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HOME1_HUMAN

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines . Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in HOME1_HUMAN
GO:0003779 actin binding 25.2874 4 no
GO:0046872 metal ion binding 24.1379 4 no
GO:0019900 kinase binding 21.8391 4 no
GO:0001664 G protein-coupled receptor binding 12.6437 4 yes
GO:0035254 glutamate receptor binding 12.6437 4 yes
GO:0035256 G protein-coupled glutamate receptor binding 8.0460 5 yes
GO:0031802 type 5 metabotropic glutamate receptor binding 4.5977 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in HOME1_HUMAN
GO:0048522 positive regulation of cellular process 65.5172 4 yes
GO:0010646 regulation of cell communication 62.0690 4 yes
GO:0048523 negative regulation of cellular process 51.7241 4 no
GO:0009966 regulation of signal transduction 44.8276 4 yes
GO:0051128 regulation of cellular component organization 43.6782 4 yes
GO:0060255 regulation of macromolecule metabolic process 41.3793 4 no
GO:0006996 organelle organization 39.0805 4 no
GO:0031323 regulation of cellular metabolic process 37.9310 4 no
GO:0008104 protein localization 36.7816 4 yes
GO:0051049 regulation of transport 36.7816 4 yes
GO:0050804 modulation of chemical synaptic transmission 35.6322 5 yes
GO:0099177 regulation of trans-synaptic signaling 35.6322 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 35.6322 4 no
GO:0080090 regulation of primary metabolic process 35.6322 4 no
GO:0022607 cellular component assembly 33.3333 4 yes
GO:0030030 cell projection organization 31.0345 4 no
GO:0009893 positive regulation of metabolic process 29.8851 4 no
GO:0051246 regulation of protein metabolic process 29.8851 5 no
GO:1902531 regulation of intracellular signal transduction 27.5862 5 no
GO:0043269 regulation of ion transport 26.4368 5 yes
GO:0009892 negative regulation of metabolic process 26.4368 4 no
GO:0051050 positive regulation of transport 25.2874 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 25.2874 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.2874 5 no
GO:0120036 plasma membrane bounded cell projection organization 25.2874 5 no
GO:0010647 positive regulation of cell communication 24.1379 5 yes
GO:0031325 positive regulation of cellular metabolic process 24.1379 5 no
GO:0033043 regulation of organelle organization 24.1379 5 no
GO:0019220 regulation of phosphate metabolic process 24.1379 6 no
GO:0051174 regulation of phosphorus metabolic process 24.1379 5 no
GO:0007010 cytoskeleton organization 24.1379 5 no
GO:0023056 positive regulation of signaling 22.9885 4 yes
GO:0031344 regulation of cell projection organization 22.9885 5 yes
GO:0044057 regulation of system process 22.9885 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.9885 6 yes
GO:0010468 regulation of gene expression 22.9885 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.9885 5 no
GO:0071702 organic substance transport 22.9885 4 no
GO:0071705 nitrogen compound transport 22.9885 4 no
GO:0044087 regulation of cellular component biogenesis 22.9885 4 no
GO:0031399 regulation of protein modification process 22.9885 6 no
GO:0010648 negative regulation of cell communication 21.8391 5 no
GO:0023057 negative regulation of signaling 21.8391 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 21.8391 5 no
GO:0032970 regulation of actin filament-based process 21.8391 4 no
GO:0051493 regulation of cytoskeleton organization 21.8391 6 no
GO:0042325 regulation of phosphorylation 21.8391 7 no
GO:0034330 cell junction organization 21.8391 4 no
GO:0022603 regulation of anatomical structure morphogenesis 20.6897 4 no
GO:0031324 negative regulation of cellular metabolic process 20.6897 5 no
GO:0036211 protein modification process 20.6897 4 no
GO:0043412 macromolecule modification 20.6897 4 no
GO:0032956 regulation of actin cytoskeleton organization 20.6897 5 no
GO:0043085 positive regulation of catalytic activity 20.6897 4 no
GO:0051248 negative regulation of protein metabolic process 20.6897 6 no
GO:1902903 regulation of supramolecular fiber organization 20.6897 5 no
GO:0010959 regulation of metal ion transport 19.5402 6 yes
GO:0034762 regulation of transmembrane transport 19.5402 4 yes
GO:0048584 positive regulation of response to stimulus 18.3908 4 yes
GO:0034765 regulation of ion transmembrane transport 17.2414 5 yes
GO:0043933 protein-containing complex organization 17.2414 4 yes
GO:0050807 regulation of synapse organization 17.2414 5 yes
GO:0007268 chemical synaptic transmission 16.0920 6 yes
GO:0009967 positive regulation of signal transduction 16.0920 5 yes
GO:0022898 regulation of transmembrane transporter activity 16.0920 4 yes
GO:0098916 anterograde trans-synaptic signaling 16.0920 5 yes
GO:0099537 trans-synaptic signaling 16.0920 4 yes
GO:1904062 regulation of cation transmembrane transport 16.0920 6 yes
GO:0032412 regulation of ion transmembrane transporter activity 14.9425 5 yes
GO:0043270 positive regulation of ion transport 14.9425 5 yes
GO:0051924 regulation of calcium ion transport 14.9425 7 yes
GO:0010038 response to metal ion 13.7931 4 yes
GO:0065003 protein-containing complex assembly 13.7931 5 yes
GO:0099175 regulation of postsynapse organization 13.7931 6 yes
GO:0048878 chemical homeostasis 12.6437 4 yes
GO:0007215 glutamate receptor signaling pathway 11.4943 4 yes
GO:0031644 regulation of nervous system process 10.3448 5 yes
GO:1902414 protein localization to cell junction 10.3448 5 yes
GO:0035418 protein localization to synapse 9.1954 6 yes
GO:0051928 positive regulation of calcium ion transport 9.1954 6 yes
GO:2001257 regulation of cation channel activity 9.1954 6 yes
GO:0051592 response to calcium ion 8.0460 5 yes
GO:0007216 G protein-coupled glutamate receptor signaling pathway 6.8966 4 yes
GO:0051259 protein complex oligomerization 6.8966 6 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 6.8966 6 yes
GO:0060249 anatomical structure homeostasis 6.8966 4 yes
GO:0099601 regulation of neurotransmitter receptor activity 6.8966 4 yes
GO:0001894 tissue homeostasis 5.7471 5 yes
GO:0006936 muscle contraction 5.7471 4 yes
GO:0006941 striated muscle contraction 4.5977 5 yes
GO:0051262 protein tetramerization 4.5977 7 yes
GO:0098962 regulation of postsynaptic neurotransmitter receptor activity 4.5977 5 yes
GO:1902950 regulation of dendritic spine maintenance 4.5977 7 yes
GO:2001256 regulation of store-operated calcium entry 4.5977 8 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 3.4483 4 yes
GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway 3.4483 5 yes
GO:0014904 myotube cell development 3.4483 5 yes
GO:0048148 behavioral response to cocaine 3.4483 4 yes
GO:0048741 skeletal muscle fiber development 3.4483 6 yes
GO:0048875 chemical homeostasis within a tissue 3.4483 5 yes
GO:0055001 muscle cell development 3.4483 4 yes
GO:0090279 regulation of calcium ion import 2.2989 8 yes
GO:0003009 skeletal muscle contraction 2.2989 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in HOME1_HUMAN
DOID:331 central nervous system disease 5.7471 3 no
DOID:0050700 cardiomyopathy 4.5977 4 no
DOID:0060036 intrinsic cardiomyopathy 4.5977 5 no
DOID:114 heart disease 4.5977 3 no
DOID:1289 neurodegenerative disease 4.5977 4 no
DOID:0050753 cerebellar ataxia 3.4483 6 no
DOID:0050951 hereditary ataxia 3.4483 5 no
DOID:2843 long QT syndrome 2.2989 6 no
DOID:0050950 autosomal recessive cerebellar ataxia 2.2989 7 no
DOID:0060674 catecholaminergic polymorphic ventricular tachycardia 2.2989 5 no
DOID:10273 heart conduction disease 2.2989 4 no
DOID:1441 autosomal dominant cerebellar ataxia 2.2989 7 no
DOID:0080000 muscular disease 2.2989 3 no
DOID:423 myopathy 2.2989 5 no
DOID:66 muscle tissue disease 2.2989 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
AGAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
PIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
FRPD4_HUMAN [view entry] [view interactions] Low throughput yes no
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
FAT1_HUMAN [view interactions] Low throughput no yes
SHAN1_HUMAN [view entry] [view interactions] Low throughput yes yes
BSN_HUMAN [view entry] [view interactions] Low throughput yes yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
RYR1_HUMAN [view interactions] Low throughput no no
ITPR1_HUMAN [view entry] [view interactions] Low throughput yes yes
HOME1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRID2_HUMAN [view entry] [view interactions] Low throughput yes no
TANC1_HUMAN [view entry] [view interactions] Low throughput yes yes
RYR2_HUMAN [view entry] [view interactions] Low throughput yes yes
DBNL_HUMAN [view entry] [view interactions] Low throughput yes yes
ANK3_HUMAN [view entry] [view interactions] Low throughput yes yes
IQEC3_HUMAN [view entry] [view interactions] Low throughput yes no
DYN3_HUMAN [view entry] [view interactions] Low throughput yes no
HOME3_HUMAN [view entry] [view interactions] High throughput yes yes
SNW1_HUMAN [view interactions] High throughput no yes
KIF3B_HUMAN [view interactions] High throughput no no
FRYL_HUMAN [view entry] [view interactions] High throughput yes yes
CTIP_HUMAN [view interactions] High throughput no no
LMA2L_HUMAN [view interactions] High throughput no yes
CEP44_HUMAN [view interactions] High throughput no yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
IFT57_HUMAN [view interactions] High throughput no yes
EMIL1_HUMAN [view interactions] High throughput no no
TCP1L_HUMAN [view interactions] High throughput no no
CSPP1_HUMAN [view interactions] High throughput no no
MS18A_HUMAN [view interactions] High throughput no yes
FBX28_HUMAN [view interactions] High throughput no yes
ACTBL_HUMAN [view interactions] High throughput no no
EF1A2_HUMAN [view entry] [view interactions] High throughput yes yes
KINH_HUMAN [view entry] [view interactions] High throughput yes no
TRAF5_HUMAN [view interactions] High throughput no yes
KIF2B_HUMAN [view entry] [view interactions] High throughput yes yes
SYCE3_HUMAN [view interactions] High throughput no no
CEP72_HUMAN [view interactions] High throughput no yes
GRM2B_HUMAN [view interactions] High throughput no yes
COL12_HUMAN [view interactions] High throughput no no
HXB2_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
MED4_HUMAN [view interactions] High throughput no yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
KPCA_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
WASF1_HUMAN [view entry] [view interactions] High throughput yes yes
RO52_HUMAN [view interactions] High throughput no yes
TENR_HUMAN [view entry] [view interactions] High throughput yes no
SPTN2_HUMAN [view entry] [view interactions] High throughput yes yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
SIRPG_HUMAN [view interactions] High throughput no no
SHPS1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN2_HUMAN [view entry] [view interactions] High throughput yes yes
PP2BA_HUMAN [view entry] [view interactions] High throughput yes yes
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
NCDN_HUMAN [view entry] [view interactions] High throughput yes yes
NCAM1_HUMAN [view entry] [view interactions] High throughput yes no
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
M3K5_HUMAN [view interactions] High throughput no yes
LZTS3_HUMAN [view entry] [view interactions] High throughput yes yes
GIPC1_HUMAN [view entry] [view interactions] High throughput yes yes
EFHD2_HUMAN [view entry] [view interactions] High throughput yes no
DOCK7_HUMAN [view entry] [view interactions] High throughput yes no
DYN1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
CYH3_HUMAN [view entry] [view interactions] High throughput yes yes
CNTN4_HUMAN [view interactions] High throughput no no
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
BIN1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
BRME1_HUMAN [view interactions] High throughput no yes
SARG_HUMAN [view interactions] High throughput no yes
NUP54_HUMAN [view interactions] High throughput no yes
RASL3_HUMAN [view interactions] High throughput no no
SYCE2_HUMAN [view interactions] High throughput no no
ABI3_HUMAN [view entry] [view interactions] High throughput yes no
ARIP4_HUMAN [view interactions] High throughput no yes
FAM9A_HUMAN [view interactions] High throughput no no
CENPQ_HUMAN [view interactions] High throughput no yes
CDC16_HUMAN [view interactions] High throughput no yes
KDM4C_HUMAN [view interactions] High throughput no no
PIAS2_HUMAN [view interactions] High throughput no yes
INADL_HUMAN [view interactions] High throughput no no
ZMYM5_HUMAN [view interactions] High throughput no yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
FCSD2_HUMAN [view interactions] High throughput no no
AIMP1_HUMAN [view interactions] High throughput no yes
TRPC1_HUMAN [view interactions] High throughput no yes
TRPC5_HUMAN [view interactions] High throughput no no
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
HOME2_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
SPTN4_HUMAN [view entry] [view interactions] High throughput yes no
KIF5C_HUMAN [view entry] [view interactions] High throughput yes yes
ASPP2_HUMAN [view interactions] High throughput no yes
MPZL1_HUMAN [view interactions] High throughput no yes
COBL1_HUMAN [view interactions] High throughput no yes
PSRC1_HUMAN [view interactions] High throughput no no
ZUP1_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
TXNIP_HUMAN [view interactions] High throughput no no
RNF41_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] High throughput yes yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CNBP_HUMAN [view interactions] High throughput no no
SPOPL_HUMAN [view interactions] High throughput no yes
IFT20_HUMAN [view interactions] High throughput no yes
KPRA_HUMAN [view interactions] High throughput no no
STXB4_HUMAN [view entry] [view interactions] High throughput yes yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
INSY1_HUMAN [view entry] [view interactions] High throughput yes yes
CD6_HUMAN [view interactions] High throughput no no
MATN2_HUMAN [view interactions] High throughput no no
MYPN_HUMAN [view interactions] High throughput no no
ADIPO_HUMAN [view interactions] High throughput no no
PALLD_HUMAN [view interactions] High throughput no yes
BORG4_HUMAN [view entry] [view interactions] High throughput yes yes
BRK1_HUMAN [view interactions] High throughput no no
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
ASTRB_HUMAN [view interactions] High throughput no yes
SGF29_HUMAN [view interactions] High throughput no yes
RABE2_HUMAN [view interactions] High throughput no yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
STK26_HUMAN [view interactions] High throughput no no
STX12_HUMAN [view entry] [view interactions] High throughput yes yes
MK11_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
GRIA1_HUMAN [view entry] [view interactions] Computational yes yes
DLGP3_HUMAN [view entry] [view interactions] Computational yes yes
ITPR3_HUMAN [view interactions] Computational no yes
SRC8_HUMAN [view entry] [view interactions] Computational yes yes
DLG2_HUMAN [view entry] [view interactions] Computational yes yes