Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

HIP1R_HUMAN

Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in HIP1R_HUMAN
GO:0017076 purine nucleotide binding 25.0000 4 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0003779 actin binding 19.6429 4 yes
GO:0035091 phosphatidylinositol binding 12.5000 4 yes
GO:0042803 protein homodimerization activity 12.5000 4 yes
GO:1901981 phosphatidylinositol phosphate binding 10.7143 5 yes
GO:1902936 phosphatidylinositol bisphosphate binding 10.7143 6 yes
GO:0017124 SH3 domain binding 8.9286 4 yes
GO:0046982 protein heterodimerization activity 8.9286 4 yes
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 7.1429 4 yes
GO:0032051 clathrin light chain binding 7.1429 4 yes
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 7.1429 4 yes
GO:0035615 clathrin adaptor activity 5.3571 4 yes
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 5.3571 4 yes
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 3.5714 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in HIP1R_HUMAN
GO:0016192 vesicle-mediated transport 60.7143 4 yes
GO:0048522 positive regulation of cellular process 51.7857 4 yes
GO:0051128 regulation of cellular component organization 51.7857 4 yes
GO:0008104 protein localization 48.2143 4 no
GO:0071702 organic substance transport 48.2143 4 no
GO:0071705 nitrogen compound transport 46.4286 4 no
GO:0006996 organelle organization 44.6429 4 yes
GO:0060255 regulation of macromolecule metabolic process 42.8571 4 yes
GO:0080090 regulation of primary metabolic process 42.8571 4 yes
GO:0015031 protein transport 42.8571 4 no
GO:0022607 cellular component assembly 41.0714 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 41.0714 4 yes
GO:0048523 negative regulation of cellular process 39.2857 4 yes
GO:0006897 endocytosis 39.2857 5 yes
GO:0031323 regulation of cellular metabolic process 35.7143 4 no
GO:0009893 positive regulation of metabolic process 35.7143 4 yes
GO:0010646 regulation of cell communication 35.7143 4 yes
GO:0051049 regulation of transport 33.9286 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 33.9286 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 33.9286 5 yes
GO:0006886 intracellular protein transport 30.3571 4 no
GO:0009966 regulation of signal transduction 30.3571 4 yes
GO:0033043 regulation of organelle organization 28.5714 5 yes
GO:0043933 protein-containing complex organization 28.5714 4 yes
GO:0048584 positive regulation of response to stimulus 26.7857 4 yes
GO:0051130 positive regulation of cellular component organization 26.7857 5 yes
GO:0051246 regulation of protein metabolic process 26.7857 5 yes
GO:0031325 positive regulation of cellular metabolic process 26.7857 5 no
GO:0006898 receptor-mediated endocytosis 26.7857 6 yes
GO:0044087 regulation of cellular component biogenesis 25.0000 4 yes
GO:0023056 positive regulation of signaling 23.2143 4 yes
GO:0009889 regulation of biosynthetic process 23.2143 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.2143 5 no
GO:0010647 positive regulation of cell communication 23.2143 5 yes
GO:0010941 regulation of cell death 23.2143 4 yes
GO:0051050 positive regulation of transport 21.4286 4 yes
GO:0051247 positive regulation of protein metabolic process 21.4286 6 yes
GO:0060627 regulation of vesicle-mediated transport 21.4286 4 yes
GO:0061024 membrane organization 21.4286 4 yes
GO:0065003 protein-containing complex assembly 21.4286 5 yes
GO:0060341 regulation of cellular localization 21.4286 4 no
GO:0030030 cell projection organization 21.4286 4 no
GO:0010468 regulation of gene expression 21.4286 5 no
GO:0009967 positive regulation of signal transduction 21.4286 5 yes
GO:0030100 regulation of endocytosis 19.6429 5 yes
GO:0042981 regulation of apoptotic process 19.6429 6 yes
GO:0043067 regulation of programmed cell death 19.6429 5 yes
GO:0043085 positive regulation of catalytic activity 16.0714 4 yes
GO:0044089 positive regulation of cellular component biogenesis 16.0714 5 yes
GO:0048268 clathrin coat assembly 16.0714 6 yes
GO:0051336 regulation of hydrolase activity 16.0714 4 yes
GO:0051493 regulation of cytoskeleton organization 16.0714 6 yes
GO:0097435 supramolecular fiber organization 16.0714 4 yes
GO:0007015 actin filament organization 16.0714 5 yes
GO:0032535 regulation of cellular component size 14.2857 4 yes
GO:0032970 regulation of actin filament-based process 14.2857 4 yes
GO:0051129 negative regulation of cellular component organization 14.2857 5 yes
GO:0051345 positive regulation of hydrolase activity 14.2857 5 yes
GO:0006915 apoptotic process 14.2857 4 yes
GO:0030162 regulation of proteolysis 12.5000 6 yes
GO:0032956 regulation of actin cytoskeleton organization 12.5000 5 yes
GO:0043254 regulation of protein-containing complex assembly 12.5000 5 yes
GO:0045862 positive regulation of proteolysis 12.5000 7 yes
GO:0048259 regulation of receptor-mediated endocytosis 12.5000 6 yes
GO:1902903 regulation of supramolecular fiber organization 12.5000 5 yes
GO:0010638 positive regulation of organelle organization 12.5000 6 yes
GO:0010942 positive regulation of cell death 12.5000 5 yes
GO:0030832 regulation of actin filament length 10.7143 5 yes
GO:0032271 regulation of protein polymerization 10.7143 6 yes
GO:0043065 positive regulation of apoptotic process 10.7143 7 yes
GO:0043068 positive regulation of programmed cell death 10.7143 6 yes
GO:0051046 regulation of secretion 10.7143 5 yes
GO:0052547 regulation of peptidase activity 10.7143 5 yes
GO:0052548 regulation of endopeptidase activity 10.7143 6 yes
GO:0060548 negative regulation of cell death 10.7143 5 yes
GO:0110053 regulation of actin filament organization 10.7143 6 yes
GO:0008064 regulation of actin polymerization or depolymerization 10.7143 6 yes
GO:0010639 negative regulation of organelle organization 10.7143 6 yes
GO:0010950 positive regulation of endopeptidase activity 10.7143 7 yes
GO:0010952 positive regulation of peptidase activity 10.7143 6 yes
GO:0030833 regulation of actin filament polymerization 8.9286 7 yes
GO:0031334 positive regulation of protein-containing complex assembly 8.9286 6 yes
GO:0042058 regulation of epidermal growth factor receptor signaling pathway 8.9286 6 yes
GO:0043066 negative regulation of apoptotic process 8.9286 7 yes
GO:0043069 negative regulation of programmed cell death 8.9286 6 yes
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 8.9286 9 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 8.9286 8 yes
GO:0044057 regulation of system process 8.9286 4 yes
GO:0051494 negative regulation of cytoskeleton organization 8.9286 7 yes
GO:1901184 regulation of ERBB signaling pathway 8.9286 5 yes
GO:1902904 negative regulation of supramolecular fiber organization 8.9286 6 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 8.9286 7 yes
GO:2000369 regulation of clathrin-dependent endocytosis 8.9286 7 yes
GO:2001056 positive regulation of cysteine-type endopeptidase activity 8.9286 8 yes
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 8.9286 10 yes
GO:0010821 regulation of mitochondrion organization 8.9286 6 yes
GO:0010822 positive regulation of mitochondrion organization 7.1429 7 yes
GO:0030837 negative regulation of actin filament polymerization 5.3571 7 yes
GO:0031333 negative regulation of protein-containing complex assembly 5.3571 6 yes
GO:0032272 negative regulation of protein polymerization 5.3571 7 yes
GO:0043393 regulation of protein binding 5.3571 4 yes
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 5.3571 7 yes
GO:0050821 protein stabilization 5.3571 4 yes
GO:1901186 positive regulation of ERBB signaling pathway 5.3571 6 yes
GO:2000586 regulation of platelet-derived growth factor receptor-beta signaling pathway 5.3571 6 yes
GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway 5.3571 7 yes
GO:0007005 mitochondrion organization 5.3571 5 yes
GO:0007006 mitochondrial membrane organization 5.3571 5 yes
GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 5.3571 5 yes
GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway 5.3571 6 yes
GO:0032092 positive regulation of protein binding 3.5714 5 yes
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 3.5714 8 yes
GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation 3.5714 8 yes
GO:0035794 positive regulation of mitochondrial membrane permeability 3.5714 5 yes
GO:0044058 regulation of digestive system process 3.5714 5 yes
GO:0046902 regulation of mitochondrial membrane permeability 3.5714 4 yes
GO:0051099 positive regulation of binding 3.5714 4 yes
GO:0051125 regulation of actin nucleation 3.5714 7 yes
GO:0051126 negative regulation of actin nucleation 3.5714 7 yes
GO:0055123 digestive system development 3.5714 4 yes
GO:0060453 regulation of gastric acid secretion 3.5714 6 yes
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 3.5714 5 yes
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 3.5714 5 yes
GO:1905443 regulation of clathrin coat assembly 3.5714 6 yes
GO:1905445 positive regulation of clathrin coat assembly 3.5714 7 yes
GO:1905710 positive regulation of membrane permeability 3.5714 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CLCA_HUMAN [view entry] [view interactions] Low throughput yes no
ACTS_HUMAN [view interactions] Low throughput no no
EPN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTB_HUMAN [view entry] [view interactions] Low throughput yes no
CLCB_HUMAN [view entry] [view interactions] Low throughput yes yes
CLH1_HUMAN [view entry] [view interactions] Low throughput yes yes
HIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
SRC8_HUMAN [view entry] [view interactions] Low throughput yes yes
HIP1R_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
FFAR1_HUMAN [view interactions] High throughput no no
EAA3_HUMAN [view entry] [view interactions] High throughput yes yes
BSND_HUMAN [view interactions] High throughput no no
SYPH_HUMAN [view entry] [view interactions] High throughput yes yes
PHF11_HUMAN [view interactions] High throughput no no
FPR1_HUMAN [view interactions] High throughput no no
TNR5_HUMAN [view interactions] High throughput no no
LRC25_HUMAN [view interactions] High throughput no yes
UPK1A_HUMAN [view interactions] High throughput no no
TYOBP_HUMAN [view interactions] High throughput no no
T150A_HUMAN [view interactions] High throughput no yes
CCR1_HUMAN [view interactions] High throughput no no
SGCA_HUMAN [view interactions] High throughput no yes
SDC2_HUMAN [view interactions] High throughput no yes
PAAT_HUMAN [view interactions] High throughput no yes
SSUH2_HUMAN [view interactions] High throughput no no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOF_HUMAN [view interactions] High throughput no no
YTDC1_HUMAN [view interactions] High throughput no yes
RTRAF_HUMAN [view interactions] High throughput no yes
CEP41_HUMAN [view interactions] High throughput no yes
CRKL_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
PUR2_HUMAN [view interactions] High throughput no yes
NDRG1_HUMAN [view entry] [view interactions] High throughput yes yes
PSPC1_HUMAN [view interactions] High throughput no yes
SYSC_HUMAN [view interactions] High throughput no yes
TRAF4_HUMAN [view interactions] High throughput no yes
TS101_HUMAN [view entry] [view interactions] High throughput yes yes
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
I2BP1_HUMAN [view interactions] High throughput no yes
MTMR6_HUMAN [view interactions] High throughput no no
TATD1_HUMAN [view interactions] High throughput no yes
VPS28_HUMAN [view entry] [view interactions] High throughput yes yes
SYWC_HUMAN [view interactions] High throughput no yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
KCRS_HUMAN [view interactions] High throughput no no
MANBA_HUMAN [view interactions] High throughput no yes
NCAM2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
VPS8_HUMAN [view entry] [view interactions] High throughput yes yes
FYV1_HUMAN [view interactions] High throughput no no
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA1_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
CXD3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
PCNT_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG1_HUMAN [view interactions] High throughput no no
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
SC24C_HUMAN [view entry] [view interactions] High throughput yes yes
GTSE1_HUMAN [view interactions] High throughput no no
PICAL_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
GAK_HUMAN [view entry] [view interactions] High throughput yes yes
CD70_HUMAN [view interactions] High throughput no no
LRFN4_HUMAN [view entry] [view interactions] High throughput yes yes
APJ_HUMAN [view interactions] High throughput no yes
S15A1_HUMAN [view interactions] High throughput no no
I13R2_HUMAN [view interactions] High throughput no no
EPHA1_HUMAN [view interactions] High throughput no yes
CMTD1_HUMAN [view entry] [view interactions] High throughput yes yes
TEX29_HUMAN [view interactions] High throughput no no
LYPD3_HUMAN [view interactions] High throughput no no
PPM1A_HUMAN [view interactions] High throughput no yes
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
SFPQ_HUMAN [view entry] [view interactions] High throughput yes yes
STALP_HUMAN [view interactions] High throughput no yes
SCN2B_HUMAN [view interactions] High throughput no no
F234B_HUMAN [view interactions] High throughput no yes
PD1L1_HUMAN [view interactions] High throughput no no
S39A9_HUMAN [view interactions] High throughput no yes
MFD4A_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
VCAM1_HUMAN [view interactions] High throughput no no
TRI63_HUMAN [view interactions] High throughput no no
WNK3_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
CD81_HUMAN [view interactions] High throughput no no
M3K1_HUMAN [view interactions] High throughput no yes
UB2V1_HUMAN [view entry] [view interactions] High throughput yes no
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2N_HUMAN [view entry] [view interactions] High throughput yes yes
NDC80_HUMAN [view interactions] High throughput no no
TFP11_HUMAN [view interactions] High throughput no no
TRI27_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
FINC_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
TM171_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
BOP1_HUMAN [view interactions] High throughput no yes
REPS1_HUMAN [view interactions] High throughput no yes
PPM1B_HUMAN [view interactions] High throughput no yes
AP1B1_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
TEDC2_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
SMC1A_HUMAN [view interactions] High throughput no yes
SMC3_HUMAN [view entry] [view interactions] High throughput yes yes
STAG2_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
WDR5_HUMAN [view interactions] High throughput no no
SMAD4_HUMAN [view interactions] High throughput no yes
UB2D2_HUMAN [view interactions] High throughput no yes
CKLF8_HUMAN [view interactions] High throughput no yes
PTH2R_HUMAN [view interactions] High throughput no no
CYB5B_HUMAN [view entry] [view interactions] High throughput yes yes
GTR9_HUMAN [view interactions] High throughput no no
HIDE1_HUMAN [view interactions] High throughput no no
GLSL_HUMAN [view entry] [view interactions] High throughput yes yes
CDHR2_HUMAN [view interactions] High throughput no yes
GLPA_HUMAN [view interactions] High throughput no no
2ABB_HUMAN [view interactions] High throughput no yes
KLC3_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
AQP3_HUMAN [view interactions] High throughput no no
S22A2_HUMAN [view interactions] High throughput no no
TACD2_HUMAN [view interactions] High throughput no no
OCAD1_HUMAN [view interactions] High throughput no yes
PGFRB_HUMAN [view interactions] High throughput no yes
VMAT2_HUMAN [view entry] [view interactions] High throughput yes no
LRAD1_HUMAN [view interactions] High throughput no no
STX17_HUMAN [view interactions] High throughput no yes
HUMMR_HUMAN [view interactions] High throughput no yes
CBPD_HUMAN [view interactions] Computational no yes
SLAP2_HUMAN [view interactions] Computational no no
YIPF6_HUMAN [view interactions] Computational no yes
DYN2_HUMAN [view entry] [view interactions] Computational yes yes
HD_HUMAN [view entry] [view interactions] Computational yes yes
AP3B1_HUMAN [view entry] [view interactions] Computational yes yes
HCLS1_HUMAN [view interactions] Computational no no
ARP2_HUMAN [view entry] [view interactions] Computational yes yes
SORT_HUMAN [view interactions] Computational no yes
SNAPN_HUMAN [view interactions] Computational no yes
SNX2_HUMAN [view entry] [view interactions] Computational yes no
SNX5_HUMAN [view entry] [view interactions] Computational yes yes
AP180_HUMAN [view entry] [view interactions] Computational yes yes
AP4E1_HUMAN [view interactions] Computational no no
AP4B1_HUMAN [view interactions] Computational no yes
AP3S1_HUMAN [view entry] [view interactions] Computational yes no
AUXI_HUMAN [view entry] [view interactions] Computational yes yes
P3C2A_HUMAN [view interactions] Computational no yes
DBNL_HUMAN [view entry] [view interactions] Computational yes yes