KCC2D_HUMAN
Evidence for PS localization
Functions
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on Ser-2808. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KCC2D_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 35.1648 | 4 | yes |
| GO:0043169 | cation binding | 31.8681 | 4 | no |
| GO:0046872 | metal ion binding | 30.7692 | 5 | no |
| GO:0019900 | kinase binding | 30.7692 | 4 | no |
| GO:0000166 | nucleotide binding | 28.5714 | 4 | yes |
| GO:0019901 | protein kinase binding | 28.5714 | 5 | no |
| GO:0017076 | purine nucleotide binding | 27.4725 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 27.4725 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.2747 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 24.1758 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 24.1758 | 5 | yes |
| GO:0003723 | RNA binding | 24.1758 | 4 | no |
| GO:0005524 | ATP binding | 21.9780 | 5 | yes |
| GO:0016301 | kinase activity | 13.1868 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 13.1868 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 12.0879 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 10.9890 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 9.8901 | 4 | yes |
| GO:0099106 | ion channel regulator activity | 8.7912 | 4 | yes |
| GO:0008200 | ion channel inhibitor activity | 6.5934 | 5 | yes |
| GO:0016248 | channel inhibitor activity | 6.5934 | 4 | yes |
| GO:0031432 | titin binding | 6.5934 | 4 | yes |
| GO:0004683 | calmodulin-dependent protein kinase activity | 5.4945 | 5 | yes |
| GO:0017080 | sodium channel regulator activity | 2.1978 | 5 | yes |
| GO:0019871 | sodium channel inhibitor activity | 2.1978 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KCC2D_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.7363 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 56.0440 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 56.0440 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 54.9451 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 52.7473 | 4 | yes |
| GO:0010646 | regulation of cell communication | 52.7473 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.5495 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 42.8571 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 42.8571 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 40.6593 | 4 | no |
| GO:0006996 | organelle organization | 39.5604 | 4 | no |
| GO:0051049 | regulation of transport | 39.5604 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 38.4615 | 5 | no |
| GO:0022607 | cellular component assembly | 37.3626 | 4 | no |
| GO:0031399 | regulation of protein modification process | 37.3626 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 37.3626 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 37.3626 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 37.3626 | 5 | yes |
| GO:0010468 | regulation of gene expression | 36.2637 | 6 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 35.1648 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 35.1648 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 35.1648 | 5 | no |
| GO:0008104 | protein localization | 34.0659 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.9670 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.7692 | 4 | no |
| GO:0036211 | protein modification process | 30.7692 | 4 | yes |
| GO:0043412 | macromolecule modification | 30.7692 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 30.7692 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.6703 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.6703 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 29.6703 | 7 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.6703 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 29.6703 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 28.5714 | 7 | no |
| GO:0023056 | positive regulation of signaling | 28.5714 | 4 | no |
| GO:0043933 | protein-containing complex organization | 28.5714 | 4 | no |
| GO:0032880 | regulation of protein localization | 28.5714 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 27.4725 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.3736 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 25.2747 | 4 | yes |
| GO:0043067 | regulation of programmed cell death | 25.2747 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 25.2747 | 5 | yes |
| GO:0051050 | positive regulation of transport | 24.1758 | 4 | no |
| GO:0051338 | regulation of transferase activity | 24.1758 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 24.1758 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 24.1758 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 24.1758 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 24.1758 | 5 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 24.1758 | 5 | yes |
| GO:0141124 | intracellular signaling cassette | 23.0769 | 4 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 23.0769 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 23.0769 | 5 | no |
| GO:0031400 | negative regulation of protein modification process | 23.0769 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.0769 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 23.0769 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.0769 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.0769 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.0769 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 23.0769 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 23.0769 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 23.0769 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.0769 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.0769 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.0769 | 7 | yes |
| GO:0044057 | regulation of system process | 23.0769 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.9780 | 6 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 21.9780 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 21.9780 | 4 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 21.9780 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 21.9780 | 4 | no |
| GO:0043549 | regulation of kinase activity | 21.9780 | 5 | no |
| GO:0009894 | regulation of catabolic process | 21.9780 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 21.9780 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 20.8791 | 4 | no |
| GO:0030030 | cell projection organization | 20.8791 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 20.8791 | 7 | no |
| GO:0071310 | cellular response to organic substance | 20.8791 | 4 | no |
| GO:0010959 | regulation of metal ion transport | 20.8791 | 6 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 19.7802 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 19.7802 | 4 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 18.6813 | 6 | yes |
| GO:0051924 | regulation of calcium ion transport | 18.6813 | 7 | yes |
| GO:0010038 | response to metal ion | 17.5824 | 4 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 17.5824 | 4 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 16.4835 | 8 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 15.3846 | 7 | yes |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 15.3846 | 5 | yes |
| GO:0051051 | negative regulation of transport | 15.3846 | 4 | yes |
| GO:0090257 | regulation of muscle system process | 14.2857 | 5 | yes |
| GO:0016310 | phosphorylation | 14.2857 | 5 | yes |
| GO:1903522 | regulation of blood circulation | 13.1868 | 5 | yes |
| GO:0008016 | regulation of heart contraction | 13.1868 | 6 | yes |
| GO:0051282 | regulation of sequestering of calcium ion | 13.1868 | 4 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 12.0879 | 6 | yes |
| GO:0001558 | regulation of cell growth | 12.0879 | 4 | yes |
| GO:0006468 | protein phosphorylation | 12.0879 | 5 | yes |
| GO:0006937 | regulation of muscle contraction | 12.0879 | 6 | yes |
| GO:0006942 | regulation of striated muscle contraction | 12.0879 | 7 | yes |
| GO:0019722 | calcium-mediated signaling | 12.0879 | 5 | yes |
| GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 12.0879 | 5 | yes |
| GO:0055117 | regulation of cardiac muscle contraction | 12.0879 | 7 | yes |
| GO:2001257 | regulation of cation channel activity | 10.9890 | 6 | yes |
| GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 10.9890 | 6 | yes |
| GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 10.9890 | 7 | yes |
| GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 10.9890 | 6 | yes |
| GO:0018193 | peptidyl-amino acid modification | 10.9890 | 5 | yes |
| GO:0032410 | negative regulation of transporter activity | 10.9890 | 4 | yes |
| GO:0034763 | negative regulation of transmembrane transport | 10.9890 | 5 | yes |
| GO:0043065 | positive regulation of apoptotic process | 10.9890 | 6 | yes |
| GO:0043068 | positive regulation of programmed cell death | 10.9890 | 5 | yes |
| GO:1904063 | negative regulation of cation transmembrane transport | 9.8901 | 7 | yes |
| GO:0006873 | intracellular monoatomic ion homeostasis | 9.8901 | 4 | yes |
| GO:0030003 | intracellular monoatomic cation homeostasis | 9.8901 | 5 | yes |
| GO:0032413 | negative regulation of ion transmembrane transporter activity | 9.8901 | 5 | yes |
| GO:0034766 | negative regulation of monoatomic ion transmembrane transport | 9.8901 | 6 | yes |
| GO:0043271 | negative regulation of monoatomic ion transport | 9.8901 | 5 | yes |
| GO:0055080 | monoatomic cation homeostasis | 9.8901 | 4 | yes |
| GO:0071241 | cellular response to inorganic substance | 8.7912 | 4 | yes |
| GO:0071248 | cellular response to metal ion | 8.7912 | 5 | yes |
| GO:0006874 | intracellular calcium ion homeostasis | 8.7912 | 5 | yes |
| GO:0055074 | calcium ion homeostasis | 8.7912 | 4 | yes |
| GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 8.7912 | 6 | yes |
| GO:0046777 | protein autophosphorylation | 7.6923 | 6 | yes |
| GO:0051592 | response to calcium ion | 7.6923 | 5 | yes |
| GO:0098901 | regulation of cardiac muscle cell action potential | 6.5934 | 4 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 6.5934 | 6 | yes |
| GO:0018209 | peptidyl-serine modification | 6.5934 | 6 | yes |
| GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction | 5.4945 | 6 | yes |
| GO:0010649 | regulation of cell communication by electrical coupling | 5.4945 | 5 | yes |
| GO:0086091 | regulation of heart rate by cardiac conduction | 4.3956 | 4 | yes |
| GO:0002028 | regulation of sodium ion transport | 4.3956 | 7 | yes |
| GO:0018107 | peptidyl-threonine phosphorylation | 4.3956 | 6 | yes |
| GO:0018210 | peptidyl-threonine modification | 4.3956 | 6 | yes |
| GO:0032469 | endoplasmic reticulum calcium ion homeostasis | 4.3956 | 6 | yes |
| GO:0043502 | regulation of muscle adaptation | 4.3956 | 4 | yes |
| GO:0061337 | cardiac conduction | 4.3956 | 7 | yes |
| GO:0071277 | cellular response to calcium ion | 3.2967 | 6 | yes |
| GO:1902305 | regulation of sodium ion transmembrane transport | 3.2967 | 7 | yes |
| GO:2000649 | regulation of sodium ion transmembrane transporter activity | 3.2967 | 6 | yes |
| GO:0003254 | regulation of membrane depolarization | 3.2967 | 4 | yes |
| GO:0010660 | regulation of muscle cell apoptotic process | 3.2967 | 6 | yes |
| GO:0010661 | positive regulation of muscle cell apoptotic process | 3.2967 | 7 | yes |
| GO:0010662 | regulation of striated muscle cell apoptotic process | 3.2967 | 7 | yes |
| GO:0010663 | positive regulation of striated muscle cell apoptotic process | 3.2967 | 8 | yes |
| GO:0010665 | regulation of cardiac muscle cell apoptotic process | 3.2967 | 8 | yes |
| GO:0010666 | positive regulation of cardiac muscle cell apoptotic process | 3.2967 | 9 | yes |
| GO:0086003 | cardiac muscle cell contraction | 2.1978 | 5 | yes |
| GO:0090075 | relaxation of muscle | 2.1978 | 4 | yes |
| GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction | 2.1978 | 5 | yes |
| GO:1901077 | regulation of relaxation of muscle | 2.1978 | 6 | yes |
| GO:1901897 | regulation of relaxation of cardiac muscle | 2.1978 | 7 | yes |
| GO:1902306 | negative regulation of sodium ion transmembrane transport | 2.1978 | 7 | yes |
| GO:1902514 | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel | 2.1978 | 8 | yes |
| GO:2000650 | negative regulation of sodium ion transmembrane transporter activity | 2.1978 | 6 | yes |
| GO:0010611 | regulation of cardiac muscle hypertrophy | 2.1978 | 5 | yes |
| GO:0010613 | positive regulation of cardiac muscle hypertrophy | 2.1978 | 6 | yes |
| GO:0010766 | negative regulation of sodium ion transport | 2.1978 | 6 | yes |
| GO:0014742 | positive regulation of muscle hypertrophy | 2.1978 | 5 | yes |
| GO:0014743 | regulation of muscle hypertrophy | 2.1978 | 6 | yes |
| GO:0055119 | relaxation of cardiac muscle | 2.1978 | 5 | yes |
| GO:0070252 | actin-mediated cell contraction | 2.1978 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RS18_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | Low throughput | no | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRF_HUMAN | [view interactions] | Low throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | Low throughput | no | yes |
| LRRF2_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TBA1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | Low throughput | no | yes |
| TBB5_HUMAN | [view interactions] | Low throughput | no | yes |
| LRRF1_HUMAN | [view interactions] | Low throughput | no | yes |
| FLII_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZN363_HUMAN | [view interactions] | Low throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SCN5A_HUMAN | [view interactions] | Low throughput | no | no |
| ACBD6_HUMAN | [view interactions] | Low throughput | no | yes |
| PPLA_HUMAN | [view interactions] | Low throughput | no | no |
| 1433G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RYR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IF4B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| FND3B_HUMAN | [view interactions] | High throughput | no | no |
| EPHAA_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| ERCC8_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO3_HUMAN | [view interactions] | High throughput | no | yes |
| UBC9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDN1A_HUMAN | [view interactions] | High throughput | no | no |
| HAUS2_HUMAN | [view interactions] | High throughput | no | yes |
| CEP76_HUMAN | [view interactions] | High throughput | no | yes |
| TSHR_HUMAN | [view interactions] | High throughput | no | no |
| TIRAP_HUMAN | [view interactions] | High throughput | no | no |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| MAGB4_HUMAN | [view interactions] | High throughput | no | no |
| SCRN2_HUMAN | [view interactions] | High throughput | no | yes |
| DACT2_HUMAN | [view interactions] | High throughput | no | yes |
| IQCF1_HUMAN | [view interactions] | High throughput | no | no |
| WNT4_HUMAN | [view interactions] | High throughput | no | no |
| RHG25_HUMAN | [view interactions] | High throughput | no | no |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYH14_HUMAN | [view interactions] | High throughput | no | no |
| UNG_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| KANL3_HUMAN | [view interactions] | High throughput | no | yes |
| MRM2_HUMAN | [view interactions] | High throughput | no | yes |
| PUSL1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM42_HUMAN | [view interactions] | High throughput | no | yes |
| MTG1_HUMAN | [view interactions] | High throughput | no | yes |
| MOK_HUMAN | [view interactions] | High throughput | no | no |
| CXXC1_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| DIDO1_HUMAN | [view interactions] | High throughput | no | yes |
| SET1A_HUMAN | [view interactions] | High throughput | no | yes |
| SENP5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ELP3_HUMAN | [view interactions] | High throughput | no | no |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| SUH_HUMAN | [view interactions] | High throughput | no | yes |
| LIN54_HUMAN | [view interactions] | High throughput | no | yes |
| TRM61_HUMAN | [view interactions] | High throughput | no | no |
| PI51A_HUMAN | [view interactions] | High throughput | no | yes |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAB3_HUMAN | [view interactions] | High throughput | no | no |
| BD1L1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN843_HUMAN | [view interactions] | High throughput | no | yes |
| CF410_HUMAN | [view interactions] | High throughput | no | yes |
| DTL_HUMAN | [view interactions] | High throughput | no | no |
| HEM1_HUMAN | [view interactions] | High throughput | no | yes |
| TPRN_HUMAN | [view interactions] | High throughput | no | yes |
| HCFC1_HUMAN | [view interactions] | High throughput | no | yes |
| NEK1_HUMAN | [view interactions] | High throughput | no | yes |
| DPH1_HUMAN | [view interactions] | High throughput | no | yes |
| TSR3_HUMAN | [view interactions] | High throughput | no | yes |
| CF141_HUMAN | [view interactions] | High throughput | no | no |
| THUM3_HUMAN | [view interactions] | High throughput | no | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| ASXL1_HUMAN | [view interactions] | High throughput | no | no |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| P121A_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| E41LB_HUMAN | [view interactions] | High throughput | no | yes |
| MAP10_HUMAN | [view interactions] | High throughput | no | no |
| F163B_HUMAN | [view interactions] | High throughput | no | yes |
| ELP1_HUMAN | [view interactions] | High throughput | no | yes |
| SHSA6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAGA9_HUMAN | [view interactions] | High throughput | no | no |
| PGAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| ELP2_HUMAN | [view interactions] | High throughput | no | yes |
| SSH3_HUMAN | [view interactions] | High throughput | no | yes |
| ARMX5_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG7_HUMAN | [view interactions] | High throughput | no | no |
| MECP2_HUMAN | [view interactions] | High throughput | no | yes |
| PLK4_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OVOL2_HUMAN | [view interactions] | High throughput | no | no |
| ZN750_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| MYO10_HUMAN | [view interactions] | High throughput | no | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH21A_HUMAN | [view interactions] | High throughput | no | no |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPBB_HUMAN | [view interactions] | High throughput | no | no |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TF2H4_HUMAN | [view interactions] | High throughput | no | no |
| RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
| PLCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| RPA49_HUMAN | [view interactions] | High throughput | no | yes |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| FAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIM2_HUMAN | [view interactions] | High throughput | no | no |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| RHG29_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKG1_HUMAN | [view interactions] | High throughput | no | no |
| KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKAP2_HUMAN | [view interactions] | High throughput | no | no |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDE4A_HUMAN | [view interactions] | High throughput | no | no |
| ITPI2_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITPR2_HUMAN | [view interactions] | High throughput | no | yes |
| ITPR3_HUMAN | [view interactions] | High throughput | no | yes |
| ITPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PON2_HUMAN | [view interactions] | High throughput | no | yes |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| CBAR2_HUMAN | [view interactions] | High throughput | no | no |
| CK2N1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCC2_HUMAN | [view interactions] | High throughput | no | yes |
| PLPL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCN1_HUMAN | [view interactions] | High throughput | no | yes |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| PIM3_HUMAN | [view interactions] | High throughput | no | no |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| AAKG3_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFIH1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| DMD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| HNMT_HUMAN | [view interactions] | High throughput | no | yes |
| INGR2_HUMAN | [view interactions] | High throughput | no | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR2BP_HUMAN | [view interactions] | High throughput | no | yes |
| F171B_HUMAN | [view interactions] | High throughput | no | yes |
| SPA24_HUMAN | [view interactions] | High throughput | no | no |
| TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
| DNAL4_HUMAN | [view interactions] | High throughput | no | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC5_HUMAN | [view interactions] | High throughput | no | yes |
| BANP_HUMAN | [view interactions] | High throughput | no | yes |
| MOAP1_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |