BCKD_HUMAN
Evidence for PS localization
Functions
Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in BCKD_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 31.9149 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 31.9149 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.9149 | 4 | yes |
| GO:0003723 | RNA binding | 25.5319 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 21.2766 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.2766 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.2766 | 6 | no |
| GO:0042803 | protein homodimerization activity | 21.2766 | 4 | no |
| GO:0005524 | ATP binding | 19.1489 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 19.1489 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 19.1489 | 5 | yes |
| GO:0016301 | kinase activity | 12.7660 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 10.6383 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 10.6383 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in BCKD_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 51.0638 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 48.9362 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 44.6809 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 42.5532 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 42.5532 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 38.2979 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 38.2979 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 36.1702 | 4 | no |
| GO:0010468 | regulation of gene expression | 34.0426 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 34.0426 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.9149 | 5 | no |
| GO:0022607 | cellular component assembly | 31.9149 | 4 | no |
| GO:0010646 | regulation of cell communication | 31.9149 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.7872 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 29.7872 | 4 | no |
| GO:0009966 | regulation of signal transduction | 29.7872 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 27.6596 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 27.6596 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.6596 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.6596 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.6596 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 27.6596 | 5 | no |
| GO:0006996 | organelle organization | 27.6596 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.5319 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 25.5319 | 5 | yes |
| GO:0008104 | protein localization | 25.5319 | 4 | no |
| GO:0009894 | regulation of catabolic process | 25.5319 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.5319 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.5319 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.5319 | 5 | no |
| GO:0043933 | protein-containing complex organization | 25.5319 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.4043 | 5 | yes |
| GO:0031329 | regulation of cellular catabolic process | 23.4043 | 5 | no |
| GO:0031399 | regulation of protein modification process | 23.4043 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.4043 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.4043 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 23.4043 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 23.4043 | 4 | no |
| GO:0036211 | protein modification process | 21.2766 | 4 | yes |
| GO:0043412 | macromolecule modification | 21.2766 | 4 | yes |
| GO:0071702 | organic substance transport | 21.2766 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.2766 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.2766 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.2766 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.2766 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.2766 | 4 | no |
| GO:0080134 | regulation of response to stress | 21.2766 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.2766 | 5 | no |
| GO:0010941 | regulation of cell death | 21.2766 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.2766 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.2766 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.2766 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.2766 | 5 | no |
| GO:0051049 | regulation of transport | 21.2766 | 4 | no |
| GO:0016310 | phosphorylation | 14.8936 | 5 | yes |
| GO:0006468 | protein phosphorylation | 12.7660 | 5 | yes |
| GO:0062012 | regulation of small molecule metabolic process | 10.6383 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 10.6383 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 8.5106 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 8.5106 | 4 | yes |
| GO:0006109 | regulation of carbohydrate metabolic process | 6.3830 | 5 | yes |
| GO:0009063 | cellular amino acid catabolic process | 6.3830 | 4 | yes |
| GO:0009081 | branched-chain amino acid metabolic process | 6.3830 | 4 | yes |
| GO:0009083 | branched-chain amino acid catabolic process | 6.3830 | 5 | yes |
| GO:0016054 | organic acid catabolic process | 6.3830 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 6.3830 | 5 | yes |
| GO:0010675 | regulation of cellular carbohydrate metabolic process | 4.2553 | 5 | yes |
| GO:0062014 | negative regulation of small molecule metabolic process | 4.2553 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ODBB_HUMAN | [view interactions] | Low throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GATA_HUMAN | [view interactions] | High throughput | no | yes |
| MYL10_HUMAN | [view interactions] | High throughput | no | no |
| SHC2_HUMAN | [view interactions] | High throughput | no | yes |
| NUD16_HUMAN | [view interactions] | High throughput | no | yes |
| ACSM5_HUMAN | [view interactions] | High throughput | no | yes |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| CT096_HUMAN | [view interactions] | High throughput | no | yes |
| SRB4D_HUMAN | [view interactions] | High throughput | no | no |
| RSLAB_HUMAN | [view interactions] | High throughput | no | no |
| KBL_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI43_HUMAN | [view interactions] | High throughput | no | no |
| DIC_HUMAN | [view interactions] | High throughput | no | yes |
| NPS3A_HUMAN | [view interactions] | High throughput | no | yes |
| KAD4_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| MRM2_HUMAN | [view interactions] | High throughput | no | yes |
| SCOT2_HUMAN | [view interactions] | High throughput | no | no |
| RM52_HUMAN | [view interactions] | High throughput | no | yes |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| CBR4_HUMAN | [view interactions] | High throughput | no | yes |
| MTU1_HUMAN | [view interactions] | High throughput | no | no |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYYM_HUMAN | [view interactions] | High throughput | no | no |
| FXRD2_HUMAN | [view interactions] | High throughput | no | yes |
| CLC11_HUMAN | [view interactions] | High throughput | no | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| SNX9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M3K4_HUMAN | [view interactions] | High throughput | no | yes |
| IL12A_HUMAN | [view interactions] | High throughput | no | no |
| KPCD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMPK_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD8_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSM8_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| CETN1_HUMAN | [view interactions] | High throughput | no | no |
| GCNT3_HUMAN | [view interactions] | High throughput | no | no |
| RM12_HUMAN | [view interactions] | High throughput | no | yes |
| MT21C_HUMAN | [view interactions] | High throughput | no | no |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| CETN2_HUMAN | [view interactions] | High throughput | no | yes |
| CETN3_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1K_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1A_HUMAN | [view interactions] | High throughput | no | yes |
| SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EPHB1_HUMAN | [view interactions] | High throughput | no | no |
| BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM13_HUMAN | [view interactions] | High throughput | no | yes |
| TIM8B_HUMAN | [view interactions] | High throughput | no | yes |
| SSRG_HUMAN | [view interactions] | High throughput | no | yes |
| GBG12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TECR_HUMAN | [view interactions] | High throughput | no | yes |
| SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
| TRABD_HUMAN | [view interactions] | High throughput | no | yes |
| GNAS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF5A1_HUMAN | [view interactions] | High throughput | no | yes |
| TMM33_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAD2_HUMAN | [view interactions] | High throughput | no | no |
| TXTP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLRV_HUMAN | [view interactions] | High throughput | no | no |
| GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYL1_HUMAN | [view interactions] | High throughput | no | no |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSMA_HUMAN | [view interactions] | High throughput | no | yes |
| DPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM8A_HUMAN | [view interactions] | High throughput | no | yes |
| PDCD5_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADCK1_HUMAN | [view interactions] | High throughput | no | no |
| SUMO1_HUMAN | [view interactions] | High throughput | no | yes |
| RTCA_HUMAN | [view interactions] | High throughput | no | yes |
| CAB39_HUMAN | [view interactions] | High throughput | no | yes |
| ODBA_HUMAN | [view interactions] | High throughput | no | yes |
| CB39L_HUMAN | [view interactions] | High throughput | no | yes |
| FA98B_HUMAN | [view interactions] | High throughput | no | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| SPTA1_HUMAN | [view interactions] | High throughput | no | no |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR5A2_HUMAN | [view interactions] | High throughput | no | yes |
| OBI1_HUMAN | [view interactions] | High throughput | no | yes |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNS2_HUMAN | [view interactions] | High throughput | no | no |
| NIT1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBP1_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BPNT1_HUMAN | [view interactions] | High throughput | no | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| HCST_HUMAN | [view interactions] | High throughput | no | no |
| AMACR_HUMAN | [view interactions] | High throughput | no | yes |
| TAZ_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ODB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |