Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

BCKD_HUMAN

Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in BCKD_HUMAN
GO:0000166 nucleotide binding 36.9231 4 yes
GO:0043168 anion binding 36.9231 4 yes
GO:0017076 purine nucleotide binding 35.3846 5 yes
GO:0032555 purine ribonucleotide binding 35.3846 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 35.3846 4 yes
GO:0043169 cation binding 27.6923 4 no
GO:0046872 metal ion binding 27.6923 5 no
GO:0005524 ATP binding 26.1538 5 yes
GO:0030554 adenyl nucleotide binding 26.1538 6 yes
GO:0032559 adenyl ribonucleotide binding 26.1538 5 yes
GO:0003723 RNA binding 23.0769 4 no
GO:0016301 kinase activity 13.8462 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 12.3077 4 yes
GO:0004674 protein serine/threonine kinase activity 10.7692 4 yes
GO:0004722 protein serine/threonine phosphatase activity 3.0769 4 yes
GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity 3.0769 4 yes
GO:0016791 phosphatase activity 3.0769 5 yes
GO:0042578 phosphoric ester hydrolase activity 3.0769 4 yes
GO:0047323 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity 3.0769 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in BCKD_HUMAN
GO:0031323 regulation of cellular metabolic process 49.2308 4 yes
GO:0048522 positive regulation of cellular process 49.2308 4 no
GO:0080090 regulation of primary metabolic process 41.5385 4 yes
GO:0060255 regulation of macromolecule metabolic process 40.0000 4 no
GO:0009893 positive regulation of metabolic process 36.9231 4 no
GO:0048523 negative regulation of cellular process 35.3846 4 no
GO:0051128 regulation of cellular component organization 35.3846 4 no
GO:0009889 regulation of biosynthetic process 35.3846 4 no
GO:0022607 cellular component assembly 33.8462 4 no
GO:0010556 regulation of macromolecule biosynthetic process 33.8462 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.8462 5 no
GO:0031326 regulation of cellular biosynthetic process 33.8462 5 no
GO:0006796 phosphate-containing compound metabolic process 32.3077 4 yes
GO:0010468 regulation of gene expression 32.3077 6 no
GO:0010646 regulation of cell communication 30.7692 4 no
GO:0010604 positive regulation of macromolecule metabolic process 30.7692 5 no
GO:0031325 positive regulation of cellular metabolic process 29.2308 5 no
GO:0009966 regulation of signal transduction 27.6923 4 no
GO:0008104 protein localization 27.6923 4 no
GO:0051246 regulation of protein metabolic process 27.6923 5 no
GO:0043933 protein-containing complex organization 27.6923 4 no
GO:0009892 negative regulation of metabolic process 26.1538 4 yes
GO:0051247 positive regulation of protein metabolic process 26.1538 6 no
GO:0051252 regulation of RNA metabolic process 26.1538 5 no
GO:0006996 organelle organization 26.1538 4 no
GO:0065003 protein-containing complex assembly 26.1538 5 no
GO:0009894 regulation of catabolic process 23.0769 4 no
GO:0019220 regulation of phosphate metabolic process 23.0769 6 no
GO:0048584 positive regulation of response to stimulus 23.0769 4 no
GO:0051174 regulation of phosphorus metabolic process 23.0769 5 no
GO:1902531 regulation of intracellular signal transduction 21.5385 5 no
GO:0009891 positive regulation of biosynthetic process 21.5385 5 no
GO:0010605 negative regulation of macromolecule metabolic process 21.5385 5 no
GO:0043085 positive regulation of catalytic activity 21.5385 4 no
GO:0031399 regulation of protein modification process 21.5385 6 no
GO:0031401 positive regulation of protein modification process 21.5385 7 no
GO:0051049 regulation of transport 21.5385 4 no
GO:0016310 phosphorylation 15.3846 5 yes
GO:0019752 carboxylic acid metabolic process 13.8462 5 yes
GO:0043436 oxoacid metabolic process 13.8462 4 yes
GO:1901565 organonitrogen compound catabolic process 13.8462 4 yes
GO:0062012 regulation of small molecule metabolic process 10.7692 4 yes
GO:0006109 regulation of carbohydrate metabolic process 7.6923 5 yes
GO:0008610 lipid biosynthetic process 7.6923 4 yes
GO:0009063 amino acid catabolic process 6.1538 4 yes
GO:0009081 branched-chain amino acid metabolic process 6.1538 4 yes
GO:0009083 branched-chain amino acid catabolic process 6.1538 5 yes
GO:0016054 organic acid catabolic process 6.1538 4 yes
GO:0046395 carboxylic acid catabolic process 6.1538 5 yes
GO:0010906 regulation of glucose metabolic process 4.6154 5 yes
GO:0033238 regulation of amine metabolic process 4.6154 4 yes
GO:0006521 regulation of cellular amino acid metabolic process 3.0769 5 yes
GO:0010565 regulation of cellular ketone metabolic process 3.0769 5 yes
GO:0033239 negative regulation of amine metabolic process 3.0769 5 yes
GO:0045763 negative regulation of cellular amino acid metabolic process 3.0769 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ODBB_HUMAN [view interactions] Low throughput no yes
SHC2_HUMAN [view interactions] High throughput no yes
NUD16_HUMAN [view interactions] High throughput no yes
ACSM5_HUMAN [view interactions] High throughput no yes
F174A_HUMAN [view interactions] High throughput no yes
CT096_HUMAN [view interactions] High throughput no yes
SRB4D_HUMAN [view interactions] High throughput no no
RSLAB_HUMAN [view interactions] High throughput no no
KBL_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
TRI43_HUMAN [view interactions] High throughput no no
DIC_HUMAN [view interactions] High throughput no yes
NPS3A_HUMAN [view interactions] High throughput no yes
KAD4_HUMAN [view interactions] High throughput no yes
ARMC8_HUMAN [view interactions] High throughput no yes
MTG2_HUMAN [view interactions] High throughput no yes
MRM2_HUMAN [view interactions] High throughput no yes
SCOT2_HUMAN [view interactions] High throughput no no
RM52_HUMAN [view interactions] High throughput no yes
FAHD1_HUMAN [view interactions] High throughput no yes
CBR4_HUMAN [view interactions] High throughput no yes
MTU1_HUMAN [view interactions] High throughput no no
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
SYYM_HUMAN [view interactions] High throughput no no
FXRD2_HUMAN [view interactions] High throughput no yes
CLC11_HUMAN [view interactions] High throughput no no
FBXW7_HUMAN [view interactions] High throughput no yes
CPSF6_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
MAP4_HUMAN [view entry] [view interactions] High throughput yes no
RBM39_HUMAN [view interactions] High throughput no yes
SNX9_HUMAN [view entry] [view interactions] High throughput yes yes
ZO2_HUMAN [view entry] [view interactions] High throughput yes no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
TRI72_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
M3K4_HUMAN [view interactions] High throughput no yes
IL12A_HUMAN [view interactions] High throughput no no
KPCD_HUMAN [view entry] [view interactions] High throughput yes yes
DMPK_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
FBX7_HUMAN [view interactions] High throughput no yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD8_HUMAN [view entry] [view interactions] High throughput yes yes
PNKP_HUMAN [view interactions] High throughput no yes
STN1_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
IF2M_HUMAN [view interactions] High throughput no yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
EXD2_HUMAN [view interactions] High throughput no yes
SEPT5_HUMAN [view interactions] High throughput no no
ACACA_HUMAN [view entry] [view interactions] High throughput yes yes
ARP3B_HUMAN [view entry] [view interactions] High throughput yes yes
ACYP1_HUMAN [view interactions] High throughput no yes
BCKD_HUMAN [view entry] [view interactions] High throughput yes yes
BPHL_HUMAN [view interactions] High throughput no no
ACBP_HUMAN [view interactions] High throughput no yes
ODB2_HUMAN [view entry] [view interactions] High throughput yes yes
ODP2_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA3_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
IDH3G_HUMAN [view entry] [view interactions] High throughput yes yes
MCCA_HUMAN [view entry] [view interactions] High throughput yes yes
RM03_HUMAN [view interactions] High throughput no yes
RT35_HUMAN [view interactions] High throughput no yes
SCOT1_HUMAN [view entry] [view interactions] High throughput yes yes
PCKGM_HUMAN [view interactions] High throughput no no
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
PDXK_HUMAN [view entry] [view interactions] High throughput yes yes
RASL1_HUMAN [view entry] [view interactions] High throughput yes yes
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
YTHD1_HUMAN [view interactions] High throughput no no
STAT3_HUMAN [view entry] [view interactions] High throughput yes yes
EPS8_HUMAN [view entry] [view interactions] High throughput yes yes
LSM8_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
MK06_HUMAN [view interactions] High throughput no yes
CETN1_HUMAN [view interactions] High throughput no no
ISLR_HUMAN [view interactions] High throughput no no
GCNT3_HUMAN [view interactions] High throughput no no
RM12_HUMAN [view interactions] High throughput no yes
MT21C_HUMAN [view interactions] High throughput no no
CETN3_HUMAN [view interactions] High throughput no yes
CETN2_HUMAN [view interactions] High throughput no yes
LG3BP_HUMAN [view interactions] High throughput no no
PPM1K_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
PPM1A_HUMAN [view interactions] High throughput no yes
SRBS2_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
EPHB1_HUMAN [view interactions] High throughput no no
BCR_HUMAN [view entry] [view interactions] High throughput yes yes
AIP_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
PDCD5_HUMAN [view interactions] High throughput no yes
TIM8A_HUMAN [view interactions] High throughput no yes
DPM1_HUMAN [view entry] [view interactions] High throughput yes yes
NSMA_HUMAN [view interactions] High throughput no yes
GNAI2_HUMAN [view entry] [view interactions] High throughput yes yes
MYL1_HUMAN [view interactions] High throughput no no
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
MLRV_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
SSRA_HUMAN [view entry] [view interactions] High throughput yes yes
TXTP_HUMAN [view entry] [view interactions] High throughput yes no
KAD2_HUMAN [view interactions] High throughput no no
TMM33_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI1_HUMAN [view entry] [view interactions] High throughput yes yes
IF5A1_HUMAN [view interactions] High throughput no yes
BASP1_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP5_HUMAN [view interactions] High throughput no yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
TEBP_HUMAN [view interactions] High throughput no yes
GNAS1_HUMAN [view entry] [view interactions] High throughput yes yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
TRABD_HUMAN [view interactions] High throughput no yes
SDF2L_HUMAN [view interactions] High throughput no yes
TECR_HUMAN [view interactions] High throughput no yes
GBG12_HUMAN [view entry] [view interactions] High throughput yes yes
SSRG_HUMAN [view interactions] High throughput no yes
TIM8B_HUMAN [view interactions] High throughput no yes
TIM13_HUMAN [view interactions] High throughput no yes
KCC1A_HUMAN [view entry] [view interactions] High throughput yes yes
ADCK1_HUMAN [view interactions] High throughput no no
SUMO1_HUMAN [view entry] [view interactions] High throughput yes yes
RTCA_HUMAN [view interactions] High throughput no yes
CAB39_HUMAN [view interactions] High throughput no yes
ODBA_HUMAN [view interactions] High throughput no yes
CB39L_HUMAN [view interactions] High throughput no yes
FA98B_HUMAN [view interactions] High throughput no yes
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
EGLN_HUMAN [view interactions] High throughput no no
CP135_HUMAN [view interactions] High throughput no no
SPTA1_HUMAN [view interactions] High throughput no no
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
TP53B_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
NR5A2_HUMAN [view interactions] High throughput no yes
OBI1_HUMAN [view interactions] High throughput no yes
TERF2_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
NDUAA_HUMAN [view entry] [view interactions] High throughput yes yes
TENS2_HUMAN [view interactions] High throughput no no
NIT1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
ZBP1_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
DNJB1_HUMAN [view entry] [view interactions] High throughput yes yes
BPNT1_HUMAN [view interactions] High throughput no yes
UCRI_HUMAN [view entry] [view interactions] High throughput yes yes
PFD5_HUMAN [view interactions] High throughput no yes
HCST_HUMAN [view interactions] High throughput no no
AMACR_HUMAN [view interactions] High throughput no yes
TAZ_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
GATA_HUMAN [view interactions] High throughput no yes
MYL10_HUMAN [view interactions] High throughput no no