KIF2B_HUMAN
Evidence for PS localization
Functions
Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed). Plays a role in chromosome congression (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KIF2B_HUMAN |
|---|---|---|---|---|
| GO:0005524 | ATP binding | 36.3636 | 5 | yes |
| GO:0008017 | microtubule binding | 36.3636 | 5 | yes |
| GO:0015631 | tubulin binding | 36.3636 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 36.3636 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 36.3636 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 36.3636 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 36.3636 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.3636 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 27.2727 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 27.2727 | 4 | yes |
| GO:0016887 | ATP hydrolysis activity | 27.2727 | 7 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 27.2727 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KIF2B_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 54.5455 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 54.5455 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 36.3636 | 5 | yes |
| GO:0022411 | cellular component disassembly | 36.3636 | 4 | yes |
| GO:0032984 | protein-containing complex disassembly | 36.3636 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 36.3636 | 4 | yes |
| GO:0008104 | protein localization | 36.3636 | 4 | no |
| GO:0022607 | cellular component assembly | 36.3636 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 36.3636 | 4 | no |
| GO:0048878 | chemical homeostasis | 36.3636 | 4 | no |
| GO:0007019 | microtubule depolymerization | 27.2727 | 5 | yes |
| GO:0031109 | microtubule polymerization or depolymerization | 27.2727 | 4 | yes |
| GO:0051261 | protein depolymerization | 27.2727 | 6 | yes |
| GO:0015031 | protein transport | 27.2727 | 4 | no |
| GO:0071702 | organic substance transport | 27.2727 | 4 | no |
| GO:0071705 | nitrogen compound transport | 27.2727 | 4 | no |
| GO:0010646 | regulation of cell communication | 27.2727 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 27.2727 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.2727 | 4 | no |
| GO:0051303 | establishment of chromosome localization | 18.1818 | 4 | yes |
| GO:0051310 | metaphase plate congression | 18.1818 | 5 | yes |
| GO:0051983 | regulation of chromosome segregation | 18.1818 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CDC23_HUMAN | [view interactions] | High throughput | no | yes |
| COMD3_HUMAN | [view interactions] | High throughput | no | yes |
| COMD8_HUMAN | [view interactions] | High throughput | no | yes |
| TXLNG_HUMAN | [view interactions] | High throughput | no | no |
| SAV1_HUMAN | [view interactions] | High throughput | no | yes |
| APC16_HUMAN | [view interactions] | High throughput | no | yes |
| CDC26_HUMAN | [view interactions] | High throughput | no | yes |
| COMD1_HUMAN | [view interactions] | High throughput | no | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI18B_HUMAN | [view interactions] | High throughput | no | no |
| COMD2_HUMAN | [view interactions] | High throughput | no | yes |
| TM164_HUMAN | [view interactions] | High throughput | no | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| CCD93_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD046_HUMAN | [view interactions] | High throughput | no | no |
| STK3_HUMAN | [view interactions] | High throughput | no | yes |
| RPB11_HUMAN | [view interactions] | High throughput | no | no |
| TXLNA_HUMAN | [view interactions] | High throughput | no | yes |
| CDC27_HUMAN | [view interactions] | High throughput | no | yes |
| CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DAPK3_HUMAN | [view interactions] | High throughput | no | yes |
| BACH1_HUMAN | [view interactions] | High throughput | no | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| H15_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SIKE1_HUMAN | [view interactions] | High throughput | no | yes |
| C170B_HUMAN | [view interactions] | High throughput | no | yes |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC16_HUMAN | [view interactions] | High throughput | no | yes |
| STK4_HUMAN | [view interactions] | High throughput | no | yes |
| CF410_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WDR62_HUMAN | [view interactions] | High throughput | no | no |
| COMD6_HUMAN | [view interactions] | High throughput | no | no |
| NEK1_HUMAN | [view interactions] | High throughput | no | yes |
| RUNX1_HUMAN | [view interactions] | High throughput | no | yes |
| ACBG2_HUMAN | [view interactions] | High throughput | no | no |
| ZG16B_HUMAN | [view interactions] | High throughput | no | no |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPC25_HUMAN | [view interactions] | High throughput | no | no |
| DSN1_HUMAN | [view interactions] | High throughput | no | yes |
| MIS12_HUMAN | [view interactions] | High throughput | no | yes |
| SPC24_HUMAN | [view interactions] | High throughput | no | no |
| ANR52_HUMAN | [view interactions] | High throughput | no | yes |
| ASB6_HUMAN | [view interactions] | High throughput | no | yes |
| VPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FEM1B_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CENPE_HUMAN | [view interactions] | Computational | no | no |
| CLAP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KI18A_HUMAN | [view interactions] | Computational | no | yes |