HOME1_HUMAN
Evidence for PS localization
Functions
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines . Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in HOME1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 26.7442 | 4 | no |
| GO:0043169 | cation binding | 25.5814 | 4 | no |
| GO:0046872 | metal ion binding | 25.5814 | 5 | no |
| GO:0003779 | actin binding | 24.4186 | 4 | no |
| GO:0019900 | kinase binding | 24.4186 | 4 | no |
| GO:0019901 | protein kinase binding | 22.0930 | 5 | no |
| GO:0001664 | G protein-coupled receptor binding | 12.7907 | 4 | yes |
| GO:0035254 | glutamate receptor binding | 12.7907 | 4 | yes |
| GO:0035256 | G protein-coupled glutamate receptor binding | 6.9767 | 5 | yes |
| GO:0031802 | type 5 metabotropic glutamate receptor binding | 4.6512 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in HOME1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 69.7674 | 4 | yes |
| GO:0010646 | regulation of cell communication | 59.3023 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 52.3256 | 4 | no |
| GO:0009966 | regulation of signal transduction | 47.6744 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 45.3488 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 45.3488 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.3488 | 4 | no |
| GO:0006996 | organelle organization | 39.5349 | 4 | no |
| GO:0022607 | cellular component assembly | 38.3721 | 4 | yes |
| GO:0051049 | regulation of transport | 38.3721 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 38.3721 | 4 | no |
| GO:0008104 | protein localization | 33.7209 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 32.5581 | 4 | no |
| GO:0030030 | cell projection organization | 32.5581 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 31.3953 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 31.3953 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 31.3953 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 30.2326 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 30.2326 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.0698 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 29.0698 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.9070 | 5 | no |
| GO:0043269 | regulation of monoatomic ion transport | 26.7442 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 26.7442 | 4 | yes |
| GO:0051050 | positive regulation of transport | 26.7442 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 26.7442 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.7442 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 26.7442 | 4 | no |
| GO:0031399 | regulation of protein modification process | 25.5814 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.5814 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 25.5814 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.5814 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 24.4186 | 7 | no |
| GO:0010468 | regulation of gene expression | 24.4186 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.4186 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.4186 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 23.2558 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 23.2558 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 23.2558 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 23.2558 | 5 | no |
| GO:0010959 | regulation of metal ion transport | 22.0930 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 22.0930 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.0930 | 6 | yes |
| GO:0001932 | regulation of protein phosphorylation | 22.0930 | 7 | no |
| GO:0044057 | regulation of system process | 22.0930 | 4 | no |
| GO:0034330 | cell junction organization | 22.0930 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.9302 | 4 | no |
| GO:0033043 | regulation of organelle organization | 20.9302 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.9302 | 5 | no |
| GO:0060341 | regulation of cellular localization | 20.9302 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 20.9302 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.9302 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.9302 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.9302 | 5 | no |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 19.7674 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 18.6047 | 5 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 18.6047 | 6 | yes |
| GO:0051924 | regulation of calcium ion transport | 17.4419 | 7 | yes |
| GO:0065003 | protein-containing complex assembly | 17.4419 | 5 | yes |
| GO:0043270 | positive regulation of monoatomic ion transport | 16.2791 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 16.2791 | 6 | yes |
| GO:0099175 | regulation of postsynapse organization | 16.2791 | 6 | yes |
| GO:0099536 | synaptic signaling | 16.2791 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 16.2791 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 16.2791 | 7 | yes |
| GO:0010038 | response to metal ion | 15.1163 | 4 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 15.1163 | 4 | yes |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 13.9535 | 5 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 11.6279 | 6 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 11.6279 | 4 | yes |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 10.4651 | 6 | yes |
| GO:1902414 | protein localization to cell junction | 10.4651 | 5 | yes |
| GO:0035418 | protein localization to synapse | 9.3023 | 6 | yes |
| GO:0051592 | response to calcium ion | 9.3023 | 5 | yes |
| GO:0051259 | protein complex oligomerization | 8.1395 | 6 | yes |
| GO:2001257 | regulation of cation channel activity | 6.9767 | 6 | yes |
| GO:0007216 | G protein-coupled glutamate receptor signaling pathway | 6.9767 | 4 | yes |
| GO:0051262 | protein tetramerization | 5.8140 | 7 | yes |
| GO:0006936 | muscle contraction | 5.8140 | 4 | yes |
| GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | 5.8140 | 4 | yes |
| GO:0090279 | regulation of calcium ion import | 4.6512 | 8 | yes |
| GO:1902950 | regulation of dendritic spine maintenance | 4.6512 | 7 | yes |
| GO:2001256 | regulation of store-operated calcium entry | 4.6512 | 8 | yes |
| GO:0006941 | striated muscle contraction | 4.6512 | 5 | yes |
| GO:0007206 | phospholipase C-activating G protein-coupled glutamate receptor signaling pathway | 4.6512 | 5 | yes |
| GO:0014904 | myotube cell development | 3.4884 | 5 | yes |
| GO:0048148 | behavioral response to cocaine | 3.4884 | 4 | yes |
| GO:0048741 | skeletal muscle fiber development | 3.4884 | 6 | yes |
| GO:0055001 | muscle cell development | 3.4884 | 4 | yes |
| GO:0003009 | skeletal muscle contraction | 2.3256 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RYR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IQEC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DYN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FRPD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAT1_HUMAN | [view interactions] | Low throughput | no | yes |
| SHAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BSN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RYR1_HUMAN | [view interactions] | Low throughput | no | no |
| ITPR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HOME1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRID2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TANC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IFT20_HUMAN | [view interactions] | High throughput | no | yes |
| KPRA_HUMAN | [view interactions] | High throughput | no | no |
| STXB4_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD6_HUMAN | [view interactions] | High throughput | no | no |
| MATN2_HUMAN | [view interactions] | High throughput | no | no |
| MYPN_HUMAN | [view interactions] | High throughput | no | no |
| ADIPO_HUMAN | [view interactions] | High throughput | no | no |
| PALLD_HUMAN | [view interactions] | High throughput | no | yes |
| BORG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASTRB_HUMAN | [view interactions] | High throughput | no | yes |
| SGF29_HUMAN | [view interactions] | High throughput | no | yes |
| RABE2_HUMAN | [view interactions] | High throughput | no | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN207_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HOME3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| LMA2L_HUMAN | [view interactions] | High throughput | no | yes |
| CTIP_HUMAN | [view interactions] | High throughput | no | no |
| FRYL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF3B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CEP44_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFT57_HUMAN | [view interactions] | High throughput | no | yes |
| EMIL1_HUMAN | [view interactions] | High throughput | no | no |
| TCP1L_HUMAN | [view interactions] | High throughput | no | no |
| CSPP1_HUMAN | [view interactions] | High throughput | no | no |
| MS18A_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF5_HUMAN | [view interactions] | High throughput | no | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EF1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTBL_HUMAN | [view interactions] | High throughput | no | no |
| FBX28_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYCE3_HUMAN | [view interactions] | High throughput | no | no |
| CEP72_HUMAN | [view interactions] | High throughput | no | yes |
| GRM2B_HUMAN | [view interactions] | High throughput | no | yes |
| COL12_HUMAN | [view interactions] | High throughput | no | no |
| HXB2_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTN4_HUMAN | [view interactions] | High throughput | no | no |
| CYH3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOCK7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EFHD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GIPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LZTS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K5_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCDN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2BA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TENR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RO52_HUMAN | [view interactions] | High throughput | no | yes |
| WASF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| BRME1_HUMAN | [view interactions] | High throughput | no | yes |
| SARG_HUMAN | [view interactions] | High throughput | no | yes |
| NUP54_HUMAN | [view interactions] | High throughput | no | yes |
| RASL3_HUMAN | [view interactions] | High throughput | no | no |
| SYCE2_HUMAN | [view interactions] | High throughput | no | no |
| ABI3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARIP4_HUMAN | [view interactions] | High throughput | no | yes |
| FAM9A_HUMAN | [view interactions] | High throughput | no | no |
| CENPQ_HUMAN | [view interactions] | High throughput | no | yes |
| CDC16_HUMAN | [view interactions] | High throughput | no | yes |
| KDM4C_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PIAS2_HUMAN | [view interactions] | High throughput | no | yes |
| INADL_HUMAN | [view interactions] | High throughput | no | no |
| ZMYM5_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCSD2_HUMAN | [view interactions] | High throughput | no | no |
| AIMP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRPC5_HUMAN | [view interactions] | High throughput | no | no |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HOME2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
| MPZL1_HUMAN | [view interactions] | High throughput | no | yes |
| COBL1_HUMAN | [view interactions] | High throughput | no | yes |
| PSRC1_HUMAN | [view interactions] | High throughput | no | no |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXNIP_HUMAN | [view interactions] | High throughput | no | no |
| RNF41_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CNBP_HUMAN | [view interactions] | High throughput | no | no |
| SPOPL_HUMAN | [view interactions] | High throughput | no | yes |