ACLY_HUMAN
Evidence for PS localization
Functions
Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 55%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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ACLY_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [ACLY_HUMAN]
Isoform [P53396-2] alignment
Isoform [P53396-3] alignment
Isoform [K7EIE7] alignment
Isoform [K7ESG8] alignment
LOADING 55%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
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Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACLY_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 33.6449 | 4 | yes |
| GO:0003723 | RNA binding | 32.7103 | 4 | no |
| GO:0000166 | nucleotide binding | 31.7757 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 31.7757 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 29.9065 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.9065 | 4 | yes |
| GO:0043169 | cation binding | 27.1028 | 4 | yes |
| GO:0046872 | metal ion binding | 27.1028 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 26.1682 | 6 | yes |
| GO:0005524 | ATP binding | 24.2991 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 24.2991 | 5 | yes |
| GO:0045296 | cadherin binding | 23.3645 | 4 | no |
| GO:0046912 | acyltransferase activity, acyl groups converted into alkyl on transfer | 2.8037 | 4 | yes |
| GO:0003878 | ATP citrate synthase activity | 1.8692 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACLY_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 67.2897 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 61.6822 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 61.6822 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 61.6822 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 55.1402 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 54.2056 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 52.3364 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 50.4673 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 47.6636 | 4 | no |
| GO:0010468 | regulation of gene expression | 47.6636 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.8598 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 43.9252 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.9907 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 42.9907 | 5 | no |
| GO:0009966 | regulation of signal transduction | 41.1215 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 41.1215 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 39.2523 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 39.2523 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 38.3178 | 5 | no |
| GO:0022607 | cellular component assembly | 38.3178 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 37.3832 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.4486 | 5 | no |
| GO:0006996 | organelle organization | 36.4486 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 36.4486 | 6 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 35.5140 | 6 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABD_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABG_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCG1_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| ACLY_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
| AMPD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |