VPS8_HUMAN
Evidence for PS localization
Functions
Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed). Functions predominantly in APPL1-containing endosomes (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VPS8_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 36.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 36.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.0000 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 32.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 32.0000 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 32.0000 | 6 | no |
| GO:0046872 | metal ion binding | 28.0000 | 4 | yes |
| GO:0003924 | GTPase activity | 24.0000 | 7 | no |
| GO:0005525 | GTP binding | 24.0000 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 24.0000 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 24.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VPS8_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 68.0000 | 4 | yes |
| GO:0006996 | organelle organization | 64.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 64.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 64.0000 | 4 | yes |
| GO:0015031 | protein transport | 60.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 56.0000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 56.0000 | 4 | no |
| GO:0006886 | intracellular protein transport | 52.0000 | 4 | no |
| GO:0016050 | vesicle organization | 44.0000 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 44.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 44.0000 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 40.0000 | 4 | no |
| GO:0048284 | organelle fusion | 36.0000 | 5 | yes |
| GO:0061024 | membrane organization | 36.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 36.0000 | 4 | no |
| GO:0007034 | vacuolar transport | 32.0000 | 4 | no |
| GO:0007041 | lysosomal transport | 32.0000 | 5 | no |
| GO:0006906 | vesicle fusion | 28.0000 | 6 | yes |
| GO:0061025 | membrane fusion | 28.0000 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 28.0000 | 6 | yes |
| GO:0051050 | positive regulation of transport | 28.0000 | 4 | no |
| GO:0008333 | endosome to lysosome transport | 28.0000 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 24.0000 | 4 | no |
| GO:0006897 | endocytosis | 24.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 24.0000 | 4 | no |
| GO:0030100 | regulation of endocytosis | 24.0000 | 5 | no |
| GO:0016197 | endosomal transport | 24.0000 | 4 | no |
| GO:0034058 | endosomal vesicle fusion | 20.0000 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in VPS8_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 8.0000 | 3 | no |
| DOID:936 | brain disease | 8.0000 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RAB5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TGFA1_HUMAN | [view interactions] | Low throughput | no | no |
| VPS11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS18_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD9_HUMAN | [view interactions] | High throughput | no | yes |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| SIGL1_HUMAN | [view interactions] | High throughput | no | no |
| PE2R3_HUMAN | [view interactions] | High throughput | no | no |
| FZD10_HUMAN | [view interactions] | High throughput | no | no |
| KIF2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| PNKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| VPS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF22_HUMAN | [view interactions] | High throughput | no | no |
| UXS1_HUMAN | [view interactions] | High throughput | no | yes |
| EDNRB_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| BTNL9_HUMAN | [view interactions] | High throughput | no | no |
| V2R_HUMAN | [view interactions] | High throughput | no | no |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| FAXC_HUMAN | [view interactions] | High throughput | no | no |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| GLR_HUMAN | [view interactions] | High throughput | no | no |
| HCST_HUMAN | [view interactions] | High throughput | no | no |
| KI2L4_HUMAN | [view interactions] | High throughput | no | no |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| HIDE1_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C5AR1_HUMAN | [view interactions] | High throughput | no | yes |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| MTLR_HUMAN | [view interactions] | High throughput | no | no |
| RUSF1_HUMAN | [view interactions] | High throughput | no | yes |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| CMTD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTK_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| TCP4_HUMAN | [view interactions] | High throughput | no | yes |
| IPRI_HUMAN | [view interactions] | High throughput | no | no |
| H2A2A_HUMAN | [view interactions] | High throughput | no | yes |
| CLCN5_HUMAN | [view interactions] | High throughput | no | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS41_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VPS36_HUMAN | [view interactions] | Computational | no | yes |
| VP33B_HUMAN | [view interactions] | Computational | no | yes |
| SPE39_HUMAN | [view interactions] | Computational | no | yes |
| VPS39_HUMAN | [view entry] [view interactions] | Computational | yes | no |