MDHC_HUMAN
Evidence for PS localization
Functions
Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MDHC_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 29.6875 | 4 | no |
| GO:0043168 | anion binding | 28.1250 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.5625 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 6 | no |
| GO:0043169 | cation binding | 25.0000 | 4 | no |
| GO:0046872 | metal ion binding | 25.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 23.4375 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.4375 | 4 | no |
| GO:0019900 | kinase binding | 23.4375 | 4 | no |
| GO:0005524 | ATP binding | 21.8750 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.8750 | 5 | no |
| GO:0003723 | RNA binding | 20.3125 | 4 | no |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 9.3750 | 4 | yes |
| GO:0004470 | malic enzyme activity | 3.1250 | 5 | yes |
| GO:0016615 | malate dehydrogenase activity | 3.1250 | 4 | yes |
| GO:0030060 | L-malate dehydrogenase activity | 3.1250 | 5 | yes |
| GO:0047860 | diiodophenylpyruvate reductase activity | 3.1250 | 5 | yes |
| GO:0047995 | hydroxyphenylpyruvate reductase activity | 3.1250 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MDHC_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 45.3125 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.7500 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 43.7500 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.7500 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.6250 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 39.0625 | 4 | no |
| GO:0009966 | regulation of signal transduction | 39.0625 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 39.0625 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 37.5000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 35.9375 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 35.9375 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.3750 | 5 | no |
| GO:0022607 | cellular component assembly | 34.3750 | 4 | no |
| GO:0006996 | organelle organization | 34.3750 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.8125 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 32.8125 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 32.8125 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.2500 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 29.6875 | 4 | no |
| GO:0043933 | protein-containing complex organization | 29.6875 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.6875 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.1250 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 28.1250 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 28.1250 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.5625 | 5 | no |
| GO:0032880 | regulation of protein localization | 26.5625 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 26.5625 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 26.5625 | 5 | no |
| GO:0051049 | regulation of transport | 26.5625 | 4 | no |
| GO:0060341 | regulation of cellular localization | 26.5625 | 4 | no |
| GO:0008104 | protein localization | 26.5625 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.5625 | 5 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 26.5625 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 26.5625 | 5 | yes |
| GO:0072521 | purine-containing compound metabolic process | 25.0000 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 25.0000 | 5 | yes |
| GO:0019752 | carboxylic acid metabolic process | 23.4375 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 23.4375 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 23.4375 | 5 | no |
| GO:1901565 | organonitrogen compound catabolic process | 23.4375 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 23.4375 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.4375 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 23.4375 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 23.4375 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.4375 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.8750 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.8750 | 6 | no |
| GO:0009894 | regulation of catabolic process | 21.8750 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.8750 | 6 | no |
| GO:0033043 | regulation of organelle organization | 21.8750 | 5 | no |
| GO:0043412 | macromolecule modification | 21.8750 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 21.8750 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.8750 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.8750 | 5 | no |
| GO:0071310 | cellular response to organic substance | 21.8750 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.8750 | 5 | no |
| GO:0010629 | negative regulation of gene expression | 20.3125 | 7 | no |
| GO:0065003 | protein-containing complex assembly | 20.3125 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 20.3125 | 7 | no |
| GO:0036211 | protein modification process | 20.3125 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 20.3125 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.3125 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.3125 | 6 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.3125 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.3125 | 4 | no |
| GO:0072524 | pyridine-containing compound metabolic process | 15.6250 | 4 | yes |
| GO:0019362 | pyridine nucleotide metabolic process | 14.0625 | 5 | yes |
| GO:0046496 | nicotinamide nucleotide metabolic process | 14.0625 | 6 | yes |
| GO:0006006 | glucose metabolic process | 10.9375 | 5 | yes |
| GO:0016051 | carbohydrate biosynthetic process | 10.9375 | 4 | yes |
| GO:0019318 | hexose metabolic process | 10.9375 | 4 | yes |
| GO:0019674 | NAD metabolic process | 9.3750 | 6 | yes |
| GO:0046364 | monosaccharide biosynthetic process | 9.3750 | 4 | yes |
| GO:0019319 | hexose biosynthetic process | 7.8125 | 5 | yes |
| GO:0006094 | gluconeogenesis | 7.8125 | 6 | yes |
| GO:0006734 | NADH metabolic process | 7.8125 | 7 | yes |
| GO:0006739 | NADP metabolic process | 7.8125 | 6 | yes |
| GO:0043648 | dicarboxylic acid metabolic process | 6.2500 | 6 | yes |
| GO:0006107 | oxaloacetate metabolic process | 4.6875 | 7 | yes |
| GO:0006108 | malate metabolic process | 3.1250 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MAOX_HUMAN | [view interactions] | Low throughput | no | yes |
| PYC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MDHC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IKBA_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSX2_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| TET5C_HUMAN | [view interactions] | High throughput | no | yes |
| CYTN_HUMAN | [view interactions] | High throughput | no | no |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHRF1_HUMAN | [view interactions] | High throughput | no | no |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESTD_HUMAN | [view interactions] | High throughput | no | yes |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| GLRX1_HUMAN | [view interactions] | High throughput | no | yes |
| 3HIDH_HUMAN | [view interactions] | High throughput | no | yes |
| LDH6A_HUMAN | [view interactions] | High throughput | no | no |
| LDH6B_HUMAN | [view interactions] | High throughput | no | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHC_HUMAN | [view interactions] | High throughput | no | no |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDXK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGM2_HUMAN | [view interactions] | High throughput | no | no |
| SCPDL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFU1_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ORN_HUMAN | [view interactions] | High throughput | no | no |
| ECI1_HUMAN | [view interactions] | High throughput | no | yes |
| HMCS1_HUMAN | [view interactions] | High throughput | no | yes |
| OAT_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUTA_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSHR_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABHDA_HUMAN | [view interactions] | High throughput | no | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPR1_HUMAN | [view interactions] | High throughput | no | no |
| GPDA_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| CATS_HUMAN | [view interactions] | High throughput | no | no |
| AK1C3_HUMAN | [view interactions] | High throughput | no | yes |
| GSTO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GABT_HUMAN | [view interactions] | High throughput | no | yes |
| FABP5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LACB2_HUMAN | [view interactions] | High throughput | no | yes |
| BROX_HUMAN | [view interactions] | High throughput | no | yes |
| CMBL_HUMAN | [view interactions] | High throughput | no | no |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| PCDH7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| MED20_HUMAN | [view interactions] | High throughput | no | no |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYLK4_HUMAN | [view interactions] | High throughput | no | no |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| MPP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| LT4R2_HUMAN | [view interactions] | High throughput | no | no |
| ACM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIF1A_HUMAN | [view interactions] | High throughput | no | yes |
| TTC3_HUMAN | [view interactions] | High throughput | no | yes |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPB5_HUMAN | [view interactions] | High throughput | no | no |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| IF44L_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| GDIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| TBCA_HUMAN | [view interactions] | High throughput | no | yes |
| DOPD_HUMAN | [view interactions] | High throughput | no | yes |
| CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYTB_HUMAN | [view interactions] | High throughput | no | no |
| RS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |