Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

HIP1R_HUMAN

Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in HIP1R_HUMAN
GO:0043168 anion binding 41.0714 4 yes
GO:0000166 nucleotide binding 32.1429 4 no
GO:0017076 purine nucleotide binding 32.1429 5 no
GO:0032555 purine ribonucleotide binding 32.1429 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.3571 4 no
GO:0030554 adenyl nucleotide binding 26.7857 6 no
GO:0032559 adenyl ribonucleotide binding 26.7857 5 no
GO:0005524 ATP binding 25.0000 5 no
GO:0003779 actin binding 16.0714 4 yes
GO:0042803 protein homodimerization activity 10.7143 4 yes
GO:0032051 clathrin light chain binding 7.1429 4 yes
GO:0035091 phosphatidylinositol binding 7.1429 4 yes
GO:0046982 protein heterodimerization activity 7.1429 4 yes
GO:1901981 phosphatidylinositol phosphate binding 7.1429 5 yes
GO:1902936 phosphatidylinositol bisphosphate binding 7.1429 6 yes
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 5.3571 5 yes
GO:0017124 SH3 domain binding 5.3571 4 yes
GO:0035615 clathrin adaptor activity 5.3571 4 yes
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 5.3571 5 yes
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 5.3571 5 yes
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 3.5714 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in HIP1R_HUMAN
GO:0051128 regulation of cellular component organization 51.7857 4 yes
GO:0048522 positive regulation of cellular process 50.0000 4 yes
GO:0048523 negative regulation of cellular process 44.6429 4 yes
GO:0060255 regulation of macromolecule metabolic process 42.8571 4 yes
GO:0022607 cellular component assembly 41.0714 4 yes
GO:0080090 regulation of primary metabolic process 41.0714 4 yes
GO:0008104 protein localization 41.0714 4 no
GO:0006996 organelle organization 39.2857 4 yes
GO:0010646 regulation of cell communication 39.2857 4 yes
GO:0031323 regulation of cellular metabolic process 35.7143 4 no
GO:0051246 regulation of protein metabolic process 33.9286 5 yes
GO:0071702 organic substance transport 33.9286 4 no
GO:0071705 nitrogen compound transport 33.9286 4 no
GO:0009966 regulation of signal transduction 32.1429 4 yes
GO:0009893 positive regulation of metabolic process 30.3571 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 30.3571 5 yes
GO:0043933 protein-containing complex organization 30.3571 4 yes
GO:0098657 import into cell 30.3571 4 yes
GO:0015031 protein transport 30.3571 4 no
GO:0033043 regulation of organelle organization 28.5714 5 yes
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0044087 regulation of cellular component biogenesis 26.7857 4 yes
GO:0048584 positive regulation of response to stimulus 26.7857 4 yes
GO:0010647 positive regulation of cell communication 25.0000 5 yes
GO:0023056 positive regulation of signaling 25.0000 4 yes
GO:0051049 regulation of transport 25.0000 4 yes
GO:0051247 positive regulation of protein metabolic process 25.0000 6 yes
GO:0006886 intracellular protein transport 25.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0009967 positive regulation of signal transduction 23.2143 5 yes
GO:0042981 regulation of apoptotic process 23.2143 5 yes
GO:0043067 regulation of programmed cell death 23.2143 4 yes
GO:0010468 regulation of gene expression 23.2143 6 no
GO:0060341 regulation of cellular localization 23.2143 4 no
GO:0051130 positive regulation of cellular component organization 21.4286 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0031325 positive regulation of cellular metabolic process 21.4286 5 no
GO:0032880 regulation of protein localization 21.4286 5 no
GO:0061024 membrane organization 19.6429 4 yes
GO:0006898 receptor-mediated endocytosis 17.8571 4 yes
GO:0051129 negative regulation of cellular component organization 17.8571 5 yes
GO:0060627 regulation of vesicle-mediated transport 17.8571 4 yes
GO:0065003 protein-containing complex assembly 17.8571 5 yes
GO:0043085 positive regulation of catalytic activity 16.0714 4 yes
GO:0043254 regulation of protein-containing complex assembly 16.0714 5 yes
GO:0051493 regulation of cytoskeleton organization 16.0714 6 yes
GO:0007015 actin filament organization 14.2857 5 yes
GO:0030100 regulation of endocytosis 14.2857 5 yes
GO:0030162 regulation of proteolysis 14.2857 6 yes
GO:0044089 positive regulation of cellular component biogenesis 14.2857 5 yes
GO:0045862 positive regulation of proteolysis 14.2857 7 yes
GO:0051050 positive regulation of transport 14.2857 4 yes
GO:0051336 regulation of hydrolase activity 14.2857 4 yes
GO:0051345 positive regulation of hydrolase activity 14.2857 5 yes
GO:0097435 supramolecular fiber organization 14.2857 4 yes
GO:1902903 regulation of supramolecular fiber organization 14.2857 5 yes
GO:0010638 positive regulation of organelle organization 12.5000 6 yes
GO:0031334 positive regulation of protein-containing complex assembly 12.5000 6 yes
GO:0032271 regulation of protein polymerization 12.5000 6 yes
GO:0032535 regulation of cellular component size 12.5000 4 yes
GO:0043066 negative regulation of apoptotic process 12.5000 6 yes
GO:0043069 negative regulation of programmed cell death 12.5000 5 yes
GO:0048268 clathrin coat assembly 12.5000 6 yes
GO:0010639 negative regulation of organelle organization 10.7143 6 yes
GO:0032970 regulation of actin filament-based process 10.7143 4 yes
GO:0051046 regulation of secretion 10.7143 5 yes
GO:0008064 regulation of actin polymerization or depolymerization 8.9286 6 yes
GO:0010821 regulation of mitochondrion organization 8.9286 6 yes
GO:0010950 positive regulation of endopeptidase activity 8.9286 7 yes
GO:0010952 positive regulation of peptidase activity 8.9286 6 yes
GO:0030832 regulation of actin filament length 8.9286 5 yes
GO:0032956 regulation of actin cytoskeleton organization 8.9286 5 yes
GO:0050821 protein stabilization 8.9286 4 yes
GO:0051494 negative regulation of cytoskeleton organization 8.9286 7 yes
GO:0052547 regulation of peptidase activity 8.9286 5 yes
GO:0052548 regulation of endopeptidase activity 8.9286 6 yes
GO:0110053 regulation of actin filament organization 8.9286 6 yes
GO:1902904 negative regulation of supramolecular fiber organization 8.9286 6 yes
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 7.1429 10 yes
GO:0007005 mitochondrion organization 7.1429 5 yes
GO:0030833 regulation of actin filament polymerization 7.1429 7 yes
GO:0042058 regulation of epidermal growth factor receptor signaling pathway 7.1429 6 yes
GO:0043065 positive regulation of apoptotic process 7.1429 6 yes
GO:0043068 positive regulation of programmed cell death 7.1429 5 yes
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 7.1429 9 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 7.1429 8 yes
GO:0044057 regulation of system process 7.1429 4 yes
GO:0048259 regulation of receptor-mediated endocytosis 7.1429 6 yes
GO:1901184 regulation of ERBB signaling pathway 7.1429 5 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 7.1429 7 yes
GO:2001056 positive regulation of cysteine-type endopeptidase activity 7.1429 8 yes
GO:0007006 mitochondrial membrane organization 5.3571 5 yes
GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 5.3571 5 yes
GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway 5.3571 6 yes
GO:0030837 negative regulation of actin filament polymerization 5.3571 7 yes
GO:0031333 negative regulation of protein-containing complex assembly 5.3571 6 yes
GO:0032272 negative regulation of protein polymerization 5.3571 7 yes
GO:0043393 regulation of protein binding 5.3571 4 yes
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 5.3571 7 yes
GO:0046902 regulation of mitochondrial membrane permeability 5.3571 4 yes
GO:0099173 postsynapse organization 5.3571 4 yes
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 5.3571 5 yes
GO:1901186 positive regulation of ERBB signaling pathway 5.3571 6 yes
GO:2000586 regulation of platelet-derived growth factor receptor-beta signaling pathway 5.3571 6 yes
GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway 5.3571 7 yes
GO:0032092 positive regulation of protein binding 3.5714 5 yes
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 3.5714 8 yes
GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation 3.5714 8 yes
GO:0035794 positive regulation of mitochondrial membrane permeability 3.5714 5 yes
GO:0044058 regulation of digestive system process 3.5714 5 yes
GO:0051099 positive regulation of binding 3.5714 4 yes
GO:0051125 regulation of actin nucleation 3.5714 7 yes
GO:0051126 negative regulation of actin nucleation 3.5714 7 yes
GO:0055123 digestive system development 3.5714 4 yes
GO:0060453 regulation of gastric acid secretion 3.5714 6 yes
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 3.5714 5 yes
GO:1905443 regulation of clathrin coat assembly 3.5714 6 yes
GO:1905445 positive regulation of clathrin coat assembly 3.5714 7 yes
GO:1905710 positive regulation of membrane permeability 3.5714 4 yes
GO:2000369 regulation of clathrin-dependent endocytosis 3.5714 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACTB_HUMAN [view entry] [view interactions] Low throughput yes no
CLCB_HUMAN [view entry] [view interactions] Low throughput yes yes
CLH1_HUMAN [view entry] [view interactions] Low throughput yes yes
HIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
SRC8_HUMAN [view entry] [view interactions] Low throughput yes yes
HIP1R_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
CLCA_HUMAN [view entry] [view interactions] Low throughput yes no
ACTS_HUMAN [view interactions] Low throughput no no
EPN1_HUMAN [view entry] [view interactions] Low throughput yes yes
TRAF4_HUMAN [view interactions] High throughput no yes
TS101_HUMAN [view entry] [view interactions] High throughput yes yes
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
I2BP1_HUMAN [view interactions] High throughput no yes
MTMR6_HUMAN [view interactions] High throughput no no
TATD1_HUMAN [view interactions] High throughput no yes
VPS28_HUMAN [view entry] [view interactions] High throughput yes yes
SYWC_HUMAN [view interactions] High throughput no yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
KCRS_HUMAN [view interactions] High throughput no no
MANBA_HUMAN [view interactions] High throughput no yes
NCAM2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
VPS8_HUMAN [view entry] [view interactions] High throughput yes yes
FYV1_HUMAN [view interactions] High throughput no no
MP2K3_HUMAN [view entry] [view interactions] High throughput yes yes
RC3H1_HUMAN [view interactions] High throughput no yes
MCCA_HUMAN [view entry] [view interactions] High throughput yes yes
RRP44_HUMAN [view interactions] High throughput no yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA1_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
CXD3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
PCNT_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
CNOT3_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
SPAST_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
ARHG1_HUMAN [view interactions] High throughput no no
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
SC24C_HUMAN [view entry] [view interactions] High throughput yes yes
GTSE1_HUMAN [view interactions] High throughput no no
PICAL_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
GAK_HUMAN [view entry] [view interactions] High throughput yes yes
CD70_HUMAN [view interactions] High throughput no no
LRFN4_HUMAN [view entry] [view interactions] High throughput yes yes
APJ_HUMAN [view interactions] High throughput no yes
S15A1_HUMAN [view interactions] High throughput no no
I13R2_HUMAN [view interactions] High throughput no no
EPHA1_HUMAN [view interactions] High throughput no yes
CMTD1_HUMAN [view entry] [view interactions] High throughput yes yes
TEX29_HUMAN [view interactions] High throughput no no
LYPD3_HUMAN [view interactions] High throughput no no
SFPQ_HUMAN [view entry] [view interactions] High throughput yes yes
PPM1A_HUMAN [view interactions] High throughput no yes
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
STALP_HUMAN [view interactions] High throughput no yes
SCN2B_HUMAN [view interactions] High throughput no no
F234B_HUMAN [view interactions] High throughput no yes
PD1L1_HUMAN [view interactions] High throughput no no
S39A9_HUMAN [view interactions] High throughput no yes
MFD4A_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
VCAM1_HUMAN [view interactions] High throughput no no
TRI63_HUMAN [view interactions] High throughput no no
WNK3_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
CD81_HUMAN [view interactions] High throughput no no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
M3K1_HUMAN [view interactions] High throughput no yes
UB2V1_HUMAN [view entry] [view interactions] High throughput yes no
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2N_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
NDC80_HUMAN [view interactions] High throughput no no
TFP11_HUMAN [view interactions] High throughput no no
TRI27_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
FINC_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
TM171_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
BOP1_HUMAN [view interactions] High throughput no yes
REPS1_HUMAN [view interactions] High throughput no yes
PPM1B_HUMAN [view interactions] High throughput no yes
AP1B1_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
TEDC2_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
SMC1A_HUMAN [view interactions] High throughput no yes
SMC3_HUMAN [view entry] [view interactions] High throughput yes yes
STAG2_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
WDR5_HUMAN [view interactions] High throughput no no
SMAD4_HUMAN [view interactions] High throughput no yes
UB2D2_HUMAN [view interactions] High throughput no yes
CKLF8_HUMAN [view interactions] High throughput no yes
PTH2R_HUMAN [view interactions] High throughput no no
CYB5B_HUMAN [view entry] [view interactions] High throughput yes yes
GTR9_HUMAN [view interactions] High throughput no no
HIDE1_HUMAN [view interactions] High throughput no no
GLSL_HUMAN [view entry] [view interactions] High throughput yes yes
CDHR2_HUMAN [view interactions] High throughput no yes
GLPA_HUMAN [view interactions] High throughput no no
2ABB_HUMAN [view interactions] High throughput no yes
KLC3_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
AQP3_HUMAN [view interactions] High throughput no no
S22A2_HUMAN [view interactions] High throughput no no
TACD2_HUMAN [view interactions] High throughput no no
OCAD1_HUMAN [view interactions] High throughput no yes
PGFRB_HUMAN [view interactions] High throughput no yes
VMAT2_HUMAN [view entry] [view interactions] High throughput yes no
LRAD1_HUMAN [view interactions] High throughput no no
STX17_HUMAN [view interactions] High throughput no yes
HUMMR_HUMAN [view interactions] High throughput no yes
FFAR1_HUMAN [view interactions] High throughput no no
EAA3_HUMAN [view entry] [view interactions] High throughput yes yes
BSND_HUMAN [view interactions] High throughput no no
SYPH_HUMAN [view entry] [view interactions] High throughput yes yes
PHF11_HUMAN [view interactions] High throughput no no
FPR1_HUMAN [view interactions] High throughput no no
TNR5_HUMAN [view interactions] High throughput no no
LRC25_HUMAN [view interactions] High throughput no yes
UPK1A_HUMAN [view interactions] High throughput no no
TYOBP_HUMAN [view interactions] High throughput no no
T150A_HUMAN [view interactions] High throughput no yes
CCR1_HUMAN [view interactions] High throughput no no
SGCA_HUMAN [view interactions] High throughput no yes
SDC2_HUMAN [view entry] [view interactions] High throughput yes yes
PAAT_HUMAN [view interactions] High throughput no yes
SSUH2_HUMAN [view interactions] High throughput no no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOF_HUMAN [view interactions] High throughput no no
YTDC1_HUMAN [view interactions] High throughput no yes
SOX2_HUMAN [view interactions] High throughput no yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
ZRAN1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
CL16A_HUMAN [view interactions] High throughput no yes
RTRAF_HUMAN [view interactions] High throughput no yes
CEP41_HUMAN [view interactions] High throughput no yes
CRKL_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
PUR2_HUMAN [view interactions] High throughput no yes
NDRG1_HUMAN [view entry] [view interactions] High throughput yes yes
PSPC1_HUMAN [view interactions] High throughput no yes
SYSC_HUMAN [view interactions] High throughput no yes