DBNL_HUMAN
Evidence for PS localization
Functions
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes . May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DBNL_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 35.5263 | 4 | no |
| GO:0000166 | nucleotide binding | 31.5789 | 4 | no |
| GO:0003779 | actin binding | 30.2632 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 30.2632 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 30.2632 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.9474 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 27.6316 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 27.6316 | 5 | no |
| GO:0005524 | ATP binding | 26.3158 | 5 | no |
| GO:0003723 | RNA binding | 23.6842 | 4 | no |
| GO:0043169 | cation binding | 21.0526 | 4 | no |
| GO:0046872 | metal ion binding | 21.0526 | 5 | no |
| GO:0045296 | cadherin binding | 15.7895 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DBNL_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 53.9474 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 51.3158 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.6842 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.0526 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.7368 | 4 | no |
| GO:0006996 | organelle organization | 43.4211 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 39.4737 | 4 | no |
| GO:0010646 | regulation of cell communication | 39.4737 | 4 | no |
| GO:0022607 | cellular component assembly | 35.5263 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 34.2105 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.2105 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.2105 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 32.8947 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.8947 | 6 | no |
| GO:0051049 | regulation of transport | 32.8947 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.2632 | 5 | no |
| GO:0009966 | regulation of signal transduction | 30.2632 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.2632 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.9474 | 4 | no |
| GO:0071310 | cellular response to organic substance | 28.9474 | 4 | no |
| GO:0008104 | protein localization | 28.9474 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.6316 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.6316 | 4 | no |
| GO:0033043 | regulation of organelle organization | 26.3158 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 23.6842 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.6842 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.3684 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.3684 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.3684 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 22.3684 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.3684 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.3684 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.3684 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.3684 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.3684 | 5 | no |
| GO:0043933 | protein-containing complex organization | 22.3684 | 4 | yes |
| GO:0007015 | actin filament organization | 22.3684 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.0526 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.0526 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.0526 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.0526 | 6 | no |
| GO:0030030 | cell projection organization | 21.0526 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 21.0526 | 7 | no |
| GO:0065003 | protein-containing complex assembly | 17.1053 | 5 | yes |
| GO:0034330 | cell junction organization | 15.7895 | 4 | yes |
| GO:0061024 | membrane organization | 15.7895 | 4 | yes |
| GO:0098657 | import into cell | 14.4737 | 4 | yes |
| GO:0050808 | synapse organization | 13.1579 | 5 | yes |
| GO:0070925 | organelle assembly | 13.1579 | 5 | yes |
| GO:0141124 | intracellular signaling cassette | 13.1579 | 4 | yes |
| GO:0048812 | neuron projection morphogenesis | 9.2105 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 9.2105 | 4 | yes |
| GO:0034329 | cell junction assembly | 7.8947 | 5 | yes |
| GO:0007264 | small GTPase-mediated signal transduction | 6.5789 | 5 | yes |
| GO:0007416 | synapse assembly | 6.5789 | 6 | yes |
| GO:0016601 | Rac protein signal transduction | 2.6316 | 6 | yes |
| GO:0071800 | podosome assembly | 2.6316 | 6 | yes |
| GO:0140694 | non-membrane-bounded organelle assembly | 2.6316 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FYB1_HUMAN | [view interactions] | Low throughput | no | no |
| 3BP2_HUMAN | [view interactions] | Low throughput | no | yes |
| COBL_HUMAN | [view interactions] | Low throughput | no | yes |
| FGD1_HUMAN | [view interactions] | Low throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SHAN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ZAP70_HUMAN | [view interactions] | Low throughput | no | no |
| M4K1_HUMAN | [view interactions] | Low throughput | no | no |
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| HOME1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CASP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPA1_HUMAN | [view interactions] | High throughput | no | yes |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM4_HUMAN | [view interactions] | High throughput | no | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPC_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
| GANAB_HUMAN | [view interactions] | High throughput | no | yes |
| PLCH1_HUMAN | [view interactions] | High throughput | no | no |
| INT3_HUMAN | [view interactions] | High throughput | no | yes |
| STAG2_HUMAN | [view interactions] | High throughput | no | yes |
| SYMPK_HUMAN | [view interactions] | High throughput | no | yes |
| PHF23_HUMAN | [view interactions] | High throughput | no | yes |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| PKRI1_HUMAN | [view interactions] | High throughput | no | no |
| TRPS1_HUMAN | [view interactions] | High throughput | no | no |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRBG1_HUMAN | [view interactions] | High throughput | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP43_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| COR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXO1_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CNPY3_HUMAN | [view interactions] | High throughput | no | yes |
| SND1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ACD_HUMAN | [view interactions] | High throughput | no | no |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK4_HUMAN | [view interactions] | High throughput | no | no |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUL4_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| CP4F8_HUMAN | [view interactions] | High throughput | no | no |
| E2AK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNPEP_HUMAN | [view interactions] | High throughput | no | yes |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH24A_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| NMDE3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IDLC_HUMAN | [view interactions] | High throughput | no | no |
| KLF11_HUMAN | [view interactions] | High throughput | no | no |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| SWAP1_HUMAN | [view interactions] | High throughput | no | no |
| GPS2_HUMAN | [view interactions] | High throughput | no | yes |
| KDM5B_HUMAN | [view interactions] | High throughput | no | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBM23_HUMAN | [view interactions] | High throughput | no | yes |
| FGD6_HUMAN | [view interactions] | High throughput | no | yes |
| ECI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUA_HUMAN | [view interactions] | High throughput | no | yes |
| UBP20_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS8_HUMAN | [view interactions] | High throughput | no | no |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M4K3_HUMAN | [view interactions] | High throughput | no | no |
| M4K5_HUMAN | [view interactions] | High throughput | no | no |
| ZF69B_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM11E_HUMAN | [view interactions] | High throughput | no | no |
| SPD2B_HUMAN | [view interactions] | High throughput | no | no |
| ALG3_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TGM1_HUMAN | [view interactions] | High throughput | no | no |
| KLH14_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAQR3_HUMAN | [view interactions] | High throughput | no | no |
| CR021_HUMAN | [view interactions] | High throughput | no | no |
| HPBP1_HUMAN | [view interactions] | High throughput | no | yes |
| RM42_HUMAN | [view interactions] | High throughput | no | yes |
| KLK10_HUMAN | [view interactions] | High throughput | no | no |
| CN37_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| MA7D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| MESH1_HUMAN | [view interactions] | High throughput | no | yes |
| ATTY_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| KAT6A_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN536_HUMAN | [view interactions] | High throughput | no | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP5L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIRA_HUMAN | [view interactions] | High throughput | no | yes |
| UBN2_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| ITCH_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGFG1_HUMAN | [view interactions] | High throughput | no | yes |
| HEM2_HUMAN | [view interactions] | High throughput | no | no |
| GON7_HUMAN | [view interactions] | High throughput | no | yes |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| LPP_HUMAN | [view interactions] | High throughput | no | yes |
| DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NC2B_HUMAN | [view interactions] | High throughput | no | yes |
| ERO1A_HUMAN | [view interactions] | High throughput | no | yes |
| GPN1_HUMAN | [view interactions] | High throughput | no | yes |
| P3H1_HUMAN | [view interactions] | High throughput | no | yes |
| LRSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPRKB_HUMAN | [view interactions] | High throughput | no | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR4_HUMAN | [view interactions] | High throughput | no | no |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLSI_HUMAN | [view interactions] | High throughput | no | no |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| URP2_HUMAN | [view interactions] | High throughput | no | no |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |