MDHC_HUMAN
Evidence for PS localization
Functions
Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MDHC_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 26.4151 | 4 | no |
| GO:0019900 | kinase binding | 22.6415 | 4 | no |
| GO:0017076 | purine nucleotide binding | 20.7547 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 20.7547 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.7547 | 4 | no |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 11.3208 | 4 | yes |
| GO:0004470 | malic enzyme activity | 3.7736 | 5 | yes |
| GO:0016615 | malate dehydrogenase activity | 3.7736 | 4 | yes |
| GO:0030060 | L-malate dehydrogenase activity | 3.7736 | 5 | yes |
| GO:0047860 | diiodophenylpyruvate reductase activity | 3.7736 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MDHC_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 45.2830 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.3962 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 43.3962 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 43.3962 | 4 | no |
| GO:0009966 | regulation of signal transduction | 39.6226 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.6226 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 39.6226 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.6226 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.7358 | 4 | no |
| GO:0022607 | cellular component assembly | 33.9623 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.9623 | 4 | no |
| GO:0006996 | organelle organization | 32.0755 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.0755 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.0755 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.0755 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 32.0755 | 5 | no |
| GO:0010941 | regulation of cell death | 30.1887 | 4 | no |
| GO:0032880 | regulation of protein localization | 30.1887 | 5 | no |
| GO:0060341 | regulation of cellular localization | 30.1887 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.1887 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.3019 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 28.3019 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 28.3019 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.3019 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 28.3019 | 5 | no |
| GO:0043933 | protein-containing complex organization | 26.4151 | 4 | no |
| GO:0051049 | regulation of transport | 26.4151 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.4151 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 26.4151 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 26.4151 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.4151 | 5 | no |
| GO:0023057 | negative regulation of signaling | 26.4151 | 4 | no |
| GO:0031399 | regulation of protein modification process | 26.4151 | 6 | no |
| GO:0071310 | cellular response to organic substance | 26.4151 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 24.5283 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 24.5283 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.5283 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 24.5283 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 24.5283 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 22.6415 | 5 | no |
| GO:0008104 | protein localization | 22.6415 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 22.6415 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 22.6415 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.6415 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.6415 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.6415 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 22.6415 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 22.6415 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 22.6415 | 4 | no |
| GO:0043412 | macromolecule modification | 22.6415 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.6415 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 22.6415 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.6415 | 6 | no |
| GO:0051338 | regulation of transferase activity | 22.6415 | 4 | no |
| GO:0060548 | negative regulation of cell death | 22.6415 | 5 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 22.6415 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 20.7547 | 6 | no |
| GO:0036211 | protein modification process | 20.7547 | 4 | no |
| GO:0043549 | regulation of kinase activity | 20.7547 | 5 | no |
| GO:0045597 | positive regulation of cell differentiation | 20.7547 | 5 | no |
| GO:0051050 | positive regulation of transport | 20.7547 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.7547 | 5 | no |
| GO:0080134 | regulation of response to stress | 20.7547 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 20.7547 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 20.7547 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.7547 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.7547 | 4 | no |
| GO:0043648 | dicarboxylic acid metabolic process | 7.5472 | 6 | yes |
| GO:0006107 | oxaloacetate metabolic process | 5.6604 | 7 | yes |
| GO:0006108 | malate metabolic process | 3.7736 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MDHC_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 7.5472 | 3 | no |
| DOID:1289 | neurodegenerative disease | 5.6604 | 4 | no |
| DOID:0050686 | organ system cancer | 3.7736 | 3 | no |
| DOID:0050557 | congenital muscular dystrophy | 3.7736 | 7 | no |
| DOID:0080000 | muscular disease | 3.7736 | 3 | no |
| DOID:423 | myopathy | 3.7736 | 5 | no |
| DOID:66 | muscle tissue disease | 3.7736 | 4 | no |
| DOID:9884 | muscular dystrophy | 3.7736 | 6 | no |
| DOID:936 | brain disease | 3.7736 | 4 | no |
| DOID:0050890 | synucleinopathy | 3.7736 | 5 | no |
| DOID:0060894 | early-onset Parkinsons disease | 3.7736 | 7 | no |
| DOID:14330 | Parkinsons disease | 3.7736 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MAOX_HUMAN | [view interactions] | Low throughput | no | yes |
| PYC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MDHC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| IF44L_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| GDIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| TBCA_HUMAN | [view interactions] | High throughput | no | yes |
| DOPD_HUMAN | [view interactions] | High throughput | no | yes |
| CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYTB_HUMAN | [view interactions] | High throughput | no | no |
| RS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IKBA_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHRF1_HUMAN | [view interactions] | High throughput | no | no |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESTD_HUMAN | [view interactions] | High throughput | no | yes |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| GLRX1_HUMAN | [view interactions] | High throughput | no | yes |
| 3HIDH_HUMAN | [view interactions] | High throughput | no | yes |
| LDH6A_HUMAN | [view interactions] | High throughput | no | no |
| LDH6B_HUMAN | [view interactions] | High throughput | no | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHC_HUMAN | [view interactions] | High throughput | no | no |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDXK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGM2_HUMAN | [view interactions] | High throughput | no | no |
| SCPDL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFU1_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ORN_HUMAN | [view interactions] | High throughput | no | no |
| ECI1_HUMAN | [view interactions] | High throughput | no | yes |
| HMCS1_HUMAN | [view interactions] | High throughput | no | yes |
| OAT_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUTA_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSHR_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABHDA_HUMAN | [view interactions] | High throughput | no | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPR1_HUMAN | [view interactions] | High throughput | no | no |
| GPDA_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| ATG5_HUMAN | [view interactions] | High throughput | no | no |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSMD2_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| MED20_HUMAN | [view interactions] | High throughput | no | no |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYLK4_HUMAN | [view interactions] | High throughput | no | no |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| MPP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| LT4R2_HUMAN | [view interactions] | High throughput | no | no |
| ACM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIF1A_HUMAN | [view interactions] | High throughput | no | yes |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPB5_HUMAN | [view interactions] | High throughput | no | no |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |