Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DBNL_HUMAN

Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes . May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in DBNL_HUMAN
GO:0003779 actin binding 33.8235 4 yes
GO:0017076 purine nucleotide binding 33.8235 4 no
GO:0030554 adenyl nucleotide binding 32.3529 5 no
GO:0032555 purine ribonucleotide binding 30.8824 4 no
GO:0032559 adenyl ribonucleotide binding 29.4118 5 no
GO:0035639 purine ribonucleoside triphosphate binding 29.4118 4 no
GO:0005524 ATP binding 27.9412 5 no
GO:0003723 RNA binding 20.5882 4 no
GO:0045296 cadherin binding 17.6471 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DBNL_HUMAN
GO:0048522 positive regulation of cellular process 64.7059 4 yes
GO:0051128 regulation of cellular component organization 54.4118 4 yes
GO:0048523 negative regulation of cellular process 48.5294 4 no
GO:0006996 organelle organization 47.0588 4 yes
GO:0060255 regulation of macromolecule metabolic process 47.0588 4 no
GO:0022607 cellular component assembly 44.1176 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 44.1176 4 no
GO:0080090 regulation of primary metabolic process 44.1176 4 no
GO:0010646 regulation of cell communication 41.1765 4 no
GO:0009893 positive regulation of metabolic process 41.1765 4 no
GO:0051049 regulation of transport 38.2353 4 no
GO:0031323 regulation of cellular metabolic process 36.7647 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.2941 5 no
GO:0033043 regulation of organelle organization 33.8235 5 yes
GO:0044087 regulation of cellular component biogenesis 33.8235 4 yes
GO:0010468 regulation of gene expression 33.8235 5 no
GO:0009966 regulation of signal transduction 32.3529 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 32.3529 5 no
GO:0051246 regulation of protein metabolic process 32.3529 5 no
GO:0051130 positive regulation of cellular component organization 30.8824 5 yes
GO:0048584 positive regulation of response to stimulus 29.4118 4 no
GO:0031325 positive regulation of cellular metabolic process 29.4118 5 no
GO:0071310 cellular response to organic substance 29.4118 4 no
GO:0016192 vesicle-mediated transport 26.4706 4 yes
GO:0043933 protein-containing complex organization 26.4706 4 yes
GO:0010647 positive regulation of cell communication 26.4706 5 no
GO:0023056 positive regulation of signaling 26.4706 4 no
GO:0010941 regulation of cell death 26.4706 4 no
GO:0045595 regulation of cell differentiation 25.0000 4 yes
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0007010 cytoskeleton organization 23.5294 5 yes
GO:0030030 cell projection organization 23.5294 4 yes
GO:0043254 regulation of protein-containing complex assembly 23.5294 5 yes
GO:0051493 regulation of cytoskeleton organization 23.5294 6 yes
GO:0065003 protein-containing complex assembly 23.5294 5 yes
GO:0007015 actin filament organization 23.5294 5 no
GO:0097435 supramolecular fiber organization 23.5294 4 no
GO:0043067 regulation of programmed cell death 23.5294 5 no
GO:0010556 regulation of macromolecule biosynthetic process 23.5294 5 no
GO:1902531 regulation of intracellular signal transduction 23.5294 5 no
GO:0060341 regulation of cellular localization 23.5294 4 no
GO:0031344 regulation of cell projection organization 22.0588 5 yes
GO:0051094 positive regulation of developmental process 22.0588 4 yes
GO:0051240 positive regulation of multicellular organismal process 22.0588 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.0588 6 yes
GO:1902903 regulation of supramolecular fiber organization 22.0588 5 yes
GO:0008104 protein localization 22.0588 4 no
GO:0009967 positive regulation of signal transduction 22.0588 5 no
GO:0042981 regulation of apoptotic process 22.0588 6 no
GO:0051247 positive regulation of protein metabolic process 22.0588 6 no
GO:0006355 regulation of DNA-templated transcription 22.0588 6 no
GO:0051252 regulation of RNA metabolic process 22.0588 5 no
GO:1903506 regulation of nucleic acid-templated transcription 22.0588 7 no
GO:2001141 regulation of RNA biosynthetic process 22.0588 6 no
GO:0031399 regulation of protein modification process 20.5882 6 no
GO:0009892 negative regulation of metabolic process 20.5882 4 no
GO:0010605 negative regulation of macromolecule metabolic process 20.5882 5 no
GO:0032880 regulation of protein localization 20.5882 5 no
GO:0045597 positive regulation of cell differentiation 19.1176 5 yes
GO:0120036 plasma membrane bounded cell projection organization 19.1176 5 yes
GO:0032956 regulation of actin cytoskeleton organization 17.6471 5 yes
GO:0032970 regulation of actin filament-based process 17.6471 4 yes
GO:0006897 endocytosis 16.1765 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 16.1765 4 yes
GO:0032271 regulation of protein polymerization 16.1765 6 yes
GO:0034330 cell junction organization 16.1765 4 yes
GO:0110053 regulation of actin filament organization 16.1765 6 yes
GO:0010720 positive regulation of cell development 14.7059 6 yes
GO:0032535 regulation of cellular component size 14.7059 4 yes
GO:0060284 regulation of cell development 14.7059 5 yes
GO:2000026 regulation of multicellular organismal development 14.7059 4 yes
GO:0008064 regulation of actin polymerization or depolymerization 13.2353 6 yes
GO:0022604 regulation of cell morphogenesis 13.2353 5 yes
GO:0030832 regulation of actin filament length 13.2353 5 yes
GO:0030833 regulation of actin filament polymerization 13.2353 7 yes
GO:0050807 regulation of synapse organization 13.2353 5 yes
GO:0050808 synapse organization 13.2353 5 yes
GO:0070925 organelle assembly 13.2353 5 yes
GO:0001558 regulation of cell growth 11.7647 4 yes
GO:0010975 regulation of neuron projection development 11.7647 7 yes
GO:0031346 positive regulation of cell projection organization 11.7647 6 yes
GO:0034329 cell junction assembly 11.7647 5 yes
GO:0099175 regulation of postsynapse organization 11.7647 6 yes
GO:0006898 receptor-mediated endocytosis 10.2941 6 yes
GO:0007416 synapse assembly 10.2941 6 yes
GO:0010769 regulation of cell morphogenesis involved in differentiation 10.2941 6 yes
GO:0010770 positive regulation of cell morphogenesis involved in differentiation 10.2941 7 yes
GO:0030031 cell projection assembly 10.2941 5 yes
GO:0032990 cell part morphogenesis 10.2941 4 yes
GO:0048812 neuron projection morphogenesis 10.2941 7 yes
GO:0048858 cell projection morphogenesis 10.2941 5 yes
GO:0120031 plasma membrane bounded cell projection assembly 10.2941 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 10.2941 6 yes
GO:0050767 regulation of neurogenesis 8.8235 6 yes
GO:0050769 positive regulation of neurogenesis 8.8235 6 yes
GO:0051960 regulation of nervous system development 8.8235 5 yes
GO:0051962 positive regulation of nervous system development 8.8235 5 yes
GO:0050773 regulation of dendrite development 7.3529 4 yes
GO:0060998 regulation of dendritic spine development 7.3529 4 yes
GO:0061001 regulation of dendritic spine morphogenesis 7.3529 5 yes
GO:0007264 small GTPase mediated signal transduction 5.8824 4 yes
GO:0007265 Ras protein signal transduction 5.8824 5 yes
GO:0010976 positive regulation of neuron projection development 5.8824 7 yes
GO:0030307 positive regulation of cell growth 5.8824 5 yes
GO:0045927 positive regulation of growth 5.8824 4 yes
GO:0048638 regulation of developmental growth 5.8824 4 yes
GO:0060999 positive regulation of dendritic spine development 5.8824 5 yes
GO:0048814 regulation of dendrite morphogenesis 4.4118 5 yes
GO:0050775 positive regulation of dendrite morphogenesis 4.4118 6 yes
GO:0061003 positive regulation of dendritic spine morphogenesis 4.4118 6 yes
GO:0098974 postsynaptic actin cytoskeleton organization 4.4118 4 yes
GO:0099188 postsynaptic cytoskeleton organization 4.4118 6 yes
GO:0016601 Rac protein signal transduction 2.9412 6 yes
GO:0030516 regulation of axon extension 2.9412 5 yes
GO:0031529 ruffle organization 2.9412 6 yes
GO:0045773 positive regulation of axon extension 2.9412 6 yes
GO:0048639 positive regulation of developmental growth 2.9412 5 yes
GO:0050770 regulation of axonogenesis 2.9412 5 yes
GO:0050772 positive regulation of axonogenesis 2.9412 6 yes
GO:0061387 regulation of extent of cell growth 2.9412 5 yes
GO:0071800 podosome assembly 2.9412 6 yes
GO:0097178 ruffle assembly 2.9412 7 yes
GO:0140694 non-membrane-bounded organelle assembly 2.9412 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in DBNL_HUMAN
DOID:0050890 synucleinopathy 2.9412 5 no
DOID:1289 neurodegenerative disease 2.9412 4 no
DOID:14330 Parkinsons disease 2.9412 6 no
DOID:331 central nervous system disease 2.9412 3 no
DOID:0080000 muscular disease 2.9412 3 no
DOID:423 myopathy 2.9412 5 no
DOID:66 muscle tissue disease 2.9412 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FYB1_HUMAN [view interactions] Low throughput no no
3BP2_HUMAN [view interactions] Low throughput no yes
COBL_HUMAN [view interactions] Low throughput no yes
FGD1_HUMAN [view interactions] Low throughput no no
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
SHAN2_HUMAN [view entry] [view interactions] Low throughput yes yes
LYN_HUMAN [view entry] [view interactions] Low throughput yes no
ZAP70_HUMAN [view interactions] Low throughput no no
M4K1_HUMAN [view interactions] Low throughput no no
CBL_HUMAN [view interactions] Low throughput no yes
HOME1_HUMAN [view entry] [view interactions] Low throughput yes yes
CASP3_HUMAN [view interactions] Low throughput no yes
SYN1_HUMAN [view entry] [view interactions] Low throughput yes no
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SYNJ1_HUMAN [view entry] [view interactions] Low throughput yes yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
FGD5_HUMAN [view interactions] High throughput no yes
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
ACD_HUMAN [view interactions] High throughput no no
PHAG1_HUMAN [view interactions] High throughput no yes
CDK4_HUMAN [view interactions] High throughput no no
DBNL_HUMAN [view entry] [view interactions] High throughput yes yes
NEUL4_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
CP4F8_HUMAN [view interactions] High throughput no no
E2AK2_HUMAN [view entry] [view interactions] High throughput yes yes
DNPEP_HUMAN [view interactions] High throughput no yes
RBCC1_HUMAN [view interactions] High throughput no no
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
SH24A_HUMAN [view interactions] High throughput no no
FGFR3_HUMAN [view interactions] High throughput no yes
NMDE3_HUMAN [view entry] [view interactions] High throughput yes no
GELS_HUMAN [view entry] [view interactions] High throughput yes no
IDLC_HUMAN [view interactions] High throughput no no
KLF11_HUMAN [view interactions] High throughput no no
UBQL1_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
TERF1_HUMAN [view interactions] High throughput no no
TE2IP_HUMAN [view interactions] High throughput no yes
POTE1_HUMAN [view interactions] High throughput no no
GPS2_HUMAN [view interactions] High throughput no yes
KDM5B_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
CUL1_HUMAN [view interactions] High throughput no yes
FOXP3_HUMAN [view interactions] High throughput no no
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
RBM23_HUMAN [view interactions] High throughput no yes
FGD6_HUMAN [view interactions] High throughput no yes
ECI2_HUMAN [view entry] [view interactions] High throughput yes yes
NEUA_HUMAN [view interactions] High throughput no yes
UBP20_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
DUS8_HUMAN [view interactions] High throughput no no
T2EB_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TES_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
M4K3_HUMAN [view interactions] High throughput no no
M4K5_HUMAN [view interactions] High throughput no no
ZF69B_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
TM11E_HUMAN [view interactions] High throughput no no
SPD2B_HUMAN [view interactions] High throughput no no
ALG3_HUMAN [view interactions] High throughput no yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
TGM1_HUMAN [view interactions] High throughput no no
KLH14_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
PAQR3_HUMAN [view interactions] High throughput no no
CR021_HUMAN [view interactions] High throughput no no
HPBP1_HUMAN [view interactions] High throughput no yes
RM42_HUMAN [view interactions] High throughput no yes
KLK10_HUMAN [view interactions] High throughput no no
CN37_HUMAN [view entry] [view interactions] High throughput yes no
CCR1_HUMAN [view interactions] High throughput no no
PLCA_HUMAN [view interactions] High throughput no yes
OSGEP_HUMAN [view interactions] High throughput no yes
MA7D1_HUMAN [view entry] [view interactions] High throughput yes no
SSUH2_HUMAN [view interactions] High throughput no no
MESH1_HUMAN [view interactions] High throughput no yes
ATTY_HUMAN [view interactions] High throughput no no
PINK1_HUMAN [view interactions] High throughput no yes
KAT6A_HUMAN [view interactions] High throughput no yes
CALD1_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
ARPC5_HUMAN [view interactions] High throughput no yes
ARPC2_HUMAN [view entry] [view interactions] High throughput yes yes
ZN536_HUMAN [view interactions] High throughput no no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
ARP5L_HUMAN [view entry] [view interactions] High throughput yes yes
ARC1A_HUMAN [view entry] [view interactions] High throughput yes yes
HIRA_HUMAN [view interactions] High throughput no yes
UBN2_HUMAN [view interactions] High throughput no yes
SAR1B_HUMAN [view interactions] High throughput no yes
ITCH_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
AGFG1_HUMAN [view interactions] High throughput no yes
HEM2_HUMAN [view interactions] High throughput no no
GON7_HUMAN [view interactions] High throughput no yes
CBS_HUMAN [view interactions] High throughput no yes
LPP_HUMAN [view interactions] High throughput no yes
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
NC2B_HUMAN [view interactions] High throughput no yes
ERO1A_HUMAN [view interactions] High throughput no yes
GPN1_HUMAN [view interactions] High throughput no yes
P3H1_HUMAN [view interactions] High throughput no yes
LRSM1_HUMAN [view entry] [view interactions] High throughput yes yes
PLIN3_HUMAN [view interactions] High throughput no yes
PPME1_HUMAN [view interactions] High throughput no yes
RAGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TPRKB_HUMAN [view interactions] High throughput no yes
UBA5_HUMAN [view interactions] High throughput no yes
UBE3A_HUMAN [view interactions] High throughput no yes
WDR4_HUMAN [view interactions] High throughput no no
COF1_HUMAN [view entry] [view interactions] High throughput yes no
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
ASAP1_HUMAN [view entry] [view interactions] High throughput yes yes
PLSI_HUMAN [view interactions] High throughput no no
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
ARP2_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
CAP1_HUMAN [view entry] [view interactions] High throughput yes yes
PLSL_HUMAN [view entry] [view interactions] High throughput yes no
URP2_HUMAN [view interactions] High throughput no no
PLST_HUMAN [view interactions] High throughput no yes
TPM4_HUMAN [view entry] [view interactions] High throughput yes yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
ACTC_HUMAN [view interactions] High throughput no no
GBF1_HUMAN [view interactions] High throughput no yes
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
DC1L2_HUMAN [view entry] [view interactions] High throughput yes yes
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
NAA40_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
CD3G_HUMAN [view interactions] Computational no no
M3K1_HUMAN [view interactions] Computational no yes
CD4_HUMAN [view interactions] Computational no no
CD3Z_HUMAN [view interactions] Computational no no
LAT_HUMAN [view interactions] Computational no no
DRA_HUMAN [view interactions] Computational no no
WASP_HUMAN [view interactions] Computational no yes
CD3E_HUMAN [view interactions] Computational no no
CRKL_HUMAN [view entry] [view interactions] Computational yes yes
HIP1R_HUMAN [view entry] [view interactions] Computational yes yes
WASL_HUMAN [view entry] [view interactions] Computational yes yes
M3K7_HUMAN [view interactions] Computational no yes
LCP2_HUMAN [view interactions] Computational no yes
CAP2_HUMAN [view entry] [view interactions] Computational yes yes
DRB1_HUMAN [view interactions] Computational no no
CRK_HUMAN [view entry] [view interactions] Computational yes no
HIP1_HUMAN [view entry] [view interactions] Computational yes yes
LCK_HUMAN [view entry] [view interactions] Computational yes no
CD3D_HUMAN [view interactions] Computational no no
GRAP2_HUMAN [view interactions] Computational no no