Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

VPS8_HUMAN

Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed). Functions predominantly in APPL1-containing endosomes (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in VPS8_HUMAN
GO:0000166 nucleotide binding 41.6667 4 no
GO:0043168 anion binding 41.6667 4 no
GO:0016462 pyrophosphatase activity 37.5000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 37.5000 4 no
GO:0017076 purine nucleotide binding 37.5000 5 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 37.5000 6 no
GO:0032555 purine ribonucleotide binding 37.5000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0043169 cation binding 25.0000 4 yes
GO:0046872 metal ion binding 25.0000 5 yes
GO:0003924 GTPase activity 25.0000 7 no
GO:0005525 GTP binding 25.0000 5 no
GO:0019001 guanyl nucleotide binding 25.0000 6 no
GO:0032561 guanyl ribonucleotide binding 25.0000 5 no
GO:0019003 GDP binding 20.8333 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in VPS8_HUMAN
GO:0006996 organelle organization 62.5000 4 yes
GO:0008104 protein localization 62.5000 4 yes
GO:0051128 regulation of cellular component organization 58.3333 4 yes
GO:0071702 organic substance transport 58.3333 4 yes
GO:0071705 nitrogen compound transport 58.3333 4 yes
GO:0015031 protein transport 54.1667 4 yes
GO:0051049 regulation of transport 54.1667 4 no
GO:0006886 intracellular protein transport 50.0000 4 yes
GO:0016050 vesicle organization 45.8333 5 yes
GO:0048522 positive regulation of cellular process 45.8333 4 no
GO:0061024 membrane organization 41.6667 4 yes
GO:0044087 regulation of cellular component biogenesis 37.5000 4 yes
GO:0060627 regulation of vesicle-mediated transport 37.5000 4 no
GO:0010646 regulation of cell communication 37.5000 4 no
GO:0006906 vesicle fusion 33.3333 6 yes
GO:0048284 organelle fusion 33.3333 5 yes
GO:0061025 membrane fusion 33.3333 5 yes
GO:0090174 organelle membrane fusion 33.3333 6 yes
GO:0007034 vacuolar transport 29.1667 4 yes
GO:0051050 positive regulation of transport 29.1667 4 no
GO:0034058 endosomal vesicle fusion 25.0000 7 yes
GO:0043254 regulation of protein-containing complex assembly 25.0000 5 yes
GO:0007041 lysosomal transport 25.0000 5 no
GO:0098657 import into cell 25.0000 4 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0035542 regulation of SNARE complex assembly 20.8333 6 yes
GO:0007033 vacuole organization 20.8333 5 no
GO:0043933 protein-containing complex organization 20.8333 4 no
GO:0033043 regulation of organelle organization 20.8333 5 no
GO:0050804 modulation of chemical synaptic transmission 20.8333 5 no
GO:0051046 regulation of secretion 20.8333 5 no
GO:0099177 regulation of trans-synaptic signaling 20.8333 4 no
GO:0022607 cellular component assembly 20.8333 4 no
GO:0060255 regulation of macromolecule metabolic process 20.8333 4 no
GO:0080090 regulation of primary metabolic process 20.8333 4 no
GO:0048523 negative regulation of cellular process 20.8333 4 no
GO:0032880 regulation of protein localization 20.8333 5 no
GO:0060341 regulation of cellular localization 20.8333 4 no
GO:0007032 endosome organization 20.8333 6 no
GO:0033365 protein localization to organelle 16.6667 5 yes
GO:0072594 establishment of protein localization to organelle 12.5000 4 yes
GO:0006605 protein targeting 8.3333 4 yes
GO:0006623 protein targeting to vacuole 8.3333 5 yes
GO:0072665 protein localization to vacuole 8.3333 6 yes
GO:0072666 establishment of protein localization to vacuole 8.3333 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RAB5C_HUMAN [view entry] [view interactions] Low throughput yes yes
TGFA1_HUMAN [view interactions] Low throughput no no
VPS11_HUMAN [view entry] [view interactions] Low throughput yes no
VPS18_HUMAN [view entry] [view interactions] Low throughput yes no
SMAD9_HUMAN [view interactions] High throughput no yes
SPTCS_HUMAN [view interactions] High throughput no yes
VIPR2_HUMAN [view interactions] High throughput no no
SIGL1_HUMAN [view interactions] High throughput no no
PE2R3_HUMAN [view interactions] High throughput no no
FZD10_HUMAN [view interactions] High throughput no no
KIF2B_HUMAN [view entry] [view interactions] High throughput yes yes
P2RY6_HUMAN [view interactions] High throughput no no
UN93B_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
PNKD_HUMAN [view entry] [view interactions] High throughput yes yes
AL3A2_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
VPS16_HUMAN [view entry] [view interactions] High throughput yes yes
KINH_HUMAN [view entry] [view interactions] High throughput yes no
KIF22_HUMAN [view interactions] High throughput no no
UXS1_HUMAN [view interactions] High throughput no yes
EDNRB_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
BTNL9_HUMAN [view interactions] High throughput no no
V2R_HUMAN [view interactions] High throughput no no
GLPA_HUMAN [view interactions] High throughput no no
FAXC_HUMAN [view interactions] High throughput no no
FPR1_HUMAN [view interactions] High throughput no no
GLR_HUMAN [view interactions] High throughput no no
HCST_HUMAN [view interactions] High throughput no no
KI2L4_HUMAN [view interactions] High throughput no no
EFNB1_HUMAN [view interactions] High throughput no yes
HIDE1_HUMAN [view interactions] High throughput no no
GPR17_HUMAN [view interactions] High throughput no no
CYB5B_HUMAN [view entry] [view interactions] High throughput yes yes
C5AR1_HUMAN [view interactions] High throughput no yes
CC018_HUMAN [view interactions] High throughput no yes
MTLR_HUMAN [view interactions] High throughput no no
RUSF1_HUMAN [view interactions] High throughput no yes
GPR45_HUMAN [view interactions] High throughput no no
CMTD1_HUMAN [view entry] [view interactions] High throughput yes yes
TTK_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
H2B1C_HUMAN [view interactions] High throughput no yes
TCP4_HUMAN [view interactions] High throughput no yes
IPRI_HUMAN [view interactions] High throughput no no
H2A2A_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
CLCN5_HUMAN [view interactions] High throughput no yes
HIP1R_HUMAN [view entry] [view interactions] High throughput yes yes
MDR1_HUMAN [view entry] [view interactions] High throughput yes no
RAB5B_HUMAN [view entry] [view interactions] High throughput yes yes
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB9A_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
ATG9A_HUMAN [view interactions] High throughput no yes
RAB25_HUMAN [view interactions] High throughput no no