Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PDXK_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5-phosphate (PLP), pyridoxine 5-phosphate (PNP) and pyridoxamine 5-phosphate (PMP), respectively (PubMed, PubMed, PubMed, PubMed, PubMed) (Probable). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
220 Arg Gln Neuropathy,hereditarymotorandsensory,6C,withopticatrophy(HMSN6C) -
228 Ala Thr Neuropathy,hereditarymotorandsensory,6C,withopticatrophy(HMSN6C) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PDXK_HUMAN
GO:0042803 protein homodimerization activity 34.7826 4 yes
GO:0031625 ubiquitin protein ligase binding 26.0870 5 no
GO:0044389 ubiquitin-like protein ligase binding 26.0870 4 no
GO:0019900 kinase binding 26.0870 4 no
GO:0019901 protein kinase binding 26.0870 5 no
GO:0003723 RNA binding 21.7391 4 no
GO:0017076 purine nucleotide binding 17.3913 4 yes
GO:0032555 purine ribonucleotide binding 17.3913 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 17.3913 4 yes
GO:0046872 metal ion binding 17.3913 4 yes
GO:0000287 magnesium ion binding 13.0435 5 yes
GO:0005524 ATP binding 13.0435 5 yes
GO:0016301 kinase activity 13.0435 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 13.0435 4 yes
GO:0030554 adenyl nucleotide binding 13.0435 5 yes
GO:0032559 adenyl ribonucleotide binding 13.0435 5 yes
GO:0008270 zinc ion binding 8.6957 6 yes
GO:0008478 pyridoxal kinase activity 8.6957 5 yes
GO:0030170 pyridoxal phosphate binding 8.6957 4 yes
GO:0030955 potassium ion binding 8.6957 6 yes
GO:0031402 sodium ion binding 8.6957 6 yes
GO:0031403 lithium ion binding 8.6957 6 yes
GO:0031420 alkali metal ion binding 8.6957 5 yes
GO:0046914 transition metal ion binding 8.6957 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PDXK_HUMAN
GO:0031323 regulation of cellular metabolic process 56.5217 4 no
GO:0048522 positive regulation of cellular process 56.5217 4 no
GO:0048523 negative regulation of cellular process 56.5217 4 no
GO:0051171 regulation of nitrogen compound metabolic process 56.5217 4 no
GO:0060255 regulation of macromolecule metabolic process 56.5217 4 no
GO:0080090 regulation of primary metabolic process 56.5217 4 no
GO:0009892 negative regulation of metabolic process 52.1739 4 no
GO:0022607 cellular component assembly 47.8261 4 no
GO:0010605 negative regulation of macromolecule metabolic process 47.8261 5 no
GO:0031324 negative regulation of cellular metabolic process 47.8261 5 no
GO:0051128 regulation of cellular component organization 47.8261 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 47.8261 5 no
GO:0051246 regulation of protein metabolic process 43.4783 5 no
GO:0010468 regulation of gene expression 43.4783 5 no
GO:0006996 organelle organization 39.1304 4 no
GO:0009889 regulation of biosynthetic process 39.1304 4 no
GO:0010556 regulation of macromolecule biosynthetic process 39.1304 5 no
GO:0031326 regulation of cellular biosynthetic process 39.1304 5 no
GO:0010646 regulation of cell communication 39.1304 4 no
GO:0043933 protein-containing complex organization 34.7826 4 no
GO:0009893 positive regulation of metabolic process 34.7826 4 no
GO:0010604 positive regulation of macromolecule metabolic process 34.7826 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 34.7826 5 no
GO:0009966 regulation of signal transduction 34.7826 4 no
GO:0008104 protein localization 34.7826 4 no
GO:0006796 phosphate-containing compound metabolic process 30.4348 4 yes
GO:1901701 cellular response to oxygen-containing compound 30.4348 4 no
GO:0010941 regulation of cell death 30.4348 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.4348 5 no
GO:0036211 protein modification process 30.4348 4 no
GO:0043412 macromolecule modification 30.4348 4 no
GO:0051130 positive regulation of cellular component organization 30.4348 5 no
GO:0051252 regulation of RNA metabolic process 30.4348 5 no
GO:0009894 regulation of catabolic process 30.4348 4 no
GO:0051247 positive regulation of protein metabolic process 30.4348 6 no
GO:1902531 regulation of intracellular signal transduction 30.4348 5 no
GO:0071702 organic substance transport 30.4348 4 no
GO:0010243 response to organonitrogen compound 26.0870 4 no
GO:0014070 response to organic cyclic compound 26.0870 4 no
GO:0031399 regulation of protein modification process 26.0870 6 no
GO:0051049 regulation of transport 26.0870 4 no
GO:0051248 negative regulation of protein metabolic process 26.0870 6 no
GO:0006355 regulation of DNA-templated transcription 26.0870 6 no
GO:0031325 positive regulation of cellular metabolic process 26.0870 5 no
GO:0044087 regulation of cellular component biogenesis 26.0870 4 no
GO:0065003 protein-containing complex assembly 26.0870 5 no
GO:1903506 regulation of nucleic acid-templated transcription 26.0870 7 no
GO:2001141 regulation of RNA biosynthetic process 26.0870 6 no
GO:0030030 cell projection organization 26.0870 4 no
GO:0033043 regulation of organelle organization 26.0870 5 no
GO:0071310 cellular response to organic substance 26.0870 4 no
GO:0009890 negative regulation of biosynthetic process 26.0870 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 26.0870 6 no
GO:0015031 protein transport 26.0870 4 no
GO:0031327 negative regulation of cellular biosynthetic process 26.0870 6 no
GO:0071705 nitrogen compound transport 26.0870 4 no
GO:0010038 response to metal ion 21.7391 4 no
GO:0070925 organelle assembly 21.7391 5 no
GO:0043067 regulation of programmed cell death 21.7391 5 no
GO:0006357 regulation of transcription by RNA polymerase II 21.7391 7 no
GO:0010629 negative regulation of gene expression 21.7391 6 no
GO:0031329 regulation of cellular catabolic process 21.7391 5 no
GO:0050804 modulation of chemical synaptic transmission 21.7391 5 no
GO:0099177 regulation of trans-synaptic signaling 21.7391 4 no
GO:0120036 plasma membrane bounded cell projection organization 21.7391 5 no
GO:0006886 intracellular protein transport 21.7391 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 21.7391 6 no
GO:0051253 negative regulation of RNA metabolic process 21.7391 6 no
GO:0016192 vesicle-mediated transport 21.7391 4 no
GO:0072524 pyridine-containing compound metabolic process 17.3913 4 yes
GO:0090407 organophosphate biosynthetic process 17.3913 4 yes
GO:0006767 water-soluble vitamin metabolic process 13.0435 4 yes
GO:0042816 vitamin B6 metabolic process 13.0435 5 yes
GO:0042822 pyridoxal phosphate metabolic process 13.0435 4 yes
GO:0046184 aldehyde biosynthetic process 13.0435 4 yes
GO:1901362 organic cyclic compound biosynthetic process 13.0435 4 yes
GO:1901617 organic hydroxy compound biosynthetic process 13.0435 4 yes
GO:0009110 vitamin biosynthetic process 8.6957 4 yes
GO:0009443 pyridoxal 5-phosphate salvage 8.6957 4 yes
GO:0018130 heterocycle biosynthetic process 8.6957 4 yes
GO:0019438 aromatic compound biosynthetic process 8.6957 4 yes
GO:0042364 water-soluble vitamin biosynthetic process 8.6957 5 yes
GO:0042819 vitamin B6 biosynthetic process 8.6957 6 yes
GO:0042823 pyridoxal phosphate biosynthetic process 8.6957 5 yes
GO:0044271 cellular nitrogen compound biosynthetic process 8.6957 4 yes
GO:0072525 pyridine-containing compound biosynthetic process 8.6957 5 yes
GO:1901566 organonitrogen compound biosynthetic process 8.6957 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PDXK_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
GBRAP_HUMAN [view interactions] High throughput no no
SAP_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
PAR12_HUMAN [view interactions] High throughput no yes
AAKB1_HUMAN [view interactions] High throughput no yes
IKKE_HUMAN [view interactions] High throughput no yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
CUL1_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
BARD1_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
ATOH1_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
KPCD2_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
BCAR1_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
ITA2B_HUMAN [view interactions] High throughput no no
GABT_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
IF4E_HUMAN [view entry] [view interactions] High throughput yes yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
G6PD_HUMAN [view entry] [view interactions] High throughput yes no
3HIDH_HUMAN [view interactions] High throughput no yes
HYI_HUMAN [view interactions] High throughput no yes
ITPA_HUMAN [view interactions] High throughput no yes
MDHC_HUMAN [view entry] [view interactions] High throughput yes yes
OAT_HUMAN [view interactions] High throughput no yes
SNX2_HUMAN [view entry] [view interactions] High throughput yes no
SODC_HUMAN [view interactions] High throughput no yes
MSS4_HUMAN [view interactions] High throughput no yes
TPIS_HUMAN [view entry] [view interactions] High throughput yes yes
RAP1B_HUMAN [view entry] [view interactions] High throughput yes no
TAXB1_HUMAN [view interactions] High throughput no yes
AOXA_HUMAN [view interactions] Computational no no
PHOP2_HUMAN [view interactions] Computational no no
PLPP_HUMAN [view entry] [view interactions] Computational yes yes
PNPO_HUMAN [view interactions] Computational no yes