no |
EWS_HUMAN | [view interactions] | High throughput | no | yes |
CXCR4_HUMAN | [view interactions] | High throughput | no | no |
DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FXYD3_HUMAN | [view interactions] | High throughput | no | yes |
C1GLT_HUMAN | [view interactions] | High throughput | no | yes |
FCERG_HUMAN | [view interactions] | High throughput | no | no |
SLAF1_HUMAN | [view interactions] | High throughput | no | no |
C2D1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ORML3_HUMAN | [view interactions] | High throughput | no | no |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
TR10B_HUMAN | [view interactions] | High throughput | no | no |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NMDE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHSS1_HUMAN | [view interactions] | High throughput | no | no |
CD3D_HUMAN | [view interactions] | High throughput | no | no |
CST9L_HUMAN | [view interactions] | High throughput | no | no |
NIPA3_HUMAN | [view interactions] | High throughput | no | no |
TM169_HUMAN | [view interactions] | High throughput | no | yes |
TSN10_HUMAN | [view interactions] | High throughput | no | no |
NHRF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CKLF8_HUMAN | [view interactions] | High throughput | no | yes |
GPHRA_HUMAN | [view interactions] | High throughput | no | no |
CXL16_HUMAN | [view interactions] | High throughput | no | no |
LAGE3_HUMAN | [view interactions] | High throughput | no | yes |
TMCO1_HUMAN | [view interactions] | High throughput | no | yes |
PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
ACSL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACSL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACSL1_HUMAN | [view interactions] | High throughput | no | no |
TMM72_HUMAN | [view interactions] | High throughput | no | no |
TM165_HUMAN | [view interactions] | High throughput | no | yes |
D19L1_HUMAN | [view interactions] | High throughput | no | yes |
TPC_HUMAN | [view interactions] | High throughput | no | no |
OPALI_HUMAN | [view interactions] | High throughput | no | yes |
COPT2_HUMAN | [view interactions] | High throughput | no | yes |
STAR3_HUMAN | [view interactions] | High throughput | no | yes |
SORT_HUMAN | [view interactions] | High throughput | no | yes |
PMGT1_HUMAN | [view interactions] | High throughput | no | yes |
CKLF6_HUMAN | [view interactions] | High throughput | no | yes |
HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VSIG4_HUMAN | [view interactions] | High throughput | no | no |
PTSS2_HUMAN | [view interactions] | High throughput | no | yes |
DERL1_HUMAN | [view interactions] | High throughput | no | yes |
TMM70_HUMAN | [view interactions] | High throughput | no | yes |
OXA1L_HUMAN | [view interactions] | High throughput | no | yes |
AGRE5_HUMAN | [view interactions] | High throughput | no | no |
IFM3_HUMAN | [view interactions] | High throughput | no | yes |
DAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AUP1_HUMAN | [view interactions] | High throughput | no | yes |
GHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FND3B_HUMAN | [view interactions] | High throughput | no | no |
VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S2540_HUMAN | [view interactions] | High throughput | no | no |
VAMP7_HUMAN | [view interactions] | High throughput | no | yes |
LRBA_HUMAN | [view interactions] | High throughput | no | yes |
TOM22_HUMAN | [view interactions] | High throughput | no | yes |
PPOX_HUMAN | [view interactions] | High throughput | no | no |
YIF1B_HUMAN | [view interactions] | High throughput | no | yes |
DQB1_HUMAN | [view interactions] | High throughput | no | no |
TV23C_HUMAN | [view interactions] | High throughput | no | no |
BI1_HUMAN | [view interactions] | High throughput | no | yes |
DRS7B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SFXN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PP4P1_HUMAN | [view interactions] | High throughput | no | yes |
RAB7L_HUMAN | [view interactions] | High throughput | no | yes |
CPT1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
ARL8A_HUMAN | [view interactions] | High throughput | no | no |
SPG7_HUMAN | [view interactions] | High throughput | no | no |
PEX3_HUMAN | [view interactions] | High throughput | no | yes |
TM9S1_HUMAN | [view interactions] | High throughput | no | yes |
ELOV1_HUMAN | [view interactions] | High throughput | no | yes |
SURF4_HUMAN | [view interactions] | High throughput | no | yes |
TM41B_HUMAN | [view interactions] | High throughput | no | yes |
MIC25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S2533_HUMAN | [view interactions] | High throughput | no | yes |
YIPF6_HUMAN | [view interactions] | High throughput | no | yes |
VMP1_HUMAN | [view interactions] | High throughput | no | yes |
NTR1_HUMAN | [view interactions] | High throughput | no | no |
AQP3_HUMAN | [view interactions] | High throughput | no | no |
TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
S61A2_HUMAN | [view interactions] | High throughput | no | no |
ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PGAP4_HUMAN | [view interactions] | High throughput | no | no |
S20A1_HUMAN | [view interactions] | High throughput | no | yes |
TM209_HUMAN | [view interactions] | High throughput | no | no |
RELL2_HUMAN | [view interactions] | High throughput | no | no |
UFO_HUMAN | [view interactions] | High throughput | no | no |
ERD21_HUMAN | [view interactions] | High throughput | no | yes |
COX15_HUMAN | [view interactions] | High throughput | no | yes |
TM9S4_HUMAN | [view interactions] | High throughput | no | yes |
LGAT1_HUMAN | [view interactions] | High throughput | no | no |
K2C73_HUMAN | [view interactions] | High throughput | no | no |
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ERD23_HUMAN | [view interactions] | High throughput | no | yes |
LEG9_HUMAN | [view interactions] | High throughput | no | yes |
GPX8_HUMAN | [view interactions] | High throughput | no | no |
ACV1B_HUMAN | [view interactions] | High throughput | no | no |
VKORL_HUMAN | [view interactions] | High throughput | no | yes |
SFXN2_HUMAN | [view interactions] | High throughput | no | no |
YIPF5_HUMAN | [view interactions] | High throughput | no | yes |
EAA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SATT_HUMAN | [view interactions] | High throughput | no | no |
RIPK3_HUMAN | [view interactions] | High throughput | no | no |
TMM9B_HUMAN | [view interactions] | High throughput | no | yes |
F210A_HUMAN | [view interactions] | High throughput | no | yes |
PLCB_HUMAN | [view interactions] | High throughput | no | yes |
S15A1_HUMAN | [view interactions] | Computational | no | no |
S38A2_HUMAN | [view interactions] | Computational | no | yes |
SC6A1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
EAA4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SLC31_HUMAN | [view interactions] | Computational | no | no |