KCC2D_HUMAN
Evidence for PS localization
Functions
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on Ser-2808. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KCC2D_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 28.4404 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.5229 | 4 | yes |
| GO:0046872 | metal ion binding | 27.5229 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.6055 | 4 | yes |
| GO:0019901 | protein kinase binding | 26.6055 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.6881 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 20.1835 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 19.2661 | 5 | yes |
| GO:0005524 | ATP binding | 18.3486 | 5 | yes |
| GO:0042803 | protein homodimerization activity | 12.8440 | 4 | yes |
| GO:0016301 | kinase activity | 11.9266 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 11.9266 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 10.0917 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 9.1743 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 8.2569 | 4 | yes |
| GO:0008200 | ion channel inhibitor activity | 5.5046 | 4 | yes |
| GO:0031432 | titin binding | 5.5046 | 4 | yes |
| GO:0004683 | calmodulin-dependent protein kinase activity | 4.5872 | 5 | yes |
| GO:0017080 | sodium channel regulator activity | 2.7523 | 4 | yes |
| GO:0019871 | sodium channel inhibitor activity | 1.8349 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KCC2D_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.0550 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 55.9633 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 55.0459 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 55.0459 | 4 | yes |
| GO:0010646 | regulation of cell communication | 54.1284 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 54.1284 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.3761 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 44.9541 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 43.1193 | 5 | yes |
| GO:0051049 | regulation of transport | 41.2844 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 40.3670 | 4 | yes |
| GO:0010468 | regulation of gene expression | 37.6147 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 37.6147 | 4 | no |
| GO:0031399 | regulation of protein modification process | 36.6972 | 6 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 35.7798 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.8624 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.9450 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 33.9450 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 33.9450 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 33.0275 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.0275 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 33.0275 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 33.0275 | 4 | no |
| GO:0006996 | organelle organization | 33.0275 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 32.1101 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 31.1927 | 7 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 30.2752 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.2752 | 5 | yes |
| GO:0043269 | regulation of ion transport | 30.2752 | 5 | yes |
| GO:0008104 | protein localization | 30.2752 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 30.2752 | 7 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.2752 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 30.2752 | 5 | no |
| GO:0010941 | regulation of cell death | 29.3578 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 29.3578 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.4404 | 5 | no |
| GO:0036211 | protein modification process | 27.5229 | 4 | yes |
| GO:0043067 | regulation of programmed cell death | 27.5229 | 5 | yes |
| GO:0043412 | macromolecule modification | 27.5229 | 4 | yes |
| GO:0051050 | positive regulation of transport | 27.5229 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.5229 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 27.5229 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.5229 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 26.6055 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 26.6055 | 6 | yes |
| GO:0051252 | regulation of RNA metabolic process | 26.6055 | 5 | yes |
| GO:0022607 | cellular component assembly | 25.6881 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 24.7706 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 24.7706 | 4 | yes |
| GO:0031401 | positive regulation of protein modification process | 24.7706 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.7706 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.8532 | 6 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 23.8532 | 4 | yes |
| GO:0044057 | regulation of system process | 23.8532 | 4 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 23.8532 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 23.8532 | 6 | yes |
| GO:0071702 | organic substance transport | 23.8532 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.8532 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.8532 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 23.8532 | 6 | no |
| GO:0071310 | cellular response to organic substance | 22.9358 | 4 | no |
| GO:1904062 | regulation of cation transmembrane transport | 22.9358 | 6 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 22.9358 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.9358 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 22.9358 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.9358 | 7 | no |
| GO:0010243 | response to organonitrogen compound | 22.9358 | 4 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 22.0183 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 22.0183 | 4 | yes |
| GO:0051338 | regulation of transferase activity | 22.0183 | 4 | no |
| GO:0080134 | regulation of response to stress | 22.0183 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 22.0183 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 21.1009 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 21.1009 | 4 | no |
| GO:0010959 | regulation of metal ion transport | 21.1009 | 6 | yes |
| GO:0043549 | regulation of kinase activity | 21.1009 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 21.1009 | 6 | no |
| GO:0032880 | regulation of protein localization | 21.1009 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.1009 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.1835 | 6 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 20.1835 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 20.1835 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 20.1835 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 20.1835 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.1835 | 4 | no |
| GO:0051924 | regulation of calcium ion transport | 17.4312 | 7 | yes |
| GO:2001257 | regulation of cation channel activity | 16.5138 | 6 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 15.5963 | 7 | yes |
| GO:0010038 | response to metal ion | 14.6789 | 4 | yes |
| GO:0010942 | positive regulation of cell death | 14.6789 | 5 | yes |
| GO:0016310 | phosphorylation | 14.6789 | 5 | yes |
| GO:0019932 | second-messenger-mediated signaling | 13.7615 | 4 | yes |
| GO:0090257 | regulation of muscle system process | 13.7615 | 5 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 13.7615 | 7 | yes |
| GO:0006468 | protein phosphorylation | 12.8440 | 5 | yes |
| GO:0008016 | regulation of heart contraction | 12.8440 | 6 | yes |
| GO:0019722 | calcium-mediated signaling | 12.8440 | 5 | yes |
| GO:0043065 | positive regulation of apoptotic process | 12.8440 | 7 | yes |
| GO:0043068 | positive regulation of programmed cell death | 12.8440 | 6 | yes |
| GO:0051051 | negative regulation of transport | 12.8440 | 4 | yes |
| GO:0051282 | regulation of sequestering of calcium ion | 12.8440 | 4 | yes |
| GO:1903522 | regulation of blood circulation | 12.8440 | 5 | yes |
| GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 11.9266 | 5 | yes |
| GO:0018193 | peptidyl-amino acid modification | 11.0092 | 5 | yes |
| GO:0048878 | chemical homeostasis | 11.0092 | 4 | yes |
| GO:0006937 | regulation of muscle contraction | 10.0917 | 6 | yes |
| GO:0006942 | regulation of striated muscle contraction | 10.0917 | 7 | yes |
| GO:0055117 | regulation of cardiac muscle contraction | 10.0917 | 7 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 10.0917 | 6 | yes |
| GO:0006873 | cellular ion homeostasis | 9.1743 | 4 | yes |
| GO:0006875 | cellular metal ion homeostasis | 9.1743 | 6 | yes |
| GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 9.1743 | 6 | yes |
| GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 9.1743 | 7 | yes |
| GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 9.1743 | 6 | yes |
| GO:0030003 | cellular cation homeostasis | 9.1743 | 5 | yes |
| GO:0034763 | negative regulation of transmembrane transport | 9.1743 | 5 | yes |
| GO:0043271 | negative regulation of ion transport | 9.1743 | 5 | yes |
| GO:0046777 | protein autophosphorylation | 9.1743 | 6 | yes |
| GO:0050801 | ion homeostasis | 9.1743 | 5 | yes |
| GO:0055065 | metal ion homeostasis | 9.1743 | 7 | yes |
| GO:0055080 | cation homeostasis | 9.1743 | 6 | yes |
| GO:0098771 | inorganic ion homeostasis | 9.1743 | 6 | yes |
| GO:0032410 | negative regulation of transporter activity | 8.2569 | 4 | yes |
| GO:0034766 | negative regulation of ion transmembrane transport | 8.2569 | 6 | yes |
| GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 8.2569 | 6 | yes |
| GO:0071241 | cellular response to inorganic substance | 8.2569 | 4 | yes |
| GO:0072503 | cellular divalent inorganic cation homeostasis | 8.2569 | 6 | yes |
| GO:0072507 | divalent inorganic cation homeostasis | 8.2569 | 7 | yes |
| GO:1904063 | negative regulation of cation transmembrane transport | 8.2569 | 7 | yes |
| GO:0006874 | cellular calcium ion homeostasis | 7.3394 | 7 | yes |
| GO:0032413 | negative regulation of ion transmembrane transporter activity | 7.3394 | 5 | yes |
| GO:0051592 | response to calcium ion | 7.3394 | 5 | yes |
| GO:0055074 | calcium ion homeostasis | 7.3394 | 8 | yes |
| GO:0071248 | cellular response to metal ion | 7.3394 | 5 | yes |
| GO:0098901 | regulation of cardiac muscle cell action potential | 6.4220 | 4 | yes |
| GO:0001558 | regulation of cell growth | 5.5046 | 4 | yes |
| GO:0010660 | regulation of muscle cell apoptotic process | 5.5046 | 7 | yes |
| GO:0018209 | peptidyl-serine modification | 5.5046 | 6 | yes |
| GO:0031056 | regulation of histone modification | 5.5046 | 7 | yes |
| GO:0043502 | regulation of muscle adaptation | 5.5046 | 4 | yes |
| GO:0002028 | regulation of sodium ion transport | 4.5872 | 7 | yes |
| GO:0010649 | regulation of cell communication by electrical coupling | 4.5872 | 5 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 4.5872 | 6 | yes |
| GO:0018107 | peptidyl-threonine phosphorylation | 4.5872 | 6 | yes |
| GO:0018210 | peptidyl-threonine modification | 4.5872 | 6 | yes |
| GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction | 4.5872 | 6 | yes |
| GO:0010611 | regulation of cardiac muscle hypertrophy | 3.6697 | 5 | yes |
| GO:0010662 | regulation of striated muscle cell apoptotic process | 3.6697 | 8 | yes |
| GO:0010665 | regulation of cardiac muscle cell apoptotic process | 3.6697 | 9 | yes |
| GO:0014743 | regulation of muscle hypertrophy | 3.6697 | 6 | yes |
| GO:0032469 | endoplasmic reticulum calcium ion homeostasis | 3.6697 | 8 | yes |
| GO:0086091 | regulation of heart rate by cardiac conduction | 3.6697 | 4 | yes |
| GO:1902305 | regulation of sodium ion transmembrane transport | 3.6697 | 7 | yes |
| GO:0003254 | regulation of membrane depolarization | 2.7523 | 4 | yes |
| GO:0010613 | positive regulation of cardiac muscle hypertrophy | 2.7523 | 6 | yes |
| GO:0010661 | positive regulation of muscle cell apoptotic process | 2.7523 | 8 | yes |
| GO:0010663 | positive regulation of striated muscle cell apoptotic process | 2.7523 | 9 | yes |
| GO:0010666 | positive regulation of cardiac muscle cell apoptotic process | 2.7523 | 10 | yes |
| GO:0014742 | positive regulation of muscle hypertrophy | 2.7523 | 5 | yes |
| GO:0071277 | cellular response to calcium ion | 2.7523 | 6 | yes |
| GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction | 2.7523 | 5 | yes |
| GO:1902514 | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel | 2.7523 | 8 | yes |
| GO:2000649 | regulation of sodium ion transmembrane transporter activity | 2.7523 | 6 | yes |
| GO:0010766 | negative regulation of sodium ion transport | 1.8349 | 6 | yes |
| GO:0031063 | regulation of histone deacetylation | 1.8349 | 8 | yes |
| GO:0055119 | relaxation of cardiac muscle | 1.8349 | 5 | yes |
| GO:0070252 | actin-mediated cell contraction | 1.8349 | 4 | yes |
| GO:0086003 | cardiac muscle cell contraction | 1.8349 | 5 | yes |
| GO:0090075 | relaxation of muscle | 1.8349 | 4 | yes |
| GO:0090311 | regulation of protein deacetylation | 1.8349 | 7 | yes |
| GO:0150065 | regulation of deacetylase activity | 1.8349 | 5 | yes |
| GO:1901077 | regulation of relaxation of muscle | 1.8349 | 6 | yes |
| GO:1901725 | regulation of histone deacetylase activity | 1.8349 | 6 | yes |
| GO:1901897 | regulation of relaxation of cardiac muscle | 1.8349 | 7 | yes |
| GO:1902306 | negative regulation of sodium ion transmembrane transport | 1.8349 | 7 | yes |
| GO:2000650 | negative regulation of sodium ion transmembrane transporter activity | 1.8349 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KCC2D_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 8.2569 | 3 | no |
| DOID:0050700 | cardiomyopathy | 7.3394 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 7.3394 | 5 | no |
| DOID:2843 | long QT syndrome | 2.7523 | 6 | no |
| DOID:12930 | dilated cardiomyopathy | 2.7523 | 6 | no |
| DOID:0080000 | muscular disease | 2.7523 | 3 | no |
| DOID:423 | myopathy | 2.7523 | 5 | no |
| DOID:66 | muscle tissue disease | 2.7523 | 4 | no |
| DOID:9884 | muscular dystrophy | 2.7523 | 6 | no |
| DOID:0060674 | catecholaminergic polymorphic ventricular tachycardia | 1.8349 | 5 | no |
| DOID:10273 | heart conduction disease | 1.8349 | 4 | no |
| DOID:0050753 | cerebellar ataxia | 1.8349 | 6 | no |
| DOID:0050951 | hereditary ataxia | 1.8349 | 5 | no |
| DOID:1289 | neurodegenerative disease | 1.8349 | 4 | no |
| DOID:1441 | autosomal dominant cerebellar ataxia | 1.8349 | 7 | no |
| DOID:331 | central nervous system disease | 1.8349 | 3 | no |
| DOID:0050686 | organ system cancer | 1.8349 | 3 | no |
| DOID:65 | connective tissue disease | 1.8349 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRF_HUMAN | [view interactions] | Low throughput | no | yes |
| FLII_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRF2_HUMAN | [view interactions] | Low throughput | no | yes |
| LRRF1_HUMAN | [view interactions] | Low throughput | no | yes |
| TBB5_HUMAN | [view interactions] | Low throughput | no | yes |
| TBB4B_HUMAN | [view interactions] | Low throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TMOD3_HUMAN | [view interactions] | Low throughput | no | yes |
| ZN363_HUMAN | [view interactions] | Low throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SCN5A_HUMAN | [view interactions] | Low throughput | no | no |
| ACBD6_HUMAN | [view interactions] | Low throughput | no | yes |
| PPLA_HUMAN | [view interactions] | Low throughput | no | no |
| KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RYR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IF4B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RS18_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | Low throughput | no | yes |
| THUM3_HUMAN | [view interactions] | High throughput | no | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| ASXL1_HUMAN | [view interactions] | High throughput | no | no |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| P121A_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| E41LB_HUMAN | [view interactions] | High throughput | no | yes |
| MAP10_HUMAN | [view interactions] | High throughput | no | no |
| F163B_HUMAN | [view interactions] | High throughput | no | yes |
| ELP1_HUMAN | [view interactions] | High throughput | no | yes |
| SHSA6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAGA9_HUMAN | [view interactions] | High throughput | no | no |
| PGAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| ELP2_HUMAN | [view interactions] | High throughput | no | yes |
| SSH3_HUMAN | [view interactions] | High throughput | no | yes |
| ARMX5_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG7_HUMAN | [view interactions] | High throughput | no | no |
| MECP2_HUMAN | [view interactions] | High throughput | no | yes |
| PLK4_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| RPA49_HUMAN | [view interactions] | High throughput | no | yes |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| FAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIM2_HUMAN | [view interactions] | High throughput | no | no |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| RHG29_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKG1_HUMAN | [view interactions] | High throughput | no | no |
| KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBAR2_HUMAN | [view interactions] | High throughput | no | no |
| GCN1_HUMAN | [view interactions] | High throughput | no | yes |
| PLPL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCC2_HUMAN | [view interactions] | High throughput | no | yes |
| CK2N1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| PON2_HUMAN | [view interactions] | High throughput | no | yes |
| ITPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITPR3_HUMAN | [view interactions] | High throughput | no | yes |
| ITPR2_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITPI2_HUMAN | [view interactions] | High throughput | no | yes |
| PDE4A_HUMAN | [view interactions] | High throughput | no | no |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SKAP2_HUMAN | [view interactions] | High throughput | no | no |
| DPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| PIM3_HUMAN | [view interactions] | High throughput | no | no |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| AAKG3_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFIH1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| DMD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| INGR2_HUMAN | [view interactions] | High throughput | no | yes |
| HNMT_HUMAN | [view interactions] | High throughput | no | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR2BP_HUMAN | [view interactions] | High throughput | no | yes |
| F171B_HUMAN | [view interactions] | High throughput | no | yes |
| SPA24_HUMAN | [view interactions] | High throughput | no | no |
| TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
| DNAL4_HUMAN | [view interactions] | High throughput | no | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC5_HUMAN | [view interactions] | High throughput | no | yes |
| BANP_HUMAN | [view interactions] | High throughput | no | yes |
| MOAP1_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| FND3B_HUMAN | [view interactions] | High throughput | no | no |
| EPHAA_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| ERCC8_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO3_HUMAN | [view interactions] | High throughput | no | yes |
| UBC9_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDN1A_HUMAN | [view interactions] | High throughput | no | no |
| HAUS2_HUMAN | [view interactions] | High throughput | no | yes |
| CEP76_HUMAN | [view interactions] | High throughput | no | yes |
| TSHR_HUMAN | [view interactions] | High throughput | no | no |
| TIRAP_HUMAN | [view interactions] | High throughput | no | no |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| MAGB4_HUMAN | [view interactions] | High throughput | no | no |
| SCRN2_HUMAN | [view interactions] | High throughput | no | yes |
| DACT2_HUMAN | [view interactions] | High throughput | no | yes |
| IQCF1_HUMAN | [view interactions] | High throughput | no | no |
| WNT4_HUMAN | [view interactions] | High throughput | no | no |
| RHG25_HUMAN | [view interactions] | High throughput | no | no |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| DYH14_HUMAN | [view interactions] | High throughput | no | no |
| UNG_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| KANL3_HUMAN | [view interactions] | High throughput | no | yes |
| MRM2_HUMAN | [view interactions] | High throughput | no | yes |
| PUSL1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM42_HUMAN | [view interactions] | High throughput | no | yes |
| MTG1_HUMAN | [view interactions] | High throughput | no | yes |
| MOK_HUMAN | [view interactions] | High throughput | no | no |
| CXXC1_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| DIDO1_HUMAN | [view interactions] | High throughput | no | yes |
| SET1A_HUMAN | [view interactions] | High throughput | no | yes |
| SENP5_HUMAN | [view interactions] | High throughput | no | no |
| ELP3_HUMAN | [view interactions] | High throughput | no | no |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| SUH_HUMAN | [view interactions] | High throughput | no | yes |
| LIN54_HUMAN | [view interactions] | High throughput | no | yes |
| TRM61_HUMAN | [view interactions] | High throughput | no | no |
| PI51A_HUMAN | [view interactions] | High throughput | no | yes |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAB3_HUMAN | [view interactions] | High throughput | no | no |
| BD1L1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN843_HUMAN | [view interactions] | High throughput | no | yes |
| CF410_HUMAN | [view interactions] | High throughput | no | yes |
| DTL_HUMAN | [view interactions] | High throughput | no | no |
| HEM1_HUMAN | [view interactions] | High throughput | no | yes |
| TPRN_HUMAN | [view interactions] | High throughput | no | yes |
| HCFC1_HUMAN | [view interactions] | High throughput | no | yes |
| NEK1_HUMAN | [view interactions] | High throughput | no | yes |
| DPH1_HUMAN | [view interactions] | High throughput | no | yes |
| TSR3_HUMAN | [view interactions] | High throughput | no | yes |
| CF141_HUMAN | [view interactions] | High throughput | no | no |
| KDM7A_HUMAN | [view interactions] | Computational | no | yes |
| K1549_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| JAK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TIF1A_HUMAN | [view interactions] | Computational | no | yes |
| FLNB_HUMAN | [view interactions] | Computational | no | no |
| MDM2_HUMAN | [view interactions] | Computational | no | yes |
| SND1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HDAC5_HUMAN | [view interactions] | Computational | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MEF2D_HUMAN | [view interactions] | Computational | no | yes |
| TRAK1_HUMAN | [view interactions] | Computational | no | yes |
| RAP1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| HSF1_HUMAN | [view interactions] | Computational | no | yes |
| HES1_HUMAN | [view interactions] | Computational | no | no |
| AP3B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AGGF1_HUMAN | [view interactions] | Computational | no | no |
| GRIA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| FLNC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRIA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCG2_HUMAN | [view interactions] | Computational | no | yes |
| CREB1_HUMAN | [view interactions] | Computational | no | yes |
| IFNG_HUMAN | [view interactions] | Computational | no | no |
| CBP_HUMAN | [view interactions] | Computational | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PK3C3_HUMAN | [view interactions] | Computational | no | yes |
| TRPV1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| F1142_HUMAN | [view interactions] | Computational | no | yes |
| TLE1_HUMAN | [view interactions] | Computational | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AKAP9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MPIP3_HUMAN | [view interactions] | Computational | no | yes |
| PPM1F_HUMAN | [view interactions] | Computational | no | yes |
| NOS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| B2L11_HUMAN | [view interactions] | Computational | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAP1B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| EP300_HUMAN | [view interactions] | Computational | no | yes |
| MARK3_HUMAN | [view interactions] | Computational | no | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AKAP5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NOS3_HUMAN | [view interactions] | Computational | no | no |
| MYO6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ATRAP_HUMAN | [view interactions] | Computational | no | yes |
| GRIA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| E41L1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MEF2C_HUMAN | [view interactions] | Computational | no | yes |
| CCG8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRM5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| 1433B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RIPK3_HUMAN | [view interactions] | Computational | no | no |
| MPRIP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| JAK1_HUMAN | [view interactions] | Computational | no | yes |
| GRM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CY24B_HUMAN | [view interactions] | Computational | no | no |
| F131B_HUMAN | [view interactions] | Computational | no | no |
| QKI_HUMAN | [view interactions] | Computational | no | no |
| FBX43_HUMAN | [view interactions] | Computational | no | no |
| MEF2A_HUMAN | [view interactions] | Computational | no | yes |
| INGR1_HUMAN | [view interactions] | Computational | no | no |
| RASK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ZCCHV_HUMAN | [view interactions] | Computational | no | yes |
| ADCY3_HUMAN | [view interactions] | Computational | no | yes |
| CLCN6_HUMAN | [view interactions] | Computational | no | yes |
| KSR1_HUMAN | [view interactions] | Computational | no | yes |
| SC6A3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ADCY8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STMN1_HUMAN | [view interactions] | Computational | no | yes |
| ESRP1_HUMAN | [view interactions] | Computational | no | yes |
| ATG7_HUMAN | [view interactions] | Computational | no | yes |
| PAPS1_HUMAN | [view interactions] | Computational | no | yes |
| CCG4_HUMAN | [view entry] [view interactions] | Computational | yes | no |