ACLY_HUMAN
Evidence for PS localization
Functions
Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACLY_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 30.4348 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 27.5362 | 4 | yes |
| GO:0003723 | RNA binding | 27.5362 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.0870 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.6377 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 23.1884 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 21.7391 | 5 | yes |
| GO:0005524 | ATP binding | 20.2899 | 5 | yes |
| GO:0019900 | kinase binding | 20.2899 | 4 | no |
| GO:0046912 | acyltransferase activity, acyl groups converted into alkyl on transfer | 4.3478 | 4 | yes |
| GO:0003878 | ATP citrate synthase activity | 2.8986 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACLY_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.5217 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 53.6232 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 52.1739 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.1739 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.7246 | 4 | no |
| GO:0010468 | regulation of gene expression | 44.9275 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 43.4783 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.4783 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.5797 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 39.1304 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 37.6812 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 37.6812 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.6812 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 37.6812 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 37.6812 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.2319 | 5 | no |
| GO:0010941 | regulation of cell death | 36.2319 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 36.2319 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 34.7826 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 34.7826 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 33.3333 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 33.3333 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 31.8841 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 31.8841 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 31.8841 | 6 | no |
| GO:0031399 | regulation of protein modification process | 30.4348 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 28.9855 | 4 | yes |
| GO:0022607 | cellular component assembly | 28.9855 | 4 | no |
| GO:0036211 | protein modification process | 28.9855 | 4 | no |
| GO:0043412 | macromolecule modification | 28.9855 | 4 | no |
| GO:0071310 | cellular response to organic substance | 28.9855 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.9855 | 4 | no |
| GO:0006996 | organelle organization | 28.9855 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.9855 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 28.9855 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.9855 | 4 | no |
| GO:0051049 | regulation of transport | 28.9855 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 27.5362 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 27.5362 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 27.5362 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.0870 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.0870 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 24.6377 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 24.6377 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.6377 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 24.6377 | 5 | no |
| GO:0010942 | positive regulation of cell death | 23.1884 | 5 | no |
| GO:0032880 | regulation of protein localization | 23.1884 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.1884 | 4 | no |
| GO:0051050 | positive regulation of transport | 23.1884 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.7391 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.7391 | 6 | no |
| GO:0033043 | regulation of organelle organization | 21.7391 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 21.7391 | 7 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.7391 | 6 | no |
| GO:0080134 | regulation of response to stress | 21.7391 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 21.7391 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.7391 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.7391 | 4 | no |
| GO:0060548 | negative regulation of cell death | 21.7391 | 5 | no |
| GO:0008104 | protein localization | 21.7391 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 20.2899 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 20.2899 | 7 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 20.2899 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.2899 | 5 | no |
| GO:0009894 | regulation of catabolic process | 20.2899 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.2899 | 6 | no |
| GO:0031400 | negative regulation of protein modification process | 20.2899 | 7 | no |
| GO:0043065 | positive regulation of apoptotic process | 20.2899 | 7 | no |
| GO:0043068 | positive regulation of programmed cell death | 20.2899 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.2899 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.2899 | 6 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.2899 | 4 | no |
| GO:0043933 | protein-containing complex organization | 20.2899 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 20.2899 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 20.2899 | 6 | no |
| GO:0051338 | regulation of transferase activity | 20.2899 | 4 | no |
| GO:0032787 | monocarboxylic acid metabolic process | 17.3913 | 6 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 17.3913 | 4 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 14.4928 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 14.4928 | 5 | yes |
| GO:0019438 | aromatic compound biosynthetic process | 14.4928 | 4 | yes |
| GO:0043603 | cellular amide metabolic process | 14.4928 | 4 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 14.4928 | 4 | yes |
| GO:0006163 | purine nucleotide metabolic process | 13.0435 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 13.0435 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 13.0435 | 5 | yes |
| GO:0018130 | heterocycle biosynthetic process | 13.0435 | 4 | yes |
| GO:0019693 | ribose phosphate metabolic process | 13.0435 | 4 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 13.0435 | 4 | yes |
| GO:0072521 | purine-containing compound metabolic process | 13.0435 | 4 | yes |
| GO:0090407 | organophosphate biosynthetic process | 13.0435 | 4 | yes |
| GO:0006164 | purine nucleotide biosynthetic process | 11.5942 | 6 | yes |
| GO:0006631 | fatty acid metabolic process | 11.5942 | 4 | yes |
| GO:0009152 | purine ribonucleotide biosynthetic process | 11.5942 | 7 | yes |
| GO:0009165 | nucleotide biosynthetic process | 11.5942 | 6 | yes |
| GO:0009260 | ribonucleotide biosynthetic process | 11.5942 | 6 | yes |
| GO:0016053 | organic acid biosynthetic process | 11.5942 | 4 | yes |
| GO:0043604 | amide biosynthetic process | 11.5942 | 5 | yes |
| GO:0043648 | dicarboxylic acid metabolic process | 11.5942 | 6 | yes |
| GO:0046390 | ribose phosphate biosynthetic process | 11.5942 | 5 | yes |
| GO:0046394 | carboxylic acid biosynthetic process | 11.5942 | 5 | yes |
| GO:0072522 | purine-containing compound biosynthetic process | 11.5942 | 5 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 11.5942 | 4 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 11.5942 | 5 | yes |
| GO:0006637 | acyl-CoA metabolic process | 8.6957 | 4 | yes |
| GO:0008610 | lipid biosynthetic process | 8.6957 | 4 | yes |
| GO:0033865 | nucleoside bisphosphate metabolic process | 8.6957 | 5 | yes |
| GO:0033866 | nucleoside bisphosphate biosynthetic process | 8.6957 | 6 | yes |
| GO:0033875 | ribonucleoside bisphosphate metabolic process | 8.6957 | 6 | yes |
| GO:0034030 | ribonucleoside bisphosphate biosynthetic process | 8.6957 | 7 | yes |
| GO:0034032 | purine nucleoside bisphosphate metabolic process | 8.6957 | 5 | yes |
| GO:0034033 | purine nucleoside bisphosphate biosynthetic process | 8.6957 | 6 | yes |
| GO:0035384 | thioester biosynthetic process | 8.6957 | 4 | yes |
| GO:0044272 | sulfur compound biosynthetic process | 8.6957 | 4 | yes |
| GO:0071616 | acyl-CoA biosynthetic process | 8.6957 | 5 | yes |
| GO:0006084 | acetyl-CoA metabolic process | 7.2464 | 5 | yes |
| GO:0006107 | oxaloacetate metabolic process | 7.2464 | 7 | yes |
| GO:0008202 | steroid metabolic process | 7.2464 | 4 | yes |
| GO:0072330 | monocarboxylic acid biosynthetic process | 7.2464 | 6 | yes |
| GO:0072350 | tricarboxylic acid metabolic process | 7.2464 | 6 | yes |
| GO:1901617 | organic hydroxy compound biosynthetic process | 7.2464 | 4 | yes |
| GO:0006085 | acetyl-CoA biosynthetic process | 5.7971 | 6 | yes |
| GO:0006101 | citrate metabolic process | 5.7971 | 7 | yes |
| GO:0006633 | fatty acid biosynthetic process | 5.7971 | 5 | yes |
| GO:0046165 | alcohol biosynthetic process | 5.7971 | 4 | yes |
| GO:1902652 | secondary alcohol metabolic process | 5.7971 | 4 | yes |
| GO:0008203 | cholesterol metabolic process | 4.3478 | 5 | yes |
| GO:0015936 | coenzyme A metabolic process | 4.3478 | 6 | yes |
| GO:0016125 | sterol metabolic process | 4.3478 | 4 | yes |
| GO:0006694 | steroid biosynthetic process | 2.8986 | 5 | yes |
| GO:0006695 | cholesterol biosynthetic process | 2.8986 | 6 | yes |
| GO:0016126 | sterol biosynthetic process | 2.8986 | 5 | yes |
| GO:1902653 | secondary alcohol biosynthetic process | 2.8986 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ACLY_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 4.3478 | 4 | no |
| DOID:331 | central nervous system disease | 4.3478 | 3 | no |
| DOID:0050686 | organ system cancer | 2.8986 | 3 | no |
| DOID:0050890 | synucleinopathy | 2.8986 | 5 | no |
| DOID:0060894 | early-onset Parkinsons disease | 2.8986 | 7 | no |
| DOID:14330 | Parkinsons disease | 2.8986 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CUL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACLY_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBR4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KAT2B_HUMAN | [view interactions] | Low throughput | no | yes |
| SIR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP13_HUMAN | [view interactions] | Low throughput | no | yes |
| KLH25_HUMAN | [view interactions] | Low throughput | no | yes |
| CIC_HUMAN | [view interactions] | Low throughput | no | yes |
| MAGD2_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MCM6_HUMAN | [view interactions] | High throughput | no | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| CGL_HUMAN | [view interactions] | High throughput | no | yes |
| EF1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNCB_HUMAN | [view interactions] | High throughput | no | no |
| P210L_HUMAN | [view interactions] | High throughput | no | no |
| RPE_HUMAN | [view interactions] | High throughput | no | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMPD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| AP2C_HUMAN | [view interactions] | High throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| NU107_HUMAN | [view interactions] | High throughput | no | no |
| OPA3_HUMAN | [view interactions] | High throughput | no | yes |
| PAK4_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG6_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDN2A_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABD_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYLK_HUMAN | [view interactions] | High throughput | no | no |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYLK4_HUMAN | [view interactions] | High throughput | no | no |
| PIM3_HUMAN | [view interactions] | High throughput | no | no |
| MK15_HUMAN | [view interactions] | High throughput | no | no |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| PAK6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNA1_HUMAN | [view interactions] | High throughput | no | no |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TR10D_HUMAN | [view interactions] | High throughput | no | no |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ATF6A_HUMAN | [view interactions] | High throughput | no | yes |
| LMBL2_HUMAN | [view interactions] | High throughput | no | no |
| DDIAS_HUMAN | [view interactions] | High throughput | no | no |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| ASB15_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRY1_HUMAN | [view interactions] | High throughput | no | yes |
| CRY2_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| ABCG1_HUMAN | [view interactions] | High throughput | no | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A1_HUMAN | [view interactions] | High throughput | no | no |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABG_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| RIOK1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF3B_HUMAN | [view interactions] | High throughput | no | yes |
| DUS28_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| HELLS_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| RMC1_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| TFDP2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAX_HUMAN | [view interactions] | High throughput | no | yes |
| VTNC_HUMAN | [view interactions] | High throughput | no | no |
| ASXL1_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| PAGE4_HUMAN | [view interactions] | High throughput | no | no |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| CTIF_HUMAN | [view interactions] | High throughput | no | yes |
| FBX43_HUMAN | [view interactions] | High throughput | no | no |
| STT3A_HUMAN | [view interactions] | High throughput | no | yes |
| HMGN5_HUMAN | [view interactions] | High throughput | no | no |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| PRP19_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO3_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMA3_HUMAN | [view interactions] | High throughput | no | yes |
| PPP6_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| FUMH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MLX_HUMAN | [view interactions] | Computational | no | yes |
| ACACB_HUMAN | [view interactions] | Computational | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| OXLA_HUMAN | [view interactions] | Computational | no | no |
| ODP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| THIC_HUMAN | [view interactions] | Computational | no | yes |
| HMCS1_HUMAN | [view interactions] | Computational | no | yes |
| SUCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PCKGC_HUMAN | [view interactions] | Computational | no | no |
| ACON_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PCKGM_HUMAN | [view interactions] | Computational | no | no |
| MUTA_HUMAN | [view interactions] | Computational | no | yes |
| HMGCL_HUMAN | [view interactions] | Computational | no | yes |
| ARLY_HUMAN | [view interactions] | Computational | no | no |
| PYC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SSDH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| THIL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RIMKB_HUMAN | [view interactions] | Computational | no | no |
| AATC2_HUMAN | [view interactions] | Computational | no | no |
| ACOHC_HUMAN | [view interactions] | Computational | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AATM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACACA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HMGC2_HUMAN | [view interactions] | Computational | no | no |
| ACSA_HUMAN | [view interactions] | Computational | no | no |
| TXTP_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PUR8_HUMAN | [view interactions] | Computational | no | yes |
| THIM_HUMAN | [view interactions] | Computational | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DHE3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DHE4_HUMAN | [view interactions] | Computational | no | yes |
| THIK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NIT2_HUMAN | [view interactions] | Computational | no | yes |
| MLXPL_HUMAN | [view interactions] | Computational | no | no |
| HMCS2_HUMAN | [view interactions] | Computational | no | no |