BCKD_HUMAN
Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in BCKD_HUMAN |
---|---|---|---|---|
GO:0000166 | nucleotide binding | 36.9231 | 4 | yes |
GO:0043168 | anion binding | 36.9231 | 4 | yes |
GO:0017076 | purine nucleotide binding | 35.3846 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 35.3846 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 35.3846 | 4 | yes |
GO:0043169 | cation binding | 27.6923 | 4 | no |
GO:0046872 | metal ion binding | 27.6923 | 5 | no |
GO:0005524 | ATP binding | 26.1538 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 26.1538 | 6 | yes |
GO:0032559 | adenyl ribonucleotide binding | 26.1538 | 5 | yes |
GO:0003723 | RNA binding | 23.0769 | 4 | no |
GO:0016301 | kinase activity | 13.8462 | 4 | yes |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 12.3077 | 4 | yes |
GO:0004674 | protein serine/threonine kinase activity | 10.7692 | 4 | yes |
GO:0004722 | protein serine/threonine phosphatase activity | 3.0769 | 4 | yes |
GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity | 3.0769 | 4 | yes |
GO:0016791 | phosphatase activity | 3.0769 | 5 | yes |
GO:0042578 | phosphoric ester hydrolase activity | 3.0769 | 4 | yes |
GO:0047323 | [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity | 3.0769 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in BCKD_HUMAN |
---|---|---|---|---|
GO:0031323 | regulation of cellular metabolic process | 49.2308 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 49.2308 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 41.5385 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 36.9231 | 4 | no |
GO:0048523 | negative regulation of cellular process | 35.3846 | 4 | no |
GO:0051128 | regulation of cellular component organization | 35.3846 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 35.3846 | 4 | no |
GO:0022607 | cellular component assembly | 33.8462 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 33.8462 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.8462 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 33.8462 | 5 | no |
GO:0006796 | phosphate-containing compound metabolic process | 32.3077 | 4 | yes |
GO:0010468 | regulation of gene expression | 32.3077 | 6 | no |
GO:0010646 | regulation of cell communication | 30.7692 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 30.7692 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 29.2308 | 5 | no |
GO:0009966 | regulation of signal transduction | 27.6923 | 4 | no |
GO:0008104 | protein localization | 27.6923 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 27.6923 | 5 | no |
GO:0043933 | protein-containing complex organization | 27.6923 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 26.1538 | 4 | yes |
GO:0051247 | positive regulation of protein metabolic process | 26.1538 | 6 | no |
GO:0051252 | regulation of RNA metabolic process | 26.1538 | 5 | no |
GO:0006996 | organelle organization | 26.1538 | 4 | no |
GO:0065003 | protein-containing complex assembly | 26.1538 | 5 | no |
GO:0009894 | regulation of catabolic process | 23.0769 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 23.0769 | 6 | no |
GO:0048584 | positive regulation of response to stimulus | 23.0769 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 23.0769 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 21.5385 | 5 | no |
GO:0009891 | positive regulation of biosynthetic process | 21.5385 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 21.5385 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 21.5385 | 4 | no |
GO:0031399 | regulation of protein modification process | 21.5385 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 21.5385 | 7 | no |
GO:0051049 | regulation of transport | 21.5385 | 4 | no |
GO:0016310 | phosphorylation | 15.3846 | 5 | yes |
GO:0019752 | carboxylic acid metabolic process | 13.8462 | 5 | yes |
GO:0043436 | oxoacid metabolic process | 13.8462 | 4 | yes |
GO:1901565 | organonitrogen compound catabolic process | 13.8462 | 4 | yes |
GO:0062012 | regulation of small molecule metabolic process | 10.7692 | 4 | yes |
GO:0006109 | regulation of carbohydrate metabolic process | 7.6923 | 5 | yes |
GO:0008610 | lipid biosynthetic process | 7.6923 | 4 | yes |
GO:0009063 | amino acid catabolic process | 6.1538 | 4 | yes |
GO:0009081 | branched-chain amino acid metabolic process | 6.1538 | 4 | yes |
GO:0009083 | branched-chain amino acid catabolic process | 6.1538 | 5 | yes |
GO:0016054 | organic acid catabolic process | 6.1538 | 4 | yes |
GO:0046395 | carboxylic acid catabolic process | 6.1538 | 5 | yes |
GO:0010906 | regulation of glucose metabolic process | 4.6154 | 5 | yes |
GO:0033238 | regulation of amine metabolic process | 4.6154 | 4 | yes |
GO:0006521 | regulation of cellular amino acid metabolic process | 3.0769 | 5 | yes |
GO:0010565 | regulation of cellular ketone metabolic process | 3.0769 | 5 | yes |
GO:0033239 | negative regulation of amine metabolic process | 3.0769 | 5 | yes |
GO:0045763 | negative regulation of cellular amino acid metabolic process | 3.0769 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ODBB_HUMAN | [view interactions] | Low throughput | no | yes |
SHC2_HUMAN | [view interactions] | High throughput | no | yes |
NUD16_HUMAN | [view interactions] | High throughput | no | yes |
ACSM5_HUMAN | [view interactions] | High throughput | no | yes |
F174A_HUMAN | [view interactions] | High throughput | no | yes |
CT096_HUMAN | [view interactions] | High throughput | no | yes |
SRB4D_HUMAN | [view interactions] | High throughput | no | no |
RSLAB_HUMAN | [view interactions] | High throughput | no | no |
KBL_HUMAN | [view interactions] | High throughput | no | yes |
CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI43_HUMAN | [view interactions] | High throughput | no | no |
DIC_HUMAN | [view interactions] | High throughput | no | yes |
NPS3A_HUMAN | [view interactions] | High throughput | no | yes |
KAD4_HUMAN | [view interactions] | High throughput | no | yes |
ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
MTG2_HUMAN | [view interactions] | High throughput | no | yes |
MRM2_HUMAN | [view interactions] | High throughput | no | yes |
SCOT2_HUMAN | [view interactions] | High throughput | no | no |
RM52_HUMAN | [view interactions] | High throughput | no | yes |
FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
CBR4_HUMAN | [view interactions] | High throughput | no | yes |
MTU1_HUMAN | [view interactions] | High throughput | no | no |
NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYYM_HUMAN | [view interactions] | High throughput | no | no |
FXRD2_HUMAN | [view interactions] | High throughput | no | yes |
CLC11_HUMAN | [view interactions] | High throughput | no | no |
FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RBM39_HUMAN | [view interactions] | High throughput | no | yes |
SNX9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
TRI72_HUMAN | [view interactions] | High throughput | no | no |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
M3K4_HUMAN | [view interactions] | High throughput | no | yes |
IL12A_HUMAN | [view interactions] | High throughput | no | no |
KPCD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DMPK_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
FBX7_HUMAN | [view interactions] | High throughput | no | yes |
ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEDD8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PNKP_HUMAN | [view interactions] | High throughput | no | yes |
STN1_HUMAN | [view interactions] | High throughput | no | no |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF2M_HUMAN | [view interactions] | High throughput | no | yes |
SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EXD2_HUMAN | [view interactions] | High throughput | no | yes |
SEPT5_HUMAN | [view interactions] | High throughput | no | no |
ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACYP1_HUMAN | [view interactions] | High throughput | no | yes |
BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BPHL_HUMAN | [view interactions] | High throughput | no | no |
ACBP_HUMAN | [view interactions] | High throughput | no | yes |
ODB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IDH3G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RM03_HUMAN | [view interactions] | High throughput | no | yes |
RT35_HUMAN | [view interactions] | High throughput | no | yes |
SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PCKGM_HUMAN | [view interactions] | High throughput | no | no |
ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDXK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
YTHD1_HUMAN | [view interactions] | High throughput | no | no |
STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LSM8_HUMAN | [view interactions] | High throughput | no | yes |
GLUT4_HUMAN | [view interactions] | High throughput | no | no |
MK06_HUMAN | [view interactions] | High throughput | no | yes |
CETN1_HUMAN | [view interactions] | High throughput | no | no |
ISLR_HUMAN | [view interactions] | High throughput | no | no |
GCNT3_HUMAN | [view interactions] | High throughput | no | no |
RM12_HUMAN | [view interactions] | High throughput | no | yes |
MT21C_HUMAN | [view interactions] | High throughput | no | no |
CETN3_HUMAN | [view interactions] | High throughput | no | yes |
CETN2_HUMAN | [view interactions] | High throughput | no | yes |
LG3BP_HUMAN | [view interactions] | High throughput | no | no |
PPM1K_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
PPM1A_HUMAN | [view interactions] | High throughput | no | yes |
SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
EPHB1_HUMAN | [view interactions] | High throughput | no | no |
BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDCD5_HUMAN | [view interactions] | High throughput | no | yes |
TIM8A_HUMAN | [view interactions] | High throughput | no | yes |
DPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NSMA_HUMAN | [view interactions] | High throughput | no | yes |
GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYL1_HUMAN | [view interactions] | High throughput | no | no |
TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MLRV_HUMAN | [view interactions] | High throughput | no | no |
STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TXTP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KAD2_HUMAN | [view interactions] | High throughput | no | no |
TMM33_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF5A1_HUMAN | [view interactions] | High throughput | no | yes |
BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
KCC2D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TEBP_HUMAN | [view interactions] | High throughput | no | yes |
GNAS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRABD_HUMAN | [view interactions] | High throughput | no | yes |
SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
TECR_HUMAN | [view interactions] | High throughput | no | yes |
GBG12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SSRG_HUMAN | [view interactions] | High throughput | no | yes |
TIM8B_HUMAN | [view interactions] | High throughput | no | yes |
TIM13_HUMAN | [view interactions] | High throughput | no | yes |
KCC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADCK1_HUMAN | [view interactions] | High throughput | no | no |
SUMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RTCA_HUMAN | [view interactions] | High throughput | no | yes |
CAB39_HUMAN | [view interactions] | High throughput | no | yes |
ODBA_HUMAN | [view interactions] | High throughput | no | yes |
CB39L_HUMAN | [view interactions] | High throughput | no | yes |
FA98B_HUMAN | [view interactions] | High throughput | no | yes |
DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGLN_HUMAN | [view interactions] | High throughput | no | no |
CP135_HUMAN | [view interactions] | High throughput | no | no |
SPTA1_HUMAN | [view interactions] | High throughput | no | no |
FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
NR5A2_HUMAN | [view interactions] | High throughput | no | yes |
OBI1_HUMAN | [view interactions] | High throughput | no | yes |
TERF2_HUMAN | [view interactions] | High throughput | no | yes |
WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TENS2_HUMAN | [view interactions] | High throughput | no | no |
NIT1_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZBP1_HUMAN | [view interactions] | High throughput | no | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BPNT1_HUMAN | [view interactions] | High throughput | no | yes |
UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PFD5_HUMAN | [view interactions] | High throughput | no | yes |
HCST_HUMAN | [view interactions] | High throughput | no | no |
AMACR_HUMAN | [view interactions] | High throughput | no | yes |
TAZ_HUMAN | [view interactions] | High throughput | no | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GATA_HUMAN | [view interactions] | High throughput | no | yes |
MYL10_HUMAN | [view interactions] | High throughput | no | no |