Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PARK7_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed, PubMed). But this function is rebuted by other works (PubMed, PubMed). As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed, PubMed, PubMed). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed). Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin (PubMed). Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels (PubMed, PubMed). Displays a very low glyoxalase activity that may reflect its deglycase activity (PubMed, PubMed, PubMed). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed, PubMed). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting . Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
26 Met Ile Parkinsondisease7(PARK7) -
64 Glu Asp Parkinsondisease7(PARK7) -
104 Ala Thr Parkinsondisease7(PARK7) -
149 Asp Ala Parkinsondisease7(PARK7) -
166 Leu Pro Parkinsondisease7(PARK7) -
39 Ala Ser - -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PARK7_HUMAN
GO:0003723 RNA binding 28.3422 4 yes
GO:0017076 purine nucleotide binding 24.0642 4 no
GO:0032555 purine ribonucleotide binding 23.5294 4 no
GO:0035639 purine ribonucleoside triphosphate binding 22.9947 4 no
GO:0046872 metal ion binding 21.9251 4 yes
GO:0019900 kinase binding 20.3209 4 yes
GO:0045296 cadherin binding 14.9733 4 yes
GO:0042803 protein homodimerization activity 9.6257 4 yes
GO:0046914 transition metal ion binding 5.8824 5 yes
GO:0002020 protease binding 4.2781 4 yes
GO:0003729 mRNA binding 4.2781 5 yes
GO:0140297 DNA-binding transcription factor binding 4.2781 4 yes
GO:1990381 ubiquitin-specific protease binding 3.2086 5 yes
GO:0016836 hydro-lyase activity 2.6738 4 yes
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 2.6738 5 yes
GO:0044390 ubiquitin-like protein conjugating enzyme binding 2.1390 4 yes
GO:0005507 copper ion binding 1.6043 6 yes
GO:0016922 nuclear receptor binding 1.6043 6 yes
GO:1903136 cuprous ion binding 1.6043 7 yes
GO:0016532 superoxide dismutase copper chaperone activity 1.0695 4 yes
GO:0036470 tyrosine 3-monooxygenase activator activity 1.0695 4 yes
GO:0036478 L-dopa decarboxylase activator activity 1.0695 4 yes
GO:0044388 small protein activating enzyme binding 1.0695 4 yes
GO:0045340 mercury ion binding 1.0695 6 yes
GO:0050681 nuclear androgen receptor binding 1.0695 7 yes
GO:1903135 cupric ion binding 1.0695 7 yes
GO:1990422 glyoxalase (glycolic acid-forming) activity 1.0695 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PARK7_HUMAN
GO:0048522 positive regulation of cellular process 45.4545 4 yes
GO:0048523 negative regulation of cellular process 44.3850 4 yes
GO:0060255 regulation of macromolecule metabolic process 43.3155 4 yes
GO:0031323 regulation of cellular metabolic process 42.7807 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 42.2460 4 yes
GO:0080090 regulation of primary metabolic process 41.7112 4 yes
GO:0010646 regulation of cell communication 36.3636 4 yes
GO:0051128 regulation of cellular component organization 35.8289 4 yes
GO:0022607 cellular component assembly 33.6898 4 no
GO:0009893 positive regulation of metabolic process 33.1551 4 yes
GO:0009966 regulation of signal transduction 32.6203 4 yes
GO:0010468 regulation of gene expression 31.0160 5 yes
GO:0006996 organelle organization 29.9465 4 yes
GO:0009889 regulation of biosynthetic process 29.4118 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 29.4118 5 yes
GO:0051246 regulation of protein metabolic process 29.4118 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 28.3422 5 yes
GO:0010941 regulation of cell death 27.8075 4 yes
GO:0031326 regulation of cellular biosynthetic process 27.8075 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 27.2727 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.2727 5 yes
GO:0031325 positive regulation of cellular metabolic process 27.2727 5 yes
GO:0008104 protein localization 26.7380 4 yes
GO:0043933 protein-containing complex organization 26.7380 4 no
GO:0009892 negative regulation of metabolic process 26.2032 4 yes
GO:0043067 regulation of programmed cell death 25.6684 5 yes
GO:0042981 regulation of apoptotic process 25.1337 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 24.0642 5 yes
GO:1902531 regulation of intracellular signal transduction 23.5294 5 yes
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 23.5294 5 yes
GO:0051049 regulation of transport 22.9947 4 yes
GO:0051252 regulation of RNA metabolic process 22.9947 5 yes
GO:0071702 organic substance transport 22.4599 4 yes
GO:0060548 negative regulation of cell death 21.9251 5 yes
GO:0033043 regulation of organelle organization 21.9251 5 yes
GO:0006796 phosphate-containing compound metabolic process 21.3904 4 yes
GO:0071705 nitrogen compound transport 21.3904 4 yes
GO:0031399 regulation of protein modification process 21.3904 6 yes
GO:0065003 protein-containing complex assembly 21.3904 5 no
GO:0048585 negative regulation of response to stimulus 21.3904 4 yes
GO:0019220 regulation of phosphate metabolic process 20.8556 6 yes
GO:1903506 regulation of nucleic acid-templated transcription 20.8556 7 yes
GO:2001141 regulation of RNA biosynthetic process 20.8556 6 yes
GO:0051174 regulation of phosphorus metabolic process 20.8556 5 yes
GO:0051247 positive regulation of protein metabolic process 20.8556 6 yes
GO:0006355 regulation of DNA-templated transcription 20.8556 6 yes
GO:0010648 negative regulation of cell communication 20.3209 5 yes
GO:0023057 negative regulation of signaling 20.3209 4 yes
GO:0009968 negative regulation of signal transduction 19.2513 5 yes
GO:0043069 negative regulation of programmed cell death 19.2513 6 yes
GO:0051130 positive regulation of cellular component organization 19.2513 5 yes
GO:0015031 protein transport 18.7166 4 yes
GO:0043066 negative regulation of apoptotic process 18.7166 7 yes
GO:0048584 positive regulation of response to stimulus 18.1818 4 yes
GO:0060341 regulation of cellular localization 18.1818 4 yes
GO:0071310 cellular response to organic substance 17.6471 4 yes
GO:0009891 positive regulation of biosynthetic process 17.6471 5 yes
GO:0010647 positive regulation of cell communication 17.6471 5 yes
GO:0023056 positive regulation of signaling 17.6471 4 yes
GO:0042325 regulation of phosphorylation 17.6471 7 yes
GO:0043412 macromolecule modification 17.6471 4 yes
GO:0051338 regulation of transferase activity 17.6471 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 17.1123 6 yes
GO:0036211 protein modification process 17.1123 4 yes
GO:0009894 regulation of catabolic process 16.5775 4 yes
GO:0009967 positive regulation of signal transduction 16.5775 5 yes
GO:0044087 regulation of cellular component biogenesis 16.5775 4 yes
GO:0001932 regulation of protein phosphorylation 16.5775 7 yes
GO:0080134 regulation of response to stress 16.0428 4 yes
GO:0019752 carboxylic acid metabolic process 16.0428 5 yes
GO:0032880 regulation of protein localization 16.0428 5 yes
GO:0043085 positive regulation of catalytic activity 16.0428 4 yes
GO:0043436 oxoacid metabolic process 16.0428 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 16.0428 6 yes
GO:0051248 negative regulation of protein metabolic process 16.0428 6 yes
GO:0043549 regulation of kinase activity 14.9733 5 yes
GO:0009890 negative regulation of biosynthetic process 14.4385 5 yes
GO:0010628 positive regulation of gene expression 14.4385 6 yes
GO:0031329 regulation of cellular catabolic process 14.4385 5 yes
GO:0031401 positive regulation of protein modification process 14.4385 7 yes
GO:0051240 positive regulation of multicellular organismal process 14.4385 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 13.9037 6 yes
GO:0043603 cellular amide metabolic process 13.9037 4 yes
GO:0045859 regulation of protein kinase activity 13.9037 6 yes
GO:0051050 positive regulation of transport 13.9037 4 yes
GO:0090304 nucleic acid metabolic process 13.3690 4 yes
GO:0010638 positive regulation of organelle organization 13.3690 6 yes
GO:1902533 positive regulation of intracellular signal transduction 13.3690 6 yes
GO:0080135 regulation of cellular response to stress 12.8342 4 yes
GO:1901701 cellular response to oxygen-containing compound 12.8342 4 yes
GO:0031400 negative regulation of protein modification process 12.8342 7 yes
GO:0032787 monocarboxylic acid metabolic process 12.8342 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 12.2995 6 yes
GO:0045937 positive regulation of phosphate metabolic process 12.2995 7 yes
GO:0051336 regulation of hydrolase activity 12.2995 4 yes
GO:1903829 positive regulation of protein localization 11.7647 5 yes
GO:0006357 regulation of transcription by RNA polymerase II 11.7647 7 yes
GO:0006753 nucleoside phosphate metabolic process 11.2299 4 yes
GO:0070201 regulation of establishment of protein localization 11.2299 6 yes
GO:0009117 nucleotide metabolic process 11.2299 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 11.2299 6 yes
GO:2001233 regulation of apoptotic signaling pathway 11.2299 5 yes
GO:0043269 regulation of ion transport 11.2299 5 yes
GO:0045936 negative regulation of phosphate metabolic process 11.2299 7 yes
GO:0051254 positive regulation of RNA metabolic process 11.2299 6 yes
GO:0051347 positive regulation of transferase activity 11.2299 5 yes
GO:0042327 positive regulation of phosphorylation 10.6952 8 yes
GO:0051129 negative regulation of cellular component organization 10.6952 5 yes
GO:0001934 positive regulation of protein phosphorylation 10.6952 8 yes
GO:0006518 peptide metabolic process 10.6952 4 yes
GO:0010942 positive regulation of cell death 10.1604 5 yes
GO:1902532 negative regulation of intracellular signal transduction 10.1604 6 yes
GO:0043086 negative regulation of catalytic activity 10.1604 4 yes
GO:1902680 positive regulation of RNA biosynthetic process 9.6257 7 yes
GO:1902903 regulation of supramolecular fiber organization 9.6257 5 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 9.6257 8 yes
GO:0042326 negative regulation of phosphorylation 9.6257 8 yes
GO:0043065 positive regulation of apoptotic process 9.6257 7 yes
GO:0043068 positive regulation of programmed cell death 9.6257 6 yes
GO:0045893 positive regulation of DNA-templated transcription 9.6257 7 yes
GO:0051223 regulation of protein transport 9.6257 5 yes
GO:0001933 negative regulation of protein phosphorylation 9.6257 8 yes
GO:0009896 positive regulation of catabolic process 9.0909 5 yes
GO:0010506 regulation of autophagy 9.0909 6 yes
GO:0033674 positive regulation of kinase activity 9.0909 6 yes
GO:0034762 regulation of transmembrane transport 9.0909 4 yes
GO:0034765 regulation of ion transmembrane transport 9.0909 5 yes
GO:0043254 regulation of protein-containing complex assembly 9.0909 5 yes
GO:0045860 positive regulation of protein kinase activity 9.0909 7 yes
GO:0007005 mitochondrion organization 8.5561 5 yes
GO:0010629 negative regulation of gene expression 8.5561 6 yes
GO:0030162 regulation of proteolysis 8.5561 6 yes
GO:0032101 regulation of response to external stimulus 8.5561 4 yes
GO:0042176 regulation of protein catabolic process 8.5561 5 yes
GO:0044089 positive regulation of cellular component biogenesis 8.5561 5 yes
GO:0051051 negative regulation of transport 8.5561 4 yes
GO:1904062 regulation of cation transmembrane transport 8.0214 6 yes
GO:2001234 negative regulation of apoptotic signaling pathway 8.0214 6 yes
GO:0050821 protein stabilization 8.0214 4 yes
GO:0001817 regulation of cytokine production 8.0214 4 yes
GO:0022898 regulation of transmembrane transporter activity 7.4866 4 yes
GO:1903320 regulation of protein modification by small protein conjugation or removal 7.4866 7 yes
GO:2001242 regulation of intrinsic apoptotic signaling pathway 7.4866 6 yes
GO:0051348 negative regulation of transferase activity 7.4866 5 yes
GO:0031331 positive regulation of cellular catabolic process 6.9519 6 yes
GO:0033673 negative regulation of kinase activity 6.9519 6 yes
GO:0001819 positive regulation of cytokine production 6.9519 5 yes
GO:0002684 positive regulation of immune system process 6.9519 4 yes
GO:0006811 ion transport 6.4171 4 yes
GO:1901214 regulation of neuron death 6.4171 5 yes
GO:0031396 regulation of protein ubiquitination 6.4171 8 yes
GO:0032386 regulation of intracellular transport 6.4171 5 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 6.4171 8 yes
GO:0006259 DNA metabolic process 6.4171 4 yes
GO:0006469 negative regulation of protein kinase activity 6.4171 7 yes
GO:0006812 cation transport 5.8824 5 yes
GO:0006974 cellular response to DNA damage stimulus 5.8824 4 yes
GO:0062197 cellular response to chemical stress 5.8824 4 yes
GO:1900407 regulation of cellular response to oxidative stress 5.8824 5 yes
GO:1902882 regulation of response to oxidative stress 5.8824 5 yes
GO:1903201 regulation of oxidative stress-induced cell death 5.8824 5 yes
GO:0034599 cellular response to oxidative stress 5.8824 4 yes
GO:2000377 regulation of reactive oxygen species metabolic process 5.8824 5 yes
GO:0048878 chemical homeostasis 5.8824 4 yes
GO:0050776 regulation of immune response 5.8824 4 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 5.8824 4 yes
GO:0051099 positive regulation of binding 5.8824 4 yes
GO:1901215 negative regulation of neuron death 5.3476 6 yes
GO:0010821 regulation of mitochondrion organization 5.3476 6 yes
GO:0031347 regulation of defense response 5.3476 5 yes
GO:0032103 positive regulation of response to external stimulus 5.3476 5 yes
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 5.3476 7 yes
GO:0043523 regulation of neuron apoptotic process 5.3476 6 yes
GO:0000302 response to reactive oxygen species 5.3476 4 yes
GO:0052547 regulation of peptidase activity 5.3476 5 yes
GO:0062012 regulation of small molecule metabolic process 4.8128 4 yes
GO:0009895 negative regulation of catabolic process 4.8128 5 yes
GO:0010822 positive regulation of mitochondrion organization 4.8128 7 yes
GO:0016053 organic acid biosynthetic process 4.8128 4 yes
GO:0018193 peptidyl-amino acid modification 4.8128 5 yes
GO:1903050 regulation of proteolysis involved in protein catabolic process 4.8128 7 yes
GO:0031334 positive regulation of protein-containing complex assembly 4.8128 6 yes
GO:0046394 carboxylic acid biosynthetic process 4.8128 5 yes
GO:0046903 secretion 4.8128 4 yes
GO:0050778 positive regulation of immune response 4.8128 5 yes
GO:0051341 regulation of oxidoreductase activity 4.8128 4 yes
GO:0052548 regulation of endopeptidase activity 4.8128 6 yes
GO:0007264 small GTPase mediated signal transduction 4.2781 4 yes
GO:0031333 negative regulation of protein-containing complex assembly 4.2781 6 yes
GO:1903202 negative regulation of oxidative stress-induced cell death 4.2781 6 yes
GO:1903321 negative regulation of protein modification by small protein conjugation or removal 4.2781 8 yes
GO:1903828 negative regulation of protein localization 4.2781 5 yes
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 4.2781 6 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 4.2781 7 yes
GO:2001236 regulation of extrinsic apoptotic signaling pathway 4.2781 6 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 4.2781 8 yes
GO:0043388 positive regulation of DNA binding 4.2781 5 yes
GO:0043393 regulation of protein binding 4.2781 4 yes
GO:0043467 regulation of generation of precursor metabolites and energy 4.2781 5 yes
GO:0050727 regulation of inflammatory response 4.2781 5 yes
GO:0051101 regulation of DNA binding 4.2781 4 yes
GO:0006281 DNA repair 4.2781 5 yes
GO:0061136 regulation of proteasomal protein catabolic process 3.7433 6 yes
GO:0007265 Ras protein signal transduction 3.7433 5 yes
GO:0008344 adult locomotory behavior 3.7433 4 yes
GO:0072330 monocarboxylic acid biosynthetic process 3.7433 6 yes
GO:1900180 regulation of protein localization to nucleus 3.7433 6 yes
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 3.7433 6 yes
GO:0023061 signal release 3.7433 4 yes
GO:1903146 regulation of autophagy of mitochondrion 3.7433 7 yes
GO:0031330 negative regulation of cellular catabolic process 3.7433 6 yes
GO:0031397 negative regulation of protein ubiquitination 3.7433 9 yes
GO:0032411 positive regulation of transporter activity 3.7433 4 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 3.7433 8 yes
GO:0033157 regulation of intracellular protein transport 3.7433 6 yes
GO:0034614 cellular response to reactive oxygen species 3.7433 5 yes
GO:2001235 positive regulation of apoptotic signaling pathway 3.7433 6 yes
GO:0042743 hydrogen peroxide metabolic process 3.7433 4 yes
GO:0051346 negative regulation of hydrolase activity 3.7433 5 yes
GO:0051438 regulation of ubiquitin-protein transferase activity 3.7433 5 yes
GO:0051881 regulation of mitochondrial membrane potential 3.7433 4 yes
GO:0006836 neurotransmitter transport 3.2086 4 yes
GO:0062013 positive regulation of small molecule metabolic process 3.2086 5 yes
GO:1900182 positive regulation of protein localization to nucleus 3.2086 6 yes
GO:0010508 positive regulation of autophagy 3.2086 7 yes
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 3.2086 7 yes
GO:0015850 organic hydroxy compound transport 3.2086 5 yes
GO:0031349 positive regulation of defense response 3.2086 5 yes
GO:0032147 activation of protein kinase activity 3.2086 8 yes
GO:1903426 regulation of reactive oxygen species biosynthetic process 3.2086 5 yes
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 3.2086 7 yes
GO:1903599 positive regulation of autophagy of mitochondrion 3.2086 8 yes
GO:0033138 positive regulation of peptidyl-serine phosphorylation 3.2086 9 yes
GO:1905897 regulation of response to endoplasmic reticulum stress 3.2086 5 yes
GO:2000379 positive regulation of reactive oxygen species metabolic process 3.2086 6 yes
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 3.2086 7 yes
GO:0042177 negative regulation of protein catabolic process 3.2086 6 yes
GO:0042542 response to hydrogen peroxide 3.2086 4 yes
GO:0043524 negative regulation of neuron apoptotic process 3.2086 7 yes
GO:0045861 negative regulation of proteolysis 3.2086 7 yes
GO:0046822 regulation of nucleocytoplasmic transport 3.2086 6 yes
GO:0051353 positive regulation of oxidoreductase activity 3.2086 5 yes
GO:0051896 regulation of protein kinase B signaling 3.2086 6 yes
GO:0006749 glutathione metabolic process 3.2086 4 yes
GO:0006954 inflammatory response 2.6738 4 yes
GO:0071692 protein localization to extracellular region 2.6738 5 yes
GO:0009306 protein secretion 2.6738 4 yes
GO:1901031 regulation of response to reactive oxygen species 2.6738 6 yes
GO:1901617 organic hydroxy compound biosynthetic process 2.6738 4 yes
GO:0015844 monoamine transport 2.6738 5 yes
GO:0015872 dopamine transport 2.6738 6 yes
GO:0031056 regulation of histone modification 2.6738 7 yes
GO:1903203 regulation of oxidative stress-induced neuron death 2.6738 6 yes
GO:1903205 regulation of hydrogen peroxide-induced cell death 2.6738 6 yes
GO:1903209 positive regulation of oxidative stress-induced cell death 2.6738 6 yes
GO:1903573 negative regulation of response to endoplasmic reticulum stress 2.6738 5 yes
GO:0032768 regulation of monooxygenase activity 2.6738 5 yes
GO:1904950 negative regulation of establishment of protein localization 2.6738 6 yes
GO:2000378 negative regulation of reactive oxygen species metabolic process 2.6738 6 yes
GO:0035592 establishment of protein localization to extracellular region 2.6738 4 yes
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 2.6738 7 yes
GO:0043457 regulation of cellular respiration 2.6738 6 yes
GO:0051224 negative regulation of protein transport 2.6738 5 yes
GO:0051897 positive regulation of protein kinase B signaling 2.6738 7 yes
GO:0051937 catecholamine transport 2.6738 6 yes
GO:0070301 cellular response to hydrogen peroxide 2.1390 5 yes
GO:0090493 catecholamine uptake 2.1390 5 yes
GO:0090494 dopamine uptake 2.1390 6 yes
GO:0098657 import into cell 2.1390 4 yes
GO:0009914 hormone transport 2.1390 4 yes
GO:0098810 neurotransmitter reuptake 2.1390 4 yes
GO:0010466 negative regulation of peptidase activity 2.1390 6 yes
GO:1901032 negative regulation of response to reactive oxygen species 2.1390 6 yes
GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death 2.1390 6 yes
GO:1901983 regulation of protein acetylation 2.1390 7 yes
GO:0010951 negative regulation of endopeptidase activity 2.1390 7 yes
GO:0015833 peptide transport 2.1390 5 yes
GO:0016570 histone modification 2.1390 5 yes
GO:1902883 negative regulation of response to oxidative stress 2.1390 5 yes
GO:1903051 negative regulation of proteolysis involved in protein catabolic process 2.1390 8 yes
GO:0030072 peptide hormone secretion 2.1390 6 yes
GO:1903204 negative regulation of oxidative stress-induced neuron death 2.1390 7 yes
GO:1903206 negative regulation of hydrogen peroxide-induced cell death 2.1390 7 yes
GO:0032148 activation of protein kinase B activity 2.1390 9 yes
GO:0032387 negative regulation of intracellular transport 2.1390 5 yes
GO:1903427 negative regulation of reactive oxygen species biosynthetic process 2.1390 6 yes
GO:1903715 regulation of aerobic respiration 2.1390 7 yes
GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 2.1390 5 yes
GO:0033238 regulation of cellular amine metabolic process 2.1390 5 yes
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 2.1390 7 yes
GO:0033500 carbohydrate homeostasis 2.1390 5 yes
GO:0035065 regulation of histone acetylation 2.1390 8 yes
GO:2000677 regulation of transcription regulatory region DNA binding 2.1390 5 yes
GO:2000679 positive regulation of transcription regulatory region DNA binding 2.1390 6 yes
GO:2000756 regulation of peptidyl-lysine acetylation 2.1390 8 yes
GO:0042053 regulation of dopamine metabolic process 2.1390 6 yes
GO:0042069 regulation of catecholamine metabolic process 2.1390 5 yes
GO:0042593 glucose homeostasis 2.1390 6 yes
GO:0042886 amide transport 2.1390 5 yes
GO:0046879 hormone secretion 2.1390 5 yes
GO:0050729 positive regulation of inflammatory response 2.1390 6 yes
GO:0051100 negative regulation of binding 2.1390 4 yes
GO:0001504 neurotransmitter uptake 2.1390 4 yes
GO:0002790 peptide secretion 2.1390 5 yes
GO:0051444 negative regulation of ubiquitin-protein transferase activity 2.1390 6 yes
GO:0051583 dopamine uptake involved in synaptic transmission 2.1390 6 yes
GO:0006089 lactate metabolic process 2.1390 4 yes
GO:0051899 membrane depolarization 2.1390 4 yes
GO:0051934 catecholamine uptake involved in synaptic transmission 2.1390 5 yes
GO:0060765 regulation of androgen receptor signaling pathway 1.6043 6 yes
GO:0072595 maintenance of protein localization in organelle 1.6043 4 yes
GO:0009438 methylglyoxal metabolic process 1.6043 4 yes
GO:0090085 regulation of protein deubiquitination 1.6043 7 yes
GO:0010155 regulation of proton transport 1.6043 7 yes
GO:0010565 regulation of cellular ketone metabolic process 1.6043 5 yes
GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death 1.6043 7 yes
GO:1901799 negative regulation of proteasomal protein catabolic process 1.6043 7 yes
GO:1901857 positive regulation of cellular respiration 1.6043 6 yes
GO:1901984 negative regulation of protein acetylation 1.6043 8 yes
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 1.6043 7 yes
GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 1.6043 7 yes
GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1.6043 6 yes
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1.6043 6 yes
GO:0018198 peptidyl-cysteine modification 1.6043 6 yes
GO:1902956 regulation of mitochondrial electron transport, NADH to ubiquinone 1.6043 8 yes
GO:1903121 regulation of TRAIL-activated apoptotic signaling pathway 1.6043 8 yes
GO:0030073 insulin secretion 1.6043 5 yes
GO:1903179 regulation of dopamine biosynthetic process 1.6043 6 yes
GO:1903181 positive regulation of dopamine biosynthetic process 1.6043 7 yes
GO:0032091 negative regulation of protein binding 1.6043 5 yes
GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 1.6043 7 yes
GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 1.6043 8 yes
GO:1903428 positive regulation of reactive oxygen species biosynthetic process 1.6043 6 yes
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 1.6043 8 yes
GO:0032677 regulation of interleukin-8 production 1.6043 5 yes
GO:0032757 positive regulation of interleukin-8 production 1.6043 6 yes
GO:0032770 positive regulation of monooxygenase activity 1.6043 6 yes
GO:1903750 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide 1.6043 7 yes
GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide 1.6043 8 yes
GO:0033233 regulation of protein sumoylation 1.6043 8 yes
GO:0033234 negative regulation of protein sumoylation 1.6043 9 yes
GO:0033240 positive regulation of cellular amine metabolic process 1.6043 6 yes
GO:2000117 negative regulation of cysteine-type endopeptidase activity 1.6043 8 yes
GO:2000273 positive regulation of signaling receptor activity 1.6043 4 yes
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 1.6043 8 yes
GO:0045915 positive regulation of catecholamine metabolic process 1.6043 6 yes
GO:0045964 positive regulation of dopamine metabolic process 1.6043 7 yes
GO:0046165 alcohol biosynthetic process 1.6043 4 yes
GO:0046825 regulation of protein export from nucleus 1.6043 7 yes
GO:0051339 regulation of lyase activity 1.6043 4 yes
GO:0002673 regulation of acute inflammatory response 1.6043 6 yes
GO:0051349 positive regulation of lyase activity 1.6043 5 yes
GO:0060081 membrane hyperpolarization 1.6043 4 yes
GO:0061727 methylglyoxal catabolic process to lactate 1.0695 5 yes
GO:0070994 detection of oxidative stress 1.0695 4 yes
GO:0009100 glycoprotein metabolic process 1.0695 4 yes
GO:0009441 glycolate metabolic process 1.0695 5 yes
GO:0090086 negative regulation of protein deubiquitination 1.0695 8 yes
GO:0090317 negative regulation of intracellular protein transport 1.0695 6 yes
GO:0106044 guanine deglycation 1.0695 6 yes
GO:0106045 guanine deglycation, methylglyoxal removal 1.0695 5 yes
GO:0106046 guanine deglycation, glyoxal removal 1.0695 7 yes
GO:0110096 cellular response to aldehyde 1.0695 4 yes
GO:0140041 cellular detoxification of methylglyoxal 1.0695 4 yes
GO:1901668 regulation of superoxide dismutase activity 1.0695 5 yes
GO:1901671 positive regulation of superoxide dismutase activity 1.0695 6 yes
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 1.0695 8 yes
GO:0018195 peptidyl-arginine modification 1.0695 6 yes
GO:0018205 peptidyl-lysine modification 1.0695 6 yes
GO:1902958 positive regulation of mitochondrial electron transport, NADH to ubiquinone 1.0695 7 yes
GO:0019249 lactate biosynthetic process 1.0695 5 yes
GO:1903072 regulation of death-inducing signaling complex assembly 1.0695 6 yes
GO:1903073 negative regulation of death-inducing signaling complex assembly 1.0695 7 yes
GO:1903093 regulation of protein K48-linked deubiquitination 1.0695 8 yes
GO:1903094 negative regulation of protein K48-linked deubiquitination 1.0695 9 yes
GO:1903122 negative regulation of TRAIL-activated apoptotic signaling pathway 1.0695 9 yes
GO:0030091 protein repair 1.0695 4 yes
GO:1903167 regulation of pyrroline-5-carboxylate reductase activity 1.0695 5 yes
GO:1903168 positive regulation of pyrroline-5-carboxylate reductase activity 1.0695 6 yes
GO:1903176 regulation of tyrosine 3-monooxygenase activity 1.0695 6 yes
GO:1903178 positive regulation of tyrosine 3-monooxygenase activity 1.0695 7 yes
GO:1903189 glyoxal metabolic process 1.0695 4 yes
GO:1903195 regulation of L-dopa biosynthetic process 1.0695 7 yes
GO:1903197 positive regulation of L-dopa biosynthetic process 1.0695 8 yes
GO:1903198 regulation of L-dopa decarboxylase activity 1.0695 5 yes
GO:1903200 positive regulation of L-dopa decarboxylase activity 1.0695 6 yes
GO:1903207 regulation of hydrogen peroxide-induced neuron death 1.0695 7 yes
GO:1903208 negative regulation of hydrogen peroxide-induced neuron death 1.0695 8 yes
GO:1903383 regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway 1.0695 8 yes
GO:1903384 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway 1.0695 9 yes
GO:1905258 regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway 1.0695 5 yes
GO:0033182 regulation of histone ubiquitination 1.0695 8 yes
GO:1905259 negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway 1.0695 6 yes
GO:2000152 regulation of ubiquitin-specific protease activity 1.0695 6 yes
GO:2000157 negative regulation of ubiquitin-specific protease activity 1.0695 7 yes
GO:0033860 regulation of NAD(P)H oxidase activity 1.0695 5 yes
GO:0033864 positive regulation of NAD(P)H oxidase activity 1.0695 6 yes
GO:2000275 regulation of oxidative phosphorylation uncoupler activity 1.0695 5 yes
GO:0034308 primary alcohol metabolic process 1.0695 4 yes
GO:2000277 positive regulation of oxidative phosphorylation uncoupler activity 1.0695 5 yes
GO:0034309 primary alcohol biosynthetic process 1.0695 5 yes
GO:2000282 regulation of cellular amino acid biosynthetic process 1.0695 6 yes
GO:2000284 positive regulation of cellular amino acid biosynthetic process 1.0695 7 yes
GO:0036471 cellular response to glyoxal 1.0695 5 yes
GO:2000825 positive regulation of androgen receptor activity 1.0695 5 yes
GO:0036525 protein deglycation 1.0695 5 yes
GO:0036526 peptidyl-cysteine deglycation 1.0695 6 yes
GO:0036527 peptidyl-arginine deglycation 1.0695 6 yes
GO:0036528 peptidyl-lysine deglycation 1.0695 6 yes
GO:0036529 protein deglycation, glyoxal removal 1.0695 5 yes
GO:0036530 protein deglycation, methylglyoxal removal 1.0695 5 yes
GO:0036531 glutathione deglycation 1.0695 5 yes
GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 1.0695 9 yes
GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 1.0695 7 yes
GO:0042182 ketone catabolic process 1.0695 4 yes
GO:0045764 positive regulation of cellular amino acid metabolic process 1.0695 6 yes
GO:0046185 aldehyde catabolic process 1.0695 4 yes
GO:0046295 glycolate biosynthetic process 1.0695 6 yes
GO:0046823 negative regulation of nucleocytoplasmic transport 1.0695 6 yes
GO:0046826 negative regulation of protein export from nucleus 1.0695 6 yes
GO:0002675 positive regulation of acute inflammatory response 1.0695 7 yes
GO:0002861 regulation of inflammatory response to antigenic stimulus 1.0695 5 yes
GO:0051457 maintenance of protein location in nucleus 1.0695 5 yes
GO:0002863 positive regulation of inflammatory response to antigenic stimulus 1.0695 6 yes
GO:0002864 regulation of acute inflammatory response to antigenic stimulus 1.0695 6 yes
GO:0051596 methylglyoxal catabolic process 1.0695 5 yes
GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus 1.0695 7 yes
GO:0006517 protein deglycosylation 1.0695 5 yes
GO:0006521 regulation of cellular amino acid metabolic process 1.0695 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in PARK7_HUMAN
DOID:331 central nervous system disease 2.6738 3 yes
DOID:0050890 synucleinopathy 2.1390 5 yes
DOID:1289 neurodegenerative disease 2.1390 4 yes
DOID:14330 Parkinsons disease 2.1390 6 yes
DOID:0060894 early-onset Parkinsons disease 1.6043 7 yes
DOID:0050700 cardiomyopathy 1.6043 4 no
DOID:0060036 intrinsic cardiomyopathy 1.6043 5 no
DOID:114 heart disease 1.6043 3 no
DOID:0060892 late onset Parkinsons disease 1.0695 7 no
DOID:0060370 Parkinsons disease 7 1.0695 8 yes
DOID:0050686 organ system cancer 1.0695 3 no
DOID:2843 long QT syndrome 1.0695 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TYDP2_HUMAN [view interactions] Low throughput no no
TENA_HUMAN [view entry] [view interactions] Low throughput yes no
BAG1_HUMAN [view interactions] Low throughput no yes
PML_HUMAN [view interactions] Low throughput no yes
PARK7_HUMAN [view entry] [view interactions] Low throughput yes yes
SAE2_HUMAN [view interactions] Low throughput no yes
UBC9_HUMAN [view interactions] Low throughput no yes
DAXX_HUMAN [view interactions] Low throughput no yes
ANDR_HUMAN [view interactions] Low throughput no no
PRDX2_HUMAN [view entry] [view interactions] Low throughput yes yes
BBS1_HUMAN [view interactions] Low throughput no no
MTA2_HUMAN [view interactions] Low throughput no yes
MTEF1_HUMAN [view interactions] Low throughput no yes
OTU7B_HUMAN [view interactions] Low throughput no yes
CLCF1_HUMAN [view interactions] Low throughput no yes
FADD_HUMAN [view interactions] Low throughput no yes
RACK1_HUMAN [view interactions] Low throughput no yes
P5CR1_HUMAN [view entry] [view interactions] Low throughput yes yes
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
BIP_HUMAN [view entry] [view interactions] Low throughput yes yes
SQSTM_HUMAN [view interactions] Low throughput no yes
GPX4_HUMAN [view entry] [view interactions] Low throughput yes no
JIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRP75_HUMAN [view entry] [view interactions] Low throughput yes yes
ITPR3_HUMAN [view interactions] Low throughput no yes
VDAC1_HUMAN [view entry] [view interactions] Low throughput yes yes
KKCC2_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
SODC_HUMAN [view interactions] Low throughput no yes
PRGC1_HUMAN [view interactions] Low throughput no no
CASP8_HUMAN [view interactions] Low throughput no yes
CASA1_HUMAN [view interactions] Low throughput no no
PITX3_HUMAN [view interactions] Low throughput no no
RAB7B_HUMAN [view interactions] Low throughput no no
RAB5B_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] Low throughput yes no
RAB3A_HUMAN [view entry] [view interactions] Low throughput yes yes
MTA1_HUMAN [view interactions] Low throughput no yes
HDAC1_HUMAN [view interactions] Low throughput no no
TR10A_HUMAN [view interactions] Low throughput no no
VHL_HUMAN [view entry] [view interactions] Low throughput yes yes
IF4A3_HUMAN [view entry] [view interactions] Low throughput yes yes
TIA1_HUMAN [view interactions] Low throughput no no
IQGA1_HUMAN [view entry] [view interactions] Low throughput yes no
PTBP1_HUMAN [view interactions] Low throughput no no
MYPT1_HUMAN [view entry] [view interactions] Low throughput yes yes
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF1B_HUMAN [view interactions] Low throughput no yes
EFCB6_HUMAN [view interactions] Low throughput no no
PIAS2_HUMAN [view interactions] Low throughput no yes
SUMO1_HUMAN [view interactions] Low throughput no yes
HIPK1_HUMAN [view interactions] Low throughput no no
MAPK5_HUMAN [view interactions] Low throughput no yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
TRAF6_HUMAN [view interactions] Low throughput no yes
RF1M_HUMAN [view interactions] Low throughput no yes
B2CL1_HUMAN [view interactions] Low throughput no yes
NONO_HUMAN [view interactions] Low throughput no yes
PINK1_HUMAN [view interactions] Low throughput no yes
MAP1B_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K5_HUMAN [view interactions] Low throughput no yes
NDUA4_HUMAN [view entry] [view interactions] Low throughput yes yes
NU1M_HUMAN [view interactions] Low throughput no yes
NDUS3_HUMAN [view entry] [view interactions] Low throughput yes yes
P53_HUMAN [view interactions] Low throughput no no
VMAT2_HUMAN [view entry] [view interactions] Low throughput yes no
PTEN_HUMAN [view entry] [view interactions] Low throughput yes yes
SFPQ_HUMAN [view entry] [view interactions] Low throughput yes yes
VAMP2_HUMAN [view entry] [view interactions] Low throughput yes no
SYPH_HUMAN [view entry] [view interactions] Low throughput yes yes
SRBP2_HUMAN [view interactions] Low throughput no yes
BAX_HUMAN [view interactions] Low throughput no yes
NDUB5_HUMAN [view interactions] High throughput no yes
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
NDUAC_HUMAN [view entry] [view interactions] High throughput yes yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB6_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
HAP28_HUMAN [view interactions] High throughput no yes
DJB11_HUMAN [view interactions] High throughput no yes
CPSF5_HUMAN [view interactions] High throughput no yes
DNJC3_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
OSCP1_HUMAN [view interactions] High throughput no yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
IFM3_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
OPTN_HUMAN [view interactions] High throughput no yes
RL24_HUMAN [view entry] [view interactions] High throughput yes yes
RL4_HUMAN [view entry] [view interactions] High throughput yes yes
ACTS_HUMAN [view interactions] High throughput no no
ACTC_HUMAN [view interactions] High throughput no no
ATPB_HUMAN [view interactions] High throughput no yes
ACLY_HUMAN [view entry] [view interactions] High throughput yes yes
COPB2_HUMAN [view entry] [view interactions] High throughput yes yes
BASP1_HUMAN [view entry] [view interactions] High throughput yes yes
CALR_HUMAN [view interactions] High throughput no yes
CATA_HUMAN [view entry] [view interactions] High throughput yes no
SEPT7_HUMAN [view entry] [view interactions] High throughput yes yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
COF1_HUMAN [view entry] [view interactions] High throughput yes no
MDHC_HUMAN [view entry] [view interactions] High throughput yes yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
EDF1_HUMAN [view interactions] High throughput no yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
HMGB1_HUMAN [view interactions] High throughput no yes
RL27_HUMAN [view entry] [view interactions] High throughput yes yes
MYL6_HUMAN [view entry] [view interactions] High throughput yes no
RS10_HUMAN [view entry] [view interactions] High throughput yes yes
RS20_HUMAN [view entry] [view interactions] High throughput yes yes
RS25_HUMAN [view entry] [view interactions] High throughput yes yes
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
RL23A_HUMAN [view entry] [view interactions] High throughput yes yes
RL32_HUMAN [view entry] [view interactions] High throughput yes yes
RL8_HUMAN [view entry] [view interactions] High throughput yes yes
MANF_HUMAN [view interactions] High throughput no yes
CYC_HUMAN [view entry] [view interactions] High throughput yes yes
IF2G_HUMAN [view interactions] High throughput no yes
ERF1_HUMAN [view interactions] High throughput no yes
T2FA_HUMAN [view interactions] High throughput no yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
GDIR1_HUMAN [view entry] [view interactions] High throughput yes yes
RL23_HUMAN [view entry] [view interactions] High throughput yes yes
YJU2B_HUMAN [view interactions] High throughput no yes
RL17_HUMAN [view entry] [view interactions] High throughput yes yes
SEP11_HUMAN [view entry] [view interactions] High throughput yes yes
SYYC_HUMAN [view interactions] High throughput no yes
QCR6L_HUMAN [view interactions] High throughput no yes
QCR6_HUMAN [view interactions] High throughput no yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
TCEA1_HUMAN [view interactions] High throughput no no
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
TBB5_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT2_HUMAN [view interactions] High throughput no no
FOXP3_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
UNK_HUMAN [view interactions] High throughput no yes
E41L5_HUMAN [view interactions] High throughput no no
UBR5_HUMAN [view interactions] High throughput no no
MCM2_HUMAN [view interactions] High throughput no no
U2AF2_HUMAN [view interactions] High throughput no yes
DUS1_HUMAN [view interactions] High throughput no no
DUS12_HUMAN [view interactions] High throughput no no
DUS19_HUMAN [view interactions] High throughput no yes
DUS2_HUMAN [view interactions] High throughput no no
DUS28_HUMAN [view interactions] High throughput no yes
DUS4_HUMAN [view entry] [view interactions] High throughput yes no
DUS6_HUMAN [view interactions] High throughput no yes
DUS9_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
PRDX1_HUMAN [view entry] [view interactions] High throughput yes yes
GLUT4_HUMAN [view interactions] High throughput no no
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
2AAB_HUMAN [view interactions] High throughput no yes
MYG_HUMAN [view interactions] High throughput no no
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
RN181_HUMAN [view interactions] High throughput no no
SLX4_HUMAN [view interactions] High throughput no yes
ACADV_HUMAN [view interactions] High throughput no yes
UBP19_HUMAN [view interactions] High throughput no no
ODP2_HUMAN [view entry] [view interactions] High throughput yes yes
BABA1_HUMAN [view interactions] High throughput no yes
CPT2_HUMAN [view entry] [view interactions] High throughput yes yes
ACSF2_HUMAN [view interactions] High throughput no no
AAPK2_HUMAN [view interactions] High throughput no yes
COPE_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
EGLN3_HUMAN [view interactions] High throughput no no
PRP8_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
OTUB1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
GAB2_HUMAN [view interactions] High throughput no yes
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
AGR2_HUMAN [view interactions] High throughput no no
HS905_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
C1TC_HUMAN [view entry] [view interactions] High throughput yes no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MYH11_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
RT09_HUMAN [view interactions] High throughput no yes
SELS_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
SPS2_HUMAN [view interactions] High throughput no no
CPSF6_HUMAN [view interactions] High throughput no yes
SELW_HUMAN [view interactions] High throughput no no
WBP11_HUMAN [view interactions] High throughput no yes
MSRB1_HUMAN [view interactions] High throughput no no
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA6_HUMAN [view entry] [view interactions] High throughput yes yes
NU2M_HUMAN [view entry] [view interactions] High throughput yes no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
NU4M_HUMAN [view interactions] High throughput no yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
NU5M_HUMAN [view interactions] High throughput no no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
COX1_HUMAN [view interactions] High throughput no yes
SAP18_HUMAN [view interactions] High throughput no yes
JUND_HUMAN [view interactions] High throughput no yes
PININ_HUMAN [view interactions] High throughput no yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
2ABG_HUMAN [view interactions] High throughput no yes
GEMI4_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
TMOD2_HUMAN [view entry] [view interactions] High throughput yes yes
TFE3_HUMAN [view interactions] High throughput no yes
PRP4_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
WWP2_HUMAN [view interactions] High throughput no no
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
ARI2_HUMAN [view interactions] High throughput no no
HDGR2_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
RT18B_HUMAN [view interactions] High throughput no yes
NGB_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
RA1L2_HUMAN [view interactions] High throughput no no
ECT2_HUMAN [view interactions] High throughput no no
EIF3B_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
IMDH2_HUMAN [view interactions] High throughput no yes
NINL_HUMAN [view interactions] High throughput no yes
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
BRD4_HUMAN [view interactions] High throughput no yes
HORN_HUMAN [view interactions] High throughput no no
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX3_HUMAN [view interactions] High throughput no yes
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
EF1G_HUMAN [view entry] [view interactions] High throughput yes yes
DKC1_HUMAN [view interactions] High throughput no yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
HNRDL_HUMAN [view interactions] High throughput no yes
PGAM1_HUMAN [view entry] [view interactions] High throughput yes yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
STMN1_HUMAN [view interactions] High throughput no yes
ILF2_HUMAN [view interactions] High throughput no yes
PTMS_HUMAN [view interactions] High throughput no yes
TAB1_HUMAN [view interactions] High throughput no yes
PDIA4_HUMAN [view interactions] High throughput no yes
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO2_HUMAN [view interactions] High throughput no yes
OAT_HUMAN [view interactions] High throughput no yes
FKBP3_HUMAN [view interactions] High throughput no yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
RBM8A_HUMAN [view interactions] High throughput no yes
PRDX6_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CHTOP_HUMAN [view interactions] High throughput no yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
AN32A_HUMAN [view interactions] High throughput no yes
ARF1_HUMAN [view entry] [view interactions] High throughput yes yes
IF6_HUMAN [view interactions] High throughput no yes
TPIS_HUMAN [view entry] [view interactions] High throughput yes yes
PPIB_HUMAN [view entry] [view interactions] High throughput yes yes
ACTBM_HUMAN [view interactions] High throughput no no
NACAM_HUMAN [view interactions] High throughput no no
PPM1B_HUMAN [view interactions] High throughput no yes
GLU2B_HUMAN [view interactions] High throughput no yes
ML12A_HUMAN [view interactions] High throughput no no
AN32B_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
THIO_HUMAN [view interactions] High throughput no yes
ANXA5_HUMAN [view entry] [view interactions] High throughput yes no
PAIRB_HUMAN [view interactions] High throughput no yes
DX39B_HUMAN [view interactions] High throughput no no
MYCBP_HUMAN [view interactions] High throughput no yes
HMGN1_HUMAN [view interactions] High throughput no yes
RNPS1_HUMAN [view interactions] High throughput no yes
PGK1_HUMAN [view entry] [view interactions] High throughput yes yes
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
MIF_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
ATIF1_HUMAN [view interactions] High throughput no yes
H2A1B_HUMAN [view interactions] High throughput no yes
HMGA1_HUMAN [view interactions] High throughput no yes
BOLA2_HUMAN [view interactions] High throughput no yes
RIN3_HUMAN [view interactions] High throughput no yes
BCLF1_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
SPNDC_HUMAN [view interactions] High throughput no yes
PD1L1_HUMAN [view interactions] High throughput no no
THOC4_HUMAN [view interactions] High throughput no no
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
TR150_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
M4K1_HUMAN [view interactions] High throughput no no
PPM1D_HUMAN [view interactions] High throughput no no
M4K5_HUMAN [view interactions] High throughput no no
PPTC7_HUMAN [view interactions] High throughput no yes
ZBTB2_HUMAN [view interactions] High throughput no yes
PHOP1_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
CLU_HUMAN [view interactions] High throughput no yes
M3K7_HUMAN [view interactions] High throughput no yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RIPK4_HUMAN [view interactions] High throughput no no
RANB9_HUMAN [view entry] [view interactions] High throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
SAR1B_HUMAN [view interactions] High throughput no yes
MYLK4_HUMAN [view interactions] High throughput no no
RET_HUMAN [view interactions] High throughput no yes
CDKL3_HUMAN [view interactions] High throughput no no
NEK7_HUMAN [view interactions] High throughput no yes
KPCD2_HUMAN [view interactions] High throughput no yes
PHAG1_HUMAN [view interactions] High throughput no yes
LMTK3_HUMAN [view entry] [view interactions] High throughput yes yes
LIN37_HUMAN [view interactions] High throughput no yes
LIN54_HUMAN [view interactions] High throughput no yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
RBBP4_HUMAN [view interactions] High throughput no yes
PRDX5_HUMAN [view entry] [view interactions] High throughput yes yes
ATP5J_HUMAN [view interactions] High throughput no yes
MBD3_HUMAN [view interactions] High throughput no yes
TALDO_HUMAN [view entry] [view interactions] High throughput yes no
ANXA7_HUMAN [view entry] [view interactions] High throughput yes yes
CHD2_HUMAN [view interactions] High throughput no yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC2_HUMAN [view interactions] High throughput no yes
IMPA2_HUMAN [view interactions] High throughput no no
RBBP7_HUMAN [view interactions] High throughput no yes
ITPA_HUMAN [view interactions] High throughput no yes
P66B_HUMAN [view interactions] High throughput no yes
LYPA1_HUMAN [view interactions] High throughput no yes
HINT1_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
NIT2_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
PIR_HUMAN [view interactions] High throughput no no
IKBE_HUMAN [view entry] [view interactions] High throughput yes yes
SPRE_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
THTM_HUMAN [view interactions] High throughput no yes
PDIP2_HUMAN [view interactions] High throughput no no
ISOC2_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
NENF_HUMAN [view interactions] High throughput no yes
GOPC_HUMAN [view entry] [view interactions] High throughput yes yes
KCY_HUMAN [view entry] [view interactions] High throughput yes yes
A2MG_HUMAN [view interactions] High throughput no yes
ACOT1_HUMAN [view interactions] High throughput no yes
NUP43_HUMAN [view interactions] High throughput no yes
KAD3_HUMAN [view entry] [view interactions] High throughput yes yes
SPA2L_HUMAN [view entry] [view interactions] High throughput yes yes
LEG3_HUMAN [view interactions] High throughput no yes
KRA92_HUMAN [view interactions] High throughput no no
HINT2_HUMAN [view interactions] High throughput no yes
LDH6B_HUMAN [view interactions] High throughput no no
KPYM_HUMAN [view interactions] High throughput no yes
WDR61_HUMAN [view interactions] High throughput no yes
GSTP1_HUMAN [view entry] [view interactions] High throughput yes no
RN112_HUMAN [view entry] [view interactions] High throughput yes yes
THIM_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
THEM4_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
6PGL_HUMAN [view interactions] High throughput no yes
GRHPR_HUMAN [view entry] [view interactions] High throughput yes no
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
COF2_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1A_HUMAN [view interactions] High throughput no yes
FAH2A_HUMAN [view interactions] High throughput no yes
TIFAB_HUMAN [view interactions] High throughput no no
QOR_HUMAN [view entry] [view interactions] High throughput yes yes
GLRX5_HUMAN [view interactions] High throughput no yes
MSRB2_HUMAN [view interactions] High throughput no no
PCNA_HUMAN [view interactions] High throughput no no
DEST_HUMAN [view entry] [view interactions] High throughput yes yes
SNF5_HUMAN [view interactions] High throughput no yes
ADA_HUMAN [view interactions] High throughput no no
EPHA6_HUMAN [view interactions] High throughput no no
COPD_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR4_HUMAN [view interactions] High throughput no no
CLIC1_HUMAN [view interactions] High throughput no no
MERTK_HUMAN [view interactions] High throughput no yes
DDAH1_HUMAN [view entry] [view interactions] High throughput yes no
DDAH2_HUMAN [view interactions] High throughput no yes
GCSH_HUMAN [view interactions] High throughput no yes
IDHP_HUMAN [view entry] [view interactions] High throughput yes yes
LACB2_HUMAN [view interactions] High throughput no yes
ACPM_HUMAN [view interactions] High throughput no yes
NOS2_HUMAN [view interactions] High throughput no yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
CA198_HUMAN [view interactions] High throughput no yes
CHD4_HUMAN [view interactions] High throughput no yes
CLIC4_HUMAN [view interactions] High throughput no no
HDHD3_HUMAN [view interactions] High throughput no yes
PDP1_HUMAN [view interactions] High throughput no yes
RFIP5_HUMAN [view entry] [view interactions] High throughput yes yes
PGM1_HUMAN [view interactions] High throughput no no
TFE2_HUMAN [view interactions] High throughput no no
UCHL1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
NDUAA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA5_HUMAN [view entry] [view interactions] High throughput yes yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB7_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS4_HUMAN [view interactions] High throughput no yes
NDUS5_HUMAN [view interactions] High throughput no yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
CYTB_HUMAN [view interactions] High throughput no no
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV3_HUMAN [view interactions] High throughput no yes
NDUA6_HUMAN [view interactions] High throughput no no
MB12A_HUMAN [view interactions] Computational no yes
HDAC6_HUMAN [view interactions] Computational no yes
HS90A_HUMAN [view entry] [view interactions] Computational yes yes
VPS28_HUMAN [view entry] [view interactions] Computational yes yes
UBAP1_HUMAN [view interactions] Computational no yes
VPS35_HUMAN [view entry] [view interactions] Computational yes yes
CHM2A_HUMAN [view interactions] Computational no yes
STRN3_HUMAN [view interactions] Computational no yes
VP37B_HUMAN [view interactions] Computational no yes
NCF1_HUMAN [view interactions] Computational no no
SODM_HUMAN [view entry] [view interactions] Computational yes no
CHMP6_HUMAN [view interactions] Computational no yes
NF2L2_HUMAN [view interactions] Computational no yes
CHM4C_HUMAN [view interactions] Computational no yes
CHM2B_HUMAN [view entry] [view interactions] Computational yes yes
MB12B_HUMAN [view interactions] Computational no no
VP37C_HUMAN [view interactions] Computational no yes
LGUL_HUMAN [view interactions] Computational no yes
KEAP1_HUMAN [view interactions] Computational no yes
HSP7C_HUMAN [view entry] [view interactions] Computational yes yes
AT132_HUMAN [view interactions] Computational no yes
CHMP7_HUMAN [view interactions] Computational no yes
VP37D_HUMAN [view interactions] Computational no no
CHM4A_HUMAN [view interactions] Computational no no
VP37A_HUMAN [view interactions] Computational no yes
ERBB3_HUMAN [view interactions] Computational no yes
TS101_HUMAN [view entry] [view interactions] Computational yes yes