Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PDXK_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5-phosphate (PLP), pyridoxine 5-phosphate (PNP) and pyridoxamine 5-phosphate (PMP), respectively (PubMed, PubMed, PubMed, PubMed, PubMed) (Probable). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
220 Arg Gln Neuropathy,hereditarymotorandsensory,6C,withopticatrophy(HMSN6C) -
228 Ala Thr Neuropathy,hereditarymotorandsensory,6C,withopticatrophy(HMSN6C) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PDXK_HUMAN
GO:0042803 protein homodimerization activity 33.3333 4 yes
GO:0019900 kinase binding 33.3333 4 no
GO:0031625 ubiquitin protein ligase binding 33.3333 5 no
GO:0044389 ubiquitin-like protein ligase binding 33.3333 4 no
GO:0019901 protein kinase binding 29.6296 5 no
GO:0000166 nucleotide binding 25.9259 4 yes
GO:0017076 purine nucleotide binding 25.9259 5 yes
GO:0030554 adenyl nucleotide binding 22.2222 6 yes
GO:0043168 anion binding 22.2222 4 yes
GO:0043169 cation binding 22.2222 4 yes
GO:0046872 metal ion binding 22.2222 5 yes
GO:0003723 RNA binding 22.2222 4 no
GO:0015631 tubulin binding 22.2222 4 no
GO:0032555 purine ribonucleotide binding 18.5185 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 18.5185 4 yes
GO:0005524 ATP binding 14.8148 5 yes
GO:0008270 zinc ion binding 14.8148 7 yes
GO:0016301 kinase activity 14.8148 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 14.8148 4 yes
GO:0032559 adenyl ribonucleotide binding 14.8148 5 yes
GO:0046914 transition metal ion binding 14.8148 6 yes
GO:0000287 magnesium ion binding 7.4074 6 yes
GO:0008478 pyridoxal kinase activity 7.4074 5 yes
GO:0030170 pyridoxal phosphate binding 7.4074 4 yes
GO:0030955 potassium ion binding 7.4074 7 yes
GO:0031402 sodium ion binding 7.4074 7 yes
GO:0031403 lithium ion binding 7.4074 7 yes
GO:0031420 alkali metal ion binding 7.4074 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PDXK_HUMAN
GO:0031323 regulation of cellular metabolic process 62.9630 4 no
GO:0060255 regulation of macromolecule metabolic process 62.9630 4 no
GO:0080090 regulation of primary metabolic process 62.9630 4 no
GO:0048522 positive regulation of cellular process 55.5556 4 no
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0009892 negative regulation of metabolic process 55.5556 4 no
GO:0051128 regulation of cellular component organization 51.8519 4 no
GO:0010605 negative regulation of macromolecule metabolic process 51.8519 5 no
GO:0010646 regulation of cell communication 48.1481 4 no
GO:0009889 regulation of biosynthetic process 48.1481 4 no
GO:0010468 regulation of gene expression 48.1481 6 no
GO:0010556 regulation of macromolecule biosynthetic process 48.1481 5 no
GO:0022607 cellular component assembly 48.1481 4 no
GO:0031326 regulation of cellular biosynthetic process 48.1481 5 no
GO:0006996 organelle organization 48.1481 4 no
GO:0031324 negative regulation of cellular metabolic process 48.1481 5 no
GO:0009966 regulation of signal transduction 44.4444 4 no
GO:0009890 negative regulation of biosynthetic process 44.4444 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 44.4444 6 no
GO:0031327 negative regulation of cellular biosynthetic process 44.4444 6 no
GO:0051246 regulation of protein metabolic process 44.4444 5 no
GO:0009893 positive regulation of metabolic process 40.7407 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.7407 5 no
GO:0043933 protein-containing complex organization 40.7407 4 no
GO:0006796 phosphate-containing compound metabolic process 37.0370 4 yes
GO:1902531 regulation of intracellular signal transduction 37.0370 5 no
GO:0009894 regulation of catabolic process 37.0370 4 no
GO:0008104 protein localization 37.0370 4 no
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0036211 protein modification process 33.3333 4 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0044087 regulation of cellular component biogenesis 29.6296 4 no
GO:0006355 regulation of DNA-templated transcription 29.6296 7 no
GO:0065003 protein-containing complex assembly 29.6296 5 no
GO:2001141 regulation of RNA biosynthetic process 29.6296 6 no
GO:0007005 mitochondrion organization 29.6296 5 no
GO:0010629 negative regulation of gene expression 29.6296 7 no
GO:0022411 cellular component disassembly 29.6296 4 no
GO:0031399 regulation of protein modification process 29.6296 6 no
GO:0032880 regulation of protein localization 29.6296 5 no
GO:0060341 regulation of cellular localization 29.6296 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 29.6296 5 no
GO:0051253 negative regulation of RNA metabolic process 29.6296 6 no
GO:0048584 positive regulation of response to stimulus 25.9259 4 no
GO:0051049 regulation of transport 25.9259 4 no
GO:0051130 positive regulation of cellular component organization 25.9259 5 no
GO:0071310 cellular response to organic substance 25.9259 4 no
GO:0006357 regulation of transcription by RNA polymerase II 25.9259 8 no
GO:0009891 positive regulation of biosynthetic process 25.9259 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.9259 6 no
GO:0031328 positive regulation of cellular biosynthetic process 25.9259 6 no
GO:0006508 proteolysis 25.9259 4 no
GO:0009968 negative regulation of signal transduction 25.9259 5 no
GO:0010648 negative regulation of cell communication 25.9259 5 no
GO:0023057 negative regulation of signaling 25.9259 4 no
GO:0033043 regulation of organelle organization 25.9259 5 no
GO:0043067 regulation of programmed cell death 25.9259 4 no
GO:0048585 negative regulation of response to stimulus 25.9259 4 no
GO:0051093 negative regulation of developmental process 25.9259 4 no
GO:0051094 positive regulation of developmental process 25.9259 4 no
GO:0051248 negative regulation of protein metabolic process 25.9259 6 no
GO:0045892 negative regulation of DNA-templated transcription 25.9259 8 no
GO:1902679 negative regulation of RNA biosynthetic process 25.9259 7 no
GO:0010038 response to metal ion 25.9259 4 no
GO:0016310 phosphorylation 22.2222 5 yes
GO:0009967 positive regulation of signal transduction 22.2222 5 no
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0010647 positive regulation of cell communication 22.2222 5 no
GO:0014070 response to organic cyclic compound 22.2222 4 no
GO:0023056 positive regulation of signaling 22.2222 4 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:0019220 regulation of phosphate metabolic process 22.2222 6 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0030162 regulation of proteolysis 22.2222 6 no
GO:0042176 regulation of protein catabolic process 22.2222 5 no
GO:0042981 regulation of apoptotic process 22.2222 5 no
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 no
GO:0051241 negative regulation of multicellular organismal process 22.2222 4 no
GO:1901565 organonitrogen compound catabolic process 22.2222 4 no
GO:0000122 negative regulation of transcription by RNA polymerase II 22.2222 9 no
GO:0033365 protein localization to organelle 22.2222 5 no
GO:0016236 macroautophagy 22.2222 4 no
GO:0070925 organelle assembly 22.2222 5 no
GO:0072524 pyridine-containing compound metabolic process 18.5185 4 yes
GO:0090407 organophosphate biosynthetic process 14.8148 4 yes
GO:1901362 organic cyclic compound biosynthetic process 14.8148 4 yes
GO:0046184 aldehyde biosynthetic process 11.1111 4 yes
GO:1901617 organic hydroxy compound biosynthetic process 11.1111 4 yes
GO:0006767 water-soluble vitamin metabolic process 7.4074 4 yes
GO:0009110 vitamin biosynthetic process 7.4074 4 yes
GO:0009443 pyridoxal 5-phosphate salvage 7.4074 4 yes
GO:0042364 water-soluble vitamin biosynthetic process 7.4074 5 yes
GO:0042816 vitamin B6 metabolic process 7.4074 5 yes
GO:0042817 pyridoxal metabolic process 7.4074 4 yes
GO:0042818 pyridoxamine metabolic process 7.4074 4 yes
GO:0042819 vitamin B6 biosynthetic process 7.4074 6 yes
GO:0042822 pyridoxal phosphate metabolic process 7.4074 4 yes
GO:0042823 pyridoxal phosphate biosynthetic process 7.4074 5 yes
GO:0072525 pyridine-containing compound biosynthetic process 7.4074 5 yes
GO:1901566 organonitrogen compound biosynthetic process 7.4074 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PDXK_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
GBRAP_HUMAN [view entry] [view interactions] High throughput yes no
SAP_HUMAN [view interactions] High throughput no yes
HLAA_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
PAR12_HUMAN [view interactions] High throughput no yes
AAKB1_HUMAN [view interactions] High throughput no yes
IKKE_HUMAN [view interactions] High throughput no yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
CUL1_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
BARD1_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
ATOH1_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
KPCD2_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
BCAR1_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
MALT1_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
MK13_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
ITA2B_HUMAN [view interactions] High throughput no no
GABT_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
IF4E_HUMAN [view entry] [view interactions] High throughput yes yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
G6PD_HUMAN [view entry] [view interactions] High throughput yes no
3HIDH_HUMAN [view interactions] High throughput no yes
HYI_HUMAN [view interactions] High throughput no yes
ITPA_HUMAN [view interactions] High throughput no yes
MDHC_HUMAN [view entry] [view interactions] High throughput yes yes
OAT_HUMAN [view interactions] High throughput no yes
SNX2_HUMAN [view entry] [view interactions] High throughput yes no
SODC_HUMAN [view interactions] High throughput no yes
MSS4_HUMAN [view interactions] High throughput no yes
TPIS_HUMAN [view entry] [view interactions] High throughput yes yes
RAP1B_HUMAN [view entry] [view interactions] High throughput yes no
DNLI3_HUMAN [view interactions] High throughput no yes
THUM1_HUMAN [view interactions] High throughput no yes
Z3H7B_HUMAN [view interactions] High throughput no no
TAXB1_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
BCKD_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes